Community on the watch: making sense of is research through the lens of espoused theories of is

Community on the Watch: Making Sense of IS Research through the Lens of Espoused Theories of IS In the IS field there has been an ongoing tradition to study the publication output of the community in order to evaluate the current and potential situation of IS research. In this work, we follow a different strategy and study what IS research claims to be. We look at those so-called 'espoused theories of IS' as found in the General Editorials Statements (GES) of IS journals. Based on the AISWorld journal ranking, we collected GES for 30 leading IS journals for the years 1997 and 2007. We applied thematic, lexicometric, and factor analyses to the datasets of the 1997 and the 2007 GES. Our results show that the representation of IS research in the GES has changed little over the last decade.: Espoused Theory, Information Systems (IS), Research, Expectations, General Editorial Statement (GES), IS Journals, Thematic Analysis, Lexicometric Analysis.

Risque d'explosion de l'Italie, l'un des trois initiateurs de l'Europe ? Application de la méthode Puzzle© à un cas macroéconomique

Le but du présent texte est de présenter la méthode Puzzle® pour l'exploitation des signaux faibles . Elle résulte des travaux de recherche d'une équipe du laboratoire CERAG-CNRS, université Pierre Mendès France, et a fait l'objet d'un grand nombre d'applications en entreprises ainsi que dans des ministères. Pour " faire plus vivant " nous avons choisi d'adopter une forme narrative et de présenter une fiction concernant la Chine. Cependant toutes les informations mentionnées sont exactes et leurs références sont précisées entre parenthèses.Risque ; explosion de l'Italie ;initiateurs de l'Europe ; Application de la méthode Puzzle© ;cas macroéconomique

The Espoused Theories of IS: A Study of General Editorial Statements.

In the IS field there has been an ongoing tradition to study the publication output of the community in order to evaluate the current and potential situation of IS research. In this work, we follow a different strategy and study what IS research claims to be. We look at those so-called 'espoused theories of IS' as found in the General Editorials Statements (GES) of IS journals. Based on the AISWorld journal ranking, we collected GES for 30 leading IS journals for the years 1997 and 2007. We applied thematic, lexicometric, and factor analyses to the datasets of the 1997 and the 2007 GES. Our results show that the representation of IS research in the GES has changed little over the last decade.Espoused Theory; Information Systems (IS); Research; Expectations; General Editorial Statement (GES); IS Journals; Thematic Analysis; Lexicometric Analysis;

Strategic Scanning and innovative design: fuel the C/K method through Strategic Scanning information

The aim of this article is to study the role of StrategicScanning in innovation processes. We seek to answer the followingquestion: how can Strategic Scanning feed an innovative designactivity? We mobilized the C-K theory which models the logic ofcreation in companies and the method of the same name. Based ona case study of 65 participants, we conducted a Strategic Scanningstudy to feed an innovative C-K design approach. The results showthat Strategic Scanning helps to provide knowledge in a C-Kprocess. It helps either to build the knowledge base of noviceparticipants, or to validate the existing knowledge of expertparticipants. The Strategic Scanning activity also makes it possibleto start the first disjunction mechanism C→K from the C0concept. &nbsp

Getting a Clean Shot on a Blurred Target: Improving Targeting for Strategic Scanning through Action Research in 10 French Organizations

Targeting comprises defining the part of the business environment that corresponds to organizations’ strategic objectives and priorities. Targeting is not an easy process because it includes the interaction of managers who come from different organizational units that might have a fragmentary and blurred understanding of the overall issue. Through an action research, we designed and evaluated a GSS to help managers target strategic scanning in fuzzy contexts. Evaluations through interventions in 10 French organizations allowed both participants to achieve relevant targets and researchers to propose four major improvements to targeting activities: 1) use suggested lists of actors and topics as starting points to trigger and facilitate discussions, 2) define actor and topic importance to produce useful targeting results, 3) evaluate the organization’s perceived capacity to be informed early enough, and 4) define a mechanism to signal scanning relevancy in the short, mid-, or long term. From a management perspective, our results help managers in their strategic scanning activity by 1) identifying information needs for strategically scanning fuzzy subjects, 2) reducing risk of strategic scanning failure, 3) enabling organizations to assess their scanning capabilities, 4) identifying scanning priorities according to a temporal horizon, and 5) fostering teamwork participation

