16 research outputs found
2 Aminoadipic Acid C O Glutamate Based Prostate Specific Membrane Antigen Ligands for Potential Use as Theranostics
No full textThe design and synthesis
of prostate specific membrane antigen
(PSMA) ligands derived from 2-aminoadipic acid, a building block that
has not previously been used to construct PSMA ligands, are reported.
The effects of both the linker length and of an N-substituent of our
PSMA ligands were probed, and X-ray structures of five of these ligands
bound to PSMA were obtained. Among the ligands disclosed herein, 13b showed the highest inhibitory activity for PSMA. As ligand 13b can readily be radiolabeled since its fluorine atom is
adjacent to the nitrogen atom of its pyridine ring, the use of this
and related compounds as theranostics can be pursued
Current State of Utilization of Financial Controlling in the Conditions of Non-Profit Organizations in the Slovak Republic
No full textBiomimetic Macrocyclic Inhibitors of Human Cathepsin D Structure Activity Relationship and Binding Mode Analysis
No full text
SOCIILNN INTELIGENCE VVZNAMNN ATRIBUT V POMMHAJJCCCH PROFESSCH (Social Intelligence A Significant Attribute in Helping Professions)
No full textGene Expression of Adrenoceptors in the Hearts of Cold-Acclimated Rats Exposed to a Novel Stressor
No full text
