114 research outputs found

    El servicio de orientación educativa y psicológica (SOEP) de la Universidade da Coruña, una mirada hacia el futuro

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    [Resumen] En el presente artículo se presentan los parámetros y la programación que se siguió en la concepción y puesta en marcha del Servicio de Orientación Educativa y Psicológica (SOEP)3, que ha comenzado su andadura dentro de la Universidad de la Coruña en Octubre de 2001 Y que se considera un paso hacia el futuro de la orientación a nivel universitario, debido en gran medida a los novedosos planteamientos en cuanto a la orientación comunitaria a nivel universitario que se pretenden llevar a cabo desde este servicio, así como el uso de las nuevas tecnologías como instrumento de acercamiento a la comunidad universitaria, ampliando así su radio de acción. Se intentará ofrecer una visión amplia de los objetivos y funciones de este servicio, así como las perspectivas que tienen de cara al nuevo curso académico, la planificación de nuevas actividades y las que se están desarrollando actualmente dentro del curso 2001/2002

    SEMPUT: La oportunidad

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    Treball Final de Grau en Comunicació Audiovisual. Codi: CA0932 Curs: 2014-2015Semput es un cortometraje de ficción realizado por un equipo de cinco personas, Mel de Romer. Este formato ha permitido una mayor libertad expresiva sin llegar a tener un gasto económico muy importante. Este proyecto audiovisual es la materialización del trabajo llevado a cabo durante meses: desde una idea hasta su rodaje y postproducción. Para ello, el equipo se organizó según las experiencias y preferencias de cada miembro, para así crear un buen ambiente de trabajo. Con esta producción se ha tratado de llevar a cabo una experimentación desde el punto de vista formal, puesto que la intención no era seguir los estándares establecidos en las producciones de suspense o cine negro, como lo es este cortometraje. Así pues, los planos abiertos y de larga duración son los recursos más empleados, utilizando lo mínimo posible (solo cuando era necesario) los planos detalle. Durante todo el proceso de trabajo, ha habido un constante aprendizaje. Se ha tratado de trabajar con la mayor profesionalidad posible. La organización y constante comunicación entre los componentes han sido cruciales. Por otro lado, este trabajo también ha posibilitado hacer frente a los problemas u obstáculos comunes en una producción profesional, que se trataron de solucionar de la mejor forma posible. Dicho de otra forma, se hizo frente a la vida real, fuera de las paredes de la universidad. Se ha llegado a comprender mejor el trabajo de realización de un producto audiovisual de principio a fin, poniendo en práctica, por supuesto, las habilidades y conocimientos adquiridos en las clases. Con este cortometraje se espera poder demostrar todos los conocimientos prácticos en esta materia, para que de esta forma sirva de puente hacia otros proyectos audiovisuales o el mundo laboral.Semput is a fiction short film made by a crew of five people, Mel de Romer. This format allows a more expressive freedom without having a high economic cost. This audiovisual project is the materialization of the work made during months: from an idea to its shooting and post-production. So, the team has organized according to the experiences and preferences of every member, creating a good job background. With this production it has attempted to experiment from the formal point of view, because the intention was not to keep the standards established in black cinema or suspense productions, as is this short film. So, long open shots are the most common resources, using as less as possible (only when necessary) close ups. During the whole working process, the team has been constantly learning. It has tried to work in the most professional way. The organization and constant communication between the members of the team have been crucial. Moreover, this work also made possible to confront problems or common obstacles in a professional production, which have been solved as best as possible. In other words, the team faced real life, outside the walls of the University, understanding better the realization work of an audiovisual product, from beginning to end. Of course, the habilities and knowledge acquired in the classes has been put into practice. With this short film is expected to be able to demonstrate all the practical knowledge in this matter to thereby bridge to other audiovisual projects or set foot into the working world

    Burnout: “técnicas de afrontamiento”

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    Decenes Jornades de Foment de la Investigació de la FCHS (Any 2004-2005

    Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

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    Pseudomonas aeruginosa; Bacteremia; NeutropeniaPseudomonas aeruginosa; Bacteriemia; NeutropeniaPseudomonas aeruginosa; Bacterièmia; NeutropèniaWe sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls were patients with PA BSI treated with other antibiotics. Risk factors for overall 7-day and 30-day case fatality rates were analyzed. We compared 44 cases with 88 controls. Overall, 91% of episodes were caused by multidrug-resistant (MDR) strains. An endogenous source was the most frequent BSI origin (35.6%), followed by pneumonia (25.8%). There were no significant differences in patient characteristics between groups. C/T was given empirically in 11 patients and as definitive therapy in 41 patients. Treatment with C/T was associated with less need for mechanical ventilation (13.6% versus 33.3%; P = 0.021) and reduced 7-day (6.8% versus 34.1%; P = 0.001) and 30-day (22.7% versus 48.9%; P = 0.005) mortality. In the multivariate analysis, pneumonia, profound neutropenia, and persistent BSI were independent risk factors for 30-day mortality, whereas lower mortality was found among patients treated with C/T (adjusted OR [aOR] of 0.19; confidence interval [CI] 95% of 0.07 to 0.55; P = 0.002). Therapy with C/T was associated with less need for mechanical ventilation and reduced 7-day and 30-day case fatality rates compared to alternative agents in neutropenic hematologic patients with PA BSI. IMPORTANCE Ceftolozane-tazobactam (C/T) has been shown to be a safe and effective alternative for the treatment of difficult to treat infections due to Pseudomonas aeruginosa (PA) in the general nonimmunocompromised population. However, the experience of this agent in immunosuppressed neutropenic patients is very limited. Our study is unique because it is focused on extremely immunosuppressed hematological patients with neutropenia and bloodstream infection (BSI) due to PA (mainly multidrug resistant [MDR]), a scenario which is often associated with very high mortality rates. In our study, we found that the use of C/T for the treatment of MDR PA BSI in hematological neutropenic patients was significantly associated with improved outcomes, and, in addition, it was found to be an independent risk factor associated with increased survival. To date, this is the largest series involving neutropenic hematologic patients with PA BSI treated with C/T.This study was supported by the Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), (CB21/13/00009), Madrid, Spain. The study was partially funded by the MSD Investigator Initiated Studies Program. The company declares no contributions toward the design and interpretation of the results of the study

    How Variable Is the Volar Subcutaneous Tissue of the Digits on B-Mode and Color Doppler Ultrasound in Non-Psoriatic Individuals and Could It Be Included in a Dactylitis Score?

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    Background Digital subcutaneous tissue (SCT) changes are involved in dactylitis, a hallmark feature of psoriatic arthritis (PsA). There are no studies on the ultrasound (US) characteristics of the digital SCT in the general population. Objectives To investigate the variability in US-measured thickness (TH) and color Doppler (CD)-detected blood flow of the SCT of the volar aspects of the fingers in a non-psoriatic population and to investigate the impact of the scanning method and demographics and clinical features on these measurements. Methods SCT TH and semiquantitative (SQD) and quantitative (QD) Doppler signals were measured in the bilateral second finger at the proximal and middle phalanges in 81 non-psoriatic volunteers [49 female, 32 men; 18-78 years]. Two scanning methods with and without (thick gel layer interposition) probe-skin contact were used. Demographics and clinical features were collected. Results There was high variability of SCT TH and Doppler measurements between individuals. All US measurements obtained without probe-skin contact were significantly greater than their corresponding measurements obtained with the probe contacting the skin (p<0.001). SCT TH was positively related to dominant hand, age, masculine gender, weight, height, body mass index, and alcohol consumption while Doppler measurements were positively related to age and non-dominant hand. Conclusions US-measured SCT thickness and Doppler-detected SCT blood flow of the volar aspect of the fingers seem to be highly variable in the non-psoriatic population as well as highly dependent on the US scanning method. This variability is of utmost importance for assessing dactylitis in PsA

