12 research outputs found
Villagers and Illiterates are More Prone to HIV
- Publication venue
- Journal of Advances in Pharmacy Practices
- Publication date
- 12/02/2019
- Field of study
This study aims to find out how far villagers and illiterates are aware of HIV in 104 patients both men women belonging to rural area around suryapet district. Non – co-operative and pregnant women are excluded from the study. Data collection was done in the period from December 8th to January 13th and analysed there education and occupational status and we found very interestingly more than 90% of the patients are not aware of HIV and its consequences and many of them don’t what is HIV and how can it will be prevented, many of the patients are spreading HIV to their spouse without unknowing that is sexually transmissible. Few patients don’t know that HIV will cause from undisposed needles. Interestingly whoever said they are affected due to un-disposed needles are not drug abusers they are affected due to malpractice done by RMPs who are using multiple use of single needle. And very few answered that HIV will transmitted through blood transfusion after they get affected. The people whoever effected mostly belongs to daily wage labour, farmers and truck drivers. So there is need to create awareness in villagers and illiterates to prevent further progression of disease and to prevent the transmission of disease to younger generation
Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review
- Author
- Abdissa A.
- Abobo C.V.
- Akeb F.
- Alsenz J.
- Amad M.H.
- Amara A.B.
- Aouri M.
- Armbruster C.
- Arts E.J.
- Arts E.J.
- Avery L.B.
- Avihingsanon A.
- Avolio A.D.
- Aymard G.
- Aymard G.
- Azoulay S.
- B. Ramesh
- Ballantyne A.D.
- Barkil M.E.
- Barone G.C.
- Barone G.C.
- Bastiani E.
- Becher F.
- Bennetto-hood C.
- Bienvenu E.
- Bloom J.
- Boffito M.
- Bossi P.
- Brereton R.G.
- Brewer E.
- Brown S.D.
- Burger D.
- Burger D.M.
- Burhenne J.
- Burugula L.
- Busti A.J.
- Campanero M.
- Campbell T.B.
- Castellino S.
- Castro A.A.
- Cateau E.
- Cattaneo D.
- Chan C.P.
- Chang D.
- Chapman T.
- Charbe N.
- Cheeseman S.H.
- Chen R.Y.
- Chi B.
- Chi J.
- Chi J.
- Chittick G.E.
- Choi S.O.
- Clark T.N.
- Clevenbergh P.
- Clumeck N.
- Cohen C.
- Colombo S.
- Colombo S.
- Colombo S.
- Cottrell M.L.
- Coulier L.
- Cozzi V.
- Cozzi V.
- Crauwels H.
- Crommentuyn K.M.
- Crommentuyn K.M.
- Custodio J.M.
- Dailly E.
- Dailly E.
- Dailly E.
- Dando T.M.
- Darque A.
- Das Mishra T.
- De Meyer S.
- Deeks E.D.
- DeJesus E.
- Delahunty T.
- Dickinson L.
- DiFrancesco R.
- Djerada Z.
- Dong M.W.
- Dorr P.
- Douglas D.J.
- Dunge A.
- D’Avolio A.
- D’Avolio A.
- D’Avolio A.
- D’Avolio A.
- D’Avolio A.
- Eagling V.A.
- Eichhorst J.C.
- Elens L.
- Elens L.
- Elens L.
- Else L.
- Emilio Clementi
- Eron J.J.
- Estrela R.C.
- Estrela Rde C.
- Faletto M.B.
- Fan B.
- Fayet A.
- Fayet A.
- Ferrer S.M.
- Findlay J.W.
- Fitzsimmons M.E.
- Fizzano M.R.
- Flavia C. Zacconi
- Fletcher C.V.
- Flexner C.
- Foldes O.
- Ford N.
- Foster R.H.
- Fraaij P.L.
- Frappier S.
- Friedland G.
- Fung E.N.
- Gallant J.E.
- Gervasoni C.
- Giraud E.
- Goldwirt L.
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- Gomes N.A.
- Granda B.W.
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- Grix R.
- Grégoire M.
- Gupta A.
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- Ha H.R.
- Haqqani A.A.
- Harker A.J.
- Havlir D.
- Hirabayashi Y.
- Hirano A.
- Hoetelmans R.M.
- Hoetelmans R.M.
- Hoffman J.T.
- Hollanders R.M.
- Hsu A.
- Hsu A.
- Hsyu P.H.
- Hurst M.
- Hurwitz S.J.
- Hwang H.
- Hyland R.
- Ibbotson T.
- Ishikawa T.
- Janoly A.
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- Jayewardene A.L.
- Jemal M.
- Jourdil J.F.
- Jullien V.
- Jung B.H.
- Justesen U.S.
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- Kabra V.
- Kakuda T.N.
- Kang J.S.
- Kassahun K.
- Kearney B.P.
- Keil K.
- Kenney K.B.
- Kilby J.M.
- Kim A.E.
- King J.R.
- King T.
- Klecker R.W.
- Klibanov O.M.
- Knebel N.G.
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- Koal T.
- Koal T.
- Koh Y.
- Koteff J.
- Kromdijk W.
- Kromdijk W.
- Kumar P.N.
- Kupferschmidt H.H.
- La Porte C.J.
- Lamotte C.
- Langmann P.
- Langmann P.
- Langmann P.
- Lau G.K.
- Laurito T.L.
- Lawless M.K.
- Lawrence C.C.
- Le Saux T.
- Lea A.P.
- Lee L.L.
- Leibenguth P.
- Leschziner G.D.
- Letendre S.
- Lewis S.R.
- Lillibridge J.H.
- Liu Z.
- Long M.C.
- Loregian A.
- Maganda B.
- Maggiolo F.
- Manzardo C.
- Marsh K.C.
- Martin J.
- Marzinke M.A.
- Marzolini C.
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- Mathias A.A.
- Matta M.K.
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- McDowell J.A.
- Mcdowell J.A.
- McIlleron H.M.
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- Merschman S.A.
- Mills E.J.
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- Molina J.M.
- Moody W.
- Moss D.M.
- Moyer T.P.
- Murphy R.L.
- Murphy R.L.
- Murtaza M. Tambuwala
- Myasein F.
- Müller A.C.
- Nadal T.
- Nandi U.
- Naxing Xu R.
- Nettles R.E.
- Nikhil Amnerkar
- Nirogi R.
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- Nitin B. Charbe
- Notari S
- Notari S.
- Notari S.
- Notari S.
- Ostrowski M.A.
- Pav J.W.
- Pedersen O.S.
- Penzak S.R.
- Pereira A.S.
