Olfactory processing and odor specificity: a meta-analysis of menstrual cycle variation in olfactory sensitivity

Cycle-correlated variation in olfactory threshold, with women becoming more sensitive to odors mid-cycle, is somewhat supported by the literature but the evidence is not entirely consistent, with several studies finding no, or mixed, effects. It has been argued that cyclic shifts in olfactory threshold might be limited to odors relevant to the mating context. We aimed to test whether the evidence currently available points in the direction of odor-specific or, rather, general changes in olfactory sensitivity and, if the former is the case, to what group of odorants in particular. We carried out a meta-analysis of relevant studies which together used a variety of different odorants, including some found in food, body odor, and some that occur in neither of these. First we tested whether there appears to be an overall effect when all studies are included. Next, we hypothesised that if cyclic changes in olfactory processing are odor-specific and tuned to biologically relevant odors, we should find changes in detection thresholds only for odorants found in body odor, or for those that are perceptually similar to it. In contrast, if threshold patterns are linked to more general fluctuations in odor processing across the cycle, we would not expect changes in relation to any particular odorant group. The results support the view that there is significant cycle-correlated variation. Thresholds were in general significantly lower in the fertile than the non-fertile phases, with effect sizes consistently in this direction. This same conclusion applied to both ‘food’ and ‘musky’ odorants, despite their different evolutionary significance, and to the androgen steroids (androstadienone, androstenone, and androsterone), but could not be applied to phenyl-ethyl alcohol. The results indicate that olfactory sensitivity may be a non-adaptive by-product of the general physiological fluctuations or differences in neural processing experienced across the cycle to a broad spectrum of odorants, rather than being specifically selected for mate choice-related odors

The French Language in sub-Saharan Africa: Revisited

Baghana, J. The French Language in sub-Saharan Africa: Revisited / J. Baghana, K. S. Novakova, J. Birova // Научный результат. Сер. Вопросы теоретической и прикладной лингвистики. - 2020. - Т.6, №1.-С. 54-64. - Doi: 10.18413/2313-8912-2020-6-1-0-6.The article discusses the role of the French language in sub-Saharan Africa. The authors analyze ideological, linguistic, historical, and sociolinguistic factors which affect the way the French language functions and the position it has in Africa. The French language is the language of inter-ethnic communication, education, the press and science in sub-Saharan Afric

Morphological and syntactic interference in the context of Franco-Congolese bilingualism

The article is devoted to the problem of language contacts in the linguistic setting of the Congo, resulting in various changes. The given work stresses the idea of the relationship between hybrid languages and the role of interference on morphological and syntactic levels of two languages: French and Kikong

Kappa free light chain index as a diagnostic biomarker in multiple sclerosis: a real-world investigation

Kappa free light chain (KFLC)-index, a measure for intrathecal production of free kappa chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis (MS) as a quantitative alternative to IgG oligoclonal-bands (OCBs). Our objective was to investigate the sensitivity, specificity, and overall diagnostic accuracy of KFLC-index in MS. KFLC-index was prospectively determined as part of the diagnostic workup in patients with suspected MS (n=327) between May 2013 and February 2020. Patients with clinically isolated syndrome (CIS), radiologically isolated syndrome (RIS), and MS had markedly higher KFLC-index (44.6, IQR 16-128) compared with subjects with other neuro-inflammatory disorders (ONID) and symptomatic controls (SC) (2.19, IQR 1.68-2.98, pIF and better than for IgG-index. We show that KFLC-index was influenced neither by DMT, nor by demographic factors or other inflammatory or degenerative processes in MS as determined by biomarkers in CSF

Study of Deep-Ocean Ferromanganese Crusts Ore Components

A complex layer-by-layer morphology and phase analysis of a ferromanganese crust aged about 70 million years, extracted from the rise of the Magellan Mountains of the Pacific Ocean, was carried out using several physics methods: digital optical microscopy, scanning electron microscopy with high resolution, X-ray fluorescence and diffraction analysis and Mossbauer spectroscopy. This analysis showed that the crust is an association of several minerals with various dispersion and crystallization degree, between which fossilized bacterial mats with Fe- and Mn- oxides are located. These phenomena indicate the biogenic nature of the crust. Changes in the crusts phase composition from the lower layer to the upper layer indicate changes in the external environmental conditions during their formation

