4,387 research outputs found
Static Load Bearing During Early Rehabilitation Of Transfemoral Amputees Using Osseointegrated Fixation
Many transfemoral amputees wearing conventional socket prostheses experience pain related to the socket-residuum interface and difficulties with socket retention or fit due to a short residuum. In consideration of these problems a direct skeletal fixation method has been developed whereby a titanium implant is screwed into the medullary canal of the residual femur. Prosthetic components are directly attached to the fixation, once osseointegrated, removing the need for a prosthetic socket. The rehabilitation program to return to ambulation involves incremental static loading of the fixation until full weight bearing is achieved. The rate of loading, which is intended to be isolated to the long axis of the fixation, is determined by the quality of the residual skeleton and a qualitative assessment of the pain experienced by the amputee on loading. Rotational loading of the implant is to be avoided at this stage. The amputee uses a domestic weigh-scale to provide feedback of the load applied. This study aims to measure the true load applied to the fixation and compare this with the clinically prescribed axial load
Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures
During postnatal development hippocampal dentate granule cells (GCs) often extend dendrites from the basal pole of their cell bodies into the hilar region. These so-called hilar basal dendrites (hBD) usually regress with maturation. However, hBDs may persist in a subset of mature GCs under certain conditions (both physiological and pathological). The functional role of these hBD-GCs remains not well understood. Here, we have studied hBD-GCs in mature (â„18 days in vitro) mouse entorhino-hippocampal slice cultures under control conditions and have compared their basic functional properties (basic intrinsic and synaptic properties) and structural properties (dendritic arborisation and spine densities) to those of neighboring GCs without hBDs in the same set of cultures. Except for the presence of hBDs, we did not detect major differences between the two GC populations. Furthermore, paired recordings of neighboring GCs with and without hBDs did not reveal evidence for a heavy aberrant GC-to-GC connectivity. Taken together, our data suggest that in control cultures the presence of hBDs on GCs is neither sufficient to predict alterations in the basic functional and structural properties of these GCs nor indicative of a heavy GC-to-GC connectivity between neighboring GCs
LâAntiquitĂ© en Basse-Normandie
Pour ce PCR organisĂ© en sept ateliers thĂ©matiques, il sâagissait de la derniĂšre annĂ©e dâun premier programme triennal. Bien que dense en travaux rĂ©alisĂ©s, cette annĂ©e 2013 nâaura pas permis dâaboutir Ă tous les objectifs initialement dĂ©finis pour chaque atelier, en raison notamment des masses documentaires quâil sâagissait de manipuler, ou des difficultĂ©s dâaccĂšs Ă la documentation ancienne en vue des publications. Cependant, des avancĂ©es importantes ont Ă©tĂ© rĂ©alisĂ©es et plusieurs ateliers (L..
Exact Combinatorial Optimization with Graph Convolutional Neural Networks
Combinatorial optimization problems are typically tackled by the
branch-and-bound paradigm. We propose a new graph convolutional neural network
model for learning branch-and-bound variable selection policies, which
leverages the natural variable-constraint bipartite graph representation of
mixed-integer linear programs. We train our model via imitation learning from
the strong branching expert rule, and demonstrate on a series of hard problems
that our approach produces policies that improve upon state-of-the-art
machine-learning methods for branching and generalize to instances
significantly larger than seen during training. Moreover, we improve for the
first time over expert-designed branching rules implemented in a
state-of-the-art solver on large problems. Code for reproducing all the
experiments can be found at https://github.com/ds4dm/learn2branch.Comment: Accepted paper at the NeurIPS 2019 conferenc
LâAntiquitĂ© en Basse-Normandie
Le PCR ARBANO organisĂ© en ateliers thĂ©matiques a poursuivi ses travaux durant cette quatriĂšme annĂ©e transitoire. En effet, certains ateliers touchent Ă leur but fixĂ© en dĂ©but de programme alors que dâautres poursuivent un labeur de plus longue haleine. AprĂšs avoir effectuĂ© un travail de recherche des limites anciennes pour les civitas des Unelles et des Abrincates, les participants de lâatelier « limite des territoires antiques » sâattachent maintenant aux frontiĂšres des BaĂŻocasses et des Vid..
First case of Cryptococcus gattii multilobar pneumonia in Switzerland and associated challenges
n/
Thorium Mono- and Bis(imido) Complexes Made by Reprotonation of cyclo-Metalated Amides
International audienceMolecules containing actinideânitrogen multiple bonds are of current interest as simple models for new actinide nitride nuclear fuels, and for their potential for the catalytic activation of inert hydrocarbon CâH bonds. Complexes with up to three uraniumânitrogen double bonds are now being widely studied, yet those with one thoriumânitrogen double bond are rare, and those with two are unknown. A new, simple mono(imido) thorium complex and the first bis(imido) thorium complex, K[Th(âNAr)Nâł3] and K2[Th(âNAr)2Nâł2], are readily made from insertion reactions (Ar = aryl, Nâł = N(SiMe3)2) into the ThâC bond of the cyclometalated thorium amides [ThNâł2(N(SiMe3)(SiMe2CH2))] and K[ThNâł(N(SiMe3)(SiMe2CH2))2]. X-ray and computational structural analyses show a âtransition-metal-likeâ cis-bis(imido) geometry and polarized ThâN bonds with twice the Wiberg bond order of the formally single ThâN bond in the same molecule
HST survey of the Orion Nebula Cluster in the HO 1.4 m absorption band: I. A census of substellar and planetary mass objects
In order to obtain a complete census of the stellar and sub-stellar
population, down to a few M in the Myr old Orion Nebula
Cluster, we used the infrared channel of the Wide Field Camera 3 of the Hubble
Space Telescope with the F139M and F130N filters. These bandpasses correspond
to the m HO absorption feature and an adjacent line-free continuum
region. Out of detected sources, (about ) appear fainter
than m (Vega mag) in the F130N filter, a brightness corresponding to
the hydrogen-burning limit mass (M) at Myr. Of
these, however, only sources have a negative F130M-139N color index,
indicative of the presence of HO vapor in absorption, and can therefore be
classified as bona-fide M and L dwarfs, with effective temperatures T K at an assumed Myr cluster age. On our color-magnitude diagram, this
population of sources with HO absorption appears clearly distinct from the
larger background population of highly reddened stars and galaxies with
positive F130M-F139N color index, and can be traced down to the sensitivity
limit of our survey, m, corresponding to a Myr old
M, planetary mass object under about 2 magnitudes of visual
extinction. Theoretical models of the BT-Settl family predicting substellar
isochrones of and Myr (down to M) fail to reproduce
the observed HO color index at MM. We perform a
Bayesian analysis to determine extinction, mass and effective temperature of
each sub-stellar member of our sample, together with its membership
probability.Comment: Accepted for publication in the Astrophysical Journal. The resolution
of several figures has been downgraded to comply with the size limit of arXiv
submission
Testing Reactive Probabilistic Processes
We define a testing equivalence in the spirit of De Nicola and Hennessy for
reactive probabilistic processes, i.e. for processes where the internal
nondeterminism is due to random behaviour. We characterize the testing
equivalence in terms of ready-traces. From the characterization it follows that
the equivalence is insensitive to the exact moment in time in which an internal
probabilistic choice occurs, which is inherent from the original testing
equivalence of De Nicola and Hennessy. We also show decidability of the testing
equivalence for finite systems for which the complete model may not be known
- âŠ