286 research outputs found
Inter-regional Migration: The UK experience
This paper looks at the scenario of intra-UK migration amongst its four regions. The level of intra-UK migration is significant and is increasing over time. Using several measures of the balance in migration we observe that, broadly speaking, the balance is improving. We also examine the impact of changes in the regional per capita GDPs and unemployment levels on regional migration using panel analysis. Several authors find these to be significant factors in international migration. However, it seems that neither regional per capita GDP nor the unemployment level has a significant effect on regional migration in the UK (although the regression coefficients have the correct signs). In the case of regional migration in the UK, it is other characteristics of the source and destination regions which appear to matter most
Description of superdeformed nuclei in the interacting boson model
The interacting boson model is extended to describe the spectroscopy of
superdeformed bands. Microscopic structure of the model in the second minimum
is discussed and superdeformed bosons are introduced as the new building
blocks. Solutions of a quadrupole Hamiltonian are implemented through the
expansion method. Effects of the quadrupole parameters on dynamic moment of
inertia and electric quadrupole transition rates are discussed and the results
are used in a description of superdeformed bands in the Hg-Pb and Gd-Dy
regions.Comment: 18 pages revtex, 9 figures available upon reques
Rates and Factors Associated with Major Modifications to First-Line Combination Antiretroviral Therapy: Results from the Asia-Pacific Region
Background: In the Asia-Pacific region many countries have adopted the WHO's public health approach to HIV care and treatment. We performed exploratory analyses of the factors associated with first major modification to first-line combination antiretroviral therapy (ART) in resource-rich and resource-limited countries in the region. Methods: We selected treatment naive HIV-positive adults from the Australian HIV Observational Database (AHOD) and the TREAT Asia HIV Observational Database (TAHOD). We dichotomised each country's per capita income into high/upper-middle (T-H) and lower-middle/low (T-L). Survival methods stratified by income were used to explore time to first major modification of first-line ART and associated factors. We defined a treatment modification as either initiation of a new class of antiretroviral (ARV) or a substitution of two or more ARV agents from within the same ARV class. Results: A total of 4250 patients had 961 major modifications to first-line ART in the first five years of therapy. The cumulative incidence (95% CI) of treatment modification was 0.48 (0.44-0.52), 0.33 (0.30-0.36) and 0.21 (0.18-0.23) for AHOD, T-H and T-L respectively. We found no strong associations between typical patient characteristic factors and rates of treatment modification. In AHOD, relative to sites that monitor twice-yearly (both CD4 and HIV RNA-VL), quarterly monitoring corresponded with a doubling of the rate of treatment modifications. In T-H, relative to sites that monitor once-yearly (both CD4 and HIV RNA-VL), monitoring twice-yearly corresponded to a 1.8 factor increase in treatment modifications. In T-L, no sites on average monitored both CD4 & HIV RNA-VL concurrently once-yearly. We found no differences in rates of modifications for once- or twice-yearly CD4 count monitoring. Conclusions: Low-income countries tended to have lower rates of major modifications made to first-line ART compared to higher-income countries. In higher-income countries, an increased rate of RNA-VL monitoring was associated with increased modifications to first-line ART. © 2013 Wright et al
Fast variability from black-hole binaries
Currently available information on fast variability of the X-ray emission
from accreting collapsed objects constitutes a complex phenomenology which is
difficult to interpret. We review the current observational standpoint for
black-hole binaries and survey models that have been proposed to interpret it.
Despite the complex structure of the accretion flow, key observational
diagnostics have been identified which can provide direct access to the
dynamics of matter motions in the close vicinity of black holes and thus to the
some of fundamental properties of curved spacetimes, where strong-field general
relativistic effects can be observed.Comment: 20 pages, 11 figures. Accepted for publication in Space Science
Reviews. Also to appear in hard cover in the Space Sciences Series of ISSI
"The Physics of Accretion onto Black Holes" (Springer Publisher
Current lookback time-redshift bounds on dark energy
We investigate observational constraints on dark energy models from lookback
time (LT) estimates of 32 old passive galaxies distributed over the redshift
interval . To build up our LT sample we combine the age
measurements for these 32 objects with estimates of the total age of the
Universe, as obtained from current CMB data. We show that LT data may provide
bounds on the cosmological parameters with accuracy competitive with type Ia
Supernova methods. In order to break possible degeneracies between models
parameters, we also discuss the bounds when our lookback time versus redshift
sample is combined with with the recent measurement of the baryonic acoustic
oscillation peak and the derived age of the Universe from current CMB
measurements.Comment: 6 pages, 4 figures, LaTe
Modelling spectral and timing properties of accreting black holes: the hybrid hot flow paradigm
The general picture that emerged by the end of 1990s from a large set of
optical and X-ray, spectral and timing data was that the X-rays are produced in
the innermost hot part of the accretion flow, while the optical/infrared (OIR)
emission is mainly produced by the irradiated outer thin accretion disc. Recent
multiwavelength observations of Galactic black hole transients show that the
situation is not so simple. Fast variability in the OIR band, OIR excesses
above the thermal emission and a complicated interplay between the X-ray and
the OIR light curves imply that the OIR emitting region is much more compact.
One of the popular hypotheses is that the jet contributes to the OIR emission
and even is responsible for the bulk of the X-rays. However, this scenario is
largely ad hoc and is in contradiction with many previously established facts.
