83 research outputs found

    Zee model and phenomenology of lepton sector

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    The virtual effects of the Zee charged scalar boson on the lepton-family-number (LFN) violating processes are studied. We obtain the constraints on the individual Yukawa coupling constants of the Zee boson to leptons. Using these constraints, we predict the upper bounds on the muonium-antimuonium conversion probability, the branching fractions of the LFN violating decays such as τeγ\tau \to e\gamma, τμγ\tau \to \mu\gamma, τμ+ee\tau^- \to \mu^+e^-e^- and τe+μμ\tau \to e^+\mu^-\mu^-. The contribution of the Zee boson to the muon anomalous magnetic moment is also consideredComment: 13pages, 2figures, Latex; Notes added, two references adde

    Ⅰ. Impact assessment of oil pollution

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    金沢大学大学院自然科学研究科 環境科学Editor : Tazaki, Kazue |田崎, 和

    The role of Majorana CP phases in the bi-maximal mixing scheme -hierarchical Dirac mass case-

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    We discuss the energy scale profile of the bi-maximal mixing which is given at the GUT energy scale in the minimal SUSY model, associated with an assumption that Y_nu^dagger Y_nu is diagonal, where Y_nu is the neutrino-Yukawa coupling matrix. In this model, the Dirac mass matrix which appears in the seesaw neutrino mass matrix is determined by three neutrino masses, two relative Majorana phases and three heavy Majorana masses. All CP phases are related by two Majorana phases. We show that the requirement that the solar mixing angle moves from the maximal mixing at GUT to the observed one as the energy scale decreases by the renormalization effect. We discuss the leptogenesis, and the lepton flavor violation process by assuming the universal soft breaking terms.Comment: 19 pages, 2 figure

    Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer's Disease in the Mild Cognitive Impairment Stage

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    We compared indices of the revised version of the Wechsler Memory Scale (WMS-R) and scaled scores of the five subtests of the revised version of the Wechsler Adult Intelligence Scale (WAIS-R) in 30 elderly schizophrenia (ES) patients and 25 Alzheimer's disease (AD) patients in the amnestic mild cognitive impairment (aMCI) stage (AD-aMCI). In the WMS-R, attention/concentration was rated lower and delayed recall was rated higher in ES than in AD-aMCI, although general memory was comparable in the two groups. In WAIS-R, digit symbol substitution, similarity, picture completion, and block design scores were significantly lower in ES than in AD-aMCI, but the information scores were comparable between the two groups. Delayed recall and forgetfulness were less impaired, and attention, working memory and executive function were more impaired in ES than in AD-aMCI. These results should help clinicians to distinguish ES combined with AD-aMCI from ES alone

    Real-world Effectiveness and Tolerability of Interferon-free Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C: A Multinational Cohort Study

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    BACKGROUND AND AIMS: As practice patterns and hepatitis C virus (HCV) genotypes (GT) vary geographically, a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination goal. This study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs, focusing on GT3 and GT6. METHODS: We analyzed the sustained virological response (SVR12) of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific, North America, and Europe between 07/01/2014-07/01/2021. RESULTS: The mean age was 62±13 years, with 49.6% male. The demographic breakdown was 91.1% Asian (52.9% Japanese, 25.7% Chinese/Taiwanese, 5.4% Korean, 3.3% Malaysian, and 2.9% Vietnamese), 6.4% White, 1.3% Hispanic/Latino, and 1% Black/African-American. Additionally, 34.8% had cirrhosis, 8.6% had hepatocellular carcinoma (HCC), and 24.9% were treatment-experienced (20.7% with interferon, 4.3% with direct-acting antivirals). The largest group was GT1 (10,246 [64.6%]), followed by GT2 (3,686 [23.2%]), GT3 (1,151 [7.2%]), GT6 (457 [2.8%]), GT4 (47 [0.3%]), GT5 (1 [0.006%]), and untyped GTs (261 [1.6%]). The overall SVR12 was 96.9%, with rates over 95% for GT1/2/3/6 but 91.5% for GT4. SVR12 for GT3 was 95.1% overall, 98.2% for GT3a, and 94.0% for GT3b. SVR12 was 98.3% overall for GT6, lower for patients with cirrhosis and treatment-experienced (TE) (93.8%) but ≥97.5% for treatment-naive patients regardless of cirrhosis status. On multivariable analysis, advanced age, prior treatment failure, cirrhosis, active HCC, and GT3/4 were independent predictors of lower SVR12, while being Asian was a significant predictor of achieving SVR12. CONCLUSIONS: In this diverse multinational real-world cohort of patients with various GTs, the overall cure rate was 96.9%, despite large numbers of patients with cirrhosis, HCC, TE, and GT3/6. SVR12 for GT3/6 with cirrhosis and TE was lower but still excellent (\u3e91%)
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