Therapy of Canine Hyperlipidemia with Bezafibrate.

BackgroundBezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs.ObjectiveTo assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations.AnimalsForty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]).MethodsProspective, uncontrolled clinical trial. Dogs were treated with bezafibrate once daily, using 200 mg tablets at a dosage of 4-10 mg/kg (depending on body weight). Serum TG and CHO concentrations and alanine aminotransferase (ALT) and creatine kinase (CK) activity before and after 30 days of treatment were compared.ResultsSixteen dogs (34.8%) had primary hyperlipidemia, and 30 dogs (65.2%) had secondary hyperlipidemia (including spontaneous hyperadrenocorticism [41.3%, n = 19/46], chronic treatment with glucocorticoids [10.8%, n = 5/46], and hypothyroidism [15.2%, n = 7/46]). After 30 days, serum TG concentration normalized (<150 mg/dL) in 42 dogs (91.3%) and CHO concentration normalized (<270 mg/dL) in 22 of 33 dogs (66.7%). There was no difference in baseline TG concentration between the primary and secondary hyperlipidemia subgroups, but the decrease in TG concentration after treatment was greater in the primary hyperlipidemia subgroup. No adverse effects were observed, but ALT activity decreased significantly after 30 days of treatment.Conclusions and clinical importanceOver 30 days, BZF was safe and effective in treatment of primary and secondary hyperlipidemia in dogs

DIFFERING HIV INFECTION RATES IN BRAZIL AND SOUTH AFRICA: A COMPARATIVE STUDY OF POLICIES AND PRACTICES

During the past twenty years much attention has been focused on HIV/AIDS globally. Despitemuch research, endless discussions and political machinations, the pandemic is largelyuncontrolled, particularly in parts of the developing world. However, some countries havemanaged to substantially reduce their rates of infection

Integration of Evidence-Based Practice in Nursing Education

Evidence based practice (EBP) has gained momentum globally, to provide effective and efficient health care. Although EBP has evolved to a great extent over the last two decades and is accepted as an important concept by all health care professionals, its integration in practice is still challenging. Integration of EBP in nursing profession both in nursing practice and nursing education is an important issue. This article describes the experience of the authors in integrating evidence based practice in nursing education in Manipal University. It focuses on the training of nurse educators in EBP, alignment of EBP in curriculum and EBP practicum in curriculum so as to enable a nurse to identify evidences, make appropriate clinical decisions and utilize EBP in rendering scientific and quality patient care

Projeto Parque Frei Veloso: levantamento detalhado dos solos do Campus da Ilha do Fundão, UFRJ.

O levantamento de solos foi realizado em nível detalhado de acordo com a metodologia desenvolvida pelo Centro Nacional de Pesquisa de Solos - Embrapa Solos. Foram usados como material básico, mapa digitalizado fornecido pela Universidade Federal do Rio de Janeiro - UFRJ, na escala 1:5.000. Foram coletadas 88 (oitenta e oito) amostras de diferentes horizontes ou camadas durante os trabalhos de campo. Estas amostras foram remetidas ao laboratório da Embrapa Solos para análise da granulometria e do complexo sortivo. De posse dos resultados das análises, elaborou-se a legenda de identificação dos aterros, dos solos da Ilha do Catalão e das áreas de mangues. O mapa final de solos é constituído por quatro unidades de aterros e duas de solos. Além disto, procedeu-se a avaliação do grau de fertilidade das amostras de solo e do comportamento e utilização das diversas áreas, conforme subsídios para projeto de revegetação

Hadron Mass Spectrum and the Shear Viscosity to Entropy Density Ratio of Hot Hadronic Matter

Lattice calculations of the QCD trace anomaly at temperatures $T<160$ MeV have been shown to match hadron resonance gas model calculations, which include an exponentially rising hadron mass spectrum. In this paper we perform a more detailed comparison of the model calculations to lattice data that confirms the need for an exponentially increasing density of hadronic states. Also, we find that the lattice data is compatible with a hadron density of states that goes as $\rho(m) \sim m^{-a}\exp(m/T_H)$ at large $m$ with $a> 5/2$ (where $T_H \sim 167$ MeV). With this specific subleading contribution to the density of states, heavy resonances are most likely undergo 2-body decay (instead of multi-particle decay), which facilitates their inclusion into hadron transport codes. Moreover, estimates for the shear viscosity and the shear relaxation time coefficient of the hadron resonance model computed within the excluded volume approximation suggest that these transport coefficients are sensitive to the parameters that define the hadron mass spectrum.Comment: 16 pages, 12 figure

Anterior Segment Optical Coherence Tomography Imaging of Filtering Blebs after Deep Sclerectomy with Esnoper-Clip Implant: One-year Follow-up

Purpose: To describe the technique of deep sclerectomy with the new Esnoper-Clip® implant, the clinical outcome and the anatomic characteristics of filtering blebs, using anterior segment optical coherence tomography (AS-OCT). Methods: A prospective case-series study was conducted in five eyes (5 patients) with open angle glaucoma. The fornixbased deep sclerectomy with Esnoper-Clip® implant was done by the same surgeon. In one case, mitomycin C was used during surgery. All participants underwent a complete ophthalmic examination and AS-OCT (Visante®) preoperatively, then at each follow-up visit, at 1 day, 1 week, 1 month, 6 months and 1 year postoperatively. Scans were obtained through sagittal and transversal plans to the implant. Results: Intraocular pressure (IOP) was significantly reduced (p < 0.05) from a mean preoperative value of 23.4 ± 8.6 mm Hg (n = 3.8 glaucoma medications) to a postoperative value of 6.0 ± 2.5 (n = 0), 10.6 ± 5.4 (n = 0), 13 ± 1.6 (n = 0.4), 12.4 ± 2.1 (n = 0.2) and 14.4 ± 1.5 (n = 0.2) at 1 day, 1 week, 1 month, 6 months and 1 year respectively. AS-OCT allowed the visualization of the two plates of the implant (scleral and suprasciliary), the trabeculodescemetic membrane and the hyporeflective spaces in the bleb wall thickness and in suprascleral and suprachoroidal localizations. An immediate postoperative hypotony and an anteriorization of the implant associated to trabeculodescemetic membrane rupture, were detected, although without significant clinical repercussions. Conclusion: Our first five deep sclerectomy with Esnoper-Clip implantation analysis suggest an effective and well-tolerated method to reduce IOP. AS-OCT is a noninvasive imaging technique that allows the anatomic analysis of the drainage mechanisms after glaucoma surgery.info:eu-repo/semantics/publishedVersio

