Multiple Equilibria in a Single-Column Model of the Tropical Atmosphere

A single-column model run under the weak temperature gradient approximation, a parameterization of large-scale dynamics appropriate for the tropical atmosphere, is shown to have multiple stable equilibria. Under conditions permitting persistent deep convection, the model has a statistically steady state in which such convection occurs, as well as an extremely dry state in which convection does not occur. Which state is reached depends on the initial moisture profile.Comment: Submitted to Geophysical Research Letter

Age-Related Olfactory Decline is Associated with the BDNF Val66met Polymorphism: Evidence from a Population-Based Study

The present study investigates the effect of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on change in olfactory function in a large scale, longitudinal population-based sample (n = 836). The subjects were tested on a 13 item force-choice odor identification test on two test occasions over a 5-year-interval. Sex, education, health-related factors, and semantic ability were controlled for in the statistical analyses. Results showed an interaction effect of age and BDNF val66met on olfactory change, such that the magnitude of olfactory decline in the older age cohort (70–90 years old at baseline) was larger for the val homozygote carriers than for the met carriers. The older met carriers did not display larger age-related decline in olfactory function compared to the younger group. The BDNF val66met polymorphism did not affect the rate of decline in the younger age cohort (45–65 years). The findings are discussed in the light of the proposed roles of BDNF in neural development and maintenance

Controlled population-based comparative study of USA and international adult [55-74] neurological deaths 1989-2014.

OBJECTIVES: A population-based controlled study to determine whether adult (55-74 years) neurological disease deaths are continuing to rise and are there significant differences between America and the twenty developed countries 1989-91 and 2012-14. METHOD: Total Neurological Deaths (TND) rates contrasted against control Cancer and Circulatory Disease Deaths (CDD) extrapolated from WHO data. Confidence intervals compare USA and the other countries over the period. The Over-75's TND and population increases are examined as a context for the 55-74 outcomes. RESULTS: Male neurological deaths rose >10% in eleven countries, the other countries average rose 20% the USA 43% over the period. Female neurological deaths rose >10% in ten counties, averaging 14%, the USA up 68%. USA male and female neurological deaths increased significantly more than twelve and seventeen countries, respectively. USA over-75s population increased by 49%, other countries 56%. Other countries TND up 187% the USA rose fourfold. Male and female cancer and CDD fell in every country averaging 26% and 21%, respectively, and 64% and 67% for CDD. Male neurological rates rose significantly more than Cancer and CCD in every country; Female neurological deaths rose significantly more than cancer in 17 countries and every country for CDD. There was no significant correlation between increases in neurological deaths and decreases in control mortalities. CONCLUSIONS: There are substantial increases in neurological deaths in most countries, significantly so in America. Rises in the 55-74 and over-75's rates are not primarily due to demographic changes and are a matter of concern warranting further investigation

Massive type IIA string theory cannot be strongly coupled

Understanding the strong coupling limit of massive type IIA string theory is a longstanding problem. We argue that perhaps this problem does not exist; namely, there may be no strongly coupled solutions of the massive theory. We show explicitly that massive type IIA string theory can never be strongly coupled in a weakly curved region of space-time. We illustrate our general claim with two classes of massive solutions in AdS4xCP3: one, previously known, with N = 1 supersymmetry, and a new one with N = 2 supersymmetry. Both solutions are dual to d = 3 Chern-Simons-matter theories. In both these massive examples, as the rank N of the gauge group is increased, the dilaton initially increases in the same way as in the corresponding massless case; before it can reach the M-theory regime, however, it enters a second regime, in which the dilaton decreases even as N increases. In the N = 2 case, we find supersymmetry-preserving gauge-invariant monopole operators whose mass is independent of N. This predicts the existence of branes which stay light even when the dilaton decreases. We show that, on the gravity side, these states originate from D2-D0 bound states wrapping the vanishing two-cycle of a conifold singularity that develops at large N.Comment: 43 pages, 5 figures. v2: added reference

Spatial quantitation of drugs in tissues using liquid extraction surface analysis mass spectrometry imaging

Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis to a quantitative analytical technique by employing a mimetic tissue model previously shown to be applicable for MALDI-MSI quantitation. Liver homogenate was used to generate a viable and molecularly relevant control matrix for spiked drug standards which can be frozen, sectioned and subsequently analyzed for the generation of calibration curves to quantify unknown tissue section samples. The effects of extraction solvent composition, tissue thickness and solvent/tissue contact time were explored prior to any quantitative studies in order to optimize the LESA-MSI method across several different chemical entities. The use of a internal standard to normalize regional differences in ionization response across tissue sections was also investigated. Data are presented comparing quantitative results generated by LESA-MSI to LC-MS/MS. Subsequent analysis of adjacent tissue sections using DESI-MSI is also reported

Perturbing gauge/gravity duals by a Romans mass

We show how to produce algorithmically gravity solutions in massive IIA (as infinitesimal first order perturbations in the Romans mass parameter) dual to assigned conformal field theories. We illustrate the procedure on a family of Chern--Simons--matter conformal field theories that we recently obtained from the N=6 theory by waiving the condition that the levels sum up to zero.Comment: 30 page

Simplifying superstring and D-brane actions in AdS(4) x CP(3) superbackground

By making an appropriate choice for gauge fixing kappa-symmetry we obtain a relatively simple form of the actions for a D=11 superparticle in AdS(4) x S(7)/Z_k, and for a D0-brane, fundamental string and D2-branes in the AdS(4) x CP(3) superbackground. They can be used to study various problems of string theory and the AdS4/CFT3 correspondence, especially in regions of the theory which are not reachable by the OSp(6|4)/U(3) x SO(1,3) supercoset sigma-model. In particular, we present a simple form of the gauge-fixed superstring action in AdS(4) x CP(3) and briefly discuss issues of its T-dualization.Comment: 1+36 pages, v2,v3 clarifications and references adde