The Espoused Theories of IS: A Study of General Editorial Statements

In the IS field there has been the ongoing debate about a potential identity crisis, which has led researchers to study the output of the community in order to evaluate where IS research currently is and where it could potentially be. This has resulted in various proposals for IS research ‘in practice’. This research follows a different strategy and studies what IS research is claimed to be (the espoused theories of IS). The section of IS journals’ General Editorials Statements (GES), that is, the informative section offered by most journals where they position themselves with regard to potential authors, already contains the answer. Basing our study on the AISWorld journal ranking, we collected GES for a sample of 30 IS journals for the years 1997 and 2007. We applied thematic, lexicometric, and factor analyses to the datasets of the 1997 and the 2007 GES. The results of the analyses show how the institutionalized discourse about IS research has changed over the last decade

Local Envy-Freeness in House Allocation Problems

International audienceWe study the fair division problem consisting in allocating one item per agent so as to avoid (or minimize) envy, in a setting where only agents connected in a given social network may experience envy. In a variant of the problem, agents themselves can be located on the network by the central authority. These problems turn out to be difficult even on very simple graph structures, but we identify several tractable cases. We further provide practical algorithms and experimental insights

Progressive Myoclonus Epilepsy Caused by a Homozygous Splicing Variant of SLC7A6OS

Exome sequencing was performed in 2 unrelated families with progressive myoclonus epilepsy. Affected individuals from both families shared a rare, homozygous c.191A > G variant affecting a splice site in SLC7A6OS. Analysis of cDNA from lymphoblastoid cells demonstrated partial splice site abolition and the creation of an abnormal isoform. Quantitative reverse transcriptase polymerase chain reaction and Western blot showed a marked reduction of protein expression. Haplotype analysis identified a similar to 0.85cM shared genomic region on chromosome 16q encompassing the c.191A > G variant, consistent with a distant ancestor common to both families. Our results suggest that biallelic loss-of-function variants in SLC7A6OS are a novel genetic cause of progressive myoclonus epilepsy. ANN NEUROL 2020Peer reviewe

Erratum: Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders (The American Journal of Human Genetics (2020) 106(3) (356–370), (S0002929720300197), (10.1016/j.ajhg.2020.01.019))

(The American Journal of Human Genetics 106, 356–370; March 5, 2020) In the version of this paper originally published, the underlying cause for Hunter McAlpine syndrome was incorrectly described in Table 1. The relevant description has been changed to read “Chr5q35-qter duplication involving NSD1” in the updated Table 1 reflected here. The authors apologize for this error

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome.

BACKGROUND: Pathogenic variants of GNB5 encoding the β5 subunit of the guanine nucleotide-binding protein cause IDDCA syndrome, an autosomal recessive neurodevelopmental disorder associated with cognitive disability and cardiac arrhythmia, particularly severe bradycardia. METHODS: We used echocardiography and telemetric ECG recordings to investigate consequences of Gnb5 loss in mouse. RESULTS: We delineated a key role of Gnb5 in heart sinus conduction and showed that Gnb5-inhibitory signalling is essential for parasympathetic control of heart rate (HR) and maintenance of the sympathovagal balance. Gnb5-/- mice were smaller and had a smaller heart than Gnb5+/+ and Gnb5+/- , but exhibited better cardiac function. Lower autonomic nervous system modulation through diminished parasympathetic control and greater sympathetic regulation resulted in a higher baseline HR in Gnb5-/- mice. In contrast, Gnb5-/- mice exhibited profound bradycardia on treatment with carbachol, while sympathetic modulation of the cardiac stimulation was not altered. Concordantly, transcriptome study pinpointed altered expression of genes involved in cardiac muscle contractility in atria and ventricles of knocked-out mice. Homozygous Gnb5 loss resulted in significantly higher frequencies of sinus arrhythmias. Moreover, we described 13 affected individuals, increasing the IDDCA cohort to 44 patients. CONCLUSIONS: Our data demonstrate that loss of negative regulation of the inhibitory G-protein signalling causes HR perturbations in Gnb5-/- mice, an effect mainly driven by impaired parasympathetic activity. We anticipate that unravelling the mechanism of Gnb5 signalling in the autonomic control of the heart will pave the way for future drug screening