- Pereira A.S.
- Peris-vicente J.
- Perry C.M.
- Perry C.M.
- Piscitelli S.C.
- Plumb R.S.
- Podany A.T.
- Poirier J.
- Poirier J.M.
- Polk R.E.
- Polli J.W.
- Pommier Y.
- Profit L.
- Proust V.
- Pruvost A.
- Pynnönen S.T.
- Quaranta S.
- Quevedo M.A.
- Rakhmanina N.Y.
- Ramachandran G.
- Ramanathan S.
- Ramanathan S.
- Raviolo M.A.
- Ravitch J.R.
- Ray J.
- Reese M.J.
- Remmel R.P.
- Rentsch K.M.
- Rezk N.L.
- Rezk N.L.
- Rezk N.L.
- Rezk N.L.
- Rezk N.L.
- Rezk N.L.
- Rezk N.L.
- Ribera E.
- Robbins B.L.
- Robbins B.L.
- Robbins B.L.
- Rotty J.
- Rouzes A.
- Rower J.E.
- Sadler B.M.
- Santoscoy M.
- Saras-Nacenta M.
- Sarasa-Nacenta M.
- Schinkel A.H.
- Schuster A.
- Schöller-Gyüre M.
- Sekar V.J.
- Sentenac S.
- Seshachalam U.
- Shah B.M.
- Shehu-Xhilaga M.
- Shibata M.
- Shimura K.
- Silverthorn C.F.
- Simiele M.
- Simon V.A.
- Solas C.
- Somboonwit C.
- Song I.
- Song I.
- Sparidans R.W.
- Sparidans R.W.
- Sparidans R.W.
- Sparidans R.W.
- Stefan R.I.
- Stoiber H.
- Svensson J.O.
- Takahashi M.
- Takahashi M.
- Talameh J.A.
- Tan X.
- Tarinas A.
- Temesgen Z.
- Ter Heine R.
- Ter Heine R.
- Ter Heine R.
- Ter Heine R.
- Ter Heine R.
- Ter Heine R.
- Tilton J.C.
- Titier K.
- Tribut O.
- Tribut O.
- Trnková L.
- Turner M.L.
- Ucpinar S.D.
- Uglietti A.
- Usami Y.
- Uslu B.
- Van Heeswijk R.
- Van Heeswijk R.P.
- Van Heeswijk R.P.
- Van Heeswijk R.P.
- Veal G.J.
- Veldkamp A.I.
- Veldkamp A.I.
- Verbesselt R.
- Verma S.
- Vermeir M.
- Verweij-van W.C.P.
- Villani P.
- Villani P.
- Vogel M.
- Volosov A.
- Vourvahis M.
- Walker D.K.
- Walmsley S.L.
- Wang L.H.
- Wang P.G.
- Watanabe K.
- Wattananat T.
- Weller D.R.
- Weller S.
- Williams D.I.
- Wiltshire H.R.
- Wood R.
- Woolf E.
- Wu E.Y.
- Yadav M.
- Yadav M.
- Yilmaz A.
- Yuen G.J.
- Zhang J.
- Zheng W.
- Zhou X.J.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- 20/01/2019
- Field of study
Combined BRAF and HSP90 Inhibition in Patients with Unresectable BRAF
- Author
- Andrew S. Brohl
- Bin Fang
- Geoffrey T. Gibney
- Gina Arnone
- Howida Ramadan
- Inna Smalley
- Jane L. Messina
- Jeffrey S. Weber
- Ji
- Jiannong Li
- John M. Koomen
- Joseph Markowitz
- Keiran S.M. Smalley
- Lancia N.F. Darville
- Leticia F. Tetteh
- Nikhil I. Khushalani
- Paraiso
- Phadke
- Ragini R. Kudchadkar
- Ritin Sharma
- Safavi
- Sharma
- Smith
- Vernon K. Sondak
- Xiuhua Zhao
- Y. Ann Chen
- Zeynep Eroglu
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- Field of study
Emergence of three dimensional printed cardiac tissue: opportunities and challenges in cardiovascular diseases
- Author
- Agarwal S.
- Ahuja P.
- Bejleri D.
- Bertassoni L.E.
- Blau H.M.
- Borriello A.
- Brothers T.E.
- Burridge P.W.
- Carrier R.L.
- Caspi O.
- Charbe N.
- Chaudhry H.W.
- Chen P.H.
- Cheng E.Y.
- Choi Y.S.
- Cohen A.
- Cui X.
- Cui X.
- Dababneh A.B.
- Dahl S.L.M.
- Dai G.
- Dinesh Pardhi
- Dvir T.
- Engbers G.H.
- Engel F.B.
- Flavia C. Zacconi
- Fujimoto K.L.
- Gary M.
- Gershlak J.R.
- Golden A.P.
- Guelcher S.A.
- Hannan E.L.
- Hansen C.J.
- Izadifar M.
- Jain R.K.
- Jain R.K.
- Jia W.
- Jiang Y.
- Jockenhoevel S.
- Kim J.J.
- Kinstlinger I.S.
- Kirkpatrick C.J.
- Koike N.
- Kolesky D.B.
- Kolesky D.B.
- Kuhn A.I.
- Lee J.B.
- Lee J.H.
- Lee V.
- Levenberg S.
- Levenberg S.
- Lu T.Y.
- Lu W.N.
- Mackay T.G.
- Maiullari F.
- Mandrycky C.
- Martinez-Fernandez A.
- Masuda S.
- Matsuda H.
- Miller J.S.
- Molitch-Hou M.
- Murphy S.V.
- Murtaza M. Tambuwala
- Narazaki G.
- Naskar D.
- Nikhil Amnerkar
- Nitin B. Charbe
- Oh H.
- Ong C.S.
- Park H.
- Patra C.
- Paul A. McCarron
- Pei D.
- Peltola S.M.
- Perez-Ilzarbe M.
- Perloff L.J.
- Peter M.G.
- Pok S.
- Priyank Shukla
- Qi J.
- Radisic M.
- Richardson T.P.
- Roy A.
- Sakaguchi K.
- Sarker M.D.
- Schechner J.S.
- Schöneberg J.
- Shengjie Li.
- Shimizu T.
- Skardal A.
- Studzinski G.P.
- Su W.F.
- Takahashi K.
- Tareq L. Mukattash
- Tijore A.
- Tomizawa Y
- Van Damme H.
- Van Laake L.W.
- Velasquillo C.
- Vrandecic M.O.
- Wang C.
- Wang G.
- Wang J.
- Wang Z.
- Wolinsky H.
- Wu S.M.
- Wu W.