The effectiveness of glucocorticoid therapy in patients with chronic glomerulonephritis, depending on the polymorphic markers of cytokine genes

The paper presents the results of a study of interrelationships of polymorphic cytokine loci (rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1 and rs1800469 TGFβ-1) with the features of glucocorticoid therapy in patients with chronic glomerulonephriti

Using the elements of traditional culture in the teaching process from the perspectiveof ethnopedagogy and ethnology

The presented study aims to briefly present the possibilities of using and implementing elements of traditional culture in the teaching processat primary and secondary schools in Slovakia. It points out all the aspects and factors that enter the educational process when using these element

Cerebrospinal fluid growth-associated protein 43 in multiple sclerosis

Neurodegeneration in multiple sclerosis (MS) correlates with disease progression and reparative processes may be triggered. Growth-associated protein 43 (GAP-43) exhibits induced expression during axonal growth and reduced expression during MS progression. We aimed to evaluate if GAP-43 can serve as a biomarker of regeneration in relapsing-remitting MS (RRMS) and whether disease-modifying therapies (DMTs) influence GAP-43 concentration in cerebrospinal fluid (CSF). GAP-43 was measured using an enzyme-linked immunosorbent assay in 105 MS patients (73 RRMS, 12 primary progressive MS, 20 secondary progressive MS) and 23 healthy controls (HCs). In 35 of the patients, lumbar puncture, clinical assessment, and magnetic resonance imaging was performed before initiation of therapeutic intervention, and at follow-up. CSF GAP-43 concentration was significantly lower in progressive MS compared with HCs (p = 0.004) and RRMS (p =  < 0.001) and correlated negatively with disability (p = 0.026). However, DMTs did not alter CSF GAP-43. Interestingly, in RRMS CSF GAP-43 levels were higher in patients with signs of active inflammatory disease than in patients in remission (p = 0.042). According to CSF GAP-43 concentrations, regeneration seems reduced in progressive MS, increased during disease activity in RRMS but is unaffected by treatment of highly active DMTs

Tissue‐engineered tendon constructs for rotator cuff repair in sheep

Current rotator cuff repair commonly involves the use of single or double row suture techniques, and despite successful outcomes, failure rates continue to range from 20 to 95%. Failure to regenerate native biomechanical properties at the enthesis is thought to contribute to failure rates. Thus, the need for technologies that improve structural healing of the enthesis after rotator cuff repair is imperative. To address this issue, our lab has previously demonstrated enthesis regeneration using a tissue‐engineered graft approach in a sheep anterior cruciate ligament (ACL) repair model. We hypothesized that our tissue‐engineered graft designed for ACL repair also will be effective in rotator cuff repair. The goal of this study was to test the efficacy of our Engineered Tissue Graft for Rotator Cuff (ETG‐RC) in a rotator cuff tear model in sheep and compare this novel graft technology to the commonly used double row suture repair technique. Following a 6‐month recovery, the grafted and contralateral shoulders were removed, imaged using X‐ray, and tested biomechanically. Additionally, the infraspinatus muscle, myotendinous junction, enthesis, and humeral head were preserved for histological analysis of muscle, tendon, and enthesis structure. Our results showed that our ETC‐RCs reached 31% of the native tendon tangent modulus, which was a modest, non‐significant, 11% increase over that of the suture‐only repairs. However, the histological analysis showed the regeneration of a native‐like enthesis in the ETG‐RC‐repaired animals. This advanced structural healing may improve over longer times and may diminish recurrence rates of rotator cuff tears and lead to better clinical outcomes. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:289–299, 2018.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142510/1/jor23642.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142510/2/jor23642_am.pd

On reminder effects, drop-outs and dominance: evidence from an online experiment on charitable giving

We present the results of an experiment that (a) shows the usefulness of screening out drop-outs and (b) tests whether different methods of payment and reminder intervals affect charitable giving. Following a lab session, participants could make online donations to charity for a total duration of three months. Our procedure justifying the exclusion of drop-outs consists in requiring participants to collect payments in person flexibly and as known in advance and as highlighted to them later. Our interpretation is that participants who failed to collect their positive payments under these circumstances are likely not to satisfy dominance. If we restrict the sample to subjects who did not drop out, but not otherwise, reminders significantly increase the overall amount of charitable giving. We also find that weekly reminders are no more effective than monthly reminders in increasing charitable giving, and that, in our three months duration experiment, standing orders do not increase giving relative to one-off donations