VV124 (UGC4879): A new transitional dwarf galaxy in the periphery of the Local Group

We present the first resolved-star photometry of VV124 (UGC4879) and find that this is the most isolated dwarf galaxy in the periphery of the Local Group. Based on imaging and spectroscopic follow up observations with the 6m BTA telescope, we resolve VV124 into 1560 stars down to the limiting magnitude levels of V~25.6 and I~23.9. The young blue stellar populations and emission gas are found near the core, but noticeably displaced from the center of the galaxy as traced by dominant evolved red stars. The mean radial velocity derived from the spectra of two Blue Supergiant stars, an HII region and unresolved continuum sources is -80+/-10 km/s. The evolved ``red tangle'' stellar populations, which contains the red giant branch (RGB), are identified at large galactocentric radii. We use the I-band luminosity function to determine the distance based on the Tip of RGB method, 1.1+/-0.1 Mpc. This is ~10 times closer than the values usually assumed in the literature, and we provide revised distance dependent parameters. From the mean (V-I) color of the RGB, we estimate the mean metallicity as [Fe/H]~-1.37 dex. Despite of its isolated location, the properties of VV124 are clearly not those of a galaxy in formation, but rather similar to a transitional dIrr/dSph type.Comment: 4 pages, submitted to MNRAS Letter

ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway

We previously reported that ABI3 expression is lost in follicular thyroid carcinomas and its restoration significantly inhibited cell growth, invasiveness, migration, and reduced tumor growth in vivo. The mechanistic basis by which ABI3 exerts its tumor suppressive effects is not fully understood. In this study, we show that ABI3 is a phosphoprotein. Using proteomic array analysis, we showed that ABI3 modulated distinct cancer-related pathways in thyroid cancer cells. The KEA analysis found that PI3K substrates were enriched and forced expression of ABI3 markedly decreased the phosphorylation of AKT and the downstream-targeted protein pGSK3 beta. We next used immunoprecipitation combined with mass spectrometry to identify ABI3-interacting proteins that may be involved in modulating/integrating signaling pathways. We identified 37 ABI3 partners, including several components of the canonical WAVE regulatory complex (WRC) such as WAVE2/CYF1P1/NAP1, suggesting that ABI3 function might be regulated through WRC. Both, pharmacological inhibition of the PI3K/AKT pathway and mutation at residue S342 of ABI3, which is predicted to be phosphorylated by AKT, provided evidences that the non-phosphorylated form of ABI3 is preferentially present in the WRC protein complex. Collectively, our findings suggest that ABI3 might be a downstream mediator of the PI3K/AKT pathway that might disrupt WRC via ABI3 phosphorylation.Sao Paulo State Research Foundation (FAPESP)Univ Fed Sao Paulo, Genet Bases Thyroid Tumors Lab, Div Genet, Dept Morphol & Genet,Escola Paulista Med, Sao Paulo, BrazilFundacao Oswaldo Cruz, FIOCRUZ, Inst Carlos Chagas, Curitiba, Parana, BrazilUniv Fed Sao Paulo, Genet Bases Thyroid Tumors Lab, Div Genet, Dept Morphol & Genet,Escola Paulista Med, Sao Paulo, BrazilFAPESP: 2013/03867-5FAPESP: 2014/046570-6Web of Scienc

Anisotropy of the space orientation of radio sources. I: The catalog

A catalog of the extended extragalactic radio sources consisting of 10461 objects is compiled based on the list of radio sources of the FIRST survey. A total of 1801 objects are identified with galaxies and quasars of the SDSS survey and the Veron-Veron catalog. The distribution of the position angles of the axes of radio sources from the catalog is determined, and the probability that this distribution is equiprobable is shown to be less then 10^(-7). This result implies that at Z equal to or smaller then 0.5, spatial orientation of the axes of radio sources is anisotropic at a statistically significant level.Comment: 8 pages, 7 figure

Double Bars, Inner Disks, and Nuclear Rings in Early-Type Disk Galaxies

We present results from an imaging survey of an unbiased sample of thirty-eight early-type (S0--Sa), low-inclination, optically barred galaxies in the field. Our goal was to find and characterize central stellar and gaseous structures: secondary bars, inner disks, and nuclear rings. Bars inside bars are surprisingly common: at least one quarter of the sample galaxies (possibly as many as 40%) are double-barred, with no preference for Hubble type or the strength of the primary bar. A typical secondary bar is ~12% of the size of its primary bar and 240--750 pc in radius. We see no significant effect of secondary bars on nuclear activity. We also find kiloparsec-scale inner disks in at least 20% of our sample, almost exclusively in S0 galaxies. These disks are on average 20% the size of their host bar, and show a wider range of relative sizes than do secondary bars. Nuclear rings are present in about a third of our sample. Most are dusty, sites of current or recent star formation, or both; such rings are preferentially found in Sa galaxies. Three S0 galaxies (15% of the S0's) appear to have purely stellar nuclear rings, with no evidence for dust or recent star formation. The fact that these central stellar structures are so common indicates that the inner regions of early-type barred galaxies typically contain dynamically cool and disklike structures. This is especially true for S0 galaxies, where secondary bars, inner disks, and/or stellar nuclear rings are present at least two thirds of the time. (abridged)Comment: LaTeX, 15 pages, 7 EPS figures; to appear in The Astronomical Journal (July 2002

