1,347 research outputs found
Analysis by x-ray microtomography of a granular packing undergoing compaction
Several acquisitions of X-ray microtomography have been performed on a beads
packing while it compacts under vertical vibrations. An image analysis allows
to study the evolution of the packing structure during its progressive
densification. In particular, the volume distribution of the pores reveals a
large tail, compatible to an exponential law, which slowly reduces as the
system gets more compact. This is quite consistent, for large pores, with the
free volume theory. These results are also in very good agreement with those
obtained by a previous numerical model of granular compaction.Comment: 4 pages, 4 figures. Latex (revtex4). to be published in Phys. Rev.
Perinatal Manganese Exposure and Hydroxyl Radical Formation in Rat Brain
The present study was designed to investigate the role of pre- and postnatal manganese (Mn) exposure on hydroxyl radical (HOâą) formation in the brains of dopamine (DA) partially denervated rats (Parkinsonian rats). Wistar rats were given tap water containing 10,000 ppm manganese chloride during the duration of pregnancy and until the time of weaning. Control rat dams consumed tap water without added Mn. Three days after birth, rats of both groups were treated with 6-hydroxydopamine at one of three doses (15, 30, or 67 ”g, intraventricular on each side), or saline vehicle. We found that Mn content in the brain, kidney, liver, and bone was significantly elevated in dams exposed to Mn during pregnancy. In neonates, the major organs that accumulated Mn were the femoral bone and liver. However, Mn was not elevated in tissues in adulthood. To determine the possible effect on generation of the reactive species, HOâą in Mn-induced neurotoxicity, we analyzed the contents of 2.3- and 2.5-dihydroxybenzoic acid (spin trap products of salicylate; HOâą being an index of in vivo HOâą generation), as well as antioxidant enzyme activities of superoxide dismutase (SOD) isoenzymes and glutathione S-transferase (GST). 6-OHDA-depletion of DA produced enhanced HOâą formation in the brain tissue of newborn and adulthood rats that had been exposed to Mn, and the latter effect did not depend on the extent of DA denervation. Additionally, the extraneuronal, microdialysate, content of HOâą in neostriatum was likewise elevated in 6-OHDA-lesioned rats. Interestingly, there was no difference in extraneuronal HOâą formation in the neostriatum of Mn-exposed versus control rats. In summary, findings in this study indicate that Mn crosses the placenta but in contrast to other heavy metals, Mn is not deposited long term in tissues. Also, damage to the dopaminergic system acts as a âtrigger mechanism,â initiating a cascade of adverse events leading to a protracted increase in HOâą generation, and the effects of Mn and 6-OHDA are compounded. Moreover, HOâą generation parallels the suppression of SOD isoenzymes and GST in the brains of rats lesioned with 6-OHDA and/or intoxicated with Mnâthe most prominent impairments being in frontal cortex, striatum, and brain stem. In conclusion, ontogenetic Mn exposure, resulting in reactive oxygen species, HOâą formation, represents a risk factor for dopaminergic neurotoxicity and development of neurodegenerative disorders
Correlated radio--X-ray variability of Galactic Black Holes: A radio--X-ray flare in Cygnus X-1
We report on the first detection of a quasi-simultaneous radio-X-ray flare of
Cygnus X-1. The detection was made on 2005 April 16 with pointed observations
by the Rossi X-ray Timing Explorer and the Ryle telescope, during a phase where
the black hole candidate was close to a transition from the its soft into its
hard state. The radio flare lagged the X-rays by approximately 7 minutes,
peaking at 3:20 hours barycentric time (TDB 2453476.63864). We discuss this lag
in the context of models explaining such flaring events as the ejection of
electron bubbles emitting synchrotron radiation.Comment: 4 pages, 4 figure
High intensity tapping regime in a frustrated lattice gas model of granular compaction
In the frame of a well established lattice gas model for granular compaction,
we investigate the high intensity tapping regime where a pile expands
significantly during external excitation. We find that this model shows the
same general trends as more sophisticated models based on molecular dynamic
type simulations. In particular, a minimum in packing fraction as a function of
tapping strength is observed in the reversible branch of an annealed tapping
protocol.Comment: 5 pages, 4 figure
An X-Ray View of the Jet-Cycle in the Radio Loud AGN 3C120
We present a study of the central engine in the broad-line radio galaxy 3C120
using a multi-epoch analysis of a deep XMM-Newton observation and two deep
Suzaku pointings (in 2012). In order to place our spectral data into the