- Xu Y.
- Yamashita J.
- Yan Y.
- Yang Y.
- Yeong W.Y.
- Zhang J.
- Zhang X.
- Zhao L.
- Zhu K.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- 12/01/2019
- Field of study
Magnetic, chemical and radionuclide studies of river sediments and their variation with different physiographic regions of Bharathapuzha river, southwestern India
- Author
- A. El-Gamal
- A. Guereschi
- A. Hunt
- A.H. Parizanganeh
- Ana M. Sinito
- B.A. Maher
- C. Elejalde
- C. Peters
- C. Roselli
- C. Yafa
- C.W. Rapela
- C.X. Zhang
- D. McCubbin
- D.J. Dunlop
- D.V. Jordanova
- E. Agustine
- E. Petrovský
- F. Desenfant
- G. Suresh
- J. Dearing
- J. Dearing
- J. King
- J.D. Milliman
- K. Sandeep
- K.L. Lecomte
- Karina L. Lecomte
- L.C. Scholten
- M. Knab
- M.A.E. Chaparro
- M.A.E. Chaparro
- M.A.E. Chaparro
- M.A.E. Chaparro
- M.A.E. Chaparro
- M.A.E. Chaparro
- M.E. Evans
- M.L. Montes
- Marcos A. E. Chaparro
- Mauro A. E. Chaparro
- N. Akhtar
- N. Kannan
- N. Krishnamoorthy
- N. Raj
- N.N. Jibiri
- N.S. Magesh
- Nanjundan Krishnamoorthy
- P. Basak
- P. Beckwith
- P. Chauhan
- P. Tume
- P.P. Nikhil Raj
- R. Chandrajith
- R. Mustonen
- R. Scholger
- R. Sreela
- R. Thompson
- R. Veiga
- R.A. Bulman
- R.A. Ligero
- R.J. Meijer De
- R.J. Meijer De
- Rohit Mehra
- S. Righi
- S. Sakthimurugan
- S. Savci
- S.M. El-Bahi
- S.R. Sreela
- Sundaram Mullainathan
- T. Magiera
- T. Yang
- UNSCEAR
- V. Ramasamy
- W. Chen
- W.R. Alharbi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Chemokines: A Potential Therapeutic Target to Suppress Autoimmune Arthritis
- Author
- Abu H. Md. G. Sarwar
- Aeberli D.
- Aerts N.E.
- Ahmad S.F.
- Aldahlawi A.M.
- Alexander S.P.
- Amat M.
- Antonelli A.
- Balasubramanian P.K.
- Bao J.
- Blaschke S.
- Borzì R.M.
- Boyle D.L.
- Bryant J.
- Brühl H.
- Bugatti S.
- Cecchinato V.
- Cesaro A.
- Chen Z.
- Cheng P.
- Choi J.
- Clanchy F.I.L.
- Coelho F.M.
- Cunha T.M.
- Cyster J.G.
- De Klerck B.
- Di Paola R.
- Duan H.
- D’Ambrosio D.
- Emu B.
- Gao B.
- Gao F.
- Gao P.
- Garcia Ede F.
- Gerlag D.M.
- Ghulam Md Ashraf
- Gladue R.P.
- Gong J.H.
- Greisen S.R.
- Halloran M.M.
- Han B.K.
- Han Y.
- Haq S.K.
- Haringman J.J.
- Hinks A.
- Hounoki H.
- Ibrahim I.
- Impellizzeri D.
- Jones J.D.
- Kawashiri S.Y.
- Kennedy W.P.
- Klimatcheva E.
- Klimiuk P.A.
- Koch A.E.
- Kotrych D.
- Krishnamurthy A.
- Kuo S.J.
- Lan Y.Y.
- Laragione T.
- Lebre M.C.
- Lee E.Y.
- Li C.H.
- Li G.
- Li N.
- Lin Y.C.
- Liu X.
- Mahmood A. Khan
- Manjavachi M.N.
- Marino F.
- Marotte H.
- Matsukawa A.
- Matsukawa A.
- Min S.H.
- Mohammad A. Kamal
- Mohan K.
- Moschovakis G.L.
- Nanki T.
- Nikhil Khurana
- Nishimura A.
- Odai T.
- Ospelt C.
- Pathak J.L.
- Paulissen S.M.
- Pereira M.M.
- Perkins E.A.
- Podolin P.L.
- Qamre Alam
- Rafat S. Ahmed
- Revesz L.
- Rodríguez-Rodríguez L.
- Rosas E.C.
- Rosengren S.
- Rosengren S.
- Rossato C.
- Rossol M.
- Sadiq Umar
- Schmidt N.
- Shahrara S.
- Shi L.J.
- Slauenwhite D.
- Strunz A.K.
- Takemura S.
- Tamamura H.
- Turner-Brannen E.
- Umemura M.
- Vergunst C.E.
- Wang B.
- Wang Y.
- Wigerblad G.
- Yamaguchi A.
- Yang R.C.
- Yellin M.
- Yeo L.
- Yokoyama W.
- Yoon C.H.
- Yoshimura S.
- Youssef S.
- Zapico I.
- Zhebrun D.A.
- Zhong C.
- Zimmerman D.H.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Pathological Perturbations in Diabetic Retinopathy: Hyperglycemia, AGEs, Oxidative Stress and Inflammatory Pathways
- Author
- Adamis A.P.
- Agardh E.
- Aiello L.P.
- Alka Chaubey
- Barile G.R.
- Baynes J.W.
- Beckman J.S.
- Behar-Cohen F.F.
- Bernstein P.S.
- Bhatwadekar A.
- Bolton W.K.
- Bone R.A.
- Broe R.
- Brownlee M.
- Brownlee M.
- Bry M.
- Candas D.
- Chang K.C.
- Chaturvedi N.
- Cheung N.
- Cowell R.M.
- Coyne T.
- Cui Y.
- Cutler R.G.
- Dagher Z.
- Dandona L.
- Daniels M.C.
- Dedov I.
- Ding J.
- Donaghue K.C.
- Donato R.
- Du X.
- Du Y.
- Egan A.M.
- El-Asrar A.M.
- El-Asrar A.M.
- El-Asrar A.M.
- Ellis E.A.
- Finkel T.
- Fosmark D.S.
- Gabbay K.H.
- Gabbay K.H.
- Gadkari S.S.
- Gardiner T.A.
- Gerstein H.C.
- Giacco F.
- Gomaa A.R.
- Gonzalez R.G.
- Granger D.N.
- Grigsby J.G.
- Gurel Z.
- Hammes H.P.
- Hammes H.P.
