Apoptosis and Predisposition To Oral Cancer

The term apoptosis, also known as programmed cell death (PCD), was coined by developmental biologists a number of years ago to describe a form of cell death characterized by several unique morphological and biochemical features. Genetic studies of the round worm Caeneorhabditis elegans, a simple multicellular organism, first revealed apoptosis to be an integral part of the developmental program. Subsequently, the importance of apoptosis in higher organisms was demonstrated in several eukaryotic systems. In mammals, apoptosis is widespread during embryogenesis and in adult tissues. It is required for normal tissue homeostasis and for clonal selection in the immune system. In both developing and adult organisms, apoptosis plays a central role in reinforcing appropriate cellular patterns and in regulating cell number by eliminating cells that are harmful or no longer needed. It is becoming increasingly clear that disruption in the apoptosis pathway can contribute to the development of a number of developmental, inflammatory, degenerative, and neoplastic diseases. The effector arm of the apoptotic program includes members of the Bcl-2 gene family that function as either death agonists or death antagonists. These proteins participate in an elaborate genetically controlled biochemical pathway that functions to maintain tissue and organ homeostasis and serve as a critical defense mechanism to guard against malignant transformation. Cancer is the result of a series of genetic lesions that include activation of oncogenes and inactivation or loss of tumor suppressor genes. Several groups of investigators have observed that deregulated expression of oncogenes can subvert apoptotic pathways, resulting in prolonged cell survival. In pathological settings such as cancer, members of the Bcl-2 gene family are able to synergize with oncogenes and tumor suppressor genes to transform cells. In this review, we describe the process of apoptosis in mammalian cells and define the role and biochemical pathways through which the Bcl-2 gene family induce and/or protect cells from apoptosis. Last, we will discuss the evidence which suggests that alterations in this pathway may play a central role in tumorigenesis by allowing genetically damaged cells normally destined for elimination to persist, predisposing them to additional mutations and driving them to malignancy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66687/2/10.1177_10454411990100020201.pd

Critical gap analysis of merging sections at Kuala Lumpur middle ring road

At merging sections, drivers normally slow down and sometimes need to stop while seeking a suitable gap before merging with the mainstream. Thus, there will always be several observed rejected gaps and an accepted gap which can be used to determine the smallest average gap, so-called critical gap. This study was carried out to determine critical gap values at selected merging sections at the Jalan Tun Razak and the DUKE Expressway uses the Maximum Likelihood method. Data were collected by using videotaping method and the gap acceptance data were extracted for analysis. A gap acceptance event at highway merging sections in this study was redefined due to unavailability of stopping vehicles at the ramp junction. Therefore, the gap data were estimated starting from a ramp’s vehicle passing the end of gore marking to where it merges with the mainstream. The analysis of the critical gap takes into consideration accepted gaps greater than 5 seconds to avoid forced entry due to lead impedance of successive vehicles on mainstream. The critical gap values obtained in this study, according to vehicle classification were ranged between 4.5 to 5.0 seconds, which are slightly smaller if compared to critical gap values for particularly left turn from minor movement at priority junction of the Arahan Teknik (Jalan) 11/87 and the United States Highway Capacity Manual 2000. The findings shall help to study driving behavior of local drivers, especially at priority control facilities such as merging sections

EEG pattern of cognitive activities for non dyslexia (engineering student) due to different gender

The purpose of this study is to identify the electroencephalogram (EEG) pattern of male and female engineering student during the cognitive activity. EEG is a method to monitoring electrical activity in the brain and has four main brainwave signal Delta Wave, Theta Wave, Alpha Wave and Beta Wave. Delta wave is a slow wave generated in deepest meditation, Theta Wave usually occurs in sleep, Alpha Wave dominant in calming, relaxing condition and Beta Wave dominant in wakeful condition. The raw data collected analysis using SPSS and Microsoft Excel to analysis the accuracy and the brainwave pattern between male and female. The average, standard derivation, correlation and Q-Q Plot are used to identify the EEG pattern between male and female during cognitive activity. Cognitive is one of the bloom taxonomy formulate for education activities. The process involves in decision making, understanding of information, attitudes and solving. Subjects are given a set of question to answer. A total of 24 students, 12 males and 12 female involve recording their EEG signal while answering the cognitive question by wearing the Emotive Insight device. All subjects are from UTHM engineering students. Data collected are focused in Alpha Wave and Beta wave which exist in when someone is in awaken condition. The difference between male and female brainwave during the cognitive activity can be observed from the analysis and discussion of the result. For future recommendation for this research is the number of subject can be increased to get more accurate data

