Diagnostics and self-certification of specialists for increase of occupational mobility level

We suggested ways to improve occupational mobility in two directions, which worked on a number of enterprises. These areas are to improve quality management and self-assessmentПредложены пути повышения профессиональной мобильности по двум направлениям, которые отработаны на ряде предприятий. Такими направлениями являются совершенствование качеств менеджера и самоаттестаци

About some economic applications of cohort analysis

Nowadays, there is the problem of evaluating the return on advertising costs for industries with a delayed conversion. Cohort analysis is a series of studies which are conducted at certain time intervals. Using cohort analysis we can better assess the effectiveness of advertising channels for industries with a delayed conversion. Cohort analysis can be used to analyze following items: efficiency in the context of "traffic sources", usefulness of changes on the web site; assessment of effectiveness of marketing campaigns; assessment of impact of seasonality on the behavior of the user; the decision-making period. The article presents an overview of tools we can use to collect data for analysis. The article also describes the method of selection and the variants of the cohorts to construct the analysis. For demonstration of the proposed method and calculation variant, there is considered the practical example of building a cohort analysis. Using these method and the example of calculating, the companies with delayed conversion can analyze the effectiveness of Internet advertising for different advertising channels. © 2018 Author(s)

Statistical analysis of the use an internal capital adequacy assessment procedure in the monitoring of banks stability

To increase the stability of the banking system, it is necessary to use effective systems of risk management and monitoring of banks. One of these systems is the internal procedure for capital adequacy assessment (IPCAA). The purpose of this study is to assess, using a statistical analysis, the impact of the IPCAA procedure on changes in the value of banks' capital adequacy ratios. Some results of monitoring data are presented on risk-weighted assets, level 1 and 2 capitals, and capital adequacy ratios (CAR) for two foreign (2008 - 2018) and three Russian banks (2014 - 2018). The study showed the direct effect of increasing the risk-weighted assets on the level of capital adequacy (CAR). The results obtained allow concluding that there is a direct significant connection between the IPCAA procedure use and the stability of banks. This procedure provides a comprehensive assessment of the overall capital adequacy of banks, taking into account the existing risks in order to maintain an adequate and stable forecast level of capital. The study also revealed the needs of banks in creating adequate structures to ensure proper management of financial and operational risks, which will simplify the IPCAA process and ensure more effective capital planning and decision-making to provide the stability of both individual banks and the entire banking system. © 2020 American Institute of Physics Inc.. All rights reserved

Development of methods of physical modeling of high-temperature processes in microwave field

In the work discusses the basics of using the microwave field to simulate individual high-temperature processes. The work outlines the applications of the microwave field for the processing of technological waste. In the work the layout technological schemes on the basis of a household microwave oven are proposed.В работе рассмотрены аспекты использования микроволнового поля для моделирования отдельных высокотемпературных процессов. Изложены варианты применения СВЧ поля для переработки техногенных отходов. Предложены компоновочные технологические схемы на основе бытовой микроволновой печи

Analysis of failures of conservative treatment of clinical forms of male Infertility

In a survey of 1012 married couples, the male factor of infertility was detected in 54.7% (p≤0.05). For the reliability of evaluation of the results of spermatogenesis correction and the effectiveness of IVF (ICSI) procedures, 292 men (28.8%) were selected with an infertility factor and healthy wives. At the same time, in 196 people, the etiologic factor was known and in 96 patients idiopathic form of infertility was established (32,87%, р≤0,05). Patients were given 2 courses of stimulating therapy depending on the etiologic cause or empirical therapy in cases of the presence of an idiopathic form. In the absence of effect, couples were sent to IVF (ICSI). The effectiveness of the treatment, depending on the presence of 1, 2 or more 2 factors of infertility, was analysed in the SPSS® 17.0 (© SPSS Inc.) tables, the reliability was considered a program Biostat, 6.1. A direct correlation was found between the clinical variant of infertility and the frequency of pregnancy in the study group, and as well as a direct correlation between the number of external factors and the results of treatment.При обследовании 1012 супружеских пар мужской фактор инфертильности был выявлен в 54,7% (р≤0,05). для достоверности оценки результатов коррекции сперматогенеза и эффективности процедур ВРТ (ЭКО-ИКСИ), было отобрано 292 мужчин (28,8%) с фактором инфертильности и здоровыми женами. При этом у 196 человек этиологический фактор был известен и у 96 пациентов была установлена идиопатическая форма инфертильности (32,87%, р≤0,05). Пациентам было проведено 2 курса стимулирующей терапии в зависимости от этиологической причины или эмпирическая терапия в случаях наличия идиопатической формы. При отсутствии эффекта пары направлялись на ВРТ (ЭКО-ИКСИ). Результативность проводимого лечения в зависимости от наличия 1, 2 и более 2 факторов инфертильности, фиксировалась в таблицах SPSS® 17.0 (© SPSS Inc.), достоверность считалась программой Biostat, 6.1. Была выявлена прямая корреляция между клиническим вариантом инфертильности и частотой возникновения беременности в исследуемой группе, а также прямая корреляция между количеством внешних факторов и результатами лечения

The role of inducing factors in the formation of Rendall plaques and the development of urolithiasis

In this article, we present the main information about some promising markers of urolithiasis-substances formed on the surface of the transitional cell epithelium and involved in the inhibition or induction of crystal formation. The reason for their formation is still not fully understood. There is a hypothesis that they are inducers of calculus formation in the renal calyceal system and are directly related to Randall's plaques, whose role in the pathogenesis of ICdd remains a subject of discussion. In this regard, the study of the relationship of certain markers of urolithiasis with dysfunction of urothelium in the zone of formation of Randalla plaques is important for understanding the pathogenesis of this disease, for which an attempt has been made to thoroughly study Russian and English literature in databases (MEdlINE, PubMed, Medscape). A total of 126 sources were studied (all studies for the period 2000 - 2017), of which 15 publications of the most significant and relevant studies were selected for this review.В данной работе представлены основные сведения о некоторых перспективных маркерах мочекаменной болезни – субстанциях, образующихся на поверхности переходно-клеточного эпителия и участвующих в ингибировании или индукции кристаллообразования. Причина их образования является сих пор до конца не ясна. Существует гипотеза о том, что они являются индукторами образования конкрементов в чашечно-лоханочной системах почек и напрямую связаны с бляшками рэндалла, роль которых в патогенезе МКБдо сих пор остается предметом дискуссии. В связи с этим, изучение связи некоторых маркеров мочекаменной болезни с дисфункцией уротелия в зоне формирования бляшек рендалла имеет важное значение для понимания патогенеза этого заболевания, для чего предпринята попытка всестороннего изучения русской и англоязычной литературы в базах данных (MEdlINE, PubMed, Medscape). Всего изучено 126 источников (все исследования за период 2000 – 2017 гг.), из них в настоящий обзор отобрано 15 публикаций наиболее значимых и релевантных исследований

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007