The fading of two transient ultraluminous x-ray sources to below the stellar mass Eddington limit

We report new detections of the two transient ultraluminous X-ray sources (ULXs) in NGC 5128 from an ongoing series of Chandra observations. Both sources have previously been observed L (2-3) × ∼10 erg s, at the lower end of the ULX luminosity range. The new observations allow us to study these sources in the luminosity regime frequented by the Galactic black hole X-ray binaries (BH XBs). We present the recent lightcurves of both ULXs. 1RXH J132519.8-430312 (ULX1) was observed at L 1 × 10 erg s, while CXOU J132518.2-430304 (ULX2) declined to L 2 × 10 erg s and then lingered at this luminosity for hundreds of days. We show that a reasonable upper limit for both duty cycles is 0.2, with a lower limit of 0.12 for ULX2. This duty cycle is larger than anticipated for transient ULXs in old stellar populations. By fitting simple spectral models in an observation with ∼50 counts we recover properties consistent with Galactic BH XBs, but inconclusive as to the spectral state. We utilize quantile analyses to demonstrate that the spectra are generally soft, and that in one observation the spectrum of ULX2 is inconsistent with a canonical hard state at >95% confidence. This is contrary to what would be expected of an accreting intermediate mass black hole primary, which we would expect to be in the hard state at these luminosities. We discuss the paucity of transient ULXs discovered in early-type galaxies and excogitate explanations. We suggest that the number of transient ULXs scales with the giant and sub-giant populations, rather than the total number of XBs.Peer reviewe

Deep Chandra Monitoring Observations of NGC 4278 : Catalog of Source Properties

We present the properties of the discrete X-ray sources detected in our monitoring program of the globular cluster (GC) rich elliptical galaxy, NGC 4278, observed with Chandra ACIS-S in six separate pointings, resulting in a co-added exposure of 458 ks. From this deep observation, 236 sources have been detected within the region overlapped by all observations, 180 of which lie within the D 25 ellipse of the galaxy. These 236 sources range in L X from 3.5 × 1036 erg s-1 (with 3σ upper limit 1 × 1038 erg s-1. From X-ray source photometry, it has been determined that the majority of the 236 point sources that have well-constrained colors have values that are consistent with typical low-mass X-ray binary spectra, with 29 of these sources expected to be background objects from the log N-log S relation. There are 103 sources in this population that exhibit long-term variability, indicating that they are accreting compact objects. Three of these sources have been identified as transient candidates, with a further three possible transients. Spectral variations have also been identified in the majority of the source population, where a diverse range of variability has been identified, indicating that there are many different source classes located within this galaxy.Peer reviewe

A Transient Sub-Eddington Black Hole X-ray Binary Candidate in the Dust Lanes of Centaurus A

We report the discovery of a bright X-ray transient, CXOU J132527.6-430023, in the nearby early-type galaxy NGC 5128. The source was first detected over the course of five Chandra observations in 2007, reaching an unabsorbed outburst luminosity of 1-2*10^38 erg/s in the 0.5-7.0 keV band before returning to quiescence. Such luminosities are possible for both stellar-mass black hole and neutron star X-ray binary transients. Here, we attempt to characterize the nature of the compact object. No counterpart has been detected in the optical or radio sky, but the proximity of the source to the dust lanes allows for the possibility of an obscured companion. The brightness of the source after a >100 fold increase in X-ray flux makes it either the first confirmed transient non-ULX black hole system in outburst to be subject to detailed spectral modeling outside the Local Group, or a bright (>10^38 erg/s) transient neutron star X-ray binary, which are very rare. Such a large increase in flux would appear to lend weight to the view that this is a black hole transient. X-ray spectral fitting of an absorbed power law yielded unphysical photon indices, while the parameters of the best-fit absorbed disc blackbody model are typical of an accreting ~10 Msol black hole in the thermally dominant state.Comment: 8 pages, 6 figures, accepted for publication in Ap

Low-Mass X-ray Binaries and Globular Clusters in Centaurus A

We present results of Hubble Space Telescope and Chandra X-ray Observatory observations of globular clusters (GCs) and low-mass X-ray binaries (LMXBs) in the central regions of Centaurus A. Out of 440 GC candidates we find that 41 host X-ray point sources that are most likely LMXBs. We fit King models to our GC candidates in order to measure their structural parameters. We find that GCs that host LMXBs are denser and more compact, and have higher encounter rates and concentrations than the GC population as a whole. We show that the higher concentrations and masses are a consequence of the dependence of LMXB incidence on central density and size plus the general trend for denser GCs to have higher masses and concentrations. We conclude that neither concentration nor mass are fundamental variables in determining the presence of LMXBs in GCs, and that the more fundamental parameters relate to central density and size.Comment: 4 pages, 2 figures. Accepted for publication in ApJ Letter

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Discovery of Hot Gas in Outflow in NGC 3379

