Cooperación al desarrollo y opinión pública

en este texto se trata de realizar una primera aproximación a las actitudes y percepciones de los ciudadanos gallegos sobre la cooperación y las políticas de desarrollo. Ante la publicación de algunos sucesos que afectaban a la imagen de las ONG’s, conocer el clima de opinión y analizar elementos fundamentales ligados a esas opiniones constituye una de las tareas más importantes de la investigación en cooperación. Nuestro análisis se centra en la relación entre el grado de eficacia de los principales actores de la cooperación y el nivel de confianza que los ciudadanos perciben y depositan en dichos actores para la gestión de los fondos de la ayuda, entendiendo que la relación entre ellos es indisoluble en las sociedades informadas

Conditions and reasons for the “procés”

Desde hace años hablamos y escuchamos hablar del proceso de independencia, el procés, catalán, pero ¿Qué es exactamente el procés?, ¿A qué nos referimos cuándo hablamos de él?, y más importante ¿Cuáles son las razones que llevan a la mayoría de catalanes a apoyar el procés?, ¿es lo mismo apoyar el procés que estar a favor de la independencia? Estas son algunas de las cuestiones a las que tratamos de dar respuesta en el presente artículo, partiendo de la idea de que proceso e independencia no son exactamente lo mismo y de que el “proceso” es la construcción estratégica del hecho independentista, un issue construido que ha condicionado el comportamiento electoral de los catalanes.We have been for years talking and listening to talk about the Catalan process of independence, el procés. But, what exactly is the process?, What do we mean when we talk about it?, and most important, What are the reasons that lead to the majority of Catalans to support the process?, Is it the same thing as supporting the process to be in favor of independence?

Comparative pharmacology of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia

There are 5 BCR/ABL tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia (CML): bosutinib, ponatinib, imatinib, nilotinib and dasatinib. The availability of several therapeutic options raises the possibility of individualizing patient treatment. When evaluating patients’ individual pharmacological profiles, it is important to take into account the differences in the chemical structures of the drugs. Bosutinib, which has a unique interaction and safety profile, is a quinazoline, unlike the other TKIs that have a pyrimidine structure. All 5 TKIs inhibit the BCR/ABL tyrosine kinase, although only ponatinib is active against the strains expressing the T315I mutation. In addition, the 5 TKIs are generally non-selective drugs that can also inhibit other tyrosine kinases, such as cKIT or PDGFR, leading to both benefits in the treatment of some gastrointestinal tumors as well as additional adverse events. These drugs are orally administered and show moderate bioavailability, a large volume of distribution, high protein binding, and elimination after intense metabolism involving various Cytochrome P450 (CYP). They are also substrates of transport proteins and interact with inducers and inhibitors. All TKIs, except bosutinib, can inhibit the activity of transport proteins, leading to important drug interactions. As such, bosutinib is the drug with the better pharmacological profile. There is a close relationship between drug concentration and the beneficial/toxic effects of imatinib, nilotinib, and dasatinib. Therefore, plasma levels should be monitored to optimize patient treatment. Currently, there is no information for ponatinib. Overall, there is a high incidence of adverse events; although these do not usually lead to treatment discontinuation. All 5 TKIs have a similar safety profile; however, each TKI has unique adverse events. Pharmacological differences can identify the drug that is best suited to each patient, helping optimize CML therapy

The Alhambra: Transformation and Change through Architectural Ceramics

In the following paper, we look at the Alhambra from a perspective of architectural ceramics, an essential element in the understanding of the monument. From the Nasrid era onward, glazed ceramic tile mosaics were used to adorn the walls, a style that extended into the Christian conquest, when the palace complex was used as a royal residence. Since then, restoration work has continued to be carried out on the alicatados that cover the Alhambra’s walls, especially during an intense period in the 19th century, when it was the subject of much interest from Romantic travellers to Granada. A detailed, documented analysis of this work shows the complexity of the palace and fortress complex, helping us to better understand a part of its history. In the following pages, we specifically focus on one room in the Alhambra, the so-called Cuarto Dorado (Golden Room), outlining the preliminary findings of a research project that we are undertaking in association with the University of Granada and the Patronato de la Alhambra y el Generalife (Council of the Alhambra and the Generalife).This research was funded by Universidad de Granada and the Patronato de la Alhambra y Generalife, grant number “The Alhambra’s Architectural Ceramics, addenda 4/2016”

La cooperación autonómica y local: algunas notas introductorias

A través de este artículo pretendemos hacer un recorrido por la cooperación descentralizada, por sus caracteres, sus principales virtualidades, los retos aún pendientes y las novedades que este enfoque ha experimentado en los últimos años, como las aparecidas en el Plan Director 2009-2012 o la apuesta de las Comunidades Autónomas por colaborar con organizaciones multinacionale

Colecciones digitales patrimoniales especializadas. Estudio de la Red ARACNE

A sample of specialised digital collections, born in the field of humanities research, is analysed in order to outline the current phase of these collections, assess the strengths and weaknesses of these systems and propose possible future actions. For this aim, the digital libraries housed in the Aracne -Network of Digital Humanities and Hispanic Letters are selected as the object of study. Four blocks of analysis have been established that deal with the contents of the collection, the standards and data models, the user interface and the added values developed. The results show that the digital collections analysed represent a singular contribution, both as tools for researchers, particularly hispanists, and as regards their notable contribution to the dissemination of documentary heritage. It is proposed to enhance synergies with libraries and archives in order to improve the visibility and dissemination of these specialised research collections and the quality of data of heritage documentary institutions

Neutron-Capture elements in planetary nebulae: first detections of near-Infrared [Te III] and [Br V] emission lines

We have identified two new near-infrared emission lines in the spectra of planetary nebulae (PNe) arising from heavy elements produced by neutron capture reactions: [Te III] 2.1019 $\mu$m and [Br V] 1.6429 $\mu$m. [Te III] was detected in both NGC 7027 and IC 418, while [Br V] was seen in NGC 7027. The observations were obtained with the medium-resolution spectrograph EMIR on the 10.4m Gran Telescopio Canarias at La Palma, and with the high-resolution spectrograph IGRINS on the 2.7m Harlan J. Smith telescope at McDonald Observatory. New calculations of atomic data for these ions, specifically A-values and collision strengths, are presented and used to derive ionic abundances of Te$^{2+}$ and Br$^{4+}$. We also derive ionic abundances of other neutron-capture elements detected in the near-infrared spectra, and estimate total elemental abundances of Se, Br, Kr, Rb, and Te after correcting for unobserved ions. Comparison of our derived enrichments to theoretical predictions from AGB evolutionary models shows reasonable agreement for solar metallicity progenitor stars of $\sim$2 - 4 M$_{\odot}$. The spectrally-isolated [Br V] 1.6429 $\mu$m line has advantages for determining nebular Br abundances over optical [Br III] emission lines that can be blended with other features. Finally, measurements of Te are of special interest because this element lies beyond the first peak of the s-process, and thus provides new leverage on the abundance pattern of trans-iron species produced by AGB stars.Comment: 9 pages, 1 figure, 4 tables. Accepted for publication in ApJ Letter