The Construction of Neighbourhoods and its Relevance for the Measurement of Social and Ethnic Segregation: Evidence from Denmark

In this paper we propose a model for constructing neighbourhoods based on geo-referenced data and administrative data. The 431,233 inhabited hectare cells in Denmark are clustered into 9,404 small and 2,296 large neighbourhoods, inhabited on average in 2004 by 572 and 2,343 persons respectively. The priorities in the clustering process are to obtain neighbourhoods that are unaltered over time, delineated by physical barriers, compact, homogeneous in terms of type of housing and ownership, relatively small, homogeneous in terms of number of inhabitants, and comprised of a contiguous cluster of cells. To illustrate the importance of detailed neighbourhood information we compare social and ethnic segregation measured by Isolation and Dissimilation indices on the levels of municipalities and of small neighbourhoods. Our findings demonstrate substantial variation in the residential mix in neighbourhoods within a given municipality, and thus show the importance of having information on a more detailed geographical level than that of the municipality.geo-referenced data, neighbourhoods, segregation

The Construction of Neighbourhoods and its Relevance for the Measurement of Social and Ethnic Segregation: Evidence from Denmark

In this paper we propose a model for constructing neighbourhoods based on georeferenced data and administrative data. The 431,233 inhabited hectare cells in Denmark are clustered into 9,404 small and 2,296 large neighbourhoods, inhabited on average in 2004 by 572 and 2,343 persons respectively. The priorities in the clustering process are to obtain neighbourhoods that are unaltered over time, delineated by physical barriers, compact, homogeneous in terms of type of housing and ownership, relatively small, homogeneous in terms of number of inhabitants, and comprised of a contiguous cluster of cells. To illustrate the importance of detailed neighbourhood information we compare social and ethnic segregation measured by Isolation and Dissimilation indices on the levels of municipalities and of small neighbourhoods. Our findings demonstrate substantial variation in the residential mix in neighbourhoods within a given municipality, and thus show the importance of having information on a more detailed geographical level than that of the municipality.Geo-referenced data, neighbourhoods, segregation

Ammonia transformation in a biotrickling air filter

[Abstract] A simple, tubular biotrickling filter was designed for optimal removal of ammonia and odour in ventilation air from a pig house. The removal and transformation of ammonia was studied in detail by analysis and modelling of chemical gradients through the filter. Good correspondence between measurements and model was obtained by using conventional substrate and inhibition kinetics of ammonium and nitrite oxidizing bacteria. Highest rates of ammonia removal were observed in the central section of the filter. Near the air outlet and water inlet the process was ammonia limited, while high nitrous acid concentrations almost excluded any biological activity near the air inlet and water outlet. Nitrous acid inhibition also stabilized pH at 6.5-7 all through the filter. Being sensitive to both ammonia and nitrous acid the nitrite oxidation process occurred mainly in the filter sections near the air outlet / water inlet, and only 8% of the nitrite was turned into nitrate. Water supply only exceeded evaporation by 20% but modelling indicated that additional watering would have limited effect on filter efficiency. The filter was also robust to varying loading, as a 4-fold increase in ammonia inlet concentration only reduced filter efficiency from 86 to 76%

Rates of induced abortion in Denmark according to age, previous births and previous abortions

Background: Whereas the effects of various socio-demographic determinants on a woman’s risk of having an abortion are relatively well-documented, less attention has been given to the effect of previous abortions and births. Objective: To study the effect of previous abortions and births on Danish women’s risk of an abortion, in addition to a number of demographic and personal characteristics. Data and methods: From the Fertility of Women and Couples Dataset we obtained data on the number of live births and induced abortions by year (1981-2001), age (16-39), county of residence and marital status. Logistic regression analysis was used to estimate the influence of the explanatory variables on the probability of having an abortion in a relevant year. Main findings and conclusion: A woman’s risk of having an abortion increases with the number of previous births and previous abortions. Some interactions were was found in the way a woman’s risk of abortion varies with calendar year, age and parity. The risk of an abortion for women with no children decreases while the risk of an abortion for women with children increases over time. Furthermore, the risk of an abortion decreases with age, but relatively more so for women with children compared to childless women. Trends for teenagers are discussed in a separate section.abortion parity, abortion rates, family situation, fertility parity, urbanization

