Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease

There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients. The mechanisms by which NSAIDs exert these effect are unclear. In a prospective, controlled clinical trial we examined the effects of oral indomethacin on the composition of human gall-bladder bile. The study included 28 patients with symptomatic cholesterol or mixed gallstones. Of these, 8 were treated with 3 × 25 mg indomethacin daily for 7 days prior to elective cholecystectomy while 20 received no treatment and served as controls. Bile and tissue samples from the gallbladder were obtained during cholecystectomy. Indomethacin tissue levels in the gallbladder mucosa, as assessed by HPLC, were 1.05±0.4 ng/mg wet weight, a concentration known to inhibit effectively cyclooxygenase activity. Nevertheless, no differences between the treated and untreated groups were found in the concentrations of biliary mucus glycoprotein (0.94±0.27 versus 0.93±0.32 mg/ml) or total protein (5.8±0.9 versus 6.4±1.3 mg/ml), cholesterol saturation (1.3±0.2 versus 1.5±0.2), or nucleation time (2.0±3.0 versus 1.5±2.0 days). However, biliary viscosity, measured using a low-shear rotation viscosimeter, was significantly lower in patients receiving indomethacin treatment (2.9±0.6 versus 5.6±1.2 mPa.s; P < 0.02). In conclusion, in man oral indomethacin decreases bile viscosity without alteration of bile lithogenicity or biliary mucus glycoprotein content. Since mucus glycoproteins are major determinants of bile viscosity, an alteration in mucin macromolecular composition may conceivably cause the indomethacin-induced decrease in biliary viscosity and explain the beneficial effects of nonsteroidal anti-inflammatory drugs in gallstone disease

Exact Multifractal Spectra for Arbitrary Laplacian Random Walks

Iterated conformal mappings are used to obtain exact multifractal spectra of the harmonic measure for arbitrary Laplacian random walks in two dimensions. Separate spectra are found to describe scaling of the growth measure in time, of the measure near the growth tip, and of the measure away from the growth tip. The spectra away from the tip coincide with those of conformally invariant equilibrium systems with arbitrary central charge $c\leq 1$, with $c$ related to the particular walk chosen, while the scaling in time and near the tip cannot be obtained from the equilibrium properties.Comment: 4 pages, 3 figures; references added, minor correction

Creation of effective magnetic fields in optical lattices: The Hofstadter butterfly for cold neutral atoms

We investigate the dynamics of neutral atoms in a 2D optical lattice which traps two distinct internal states of the atoms in different columns. Two Raman lasers are used to coherently transfer atoms from one internal state to the other, thereby causing hopping between the different columns. By adjusting the laser parameters appropriately we can induce a non vanishing phase of particles moving along a closed path on the lattice. This phase is proportional to the enclosed area and we thus simulate a magnetic flux through the lattice. This setup is described by a Hamiltonian identical to the one for electrons on a lattice subject to a magnetic field and thus allows us to study this equivalent situation under very well defined controllable conditions. We consider the limiting case of huge magnetic fields -- which is not experimentally accessible for electrons in metals -- where a fractal band structure, the Hofstadter butterfly, characterizes the system.Comment: 6 pages, RevTe

Preparation and characterisation of single phase (MoVW)₅O₁₄-type catalyst material

MoVW based materials are highly effective catalysts for partial oxidation reactions such as conversion of acrolein to acrylic acid. They offer a high selectivity, high yields and a good long term stability. Preceding work has identified the catalytically active phase of the MoVW catalyst and characterised it by Raman spectroscopy. The current work has been carried out to synthesise and characterise this active (MoVW)5O14 type structure

Thermonuclear Burning Regimes and the Use of SNe Ia in Cosmology

The calculations of the light curves of thermonuclear supernovae are carried out by a method of multi-group radiation hydrodynamics. The effects of spectral lines and expansion opacity are taken into account. The predictions for UBVI fluxes are given. The values of rise time for B and V bands found in our calculations are in good agreement with the observed values. We explain why our results for the rise time have more solid physical justification than those obtained by other authors. It is shown that small variations in the chemical composition of the ejecta, produced in the explosions with different regimes of nuclear burning, can influence drastically the light curve decline in the B band and, to a lesser extent, in the V band. We argue that recent results on positive cosmological constant Lambda, found from the high redshift supernova observations, could be wrong in the case of possible variations of the preferred mode of nuclear burning in the earlier Universe.Comment: 20 pages, 5 figures, presented at the conference "Astronomy at the Eve of the New Century", Puschino, May 17-22, 1999. A few references and a table added, typos correcte

Transdimensional physics and inflation

Within the framework of a five-dimensional brane world with a stabilized radion, we compute the cosmological perturbations generated during inflation and show that the perturbations are a powerful tool to probe the physics of extra dimensions. While we find that the power spectrum of scalar perturbations is unchanged, we show that the existence of the fifth dimension is imprinted on the spectrum of gravitational waves generated during inflation. In particular, we find that the tensor perturbations receive a correction proportional to $(HR)^2$, where $H$ is the Hubble expansion rate during inflation and $R$ is the size of the extra dimension. We also generalize our findings to the case of several extra dimensions as well as to warped geometries.Comment: RevTeX file, 30 pages, 1 figure. Final version to appear in PR

Collective Particle Flow through Random Media

A simple model for the nonlinear collective transport of interacting particles in a random medium with strong disorder is introduced and analyzed. A finite threshold for the driving force divides the behavior into two regimes characterized by the presence or absence of a steady-state particle current. Below this threshold, transient motion is found in response to an increase in the force, while above threshold the flow approaches a steady state with motion only on a network of channels which is sparse near threshold. Some of the critical behavior near threshold is analyzed via mean field theory, and analytic results on the statistics of the moving phase are derived. Many of the results should apply, at least qualitatively, to the motion of magnetic bubble arrays and to the driven motion of vortices in thin film superconductors when the randomness is strong enough to destroy the tendencies to lattice order even on short length scales. Various history dependent phenomena are also discussed.Comment: 63 preprint pages plus 6 figures. Submitted to Phys Rev

NASA's Internal Space Weather Working Group

Measurements from many of NASA's scientific spacecraft are used routinely by space weather forecasters, both in the U.S. and internationally. ACE, SOHO (an ESA/NASA collaboration), STEREO, and SDO provide images and in situ measurements that are assimilated into models and cited in alerts and warnings. A number of years ago, the Space Weather laboratory was established at NASA-Goddard, along with the Community Coordinated Modeling Center. Within that organization, a space weather service center has begun issuing alerts for NASA's operational users. NASA's operational user community includes flight operations for human and robotic explorers; atmospheric drag concerns for low-Earth orbit; interplanetary navigation and communication; and the fleet of unmanned aerial vehicles, high altitude aircraft, and launch vehicles. Over the past three years we have identified internal stakeholders within NASA and formed a Working Group to better coordinate their expertise and their needs. In this presentation we will describe this activity and some of the challenges in forming a diverse working group

Spontaneous Branching of Anode-Directed Streamers between Planar Electrodes

Non-ionized media subject to strong fields can become locally ionized by penetration of finger-shaped streamers. We study negative streamers between planar electrodes in a simple deterministic continuum approximation. We observe that for sufficiently large fields, the streamer tip can split. This happens close to Firsov's limit of `ideal conductivity'. Qualitatively the tip splitting is due to a Laplacian instability quite like in viscous fingering. For future quantitative analytical progress, our stability analysis of planar fronts identifies the screening length as a regularization mechanism.Comment: 4 pages, 6 figures, submitted to PRL on Nov. 16, 2001, revised version of March 10, 200