- Hammes H.P.
- Handelman G.J.
- Harjutsalo V.
- Haskins K.
- Haskins K.
- Hautala N.
- Hu B.J.
- Izuta H.
- Jee D.
- Jin P.
- Jones C.D.
- José Pedro De La Cruz M.D.
- Kajiwara A.
- Kan S.
- Kanwar M.
- Kempen J.H.
- Kern T.S.
- Kern T.S.
- Kimura K.
- Klein R.
- Kobrin Klein B.E.
- Kolm V.
- Kolm-Litty V.
- Kowluru A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kowluru R.A.
- Kuhla B.
- Kung K.
- Lal S.
- Lassegue B.
- Le L.M.
- LeRoith D.
- Lingen M.W.
- Liu L.
- Lorenzi M.
- Malecaze F.
- Mancino R.
- Marshall S.
- Marshall S.
- Miller A.G.
- Mohamed A.K.
- Mohamed Q.
- Murata T.
- Murphy M.P.
- Nakamura M.
- Naldini A.
- Narayanan S.P.
- Narendran V.
- Nikhil Shri Sahajpal
- Oates P.
- Oates P.J.
- Obrosova I.G.
- Ok T.
- Olsen B.S.
- Ono Y.
- Osaadon P.
- Perrin R.M.
- Puppala M.
- Radi R.
- Rahbar S.
- Rajesh Kumar Goel
- Raman R.
- Raman R.
- Rema M.
- Ren X.Y.
- Rocco M.V.
- Rohan Aurora
- Romeo G.
- Romero-Aroca P.
- Romero-Aroca P.
- Roy M.S.
- Safi S.Z.
- Sahajpal N.S.
- Sahajpal N.S.
- Salinero-Fort M.A.
- Schalkwijk C.G.
- Semeraro F.
- Senthilkumari S.
- Sharma K.
- Simó R.
- Sjolie A.K.
- Stitt A.
- Stitt A.W.
- Stitt A.W.
- Stitt A.W.
- Stratton I.M.
- Subheet Kumar Jain
- Sugiyama S.
- Sun L.
- Thomas R.L.
- Thompson K.
- Thorpe S.R.
- Travis S.F.
- Tsai T.
- Tsin A.T.
- Tudor S.M.
- Vasan S.
- Wang F.H.
- Winges A.
- Xu J.
- Yamaguchi M.
- Yau J.W.
- Yokoi M.
- Yoshida S.
- Yu Y.
- Zhang X.
- Zhang X.
- Zheng L.
- Ziyadeh F.N.
- Zong H.
- Zong H.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
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- Whiteley Simon
- Whiteside J.
- Whittle H.
- Whitton Christopher
- Whyte Clare
- Wicks S.J.
- Wilby Elizabeth
- Wilcox L.
- Wilcox R.
- Wild H.
- Wild Laura
- Wiles M.
- Wilkins J.
- Wilkinson Ami
- Wilkinson B.
- Willer C.
- Williams A.
- Williams A.
- Williams A.
- Williams Alexander T.
- Williams D.
- Williams E.
- Williams F.
- Williams Gemma
- Williams H.
- Williams Karen
- Williams Marie
- Williams P.
- Williams S.
- Williams Toran
- Willis C.
- Willis Heather
- Wills M.
- Willson J.
- Wilson A.
- Wilson D.J.
- Wilson James F.
- Wilson Jean
- Winnard Sarah
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford Brooke N.
- Wong Joanna
- Wood D.
- Wood Hannah-Louise
- Wood Suzanne
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt Wiesia
- Woolley A.E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wright D.
- Wright J.
- Wright M.
- Wrobel Nicola
- Wu Yang
- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier Kugan
- Xue X.
- Yadav A.
- Yang Jian
- Yassen Amr M.
- Yates Brian
- Ye C.
- Yun Nikki
- Zainy Tala
- Zak Anne
- Zaki Ahmed
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg Hugo
- Zechner Marie
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng Chenqing
- Zhou W.
- Zitter L.
- Zlatopolsky Menachem
- Zongo Olivier
- Zucchi P.
- Zyndorf Marissa
- Zöllner S.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Protein-Protein Interactions and Aggregation Inhibitors in Alzheimer’s Disease
- Author
- Ahlijanian M.K.
- Albasanz J.L.
- Alptüzün V.
- Alvarez A.
- Ankit Ganeshpurkar
- Arai A.
- Araki Y.
- Arnold C.S.
- Ashok Kumar
- Aydın A.
- Azimi S.
- Azzarito V.
- Bach A.
- Bach A.
- Balducci C.
- Ballatore C.
- Barry A.E.
- Bartolini M.
- Basha S.J.
- Baxter D.
- Belluti F.
- Belluti F.
- Berg T.
- Biederer T.
- Binder L.I.
- Bitan G.
- Black W.
- Blackwell H.E.
- Brogi S.
- Brown B.A.
- Bruggink K.A.
- Bulic B.
- Burdick D.
- Bush A.I.
- Camps P.
- Canu N.
- Capell A.
- Carson K.A.
- Chakraborty S.
- Chang K.H.
- Chang T.S.
- Chatterjee A.
- Chen J.J.
- Chen S.
- Chen X.
- Chioua M.
- Cho K.J.
- Chorev M.
- Citron M.
- Cottrell D.A.
- Crowe A.
- Cumming J.
- Cumming J.
- Cumming J.N.
- Cumming J.N.
- Cummings J.
- Daccache A.
- Dehbi O.
- Demange L.
- Devendra Kumar
- Dileep Kumar
- Dineen T.A.
- Driggers E.M.
- Duquesne A.E.
- Farrés J.
- Fletcher S.
- Fletcher S.
- Freir D.B.
- Fry D.C.
- Ghosh A.K.
- Gong C.X.
- Gong C.X.
- Gong Y.
- González-Ruiz D.
- Gopichand Gutti
- Gore P. Gangaram
- Grandy D.
- Greenfield J.P.
- Guharoy M.
- Gul S.
- Guzior N.
- Haass C.
- Haniu M.
- Hansen R.A.
- Hartley D.M.
- Hartmann T.
- Hattori C.
- Hattori M.
- Hawkes C.A.
- He W.
- He X.
- Heinemann U.
- Helal C.J.
- Helal C.J.
- Hill K.
- Holsinger R.M.
- Hong L.
- Honson N.S.
- Huang L.
- Hunt K.W.
- Huse J.T.
- Hussain I.
- Hébert S.S.
- Inestrosa N.C.
- Iwamoto N.
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- Jain P.
- Janssens V.