Oviposition rate as a tool for evaluating species of Manihot for resistance to cassava green mite (CGM), Mononychellus tanajoa (Acari: Tetranychidae).

Organized by G. J. de Moraes, R. C. Castilho, C. H. W. Flechtmann

Tkachenko modes as sources of quasiperiodic pulsar spin variations

We study the long wavelength shear modes (Tkachenko waves) of triangular lattices of singly quantized vortices in neutron star interiors taking into account the mutual friction between the superfluid and the normal fluid and the shear viscosity of the normal fluid. The set of Tkachenko modes that propagate in the plane orthogonal to the spin vector are weakly damped if the coupling between the superfluid and normal fluid is small. In strong coupling, their oscillation frequencies are lower and are undamped for small and moderate shear viscosities. The periods of these modes are consistent with the observed ~100-1000 day variations in spin of PSR 1828-11.Comment: 7 pages, 3 figures, uses RevTex, v2: added discussion/references, matches published versio

Da Crítica à Religião à Teoria do Fetichismo em Marx

Seria possível sintetizar a crítica marxiana à religião na famosa assertiva em que nosso autor relaciona religião ao ópio? Grande parte dos defensores, assim como os acusadores, diria que sim. Para investigar os fundamentos teóricos e filosóficos desta leitura hegemônica, precisaremos retornar a Hegel, pois para Marx a religião é o que Hegel entendia como tal. Isso é, a religião verdadeira alicerceia ético-politicamente o Estado verdadeiro. Este Estado divinizado em Hegel é o que é combatido por Marx, primordialmente a partir de Feuerbach. Em seguida, apresentaremos a crítica à religião no original pensamento de Marx a partir de sua bibliografia primária, suas elaborações, continuidades e descontinuidades ao longo de sua trajetória intelectual. Pretendemos considerar os diálogos, aproximações, afastamentos e superações que se dão em relação a Hegel e Feuerbach, as duas maiores fontes do pensamento marxiano no que diz respeito ao fenômeno religioso. Por fim, adentraremos detidamente na teoria do fetichismo em Marx, apresentando a leitura enquanto Santíssima Trindade de Mammon (mercadoria, dinheiro e capital), proposta de inversão dialética a partir da categoria Santíssima Trindade em Hegel. A crítica à religião dá um passo fundamental e se torna momento negativo para a teoria do fetichismo, surge algo epistemologicamente e ontologicamente novo. O fetiche é a categoria central para se compreender o capitalismo como religião, é a mediação entre a vida real e o reflexo religioso que ocorre pelo valor (nas três formas funcionais, mercadoria, dinheiro e capital), sujeito das relações sociais. Ainda, faremos uma crítica à Marx por não ter aplicado a sua dialética universal-particular na religião, tal como fez por exemplo com a filosofia e a política, permanecendo ainda tributário do pensamento de identidade hegeliano, o que significa um grave problema lógico-metodológico interno ao pensamento de Marx. Mesmo que consiga captar o caráter dialético da religião protesto e legitimação, ao mesmo tempo , acaba abandonando sua coerência lógica de unidade dialética entre teoria e práxis, não dá o devido relevo ao potencial utópico da religião e a possibilidade concreta de existência de uma religião antifetichista

Phaeochromocytoma Associated to Von Recklinghausen Neurofibromatosis Type I: a Rare Clinical Case

Os feocromocitomas são neoplasias originárias das células cromafins da crista neural localizados, na sua grande maioria, na medula supra-renal, podendo também aparecer nos gânglios simpáticos (paragangliomas). Ocorrem de forma esporádica em 90% dos casos; contudo, em cerca de 10% são um componente de síndromes neoplásicas de transmissão autossómica dominante, como a doença de von Hippel-Lindau, a neoplasia endócrina múltipla tipo 2 (MEN 2) e, mais raramente, associados à Neurofibromatose de von Recklinghausen tipo I (3-5%). A este propósito, os autores apresentam o caso de um homem de 54 anos, com uma história pessoal e familiar de Neurofibromatose de von Recklinghausen tipo I em que foi detectado um tumor da supra-renal direita, assintomátic(“incidentaloma”), cuja investigação posterior comprovou ser um feocromocitoma produtor de elevados níveis de epinefrina e nor-epinefrina. Apesar do padrão secretório de catecolaminas apresentado, foi confirmada, por pressurometria de 24 horas, a existência de normotensão e ausência de história familiar de hipertensão arterial, factos igualmente pouco comuns. Discutem-se alguns dos mecanismos patogénicos envolvidos nestas entidades sindromáticas tumorais, bem como o seu comportamento clínico; salienta-se, igualmente, a importância do rastreio oncológico sistemático, nomeadamente de feocromocitomas, em familiares de indivíduos portadores deste tipo de neoplasia autossómica dominante, mesmo que assintomáticos