Alternatively, the hot accretion flow, known to be consistent with the X-ray
spectral and timing data, is also a viable candidate to produce the OIR
radiation. The hot-flow scenario naturally explains the power-law like OIR
spectra, fast OIR variability and its complex relation to the X-rays if the hot
flow contains non-thermal electrons (even in energetically negligible
quantities), which are required by the presence of the MeV tail in Cyg X-1. The
presence of non-thermal electrons also lowers the equilibrium electron
temperature in the hot flow model to <100 keV, making it more consistent with
observations. Here we argue that any viable model should simultaneously explain
a large set of spectral and timing data and show that the hybrid
(thermal/non-thermal) hot flow model satisfies most of the constraints.Comment: 26 pages, 13 figures. To be published in the Space Science Reviews
and as hard cover in the Space Sciences Series of ISSI - The Physics of
Accretion on to Black Holes (Springer Publisher
States and transitions in black-hole binaries
With the availability of the large database of black-hole transients from the
Rossi X-Ray Timing Explorer, the observed phenomenology has become very
complex. The original classification of the properties of these systems in a
series of static states sorted by mass accretion rate proved not to be able to
encompass the new picture. I outline here a summary of the current situation
and show that a coherent picture emerges when simple properties such as X-ray
spectral hardness and fractional variability are considered. In particular,
fast transition in the properties of the fast time variability appear to be
crucial to describe the evolution of black-hole transients. Based on this
picture, I present a state-classification which takes into account the observed
transitions. I show that, in addition to transients systems, other black-hole
binaries and Active Galactic Nuclei can be interpreted within this framework.
The association between these states and the physics of the accretion flow
around black holes will be possible only through modeling of the full time
evolution of galactic transient systems.Comment: 30 pages, 11 figures, To appear in Belloni, T. (ed.): The Jet
Paradigm - From Microquasars to Quasars, Lect. Notes Phys. 794 (2009
Demystifying an unidentified EGRET source by VHE gamma-ray observations
In a novel approach in observational high-energy gamma-ray astronomy,
observations carried out by imaging atmospheric Cherenkov telescopes provide
necessary templates to pinpoint the nature of intriguing, yet unidentified
EGRET gamma-ray sources. Using GeV-photons detected by CGRO EGRET and taking
advantage of high spatial resolution images from H.E.S.S. observations, we were
able to shed new light on the EGRET observed gamma-ray emission in the
Kookaburra complex, whose previous coverage in the literature is somewhat
contradictory. 3EGJ1420-6038 very likely accounts for two GeV gamma-ray sources
(E>1 GeV), both in positional coincidence with the recently reported pulsar
wind nebulae (PWN) by HESS in the Kookaburra/Rabbit complex. PWN associations
at VHE energies, supported by accumulating evidence from observations in the
radio and X-ray band, are indicative for the PSR/plerionic origin of spatially
coincident, but still unidentified Galactic gamma-ray sources from EGRET. This
not only supports the already suggested connection between variable, but
unidentified low-latitude gamma-ray sources with pulsar wind nebulae
(3EGJ1420-6038 has been suggested as PWN candidate previoulsy), it also
documents the ability of resolving apparently confused EGRET sources by
connecting the GeV emission as measured from a large-aperture space-based
gamma-ray instrument with narrow field-of-view but superior spatial resolution
observations by ground-based atmospheric Cherenkov telescopes, a very promising
identification technique for achieving convincing individual source
identifications in the era of GLAST-LAT.Comment: 4 pages, 5 figures, Accepted for publication in Astrophysics and
Space Science, Proc. of "The Multi-Messenger Approach to High-Energy
Gamma-ray Sources (Third Workshop on the Nature of Unidentified High-Energy
Sources)", Barcelona, July 4-7, 2006, one typo correcte
The Similarity Hypothesis in General Relativity
Self-similar models are important in general relativity and other fundamental
theories. In this paper we shall discuss the ``similarity hypothesis'', which
asserts that under a variety of physical circumstances solutions of these
theories will naturally evolve to a self-similar form. We will find there is
good evidence for this in the context of both spatially homogenous and
inhomogeneous cosmological models, although in some cases the self-similar
model is only an intermediate attractor. There are also a wide variety of
situations, including critical pheneomena, in which spherically symmetric
models tend towards self-similarity. However, this does not happen in all cases
and it is it is important to understand the prerequisites for the conjecture.Comment: to be submitted to Gen. Rel. Gra
HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer
Human epidermal growth factor receptor 2 (HER2) plays an important role in breast cancer progression and provides predictive information for response to targeted therapy including trastuzumab although this is limited. Downstream pathways, such as PI3K/Akt, are associated with HER2/HER3 heterodimerization promoting survival and proliferation amongst cancer cells. Thus, patient outcome and trastuzumab therapy effectiveness might be further characterised by HER2/HER3 dimerisation and its signalling pathways. HER2/HER3 dimerisation status was assessed, using chromogenic in situ Proximity Ligation Assay, in two breast cancer series: early stage primary breast cancer, including 224 HER2+ patients that were not submitted to trastuzumab, and HER2+ breast cancer where patients were treated with adjuvant trastuzumab (n = 143). Levels of biomarkers including PI3K, pAKT, ER, PgR, HER3, BCL2, p53, PTEN and p21 were measured using immunohistochemistry. Levels of HER2/HER3 heterodimers were compared with biomarker expression and patient outcome. An association between high levels of HER2/HER3 dimerisation and absence of hormone receptors, ER and PgR, was observed. We further show for the first time the presence of HER2/HER3 heterodimers and the loss of p21 expression in HER2+ breast cancer predicts a significantly poorer outcome when submitted to adjuvant trastuzumab. Breast cancer patients that reveal high levels of HER2/HER3 dimerisation and loss of p21 are associated with poor survival prognosis in patients with HER2+ breast cancer treated with adjuvant trastuzumab. Further quantification analysis of HER dimer/ligand complexes and downstream signalling pathways will begin to unravel the complex associations with patient outcome and its relationship with sensitivity to targeted treatment
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