    Discovery of the elusive carbonic acid (HOCOOH) in space

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    After a quarter century since the detection of the last interstellar carboxylic acid, acetic acid (CH3_3COOH), we report the discovery of a new one, the cis-trans form of carbonic acid (HOCOOH), toward the Galactic Center molecular cloud G+0.693-0.027. HOCOOH stands as the first interstellar molecule containing three oxygen atoms and also the third carboxylic acid detected so far in the interstellar medium. Albeit the limited available laboratory measurements (up to 65 GHz), we have also identified several pairs of unblended lines directly in the astronomical data (between 75-120 GHz), which allowed us to slightly improve the set of spectroscopic constants. We derive a column density for cis-trans HOCOOH of NN = (6.4 ±\pm 0.4) ×\times 1012^{12} cm2^{-2}, which yields an abundance with respect to molecular H2_2 of 4.7 ×\times 1011^{-11}. Meanwhile, the extremely low dipole moment (about fifteen times lower) of the lower-energy conformer, cis-cis HOCOOH, precludes its detection. We obtain an upper limit to its abundance with respect to H2_2 of \leq 1.2 ×\times109^{-9}, which suggests that cis-cis HOCOOH might be fairly abundant in interstellar space, although it is nearly undetectable by radio astronomical observations. We derive a cis-cis/cis-trans ratio \leq 25, consistent with the smaller energy difference between both conformers compared with the relative stability of trans- and cis-formic acid (HCOOH). Finally, we compare the abundance of these acids in different astronomical environments, further suggesting a relationship between the chemical content found in the interstellar medium and the chemical composition of the minor bodies of the Solar System, which could be inherited during the star formation process.Comment: Accepted for publication in The Astrophysical Journa

    Interstellar detection of O-protonated carbonyl sulfide, HOCS+

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    We present the first detection in space of O-protonated carbonyl sulfide (\ch{HOCS+}), in the midst of an ultradeep molecular line survey toward the G+0.693-0.027 molecular cloud. From the observation of all KKa_a = 0 transitions ranging from JJlo_{lo} = 2 to JJlo_{lo} = 13 of \ch{HOCS+} covered by our survey, we derive a column density of NN = (9 ±\pm 2)×\times1012^{12} cm2^{-2}, translating into a fractional abundance relative to H2_2 of \sim7×\times1011^{-11}. Conversely, the S-protonated \ch{HSCO+} isomer remains undetected, and we derive an upper limit to its abundance with respect to H2_2 of \leq3×\times1011^{-11}, a factor of \geq2.3 less abundant than \ch{HOCS+}. We obtain a \ch{HOCS+}/OCS ratio of \sim2.5×\times103^{-3}, in good agreement with the prediction of astrochemical models. These models show that one of the main chemical routes to the interstellar formation of \ch{HOCS+} is likely the protonation of OCS, which appears to be more efficient at the oxygen end. Also, we find that high values of cosmic-ray ionisation rates (1015^{-15}-1014^{-14} s1^{-1}) are needed to reproduce the observed abundance of \ch{HOCS+}. In addition, we compare the O/S ratio across different interstellar environments. G+0.693-0.027 appears as the source with the lowest O/S ratio. We find a \ch{HOCO+}/\ch{HOCS+} ratio of \sim31, in accordance with other O/S molecular pairs detected toward this region and also close to the O/S solar value (\sim37). This fact indicates that S is not significantly depleted within this cloud due to the action of large-scale shocks, unlike in other sources where S-bearing species remain trapped on icy dust grains.Comment: Forthcoming paper in The Astrophysical Journal (in press

    Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses

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    Inflammation plays a major role in the onset and development of chronic non-communicable diseases like obesity, cardiovascular diseases and cancer. Combined, these diseases represent the most common causes of death worldwide, thus development of novel pharmacological approaches is crucial. Electrophilic nitroalkenes derived from fatty acids are formed endogenously and exert anti-inflammatory actions by the modification of proteins involved in inflammation signaling cascades. We have developed novel nitroalkenes derived from α-tocopherol aiming to increase its salutary actions by adding anti-inflammatory properties to a well-known nutraceutical. We synthesized and characterized an α-tocopherol-nitroalkene (NATOH) and two hydrosoluble analogues derived from Trolox (NATxME and NATx0). We analyzed the kinetics of the Michael addition reaction of these compounds with thiols in micellar systems aiming to understand the effect of hydrophobic partition on the reactivity of nitroalkenes. We studied NATxME in vitro showing it exerts non-conventional anti-inflammatory responses by inducing Nrf2-Keap1-dependent gene expression and inhibiting the secretion of NF-κB dependent pro-inflammatory cytokines. NATxME was also effective in vivo, inhibiting neutrophil recruitment in a zebrafish model of inflammation. This work lays the foundation for the rational design of a new therapeutic strategy for the prevention and treatment of metabolic and inflammation-related disease

    First glycine isomer detected in the interstellar medium: glycolamide (NH2_2C(O)CH2_2OH)

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    We report the first detection in the interstellar medium of a C2_2H5_5O2_2N isomer: synsyn-glycolamide (NH2_2C(O)CH2_2OH). The exquisite sensitivity at sub-mK levels of an ultra-deep spectral survey carried out with the Yebes 40m and IRAM 30m telescopes towards the G+0.693-0.027 molecular cloud have allowed us to unambiguously identify multiple transitions of this species. We derived a column density of (7.4 ±\pm 0.7)×\times1012^{12} cm2^{-2}, which implies a molecular abundance with respect to H2_2 of 5.5×\times1011^{-11}. The other C2_2H5_5O2_2N isomers, including the higher-energy antianti conformer of glycolamide, and two conformers of glycine, were not detected. The upper limit derived for the abundance of glycine indicates that this amino acid is surely less abundant than its isomer glycolamide in the ISM. The abundances of the C2_2H5_5O2_2N isomers cannot be explained in terms of thermodynamic equilibrium, and thus chemical kinetics need to be invoked. While the low abundance of glycine might not be surprising, based on the relative low abundances of acids in the ISM compared to other compounds (e.g. alcohols, aldehydes or amines), several chemical pathways can favour the formation of its isomer glycolamide. It can be formed through radical-radical reactions on the surface of dust grains. The abundances of these radicals can be significantly boosted in an environment affected by a strong ultraviolet field induced by cosmic rays, such as that expected in G+0.693-0.027. Therefore, as shown by several recent molecular detections towards this molecular cloud, it stands out as the best target to discover new species with carbon, oxygen and nitrogen with increasing chemical complexity.Comment: Accepted in The Astrophysical Journal Letter

    Plataforma de apoyo en el diagnóstico de COVID y otras patologías mediante Deep Learning

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    Congreso celebrado en el Hotel NH Collection, Madrid (España), el 22-24 de marzo de 2022La gravedad de la pandemia producida por la Covid-19 ha promovido el desarrollo de proyectos que buscan soluciones a la crisis sanitaria derivada de esta enfermedad. El Complejo Hospitalario Universitario A Coruña (CHUAC) con el liderazgo del Grupo de Visión Artificial y Reconocimiento de Patrones (VARPA) del INIBIC-UDC han participado en un proyecto nacional con el fin de desarrollar un sistema de diagnóstico temprano de Covid-19 y otras patologías a partir de radiografías de tórax mediante técnicas de inteligencia artificial [1, 2, 3]. La incorporación al sistema sanitario público de sistemas expertos desarrollados en el ámbito académico presenta dos retos principales: El grado de aceptación de una herramienta novedosa por parte de los usuarios y el correcto manejo de información sensible. En este trabajo se muestra como desde el CHUAC se han afrontado estos retos a la hora de incorporar el sistema inteligente a la rutina de los facultativos
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