- Jochim A.L.
- Joshi M.
- Kaller M.R.
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- Lee H.J.
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- Liang B.
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- Luo W.
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- Mannhold R.
- Mapelli M.
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- Mehta D.
- Meijer L.
- Meireles L.M.
- Meuer K.
- Miguel-Hidalgo J.J.
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- Modell A.E.
- Monenschein H.
- Moradi S.
- Moreira I.S.
- Moritz W.
- Morán M.A.
- Mullard A.
- Murray J.K.
- Müller U.C.
- Nath R.
- Necula M.
- Nepovimova E.
- Nicolakakis N.
- Niethammer M.
- Nikhil K.
- Nixon R.A.
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- Panek D.
- Panek D.
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- Patgiri A.
- Patrick G.N.
- Pennington L.D.
- Petkova A.T.
- Phan T.
- Phiel C.J.
- Phizicky E.M.
- Pickhardt M.
- Pickhardt M.
- Pike C.J.
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- Podlisny M.B.
- Prinz M.
- Prior R.
- Rao V.S.
- Rapoport M.
- Ravi Singh
- Rayala Swetha
- Reitz C.
- Renner M.
- Riemenschneider M.
- Rizzo S.
- Roberds S.L.
- Rogelj B.
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- Rual J.F.
- Ruan J.
- Rueeger H.
- Rygiel K.
- Saftig P.
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- Saupe J.
- Schweers O.
- Scott D.E.
- Seubert P.
- Sgrignani J.
- Shan W.J.
- Shankar G.M.
- Shi A.
- Shimohama S.
- Shiradkar M.
- Shiradkar M.R.
- Sillerud L.O.
- Siman R.
- Sinha S.
- Snyder E.M.
- Sontag E.
- Soto-Ortega D.D.
- Sperandio O.
- Srabanti Jana
- Srinivasa Rao V.
- Srinivasula S.M.
- Stamford A.W.
- Steinhilb M.L.
- Stevers L.M.
- Struble R.G.
- Sullivan S.E.
- Sun K.H.
- Sun Q.
- Sushil K. Singh
- Swetha R.
- Takashima A.
- Tang D.
- Tang H.
- Tang H.
- Taniguchi S.
- Tanimukai H.
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- Tarricone C.
- Thompson A.D.
- Tumiatti V.
- Uetz P.
- Valkov E.
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- Venugopal C.
- Vetrivel K.S.
- Viayna E.
- Villar E.A.
- Vinters H.V.
- Volkman H.M.
- von Bergen M.
- Voronkov M.
- Vyas N.A.
- Walsh D.M.
- Walter J.
- Wang S.
- Wang X.X.
- Watkins A.M.
- Westmeyer G.G.
- Whitebread S.
- Więckowska A.
- Xie J.
- Xie X.
- Yan J.W.
- Yan R.
- Yang L.B.
- Yeh C.H.
- Zekonyte J.
- Zha G.F.
- Zhang B.
- Zhang B.
- Zhang W.
- Zhong W.
- Zinzalla G.
- Zlokovic B.V.
- Zou Y.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module
- Author
- A. Ahmad Zaatari
- A. Ahmed
- A. Alves De Oliveira
- A. Anirban Karmakar
- A. Anwar Al Souheil
- A. Argüello-Ruiz
- A. Azim
- A. Bat-Erdene
- A. Bhakta
- A. Borgi
- A. Bouziri
- A. Cerero-Gudino
- A. Chawla
- A. Dagys
- A. Dilek
- A. Dwivedy
- A. Engin
- A. Flores-Alvarado
- A. Florin-Rogobete
- A. Gashi
- A. Gunduz
- A. Kaya
- A. Kubler
- A. Lagares-Guzmán
- A. Lesnakova
- A. Martínez
- A. Molkov
- A. Mubarak
- A. Oncul
- A. Ozgultekin
- A. Palaoro
- A. Patil
- A. Poojary
- A. Ramazanoglu
- A. Romani
- A. Romario-Mendes
- A. Sasidharan
- A. Simic
- A. Solano-Chinchilla
- A. Thakur
- A. Willke
- A. Zamores-Pedroza
- A.A. Zeggwagh
- A.C. Bianchi
- A.M. Elansary
- A.M. Mathew
- A.M. Mohamed
- A.M. Montanini
- A.M. Ríos
- A.N. Manked
- A.N. Yalcin
- A.P. González
- A.R. Vargas-García
- A.S.K. Rillorta
- A.V. Dharan
- Aamer Ikram
- Abd El Moniem Moustafa
- Abdulrahim Al Khamis
- Abeer A. Omar
- Abeera Ahmed
- Adnan Soliman Alsaadi
- Ahmad Mahmoud Ali
- Ahmed Abdoh Al-Jarie
- Ahmed Hasanin
- Ainul Auzani Othman
- Aisha Hassan Mutwalli
- Alejandra Sepulveda-Chavez
- Ali Pekcan Demiroz
- Aliza Mohamad Yusof
- Amani Ali El-Kholy
- Ameena Isa Alsayegh
- Ana Marcela Quesada-Mora
- Ana P. Dy
- Anahita Sanaei
- Anamma Philip
- Andrew Trotter
- Anil Kumar Bilolikar
- Anis Siham Zainal Abidin
- Anjeela Koirala
- Anna Lyn N. Tajanlangit
- Antoine Abdel Messih
- Anucha Apisarnthanarak
- Anuja Kulkarni
- Anumol Thomas
- Anuradha Agarwal
- Anuradha Sriram
- Arnab Dasgupta
- Arnefelina S. Tamayo
- Arul Rose Suganya
- Arwa Ramadan
- Ashraf Elhoufi
- Ashraf Kelany
- Ashwin Kumar Mani
- Asmita Sakle
- Asuman Inan
- Athena Manao
- Aun Raza
- Azra Parveen
- B. Barteczko-Grajek
