Facile synthesis of iron-titanate nanocomposite as a sustainable material for selective amination of substitued nitro-arenes

The fabrication of durable and low-cost nanostructured materials remains important in chemical, biologic and medicinal applications. Particularly, iron-based nanomaterials are of central importance due to the ‘noble’ features of iron such as its high abundance, low cost and non-toxicity. Herein we report a simple sol–gel method for the synthesis of novel iron–titanium nanocomposite-based material (Fe9TiO15@TiO2). In order to prepare this material, we made a polymeric gel using ferrocene, titanium isopropoxide and THF precursors. The calcination of this gel in air at 500◦C produced Fe-Ti bimetallic nanoparticles-based composite and nano-TiO2 as support. Noteworthy, our methodology provides an excellent control over composition, size and shape of the resulting nanoparticles. The resulted Fe-based material provides a sustainable catalyst for selective synthesis of anilines, which are key intermediates for the synthesis of several chemicals, dyes and materials, via reduction of structurally diverse and functionalized nitroarenes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Medical perspective of cupping therapy (Ḥijama): a review

Traditional and alternative medicine practitioners have used cupping therapy for centuries.Growing data suggests that it may help treat disorders that are associated to pain in recentyears. An overview of the use of cupping therapy is provided in this article. One of themost effective treatments for Ilaj bil Tadbeer is hijama. A vacuum is created to eitherrelease blood from beneath the skin's surface or merely suction the area without allowingany blood out in this unique therapeutic method, which involves positioning cup-shapedveins on the body's surface. However, the effects in certain clinical trials were really strong.It is suggested that medical professionals or researchers in order to ascertain the efficacyof hijama in the treatment of various illnesses

Acute pancreatitis: A narrative review

Acute pancreatitis is a common cause of acute abdominal pain and can range from mild oedema to severe necrosis of the pancreas. It has a significant impact on morbidity, mortality and financial burden. The global prevalence of pancreatitis is substantial, with the highest rates observed in central and eastern Europe. Diagnosing acute pancreatitis involves considering clinical symptoms, elevated serum amylase and/or lipase levels, and characteristic imaging findings. The causes of acute pancreatitis include obstructive disorders, such as gallstones and biliary sludge, alcohol consumption, smoking, drug-induced pancreatitis, metabolic disorders, trauma, medical procedures, infections, vascular diseases and autoimmune pancreatitis. Appropriate management of acute pancreatitis involves determining the severity of the condition, providing supportive care, addressing the underlying cause, and preventing complications. Advances in classifying the severity of acute pancreatitis and implementing goal-directed therapy have contributed to a decrease in mortality rates. Understanding its prevalence, aetiology and management principles is crucial for clinicians to appropriately diagnose and manage patients with acute pancreatitis

Facile Synthesis of Iron-Titanate Nanocomposite as a Sustainable Material for Selective Amination of Substitued Nitro-Arenes

The fabrication of durable and low-cost nanostructured materials remains important in chemical, biologic and medicinal applications. Particularly, iron-based nanomaterials are of central importance due to the ‘noble’ features of iron such as its high abundance, low cost and non-toxicity. Herein we report a simple sol–gel method for the synthesis of novel iron–titanium nanocomposite-based material (Fe9TiO15@TiO2). In order to prepare this material, we made a polymeric gel using ferrocene, titanium isopropoxide and THF precursors. The calcination of this gel in air at 500 °C produced Fe-Ti bimetallic nanoparticles-based composite and nano-TiO2 as support. Noteworthy, our methodology provides an excellent control over composition, size and shape of the resulting nanoparticles. The resulted Fe-based material provides a sustainable catalyst for selective synthesis of anilines, which are key intermediates for the synthesis of several chemicals, dyes and materials, via reduction of structurally diverse and functionalized nitroarenes

Aetiology, presentation and outcomes of patients presenting with acute pancreatitis in a tertiary care hospital

Acute pancreatitis (AP) is a multi-causal disease with a high rate of hospitalisation. Only a few clinical studies have investigated the aetiological background, severity, and outcome of AP in Pakistan. Hence, this study was carried out to determine the aforementioned factors and correlate them with outcomes in a tertiary care setting. This was a cross-sectional, retrospective study conducted at the Department of Gastroenterology, Aga Khan University Hospital, Karachi, from January 1, 2022, to December 31, 2022. Data was analysed using statistical software SPSS version 25. Vomiting was the predominant presenting complaint and was seen in 139 (78.5%) patients. Gallstones were the predominant cause in 68 (37%) patients, followed by idiopathic pancreatitis in 22 (12%) patients. Thirteen (7.1%) patients passed away. Patients with systemic complications were likely to suffer from severe disease (p=0.02), whereas those with local complications were at an increased risk of mortality (p=0.04). ---Continu

Drought-induced changes in plant-yield interlinked biochemistry of cauliflower (Brassica oleracea L. var. botrytis) by exogenously applied alpha-tocopherol