Projecting the future smoking prevalence in Norway

Background: Norway has achieved a noteworthy reduction in smoking prevalence over the past forty years. In 2015, 13% of Norwegians aged 13-74 smoked daily and a further 9% smoked occasionally. One of the objectives of the Norwegian 2013-16 national strategy for tobacco control is to achieve a reduction in the daily smoking prevalence t

The Impact of Parameter Identification Methods on Drug Therapy Control in an Intensive Care Unit

This paper investigates the impact of fast parameter identification methods, which do not require any forward simulations, on model-based glucose control, using retrospective data in the Christchurch Hospital Intensive Care Unit. The integral-based identification method has been previously clinically validated and extensively applied in a number of biomedical applications; and is a crucial element in the presented model-based therapeutics approach. Common non-linear regression and gradient descent approaches are too computationally intense and not suitable for the glucose control applications presented. The main focus in this paper is on better characterizing and understanding the importance of the integral in the formulation and the effect it has on model-based drug therapy control. As a comparison, a potentially more natural derivative formulation which has the same computation speed advantages is investigated, and is shown to go unstable with respect to modelling error which is always present clinically. The integral method remains robust

An Annotated Checklist Of Herpetofauna Of Langkawi Island, Kedah, Malaysia.

The herpetofauna ofLangkawi Island was recorded during the Scientific & Heritage Expedition ofthe Langkawi Islands, Kedah from 10 -15 April 2003. The reptiles such as snakes, lizards and turtles and amphibians such as toads and frogs were captured or observed and then identified. The reptiles and amphibians were captured and observed during trekking bouts along used and unused trails, along rivers and streams and during chance encounter

Modes of Foreign Entry under Asymmetric Information about Potential Technology Spillovers

This paper studies the effect of technology spillovers on the entry decision of a multinational enterprise into a foreign market. Two alternative entry modes for a foreign direct investment are considered: Greenfield investment versus acquisition. We find that with quantity competition a spillover makes acquisitions less attractive, while with price competition acquisitions become more attractive. Asymmetric information about potential spillovers always reduces the number of acquisitions independently of whether the host country or the entrant has private information. Interestingly, we find that asymmetric information always hurts the entrant, while it sometimes is in favor of the host country

Mobile ad hoc network testbed using mobile robot technology

MANET (Mobile Ad Hoc Network) researchers have shown increased interest in using mobile robot technology for their testbed platforms. Thus, the main motivation of this paper is to review various robot-based MANET testbeds that have been developed in previously reported research. Additionally, suggestions to heighten mobility mechanisms by using mobile robots to be more practical, easy and inexpensive are also included in this paper, as we unveils ToMRobot, a low-cost MANET robot created from an ordinary remote control car that is capable of performing a real system MANET testbed with the addition of only a few low-cost electronic components. Despite greatly reduced costs, the ToMRobot does not sacrifice any of the necessary MANET basic structures and will still be easily customizable and upgradeable through the use of open hardware technology like Cubieboard2 and Arduino, as its robot controller. This paper will also include guidelines to enable technically limited MANET researchers to design and develop the ToMRobot. It is hoped that this paper achieves its two pronged objectives namely (i) to facilitate other MANET researchers by providing them with a source of reference that eases their decision making for selecting the best and most suitable MANET mobile robots for real mobility in their MANET testbeds (ii) to provide MANET researchers with a prospect of building their own MANET robots that can be applied in their own MANET testbed in the future

Callers’ attitudes and experiences of UK breastfeeding helpline support

Background: Breastfeeding peer support, is considered to be a key intervention for increasing breastfeeding duration rates. Whilst a number of national organisations provide telephone based breastfeeding peer support, to date there have been no published evaluations into callers’ experiences and attitudes of this support. In this study we report on the descriptive and qualitative insights provided by 908 callers as part of an evaluation of UK-based breastfeeding helpline(s). Methods: A structured telephone interview, incorporating Likert scale responses and open-ended questions was undertaken with 908 callers over May to August, 2011 to explore callers’ experiences of the help and support received via the breastfeeding helpline(s). Results: Overall satisfaction with the helpline was high, with the vast majority of callers’ recalling positive experiences of the help and support received. Thematic analysis was undertaken on all qualitative and descriptive data recorded during the evaluation, contextualised within the main areas addressed within the interview schedule in terms of ‘contact with the helplines’; ‘experiences of the helpline service’, ‘perceived effectiveness of support provision’ and ‘impact on caller wellbeing’. Conclusion: Callers valued the opportunity for accessible, targeted, non-judgmental and convenient support. Whilst the telephone support did not necessarily influence women’s breastfeeding decisions, the support they received left them feeling reassured, confident and more determined to continue breastfeeding. We recommend extending the helpline service to ensure support can be accessed when needed, and ongoing training and support for volunteers. Further advertising and promotion of the service within wider demographic groups is warranted