- B. Cano-Munoz
- B. Dragan
- B. Herrera
- B. Ramachandran
- B.A. El Awady
- B.E. Hernandez-Chena
- Babu K. Abraham
- Baby Padmini
- Banambar Ray
- Basak Ceyda Meco
- Basanta Kumar Pati
- Bat Erdene Ider
- Batsaikhan Narankhuu
- Batsuren Choijamts
- Battsetseg Tuvdennyam
- Behzad Maghsudi
- Bhaskar Narayan Chaudhury
- Bijie Hu
- Biraj Mohan Mishra
- Braulio Matias De Carvalho
- Burhan Q. Jawadwala
- Byambadorj Batkhuu
- C. Aygun
- C. Becerik
- C. Bulut
- C. Cevallos
- C. Daliborca Vlad
- C. Domínguez
- C. Díaz
- C. Fernandes-Valente
- C. Linares
- C. Pelaez
- C. Rodrigues
- C. Santos
- C. Uzun
- C. Wang
- C. Ávila-Acosta
- C.C. Carreon-Martinez
- C.E. La Hoz Vergara
- C.F. Linares-Calderon
- C.G. Rodríguez
- C.G. Silva
- Carlos Alvarez-Moreno
- Chin Seng Gan
- Chirag Modi
- Chirag Patel
- Cigdem Ataman Hatipoglu
- Cigdem Yildirim Guclu
- Cristina Mari Jean P. Llames
- D. Azevedo-Ferreira Lima
- D. Azevedo-Pereira
- D. Enkhtsetseg
- D. Escudeiro
- D. Galishevskiy
- D. Grinkeviciute
- D. Lekic
- D. Moreno
- D. Muntean
- D. Ozdemir
- D. Sandesc
- D. Santofimio
- D. Ugurcan
- D. Yepes-Gomez
- D. Yildizdas
- D.A. Marin-Tobar
- D.K. Khanna
- D.M. Hassan
- D.M. Maurizi
- D.M. Rivera
- D.P. Mazo-Elorza
- D.Q. Quintana
- Daisy Aguilar de Moros
- Dale Fisher
- Dang Thi Van Trang
- Dao Quang Minh
- Dao Xuan Co
- Dedeepiya Devaprasad
- Deepa Divekar
- Deepesh G. Aggarwal
- Denis Padgett
- Dhaffer Moghram Alamri
- Dinh Pham Phuong Anh
- Doaa Abd El Aziz
- Dolatsinh Zala
- E. Alcala-Martinez
- E. Azak
- E. Bogdanowicz
- E. Garcia-Mayorca
- E. Gonzalez-Diaz
- E. Guclu
- E. Hristozova
- E. Jara
- E. Ramirez
- E. Rodriguez-Noriega
- E. Sachez
- E.A. Medeiros
- E.B. Santiago
- E.D. Kostadinov
- E.E. Coello-Gordon
- E.G. Castaño
- E.G. Chapeta-Parada
- E.M. Onzi-Siliprandi
- E.P. Cruzpero
- Edwin Pathrose
- Eleni Apostolopoulou
- Esmeray Mutlu Yilmaz
- Estuardo Salgado-Yepez
- Ever Labro
- F. Aguiar-Leitao
- F. Corona-Jimenez
- F. Perez
- F. Picoita
- F. Sebnem-Erdinc
- F. Serpa-Maia
- F. Sirmatel
- F. Ulger
- F. Valencia
- F.M. Guerra-Infante
- F.M. Guerrero-Toapant
- F.M. Ramírez Wong
- F.M. Rebello
- F.O. Riera
- Fadzlina Abdul Aziz
- Fahad Ahmed Sawan
- Faisal Sultan
- Farid Zand
- Fatema Hasan Yaseen
- Fatima Abdullah Al Qasmah
- Fazil Abubakar
- Felcy Chacko
- Ferhat Sari
- Filiz Kizilates
- Florin George Horhat
- Foong Kit Weng
- G. Aguirre-Avalos
- G. Arteaga-Troncoso
- G. Assuncao-Ponte
- G. Batjargal
- G. Bayasgalan
- G. Benchetrit
- G. Camacho-Moreno
- G. Ceylan
- G. Ersoz
- G. Kaya
- G. Leon-Garnica
- G. Martinez-Falcon
- G. Ristic
- G. Santacruz
- G. Senol
- G. Song
- G. Spahija
- G. Usluer
- G. Ye
- G. Álvarez
- G.A. Muñoz-Gutierrez
- G.D. Empaire
- G.E. Roncancio-Vill
- G.J. Chaparro
- G.M. Montenegro-Orrego
- G.S. Gehlot
- G.Y. Ramos-Ortiz
- Gabriela Di Silvestre
- Gautam Khanna
- Gloria Y. Ramos-Ortiz
- Golnar Sabetian
- Gortap Sitohang
- Gunay Tuncer Ertem
- H. Ayash
- H. Coronado-Magana
- H. Gonzalez
- H. Turgut
- H. Vidal
- H. Yilmaz
- H. Yu
- H.A. Delgado-Aguirre
- H.K. Sale
- H.R. Perez-Gomez
- H.R. Sandoval-Castillo
- Haeel Alabdaly
- Haifaa Hassan Almousa
- Hail M. Al-Abdely
- Hajer Am Al-Dossary
- Hakan Leblebicioglu
- Hala Ahmed
- Hala Hamza
- Hala Mounir Agha
- Hala Roshdi
- Halima Yahia Al-Alkami
- Hana Hanafi
- Hasan Agin
- Hasimah Zainol
- Hassan Eisa Ammari
- Hatem Mohd Al Hani
- Hatice Cabadak
- Hector Miguel Telechea
- Hindra Irawan Satari
- Hulya Sungurtekin
- Humberto Guanche-Garcell
- Humeyra Zengin
- Hussain Alrahma
- I. Calvo-Hernández
- I. Devrim
- I. Erdem
- I. Ozgunes
- I. Perez
- I. Zeid
- I.A. Valderrama-Marquez
- I.E. Sosa-Gonzalez
- Ibrahim A.M. Alzaydani Asiri
- Indranil Roy
- Inşa Gul Ekiz Işcanlı
- Islam Abdullorziz Ghazi
- J. Dos Anjos-Lima
- J. ElKholy
- J. Eremija
- J. Kojovic
- J. Mueras-Quevedo
- J. Olszewski
- J. Osorio
- J. Pichilingue-Chagray
- J. Rodriguez-Pacheco
- J. Tannous
- J. Vimercati
- J.A. Galindo-Olmeda
- J.A. Lopez-Pulgarin
- J.A. Navoa-Ng
- J.C. López
- J.C. Mijangos-Mendez
- J.D. Fortin
- J.E. Desse
- J.E. Ruiz-Gallardo
- J.I. Marín-Uribe
- J.J. Ayala-Gaytan
- J.L. Moreno-Castillo
- J.M. Ballinas-Aquino
- J.O. Ospina-Martínez
- J.P. Stagnaro
- J.P. Stagnaro
- J.R. Rojas
- J.V. Divatia