To assess the potential of exogenously-applied vitamin E commonly known as alpha-tocopherol (α-TOC) in drought stress tolerance, an experiment was performed on cauliflower (Brassica oleracea L. var. botrytis) plants. Two cultivars (TCF-605 and White Figer) of cauliflower were subjected to control and drought stress conditions. After thirty days of drought stress treatment, cauliflower plants were treated with α-TOC (150 and 300 mg/L) as a foliage spray. Drought stress markedly inhibited the plant biomass, leaf characteristics such as relative water contents (RWC), chlorophyll pigments (a and b), proline, ascorbic acid (AsA), GB, however it elevated RMP, total phenolics, activities of antioxidant enzymes e.g., CAT, SOD and POD. Drought stress also adversely affected curd characteristics including its fresh weight, GB, proline, total phenolics and enzymes activities (SOD and CAT). Exogenously applied α-TOC considerably suppressed RMP, while it improved plant growth, yield, RWC, total phenolics, ascorbic acid and POD, SOD, and CAT enzyme activities in the leaves of the cauliflower. Exogenous application of α-TOC also raised curd total phenolics, AsA and the activities of all observed enzymes under water deficiency. The cv. TCF-605 was better in shoot weight, shoot length, RWC, proline as well as GB contents, while cv. White Figer was higher in leaf RMP, proline and AsA levels under drought stress conditions. Overall, the results exhibited that cauliflower cv. TCF-605 was relatively tolerant to water stress in relation to growth and yield outcomes, which was interlinked with α-TOC-induced improved leaf and curd osmoprotection and antioxidative defense system. So, exogenous application of α-TOC can be suggested for improving growth and yield potential of crops subjected to drought stress

Association of COVID19-affected Mental Health with Menstrual Abnormalities among University Students: A cross sectional study from Pakistan

Introduction: Mental health is crucial for wellbeing. COVID-19 pandemic has caused mental health problems. In this study it was hypothesized that COVID19 related mental health disturbances may have impacted the menstrual health. Objective of this study was to evaluate the impact of COVID-19 affected mental health on the menstrual health of university students. Methods: A cross sectional study was conducted at University of Sindh, Jamshoro between July to August 2021 during fourth wave. A pre-tested questionnaire was administered to collect the data. Healthy unmarried female students were included in the study. Mental health parameters were assessed using DAS Scale. Results:  For a total 400 study participants the mean age was 20.82±1.69. The prevalence of mild to severe depression, mild to severe anxiety, and mild to moderate stress was 46.3%, 62% and 29.3% respectively. In moderately depressed females there was an increased prevalence of oligomenorrhea [ꭓ2=34.5 p<0.0001], heavy menstrual blood flow [ꭓ2=21.8 p<0.001], increased duration of menstrual bleeding [ꭓ2=21.56 p<0.001], and heavy menstrual dysmenorrhea [ꭓ2=18.78 p<0.002]. In moderately anxious females there was an increased prevalence of oligomenorrhea [ꭓ2=15.5 p<0.07], heavy menstrual blood flow [ꭓ2=12.4 p<0.03], and increased duration of menstrual bleeding [ꭓ2=21.56 p<0.001]. In moderately stressed females there was increased prevalence of polymenorrhagia [ꭓ2=22.3 p<0.001], increased duration of menstrual bleeding [ꭓ2=24.23 p<0.0001], heavy menstrual dysmenorrhea [ꭓ2=21.28 p<0.01] and secondary amenorrhea [ꭓ2=4.28 p<0.01]. Conclusion: COVID19-affected Mental Health affected menstrual health. Healthcare system of Pakistan should address this issue while planning to mitigate the impacts of COVID-19 on human health

Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data

Neurodegeneration is a progressive loss of neuronal cells in certain regions of the brain. Most of the neurodegenerative disorders (NDDs) share the communal characteristic such as damage or reduction of various cell types typically including astrocytes and microglial activity. Several compounds are being trialed to treat NDDs but they possess solitary symptomatic advantages along with copious side effects. The finding of more enthralling and captivating compounds to suspend and standstill the pathology of NDDs will be considered as a hallmark of present times. Phytochemicals possess the potential to alternate the synthetic line of therapy against NDDs. The present review explores the potential efficacy of plant-derived flavonoids against most common NDDs including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Flavonoids are biologically active phytochemicals which possess potential pharmacological effects, including antiviral, anti-allergic, antiplatelet, anti-inflammatory, anti-tumor, anti-apoptotic and anti-oxidant effects and are able to attenuate the pathology of various NDDs through down-regulating the nitric oxide (NO) production, by reducing the tumor necrosis factor-α (TNF-α), by reducing the excitotoxicity of superoxide as well as acting as tyrosine kinase (TK) and monoamine oxidase (MAO) inhibiting enzyme