Crystal Structure Of The Human Tip41 Orthologue, Tiprl, Reveals A Novel Fold And A Binding Site For The Pp2ac C-terminus

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)TOR signaling pathway regulator-like (TIPRL) is a regulatory protein which inhibits the catalytic subunits of Type 2A phosphatases. Several cellular contexts have been proposed for TIPRL, such as regulation of mTOR signaling, inhibition of apoptosis and biogenesis and recycling of PP2A, however, the underlying molecular mechanism is still poorly understood. We have solved the crystal structure of human TIPRL at 2.15 angstrom resolution. The structure is a novel fold organized around a central core of antiparallel beta-sheet, showing an N-terminal alpha/beta region at one of its surfaces and a conserved cleft at the opposite surface. Inside this cleft, we found a peptide derived from TEV-mediated cleavage of the affinity tag. We show by mutagenesis, pulldown and hydrogen/deuterium exchange mass spectrometry that this peptide is a mimic for the conserved C-terminal tail of PP2A, an important region of the phosphatase which regulates holoenzyme assembly, and TIPRL preferentially binds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-phosphorylated version. A docking model of the TIPRL-PP2Ac complex suggests that TIPRL blocks the phosphatase's active site, providing a structural framework for the function of TIPRL in PP2A inhibition.6Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)FAPESP fellowship [2011/03054-9]CAPES fellowshipCNPq productivity fellowshipsLNBio/CNPEMFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Evolutive follow-up of the photocatalytic degradation of real textile effluents in TiO2 and TiO2/H2O2 systems and their toxic effects on Lactuca sativa seedlings

Textile industry wastes raise a great concern due to their strong coloration and toxicity. The objective of the present work was to characterize the degradation and mineralization of textile effluents by advanced oxidative processes using either TiO2 or TiO2/H2O2 association and to monitor the toxicity of the products formed during 6 h irradiation in relation to that of the in natura effluent. The results obtained demonstrated that the TiO2/H2O2 association was more efficient in the mineralization of textile effluents than TiO2 alone, with high mineralized ion concentrations (NH4+, NO3-, and SO4(2-)) and significant organic matter reduction rates (represented by the COD and TOC). The toxicity of the degradation products to lettuce seeds (Lactuca sativa) was not significant, since percent germination was not significantly affected and neither was root and sprout percent growth. However, while the TiO2/H2O2 association was more toxic in the first hours of irradiation and less so in the end of the 6 h irradiation, the toxicity of TiO2 increased only slightly in the end of the experiments. Comparatively, the photogenerated products of both the TiO2 and the TiO2/H2O2 association were less toxic than the in natura effluent

An Imaging Survey of Early-Type Barred Galaxies

This paper presents the results of a high-resolution imaging survey, using both ground-based and Hubble Space Telescope images, of a complete sample of nearby barred S0--Sa galaxies in the field, with a particular emphasis on identifying and measuring central structures within the bars: secondary bars, inner disks, nuclear rings and spirals, and off-plane dust. A discussion of the frequency and statistical properties of the various types of inner structures has already been published. Here, we present the data for the individual galaxies and measurements of their bars and inner structures. We set out the methods we use to find and measure these structures, and how we discriminate between them. In particular, we discuss some of the deficiencies of ellipse fitting of the isophotes, which by itself cannot always distinguish between bars, rings, spirals, and dust, and which can produce erroneous measurements of bar sizes and orientations.Comment: LaTeX, 66 pages (including 42 figures, 36 in color). To appear in The Astrophysical Journal Supplement. Full-resolution and text-only versions available at http://www.iac.es/galeria/erwin/research

Political brand image: an investigation into the operationalisation of the external orientation of David Cameron’s Conservative brand

This paper seeks to address the limited understanding of how to operationalise the external brand image of a political brand. More specifically, this research critically assesses the transfer potential of the six variables of brand image by Bosch, Venter, Han and Boshoff to deconstruct the UK Conservative Party brand from the perspective of young people aged 18–24 years during the 2010 UK General Election campaign. This research demonstrates the applicability of the six variables otherwise known as the ‘brand image framework’ to the political environment. However, the application of the brand image framework in its original conceptualisation proved problematic. Many of the brand image variables were clarified, rearticulated and simplified to address the political context. This refined conceptualisation provided an in-depth understanding of how to investigate the political brand image of David Cameron’s Conservative Party. This study addresses the paucity of research that operationalises external brand image and provides practitioners and academics within and beyond the context of political branding a mechanism to understand the external orientation of brands. This research may also be used by political and non-political brands as a basis to explore external brand image and compare its consistency with internal brand identity