A Shot at a Healthy Future

In this article, we present an extended case analysis of the unruly reception of the HPV vaccine in Denmark. More specifically, we explore what happens to visions of a healthy future when high levels of social trust in a public vaccination programme are suddenly infused with uncertainty and doubt. Capturing the Danish public in 2013-2015, national news and social media platforms shared dra-matic stories of young women confined to their beds following their HPV vaccinations. The Danish healthcare authorities reacted to this seemingly accelerating problem by setting up HPV clinics to care for the women. Simultaneously, HPV vaccination uptake plunged. Based on long-term ethno-graphic field research, we present the experiences of two main interlocutors, who both find them-selves in difficult situations and having to revise their visions of the future: Sophie, a young woman with suspected HPV vaccine side effects and Martin, a physician working in an HPV clinic. Overall, their accounts shed light on situations emerging during a challenging period in the 2010s in which the Danish healthcare system was adjusting to a new information and media landscape. We show that the promise of a healthy future – sustained by welfare and vaccine technologies – is indeed a communal venture that is vulnerable to suspension and even collapse. When sufferings (such as pain or fatigue) were publicly paired and un-paired with the vaccine, it generated and sustained pervasive uncertainties and painful feelings of being doubted by others – reflecting and highlighting inherent tensions of preventative medicine and the Danish welfare society, including the subtle acts of power and resistance that occur within it

Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.

Importance: Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an injection. Objectives: To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemic control in patients with type 2 diabetes. Design, Setting, and Patients: Phase 2, randomized, parallel-group, dosage-finding, 26-week trial with 5-week follow-up at 100 sites (hospital clinics, general practices, and clinical research centers) in 14 countries conducted between December 2013 and December 2014. Of 1106 participants assessed, 632 with type 2 diabetes and insufficient glycemic control using diet and exercise alone or a stable dose of metformin were randomized. Randomization was stratified by metformin use. Interventions: Once-daily oral semaglutide of 2.5 mg (n = 70), 5 mg (n = 70), 10 mg (n = 70), 20 mg (n = 70), 40-mg 4-week dose escalation (standard escalation; n = 71), 40-mg 8-week dose escalation (slow escalation; n = 70), 40-mg 2-week dose escalation (fast escalation, n = 70), oral placebo (n = 71; double-blind) or once-weekly subcutaneous semaglutide of 1.0 mg (n = 70) for 26 weeks. Main Outcomes and Measures: The primary end point was change in hemoglobin A1c (HbA1c) from baseline to week 26. Secondary end points included change from baseline in body weight and adverse events. Results: Baseline characteristics were comparable across treatment groups. Of the 632 randomized patients (mean age, 57.1 years [SD, 10.6]; men, 395 (62.7%); diabetes duration, 6.3 years [SD, 5.2]; body weight, 92.3 kg [SD, 16.8]; BMI, 31.7 [SD, 4.3]), 583 (92%) completed the trial. Mean change in HbA1c level from baseline to week 26 decreased with oral semaglutide (dosage-dependent range, -0.7% to -1.9%) and subcutaneous semaglutide (-1.9%) and placebo (-0.3%); oral semaglutide reductions were significant vs placebo (dosage-dependent estimated treatment difference [ETD] range for oral semaglutide vs placebo, -0.4% to -1.6%; P = .01 for 2.5 mg, Conclusions and Relevance: Among patients with type 2 diabetes, oral semaglutide resulted in better glycemic control than placebo over 26 weeks. These findings support phase 3 studies to assess longer-term and clinical outcomes, as well as safety. Trial Registration: clinicaltrials.gov Identifier: NCT01923181

