Low-Grade Osteosarcoma: An Elusive Diagnosis

Low-grade Osteosarcoma is a rare entity that usually occurs on long bones and often has misleading radiographic and histopathologic findings that initially lead to misdiagnosis in 32-66% of cases1,2. Here we present a patient whose histopathologic findings and clinical course differed significantly

Thyroid Eye Disease Related Epiblepharon: A Comparative Case Study

Neuro-ophthalmologists are often the central care provider for patients with thyroid eye disease (TED). This study describe the clinical features and management of epiblepharon as a manifestation of TED. In a clinic-based population, we compare the frequency and age in Asian and non-Asian patients, and discuss pathophysiologic implications

Recurrent Fibrous Dysplasia

Fibrous dysplasia is a benign disease of the bone characterized by the replacement of normal bone with fibro-osseous tissue. We present an aggressive case of a recurrent fibro-osseous lesion

Pituitary Adenoma Apoplexy of the Orbit

Descriptions of pituitary adenomas invading the orbit are extremely uncommon with patients presenting with diminishing visual function and proptosis.[1,2] In this report, we describe an elderly patient with hemorrhage of a pituitary tumor within the orbit. To our knowledge this is the only description of a patient diagnosed with pituitary apoplexy of the orbit. We present the first reported case of a female with a large invasive and hemorrhagic prolactinoma of the orbit

Results of an Experimental Model of Traumatic Optic Neuropathy

The mechanism of indirect traumatic optic neuropathy, based on laser interferometer study of cadaver crania, is presumed to occur by force transmission through bone.1 We propose an alternate mechanism, i.e., the amplification of a soft tissue shock wave within the orbit. When travelling through the conical orbital space in an anterior to posterior direction, amplification theoretically occurs with a magnitude inversely proportional to cross sectional area. This study investigates the mechanism and location of tissue damage in indirect traumatic optic neuropathy

Traumatic Optic Neuropathy Biomechanics: High Speed Camera Assessment In An Animal Model

Indirect traumatic optic neuropathy refers to optic nerve injury with blunt head trauma remote to the optic nerve. Although tied with frontal blows or deceleration, the precise mechanism of axonal disruption remains unknown. In this initial phase of our study, high speed video acquisition was utilized in an animal model to evaluate the biomechanics of indirect traumatic optic neuropathy