1,653 research outputs found
Functional role of HLA class I cell-surface molecules in human T-lymphocyte activation and proliferation.
Ultrasonic monitoring of friction contacts during shear vibration cycles
Complex high-value jointed structures such as aero-engines are carefully designed and optimized to prevent failure and maximise their life. In the design process, physically-based numerical models are employed to predict the nonlinear dynamic response of the structure. However, the reliability of these models is limited due to the lack of accurate validation data from metallic contact interfaces subjected to high-frequency vibration cycles. In this study, ultrasonic shear waves are used to characterise metallic contact interfaces during vibration cycles, hence providing new validation data for an understanding of the state of the friction contact. Supported by numerical simulations of wave propagation within the material, a novel experimental method is developed to simultaneously acquire ultrasonic measurements and friction hysteresis loops within the same test on a high-frequency friction rig. Large variability in the ultrasound reflection/transmission is observed within each hysteresis loop and is associated with stick/slip transitions. The measurement results reveal that the ultrasound technique can be used to detect stick and slip states in contact interfaces subjected to high-frequency shear vibration. This is the first observation of this type and paves the way towards real-time monitoring of vibrating contact interfaces in jointed structures, leading to a new physical understanding of the contact states and new validation data needed for improved nonlinear dynamic analyses
Phylogenetic relationships of haplolepideous mosses (Dicranidae) inferred from rps4 gene sequences
The haplolepideous mosses (Dicranidae) constitute a large group of ecologically and
morphologically diverse species recognised primarily by having peristome teeth with a
single row of cells on the dorsal surface
A variable amplitude fretting fatigue life estimation technique: formulation and experimental validation
The aims of the research work summarised in this paper are twofold. The first goal is to make available a large number of new experimental results generated by testing specimens of grey cast iron under both constant and variable amplitude fretting fatigue loading. The second goal is to formulate an advanced fretting fatigue design approach based on the combined use of the Modified Wӧhler Curve Method, the Theory of Critical Distances and the Shear Stress-Maximum Variance Method. The validation exercise based on the experimental results being produced demonstrates that the proposed methodology is a powerful tool suitable for designing mechanical assemblies against fretting fatigue
Stress analysis of V-notches with and without cracks, with application to foreign object damage
Published versio
European wildcat populations are subdivided into five main biogeographic groups: consequences of Pleistocene climate changes or recent anthropogenic fragmentation?
Extant populations of the European wildcat are fragmented across the continent, the likely consequence of recent extirpations due to habitat loss and over-hunting. However, their underlying phylogeographic history has never been reconstructed. For testing the hypothesis that the European wildcat survived the Ice Age fragmented in Mediterranean refuges, we assayed the genetic variation at 31 microsatellites in 668 presumptive European wildcats sampled in 15 European countries. Moreover, to evaluate the extent of subspecies/population divergence and identify eventual wild × domestic cat hybrids, we genotyped 26 African wildcats from Sardinia and North Africa and 294 random-bred domestic cats. Results of multivariate analyses and Bayesian clustering confirmed that the European wild and the domestic cats (plus the African wildcats) belong to two well-differentiated clusters (average Ф ST = 0.159, r st = 0.392, P > 0.001; Analysis of molecular variance [AMOVA]). We identified from c. 5% to 10% cryptic hybrids in southern and central European populations. In contrast, wild-living cats in Hungary and Scotland showed deep signatures of genetic admixture and introgression with domestic cats. The European wildcats are subdivided into five main genetic clusters (average Ф ST = 0.103, r st = 0.143, P > 0.001; AMOVA) corresponding to five biogeographic groups, respectively, distributed in the Iberian Peninsula, central Europe, central Germany, Italian Peninsula and the island of Sicily, and in north-eastern Italy and northern Balkan regions (Dinaric Alps). Approximate Bayesian Computation simulations supported late Pleistocene-early Holocene population splittings (from c. 60 k to 10 k years ago), contemporary to the last Ice Age climatic changes. These results provide evidences for wildcat Mediterranean refuges in southwestern Europe, but the evolution history of eastern wildcat populations remains to be clarified. Historical genetic subdivisions suggest conservation strategies aimed at enhancing gene flow through the restoration of ecological corridors within each biogeographic units. Concomitantly, the risk of hybridization with free-ranging domestic cats along corridor edges should be carefully monitored
The impact of fretting wear on structural dynamics: Experiment and simulation
This paper investigates the effects of fretting wear on frictional contacts. A high frequency friction rig is used to measure the evolution of hysteresis loops, friction coefficient and tangential contact stiffness over time. This evolution of the contact parameters is linked to significant changes in natural frequencies and damping of the rig. Hysteresis loops are replicated by using a Bouc-Wen modified formulation, which includes wear to simulate the evolution of contact parameters and to model the evolving dynamic behaviour of the rig. A comparison of the measured and predicted dynamic behaviour demonstrates the feasibility of the proposed approach and highlights the need to consider wear to accurately capture the dynamic response of a system with frictional joints over its lifetime
The impact of fretting wear on structural dynamics: Experiment and simulation
This paper investigates the effects of fretting wear on frictional contacts. A high frequency friction rig is used to measure the evolution of hysteresis loops, friction coefficient and tangential contact stiffness over time. This evolution of the contact parameters is linked to significant changes in natural frequencies and damping of the rig. Hysteresis loops are replicated by using a Bouc-Wen modified formulation, which includes wear to simulate the evolution of contact parameters and to model the evolving dynamic behaviour of the rig. A comparison of the measured and predicted dynamic behaviour demonstrates the feasibility of the proposed approach and highlights the need to consider wear to accurately capture the dynamic response of a system with frictional joints over its lifetime
A reaction-diffusion model for the growth of avascular tumor
A nutrient-limited model for avascular cancer growth including cell
proliferation, motility and death is presented. The model qualitatively
reproduces commonly observed morphologies for primary tumors, and the simulated
patterns are characterized by its gyration radius, total number of cancer
cells, and number of cells on tumor periphery. These very distinct
morphological patterns follow Gompertz growth curves, but exhibit different
scaling laws for their surfaces. Also, the simulated tumors incorporate a
spatial structure composed of a central necrotic core, an inner rim of
quiescent cells and a narrow outer shell of proliferating cells in agreement
with biological data. Finally, our results indicate that the competition for
nutrients among normal and cancer cells may be a determinant factor in
generating papillary tumor morphology.Comment: 9 pages, 6 figures, to appear in PR
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