context of the disk-disruption/jet-ejection cycles displayed by this object, we
monitor the source in the UV/X-ray bands, and in the radio band. We find three
statistically acceptable spectral models, a disk-reflection model, a jet-model
and a jet+disk model. Despite being good descriptions of the data, the
disk-reflection model violates the radio constraints on the inclination, and
the jet-model has a fine-tuning problem, requiring a jet contribution exceeding
that expected. Thus, we argue for a composite jet+disk model. Within the
context of this model, we verify the basic predictions of the jet-cycle
paradigm, finding a truncated/refilling disk during the Suzaku observations and
a complete disk extending down to the innermost stable circular orbit (ISCO)
during the XMM-Newton observation. The idea of a refilling disk is further
supported by the detection of the ejection of a new jet knot approximately one
month after the Suzaku pointings. We also discover a step-like event in one of
the Suzaku pointings in which the soft band lags the hard band. We suggest that
we are witnessing the propagation of a disturbance from the disk into the jet
on a timescale set by the magnetic field.Comment: 14 pages, 10 figures, accepted for publication in Ap
A Review of the Federal Guidelines That Inform and Influence Relationships Between Physicians and Industry
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73492/1/j.1553-2712.2009.00460.x.pd
Prognostic Utility of a Modified HEART Score When Different Troponin Cut-points Are Used
BACKGROUND: Although the recommended cut-point for cardiac troponin (cTn) is the 99th percentile, many institutions use cut-points that are multiples higher than the 99th percentile for diagnosing acute myocardial infarction (AMI). Prior studies have shown that patients with a HEART score (HS) †3 and normal serial cTn values (modified HS) are at low risk for adverse events. This study aimed to evaluate the prognostic utility of the HS when various cTn cut-points are used.
METHODS: This was a sub-study of TRAPID-AMI, a multicenter, international trial evaluating a rapid rule-out AMI study using high sensitivity cTnT (hs-cTnT). 1,282 patients were evaluated for AMI from 12 centers in Europe, United States of America, and Australia from 2011-2013. Blood samples of hs-cTnT were collected at presentation and 2 hours, and each patient had a HS calculated. The US Food and Drug Administration approved 99th percentile for hs-cTnT (19âng/L) was used.
RESULTS: There were 213 (17%) AMIs. Within 30 days, there were an additional 2 AMIs and 8 deaths. The adverse event rates at 30 days (death/AMI) for a HS †3 and non-elevated hs-cTnT over 2 hours using increasing hs-cTnT cut-points ranged from 0.6% to 5.1%.
CONCLUSIONS: Using the recommended 99th percentile cut-point for hs-cTnT, the combination of a HS †3 with non-elevated hs-cTnT values over 2 hours identifies a low-risk cohort who can be considered for discharge from the emergency department without further testing. The prognostic utility of this strategy is greatly lessened as higher hs-cTnT cut-points are used
The Association Between Money and Opinion in Academic Emergency Medicine
Objectives: Financial conflicts of interest have come under increasing scrutiny in medicine, but their impact has not been quantified. Our objective was to use the results of a national survey of academic emergency medicine (EM) faculty to determine if an association between money and personal opinion exists.Methods: We conducted a web-based survey of EM faculty. Opinion questions were analyzed with regard to whether the respondent had either 1) received research grant money or 2) received money from industry as a speaker, consultant, or advisor. Responses were unweighted, and tests of differences in proportions were made using Chi-squared tests, with p<0.05 set for significance.Results: We received responses from 430 members; 98 (23%) received research grants from industry, while 145 (34%) reported fee-for-service money. Respondents with research money were more likely to be comfortable accepting gifts (40% vs. 29%) and acting as paid consultants (50% vs. 37%). They had a more favorable attitude with regard to societal interactions with industry and felt that industry-sponsored lectures could be fair and unbiased (52% vs. 29%). Faculty with fee-for-service money mirrored those with research money. They were also more likely to believe that industry-sponsored research produces fair and unbiased results (61% vs. 45%) and less likely to believe that honoraria biased speakers (49% vs. 69%).Conclusion: Accepting money for either service or research identified a distinct population defined by their opinions. Faculty engaged in industry-sponsored research benefitted socially (collaborations), academically (publications), and financially from the relationship. [West J Emerg Med. 2010; 11(2):126-132.
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