Hyperfine interactions in titanates: Study of orbital ordering and local magnetic properties

Hyperfine magnetic fields induced on the nuclei of nonmagnetic ions 139La and 89Y in LaTiO3 and YTiO3, respectively, have been microscopically calculated. The dependence of the hyperfine fields on the orbital and magnetic structures of the compounds under study has been analyzed. The comparative analysis of the calculated and known experimental data confirms the existence of the static orbital structure in lanthanum and yttrium titanates. © 2013 Pleiades Publishing, Ltd

Thyroseq V3 Molecular Profiling for Tailoring the Surgical Management of Hürthle Cell Neoplasms.

Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. The patient had initially requested a diagnostic lobectomy for a definitive diagnosis despite a higher risk of malignancy based on the size of the nodule \u3e 4 cm alone. To better tailor this patient\u27s treatment plan, a newer expanded gene mutation panel, ThyroSeq® v3 that includes copy number alterations (CNAs) and was recently found to have greater positive predictive value (PPV) for identifying Hürthle cell carcinoma (HCC), was performed on the FNAB material. Molecular profiling with ThyroSeq® v3 was able to predict a greater risk of carcinoma, making a more convincing argument in favor of total thyroidectomy. Surgical pathology confirmed a Hürthle cell carcinoma with 5 foci of angioinvasion and foci of capsular invasion

Optical evidence for symmetry changes above the Neel temperature in KCuF3

We report on optical measurements of the 1D Heisenberg antiferromagnet KCuF3. The crystal-field excitations of the Cu2+ ions have been observed and their temperature dependence can be understood in terms of magnetic and exchange-induced dipole mechanisms and vibronic interactions. Above T_N we observe a new temperature scale T_S characterized by the emergence of narrow absorption features that correlate with changes of the orbital ordering as observed by Paolasini et al. [Phys. Rev. Lett. 88, 106403 (2002)]. The appearance of these optical transitions provides evidence for a symmetry change above the Neel temperature that affects the orbital ordering and paves the way for the antiferromagnetic ordering.Comment: 4 pages, 2 figure

Systematical Approach to the Exact Solution of the Dirac Equation for A Special Form of the Woods-Saxon Potential

Exact solution of the Dirac equation for a special form of the Woods-Saxon potential is obtained for the s-states. The energy eigenvalues and two-component spinor wave functions are derived by using a systematical method which is called as Nikiforov-Uvarov. It is seen that the energy eigenvalues strongly depend on the potential parameters. In addition, it is also shown that the non-relativistic limit can be reached easily and directly.Comment: 10 pages, no figures, submitted for Publicatio

DNA topoisomerases participate in fragility of the oncogene RET

Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under conditions that partially inhibit DNA replication, and often coincide with genes deleted, amplified, or rearranged in cancer. While a substantial amount of work has been performed investigating DNA repair and cell cycle checkpoint proteins vital for maintaining stability at fragile sites, little is known about the initial events leading to DNA breakage at these sites. The purpose of this study was to investigate these initial events through the detection of aphidicolin (APH)-induced DNA breakage within the RET oncogene, in which 144 APHinduced DNA breakpoints were mapped on the nucleotide level in human thyroid cells within intron 11 of RET, the breakpoint cluster region found in patients. These breakpoints were located at or near DNA topoisomerase I and/or II predicted cleavage sites, as well as at DNA secondary structural features recognized and preferentially cleaved by DNA topoisomerases I and II. Co-treatment of thyroid cells with APH and the topoisomerase catalytic inhibitors, betulinic acid and merbarone, significantly decreased APH-induced fragile site breakage within RET intron 11 and within the common fragile site FRA3B. These data demonstrate that DNA topoisomerases I and II are involved in initiating APH-induced common fragile site breakage at RET, and may engage the recognition of DNA secondary structures formed during perturbed DNA replication

Regulatory Documentation for Certified Objects Used at the Beloyarsk Nuclear Power Plant

В статье описывается необходимость разработки такого нормативного документа, как свидетельства на аттестованный объект. Также предложены основные пункты, из которых должно состоять свидетельство, обоснован их выбор, приведен пример свидетельства.The article describes the need to develop such a regulatory document as a certificate for a certified object. The main points of which the certificate should consist are proposed, their choice is justified, and an example of the certificate is given

DEVELOPMENT OF A STANDARD CERTIFICATE FOR CERTIFIED OBJECTS USED IN NUCLEAR POWER UTILIZATION

The article describes the need to develop a certificate for a certified object. The main points of which the certificate should consist are proposed in the article, their choice is justi-fied, and an example of the certificate is given

Derivation of determinantal structures for random matrix ensembles in a new way

There are several methods to treat ensembles of random matrices in symmetric spaces, circular matrices, chiral matrices and others. Orthogonal polynomials and the supersymmetry method are particular powerful techniques. Here, we present a new approach to calculate averages over ratios of characteristic polynomials. At first sight paradoxically, one can coin our approach "supersymmetry without supersymmetry" because we use structures from supersymmetry without actually mapping onto superspaces. We address two kinds of integrals which cover a wide range of applications for random matrix ensembles. For probability densities factorizing in the eigenvalues we find determinantal structures in a unifying way. As a new application we derive an expression for the k-point correlation function of an arbitrary rotation invariant probability density over the Hermitian matrices in the presence of an external field.Comment: 36 pages; 2 table