Proteome analysis of Aspergillus niger: Lactate added in starch-containing medium can increase production of the mycotoxin fumonisin B2 by modifying acetyl-CoA metabolism

<p>Abstract</p> <p>Background</p> <p><it>Aspergillus niger </it>is a filamentous fungus found in the environment, on foods and feeds and is used as host for production of organic acids, enzymes and proteins. The mycotoxin fumonisin B₂was recently found to be produced by <it>A. niger </it>and hence very little is known about production and regulation of this metabolite. Proteome analysis was used with the purpose to reveal how fumonisin B₂production by <it>A. niger </it>is influenced by starch and lactate in the medium.</p> <p>Results</p> <p>Fumonisin B₂production by <it>A. niger </it>was significantly increased when lactate and starch were combined in the medium. Production of a few other <it>A. niger </it>secondary metabolites was affected similarly by lactate and starch (fumonisin B₄, orlandin, desmethylkotanin and pyranonigrin A), while production of others was not (ochratoxin A, ochratoxin alpha, malformin A, malformin C, kotanin, aurasperone B and tensidol B). The proteome of <it>A. niger </it>was clearly different during growth on media containing 3% starch, 3% starch + 3% lactate or 3% lactate. The identity of 59 spots was obtained, mainly those showing higher or lower expression levels on medium with starch and lactate. Many of them were enzymes in primary metabolism and other processes that affect the intracellular level of acetyl-CoA or NADPH. This included enzymes in the pentose phosphate pathway, pyruvate metabolism, the tricarboxylic acid cycle, ammonium assimilation, fatty acid biosynthesis and oxidative stress protection.</p> <p>Conclusions</p> <p>Lactate added in a medium containing nitrate and starch can increase fumonisin B₂production by <it>A. niger </it>as well as production of some other secondary metabolites. Changes in the balance of intracellular metabolites towards a higher level of carbon passing through acetyl-CoA and a high capacity to regenerate NADPH during growth on medium with starch and lactate were found to be the likely cause of this effect. The results lead to the hypothesis that fumonisin production by <it>A. niger </it>is regulated by acetyl-CoA.</p

Effects of the Commercial Flame Retardant Mixture DE-71 on Cytokine Production by Human Immune Cells

INTRODUCTION:Although production of polybrominated diphenyl ethers (PBDEs) is now banned, release from existing products will continue for many years. The PBDEs are assumed to be neurotoxic and toxic to endocrine organs at low concentrations. Their effect on the immune system has not been investigated thoroughly. We aimed to investigate the influence of DE-71 on cytokine production by peripheral blood mononuclear cells (PBMCs) stimulated with Escherichia Coli lipopolysaccharide (LPS) or phytohaemagglutinin-L (PHA-L). MATERIAL AND METHODS:PBMCs isolated from healthy donors were pre-incubated with DE-71 at various concentrations and subsequently incubated with the monocyte stimulator LPS, or the T-cell activator PHA-L. Interferon (IFN)-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, IL-17A, and IL-17F were quantified in the supernatants by Luminex kits. RESULTS:At non-cytotoxic concentrations (0.01-10 μg/mL), DE-71 significantly enhanced secretion of IL-1β, IL-6, CXCL8, IL-10, and TNF-α (p<0.001-0.019; n = 6) from LPS-stimulated PBMCs. IFN-γ, TNF-α, IL-17A, and IL-17F (p = <0.001-0.043; n = 6) secretion were enhanced from PHA-L-stimulated PBMCs as well. Secretion of IL-1β, IL-2, IL-10, IL-8 and IL-6 was not significantly affected by DE-71. CONCLUSIONS:We demonstrate an enhancing effect of DE-71 on cytokine production by normal human PBMCs stimulated with LPS or PHA-L ex vivo