16 research outputs found
2 Aminoadipic Acid C O Glutamate Based Prostate Specific Membrane Antigen Ligands for Potential Use as Theranostics
The design and synthesis
of prostate specific membrane antigen
(PSMA) ligands derived from 2-aminoadipic acid, a building block that
has not previously been used to construct PSMA ligands, are reported.
The effects of both the linker length and of an N-substituent of our
PSMA ligands were probed, and X-ray structures of five of these ligands
bound to PSMA were obtained. Among the ligands disclosed herein, 13b showed the highest inhibitory activity for PSMA. As ligand 13b can readily be radiolabeled since its fluorine atom is
adjacent to the nitrogen atom of its pyridine ring, the use of this
and related compounds as theranostics can be pursued