Large hemorrhagic pericardial effusion with cardiac tamponade in a 16-year-old adolescent in an endemic area of tuberculosis: a case report

Pericardial effusion complicated by cardiac tamponade is a medical emergency. Large pericardial effusion and tamponade are rare in childhood. Tuberculosis remains a major cause of pericardial effusion in endemic areas. A 16-year-old adolescent with no significant past history was admitted to the medical unit of the Buea Regional hospital in the South West region of Cameroon for heart failure after presenting with abdominal distension, shortness of breath and fever of two weeks duration. Echocardiographic study during admission revealed a large pericardial effusion (27mm in thickness) with echocardiographic signs of tamponade. Echocardiographic guided pericardiocentesis was performed through a sub-xiphoid route and about 500 cc of heavily stained blood fluid that was not coagulating was drained. Pericardial fluid analysis for acid fast bacilli was negative. There was no evidence of malignancy. A strong suspicion of tuberculosis was made and he was started on anti-tuberculosis medications for presumptive hemorrhagic tuberculous pericarditis. Patient was asymptomatic during follow up and repeat echocardiographic examinations showed no re-accumulation of pericardial fluid. Tuberculosis should be considered as the etiology of pericardial effusion in endemic areas although the identification of mycobacterium is challenging in these settings

Differences in socio-demographic and risk factor profile, clinical presentation, and outcomes between patients with and without RHD heart failure in Sub-Saharan Africa: results from the THESUS-HF registry

Background: Rheumatic heart disease (RHD) was found in the THESUS-HF registry to be the third most common cause of acute heart failure (AHF) in Sub-Saharan Africa. Methods: One thousand six patients with AHF from 9 Sub-Saharan African countries were recruited in THESUS-HF, of which 143 (14.3%) had RHD-AHF. Clinical characteristics and outcomes in patients with RHD-AHF and non-RHD-AHF were compared. Kaplan-Meier plots for time to all-cause death and/or HF readmission according to the presence of RHD-AHF and non-RHD-AHF were performed and survival distributions compared using the log-rank test. Cox regression was used to determine the hazard ratio of death to day 180 and death or readmission to day 60 after adjusting for confounders. Results: Patients with RHD-AHF were younger, more often females, had higher rates of atrial fibrillation, had less hypertension, hyperlipidemia and diabetes, had lower BP, and higher pulse rate and better kidney function and echocardiographic higher ejection fraction larger left atria and more diastolic dysfunction. Patients with RHD-AHF had a numerically longer mean stay in the hospital (10.5 vs. 8.8 days) and significantly higher initial hospitalization mortality (9.1% vs. 3.4%). Conclusions: In conclusion, patients with HF related to RHD were younger, have higher rate of atrial fibrillation and have a worse short-term outcome compared to HF related to other etiologies in Sub-Saharan Afric

Elephant poaching and the ivory trade: The impact of demand reduction and enforcement efforts by China from 2005 – 2017

African elephants are iconic species threatened by poaching and China was considered as one of the main destinations for illegally sourced ivory. In this article we combine two surveys of ivory carving enterprises with other data sets, including Chinese government seizure statistics, market prices for illegal ivory and substitute goods, to understand the impact of enforcement and demand reduction measures on ivory prices and poaching. Our analysis indicates the strong enforcement measures to combat ivory smuggling temporarily suppressed the tendency of illegal trade while stimulating a steep rise in illegal ivory prices thereafter. Peaking in 2012–2013, prices thereafter fell due to government measures to reduce demand under China's ‘Ecological Civilization’ programme and the announcement of ‘The Eight-point Regulation of the Centre’. Our survey suggests that most Chinese carving enterprises were intending to close or to diversify their business activities away from ivory carving as a result of the total ban on domestic ivory trading by 31st December 2017. And China had banned domestic ivory trade for over half a year and all ivory carving enterprises closed their ivory business activities since this domestic ban. In order to prevent ivory demand in other countries that may undermine Chinese efforts, we argue that other countries now also need to adopt multifaceted actions to curtail their domestic ivory trade

A case series of venous thromboembolic disease in a semi-urban setting in Cameroon

Abstract Objective Our goal was to study the clinical characteristics, risk factors and outcome of patients admitted for venous thromboembolism (VTE) in the medical unit of the Buea Regional Hospital, Cameroon between 1st July 2016 and 30th November 2017. Results Twenty-two patients were admitted for VTE. There were 12 (54.4%) men. The mean age was 54.9 ± 13.9 years (range: 31–77 years). The main risk factors were immobilization (40.9%), HIV infection (22.7%), tuberculosis (18.2%), obesity (13.6%) and cancer (13.6%). Nineteen (86.4%) patients had deep venous thrombosis (DVT), 3(13.6%) had pulmonary embolism (PE). One patient had a concomitant DVT and PE. All patients received low molecular weight heparin and 76.2% were discharged on oral vitamin K antagonist while 23.8% were discharged on direct oral anticoagulants. The median length of hospital stay was 9.5 days (range: 4–34). Three deaths (13.6%) were recorded. This study describes VTE in a semi-urban setting in Cameroon and shows that immobility, HIV infection and tuberculosis are common risk factors for VTE in this semi-urban setting

Fatal monomorphic ventricular tachycardia in a semi-urban setting in Cameroon:A case report

Background: Ventricular tachycardia is a life threatening cardiac arrhythmia. It needs management with defibrillation, without which, immediate death may occur. Case presentation: A 66 year old black African patient with a 2 year history of hypertension was admitted to the emergency department of the Buea Regional hospital, a semi-urban setting in Cameroon, after presenting with syncope while in church. The wife described a similar episode 2 weeks prior without any further evaluation. Upon arrival at the emergency, patient had regained consciousness but lethargic, tachypneic and diaphoretic. The blood pressure was 85/61 mmHg; the pulse was 219/min, weak and thready. He had cold extremities. A 12 lead electrocardiogram performed showed a sustained monomorphic ventricular tachycardia at 230/min. He was administered six tablets of amiodarone, oxygen by nasal cannula and intravenous fluids. No electrical cardioversion was attempted due to the non availability of a defibrillator. Outcome was fatal with death of the patient 30 min after his arrival to the emergency. Conclusion: Our health facilities should be well equipped for resuscitative measures by adopting Advanced Cardiac Life Support as cardiovascular diseases are becoming more frequent in our settings