- Jayant Shelgaonkar
- Jeffrey Asidera Mendoza
- Jehangir Sorabjee
- Jincy Eappen
- Jomol Philipose
- Joy Ola Selga
- Justin Mathew
- Jyotishka Pal
- K. Abidi
- K. Angelova
- K. Berechid
- K. Gomez-Nieto
- K. Harten Pinto Coelho
- K. Liu
- K.F. Aibar-Yaranga
- K.H. Chuluunchimeg
- Kamal Bashar Abu Bakar
- Karthikeya Varma
- Kashmira Limaye Joshi
- Katarina Furova
- Katerina Jankovska
- Katja Popovska
- Kavita Sandhu
- Khalid Mohammed Ghalilah
- Kushlani Jayatilleke
- L. Josph
- L. Lara
- L. Maroto-Vargas
- L. Meneses-Ovallos
- L. Montes-Bravo
- L. Nikolic
- L. Pushparaj
- L. Ramasco
- L. Song
- L. Zamorano-Flores
- L.D. Bergosa
- L.D. Burgos-Florez
- L.F. Alves De Lima
- L.G. Salvio
- L.I. Castillo-Bravo
- L.M. Canas-Giraldo
- L.M. Santivanez-Monge
- L.N. Pazmino
- L.S. Marcos
- L.Y.M. Rincon
- Lakshmi Ranganathan
- Lateefa Fardan Hani
- Le Thi Anh Thu
- Le Thi Diem Tuyet
- Le Thi Thu Nguyet
- Leide Shyrine Redito
- Lucy Chai See Lum
- Luis Kushner-Davalos
- Lul Raka
- M. Al-Alawi
- M. Altindis
- M. Amaral-Almeida Costa
- M. Andrade-Oliveira-Reis
- M. Arboleda
- M. Bernan
- M. Bhattacharyya
- M. Bjelovic
- M. Bri Saibala
- M. Caridi
- M. Cengiz
- M. Chakravarthy
- M. De Guzman
- M. Dorj
- M. Furman
- M. Girvan
- M. Gonzalez-Martinez
- M. Karpagam
- M. Kasten-Monges
- M. Lascano
- M. Licker
- M. Lopez-Hurtado
- M. Lozano
- M. Mansour
- M. Mehmet Bakir
- M. Mendonca
- M. Meric
- M. Mikaszewska-Sokolewicz
- M. Moreira
- M. Oral
- M. Ozcelik
- M. Papurica
- M. Ramírez
- M. Rodriguez
- M. Sanchez-Vargas
- M. Sunbul
- M. Valverde-Hernandez
- M. Vargas
- M. Ximenes-Rocha Batista
- M. Zielinska
- M. Zurawska
- M.A. Altuzar-Figueroa
- M.A. Cureno-Diaz
- M.A. Zuniga
- M.C. Culebro-Burguet
- M.C. Oyola
- M.C. Rodríguez
- M.C. Sg-Buenaflor
- M.E. Gomez
- M.E. Guzman Siritt
- M.E. Sanchez-Castuera
- M.F. Garcia
- M.F. Geyik
- M.F. Trajano
- M.G. Manuel
- M.G. Miranda-Novales
- M.I. Rojas-Bonilla
- M.J. Mayorga-Espichan
- M.L. Maciel-Canuto Amaral
- M.L. Spadaro
- M.L.G. Rosario-Tueros
- M.M. Bovera
- M.M.A. Haleim
- M.N. Sivakumar
- M.O. Gamar-Elanbya
- M.S. Olivieri
- M.T. Mendoza
- M.T. Tenorio
- M.V. Changano-Rodriguez
- Madhav Lavate
- Madhavi Latha
- Madhupriya Suryawanshi
- Maithili Kavathekar
- Manal Mansour Al-Gethamy
- Manoj Kumar Agarwal
- Mansoor Masjedi
- Maria Carmen S.G. Buenaflor
- Maria Khan
- Marjory Madco
- Marzida Mansor
- Masoud Alebouyeh
- May Abdel Fattah
- May Osman Gamar Elanbya
- Mayur Patel
- Mazuin Kamarul Zaman
- Mehul Shah
- Mervat Aldalaton
- Mervat Elanany
- Michael M. Petrov
- Milena Petrovska
- Modhi Alkhamaly
- Mohamad Fadhil Hadi Jamaluddin
- Mohammad Masfar
- Mohammed Ahmed Ali Karrar
- Mohd Shahnaz Hasan
- Mohit Kharbanda
- Mona Foda Salama
- Mrinmoy Bej
- Mrunalini Potdar
- Munayfa Musallam Al Azmi
- Myrna Lim Quisai
- Myrna Misador Torres
- N. Al Zharani
- N. Al-Abdullah
- N. Alquinga
- N. Baftiu
- N. Barahona-Guzmán
- N. Ben-Jaballah
- N. Elaldi
- N. Gad
- N. Gita
- N. Jaggi
- N. Kuyucu
- N. Madani
- N. Navarrete
- N. Orozco
- N. Oztoprak
- N. Ramakrishnan
- N. Saini
- N. Sen
- N. Unal
- N. Yasar
- N.E. Salazar-Ramirez
- N.K. Pawar
- N.K. Zahreddine
- N.P. Rao
- Nadeem Paul
- Nader Ahmed Tawfic
- Naglaa Mahmoud Abdo
- Naheed Elahi
- Najla Ben Jaballah
- Namphon Supa
- Naranpurev Mendsaikhan
- Nargis Daud
- Nashwa Elsayed
- Nawal Salah Abdulkhalik
- Nehad Abdulshakour Bugis
- Neilia Cardinal Ariola
- Nepomuceno Mejia
- Nesreen Alghosn
- Ngo uy Chau
- Nguyen Gia Binh
- Nguyen Phuc Tien
- Nguyen Quoc Anh
- Nguyen Viet Hung
- Nidal Tashkandi
- Nikhil Modi
- Nirav Pandya
- Nisith Mohanty
- null Kehkashan
- null Sijo
- null Tsuyanga
- null Velupandi
- Nurettin Erben
- Nuri Bayram
- O. Chavarria-Ugalde
- O. Coskun
- O. Mancera-Paez
- O.G. Ramires
- O.P. Javellana
- O.S. Espinosa
- Oguz Dursun
- Oguz Karabay
- Otgon Baatar
- Ovidiu Horea Bedreag
- Ozden Ozgur Horoz
- Ozge Turhan
- Ozlem Sarac Sandal
- P. Botta
- P. Mathur
- P. Saul
- P. Suvderdene
- P.A. De Vera
- P.A. Rios-Arana
- P.D. Juarez
- Phan Thi Hang
- Pooja Thakkar
- Pornpheth Prasan
- Pradnya Joshi
- Prafulla Kumar Sahoo
- Pravin Kumar Nair
- Priyadarshini Senthil Kumar
- Priyanka Patil
- Purnima Mukherjee
- Purvi Shah
- R. Abouqal
- R. Ahmadieh
- R. Amaral De Moraes