We report the discovery of a faint (LX~4+/-1.5×1037 ergs s-1, 0.5-2 keV), outflowing gaseous hot interstellar medium (ISM) in NGC 3379. This represents the lowest X-ray luminosity ever measured from a hot phase of the ISM in a nearby early-type galaxy. The discovery of the hot ISM in a very deep Chandra observation was possible thanks to its unique spectral and spatial signatures, which distinguish it from the integrated stellar X-ray emission, responsible for most of the unresolved emission in the Chandra data. This hot component is found in a region of ~800 pc in radius at the center of the galaxy and has a total mass M~3+/-1×105 Msolar. Independent theoretical prediction of the characteristics of an ISM in this galaxy, based on the intrinsic properties of NGC 3379, reproduce well the observed luminosity, temperature, and radial distribution and mass of the hot gas, and indicate that the gas is in an outflowing phase, predicted by models but not observed in any system so far.Peer reviewe

FIELD AND GLOBULAR CLUSTER LOW-MASS X-RAY BINARIES IN NGC 4278

We report a detailed spectral analysis of the population of low-mass X-ray binaries (LMXBs) detected in the elliptical galaxy NGC 4278 with Chandra. Seven luminous sources were studied individually, four in globular clusters (GCs) and three in the stellar field. The range of (0.3-8 keV) L-X for these sources is similar to(3-8) x 10(38) erg s(-1), suggesting that they may be black hole binaries (BHBs). Fitting the data with either single thermal accretion disk or power-law (PO) models results in best-fit temperatures of similar to 0.7-1.7 keV and Gamma similar to 1.2-2.0, consistent with those measured in Galactic BHBs. Comparison of our results with simulations allows us to discriminate between disk and power-law-dominated emission, pointing to spectral/luminosity variability, reminiscent of Galactic BHBs. The BH masses derived from a comparison of our spectral results with the L-X similar to T-in(4) relation of Galactic BHBs are in the 5-15 M-circle dot range, as observed in the Milky Way. The analysis of joint spectra of sources selected in three luminosity ranges (L-X >= 1.5 x 10(38) erg s(-1), 6 x 10(37) erg s(-1) <= L-X < 1.5 x 10(38) erg s(-1), and L-X < 6 x 10(37) erg s(-1)) suggests that while the high-luminosity sources have prominent thermal disk emission components, power-law components are likely to be important in the mid-and low-luminosity spectra. Comparing low-luminosity average spectra, we find a relatively larger N-H in the GC spectrum; we speculate that this may point to either a metallicity effect or to intrinsic physical differences between field and GC accreting binaries. Analysis of average sample properties uncovers a previously unreported L-X-R-G correlation (where R-G is the galactocentric radius) in the GC-LMXB sample, implying richer LMXB populations in more central GCs. No such trend is seen in the field LMXB sample. We can exclude that the GC L-X-R-G correlation is the by-product of a luminosity effect and suggest that it may be related to the presence of more compact GCs at smaller galactocentric radii, fostering more efficient binary formation.Peer reviewe

Spectral properties of X-ray binaries in Centaurus A

We present a spectral investigation of X-ray binaries (XBs) in NGC 5128 (Cen A), using six 100 ks Chandra observations taken over two months in 2007. We divide our sample into thermally and non-thermally dominated states based on the behavior of the fitted absorption column N , and present the spectral parameters of sources with L ≳ 2 × 10 erg s. The majority of sources are consistent with being neutron star low-mass X-ray binaries (NS LMXBs) and we identify three transient black hole (BH) LMXB candidates coincident with the dust lane, which is the remnant of a small late-type galaxy. Our results also provide tentative support for the apparent "gap" in the mass distribution of compact objects between ∼2-5 M . We propose that BH LMXBs are preferentially found in the dust lane, and suggest this is because of the younger stellar population. The majority (∼70%-80%) of potential Roche lobe filling donors in the Cen A halo are ≳ 12 Gyr old, while BH LMXBs require donors ≳ 1 M to produce the observed peak luminosities. This requirement for more massive donors may also explain recent results that claim a steepening of the X-ray luminosity function with age at L ≥ 5 × 10 erg s for the XB population of early-type galaxies; for older stellar populations, there are fewer stars ≳ 1 M , which are required to form the more luminous sources.Peer reviewe

Immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. This protocol is for two separate reviews to assess the effects (benefits and harms) of immunosuppressant and immunomodulatory treatments for the idiopathic inflammatory myopathies. Targeted treatments To assess the effects (benefits and harms) of targeted immunosuppressant and immunomodulatory treatments for the idiopathic inflammatory myopathies: dermatomyositis (DM, including juvenile dermatomyositis, jDM), immune mediated necrotising myopathy (IMNM), anti-synthetase syndrome (ASS), overlap-myositis (OM) and polymyositis (PM). We will also include cancer-related myositis and amyopathic dermatomyositis. Non-targeted treatments To assess the effects (benefits and harms) of non-targeted immunosuppressant and immunomodulatory treatments for the idiopathic inflammatory myopathies: dermatomyositis (DM, including juvenile dermatomyositis, jDM), immune mediated necrotising myopathy (IMNM), anti-synthetase syndrome (ASS), overlap-myositis (OM) and polymyositis (PM). We will also include cancer-related myositis and amyopathic dermatomyositis