- R. Cabrera-Montesino
- R. De Leon-Escobedo
- R. Fouda
- R. Kelkar
- R. Kevalas
- R. Li
- R. Ortega
- R. Penuliar
- R. Popescu
- R. Rocha-Vasconcelos Carneiro
- R. Ruiz-Rendon
- R. Salas-Flores
- R. Sukanya
- R.H. Pérez
- R.R. Maglente
- R.S. Campos-Uchoa
- R.V. Lozada
- Radhika Krishnan
- Raed Hassan Al Shehri
- Raha Abdul Rahman
- Rajalakshmi Arjun
- Rajesh Chawla
- Ram Gopalakrishnan
- Ramesh Venkataraman
- Rasha Hamed El-Sherif
- Rasha Nour Aldeen Jaha
- Rashmi Giri
- Ravikumar Krupanandan
- Rayo Morfin Otero
- Recep Tekin
- Reham H.A. Yousef
- Reny Thomas
- Reshma Tejam
- Retno Kadarsih
- Rhea Lynn Cresencia
- Rhendra Hardy Mohamad Zaini
- Richa Misra
- Ritesh Debroy
- Rosliza Zhazali
- Rungratchanee Pimathai
- S. Al Qahtani
- S. Baigalmaa
- S. Basu
- S. Bekeit
- S. Biswas
- S. Esparza-Ahumada
- S. Gerah
- S. Gualtero
- S. Hlinkova
- S. Petersen-Morfin
- S. Raut
- S. Sahu
- S. Saranya
- S. Shah
- S. Shetty
- S. Singh
- S. Singh
- S. Valderrama
- S. Vega-Gonzalez
- S.A. Aguirre-Diaz
- S.C. Do Nascimento
- S.D. Grecu
- S.J. Ramos
- S.K. Patnaik
- S.K. Todi
- S.L. Romero-Torres
- S.M. George
- S.M. Pulido-Leon
- S.N. Myatra
- S.S. Dalal
- Saban Esen
- Safa A Aziz AlKhawaja
- Sajith Narayanan
- Saleh Fakher Sowar
- Samana Sainju
- Sameh Twfik
- Sana Yusuf
- Sanghamitra Mishra
- Sanjith Saseedharan
- Sankar Sengupta
- Sarah Hassan Al Faraj
- Sasheela Sri La Sri Ponnampala
- Saswati Sinha
- Seelas Blessymole
- Seema Rohra
- Selvi Yener Erdogan
- Senthilkumar Rajagopal
- Serhat Unal
- Sevim Karacorlu
- Shanta Mukherjee
- Sharmila Sengupta
- Sheeba John
- Shefali Bhattacharya
- Sherin El-Sherbiny
- Sinchan Bhattacharyya
- Siti Jhulmina B. Alih
- Snezana Tufekcievska Guroska
- Soad Khamis
- Solita Briones
- Somayeh Jahani Sherafat
- Sonali Vadi
- Soo Lin Chuah
- Souha Sami Kanj
- Subhash Prasad Acharya
- Subodh Kumar
- Sudha Kansal
- Sudhjan Misra
- Sudipta Bhattacharyya
- Suha Sen
- Suha Sen
- Suhas Nirkhiwale
- Suja Thomas
- Sujit Kar Purkayastha
- Sujoy Mukherjee
- Summiya Nizamuddin
- Sunil Sharma
- Suresh Kumar
- Suthinee Wanitanukool
- Suwara Somabutr
- Suzan Sacar
- Syed Zahid Bukhari
- T. De Jesus Pinheiro-Bandeira
- T. Kardas
- T. Khajidmaa
- T. Kondratas
- T. Liu
- T. Mahfouz
- T. Mapp
- T. Moreira-Matos
- T. Singhal
- T. Sohanlal
- T.M. Lima-De Barros Araujo
- Tahira Anwar Magray
- Tanja Anguseva
- Tarek Dendane
- Tariq Saad Abdulhadi Alotaibi
- Thara Francis
- Thejasvini Anand
- Tran Thi My Hanh
- Tran Thi Thuy Hang
- Truong Anh Thu
- Tsolmon Begzjav
- Uma Gopal
- Umesh Gupta
- Usha Nair
- V. Bayani
- V. Bermudez
- V. Chediack
- V. De Iturrado
- V. Delgado
- V. Dumitrascu
- V. Gaona-Flores
- V. Kothari
- V. Ramírez
- V. Tanzi
- V. Venkateshwar
- V.A. Marquez-Mondalgo
- V.A. Monroy-Colin
- V.A. Velinova
- V.J. Dicheva
- V.L. Machado-Silva
- V.M. Moreno-Mejia
- Vaidotas Gurskis
- Valsa Thomas
- Vesna Mioljevic
- Vineya Rai
- Vini Kantroo
- Vladislav Belskiy
- Vo Thi Hong Thoa
- Volkan Yarar
- Víctor Daniel Rosenthal
- W. Chilon
- W. Raigoza-Martinez
- W. Villamil-Gomez
- W.M. Santos Monteiro
- Wael Abdulrahman Abdulatif
- Waleed Mohd Hussain
- Walter Enrique Prudencio Leon
- Wan Fadzlina Wan Mohd Shukeri
- Wan Nazaruddin Wan Hassan
- Wan Nurbayah Wan Yusoff
- Wan Rahiza Wan Mat
- Wieslawa Duszynska
- Wynndale Mae Demotica
- X. Guo
- X. Yang
- Y. Arreza-Galapia
- Y. Ruiz
- Y. Yang
- Y.A. Pardo-Lopez
- Y.M. Abdelhamid
- Y.S. Elkholy
- Yassir Khidir Mohamed
- Yatin Mehta
- Yeliz Oruc
- Yusuf Sahip
- Z. Ariyasuren
- Z. Cruz-Rivera
- Z. Duran-Gil De Anez
- Z. Hammoud
- Z. Kanafani
- Zan Mitrev
- Zaneta Bogoevska Miteva
- Zeinab Salah
- Zeynep Kaya
- Publication venue
- Elsevier Inc
- Publication date
- 01/12/2016
- Field of study
•We report INICC device-associated module data of 50 countries from 2010-2015.•We collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.•DA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.•Device utilization ratio in the INICC ICUs was similar to CDC-NHSN's.
Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific.
Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days.
Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs.
Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically