A New Shear Estimator for Weak Lensing Observations

We present a new shear estimator for weak lensing observations which properly accounts for the effects of a realistic point spread function (PSF). Images of faint galaxies are subject to gravitational shearing followed by smearing with the instrumental and/or atmospheric PSF. We construct a `finite resolution shear operator' which when applied to an observed image has the same effect as a gravitational shear applied prior to smearing. This operator allows one to calibrate essentially any shear estimator. We then specialize to the case of weighted second moment shear estimators. We compute the shear polarizability which gives the response of an individual galaxy's polarization to a gravitational shear. We then compute the response of the population of galaxies, and thereby construct an optimal weighting scheme for combining shear estimates from galaxies of various shapes, luminosities and sizes. We define a figure of merit --- an inverse shear variance per unit solid angle --- which characterizes the quality of image data for shear measurement. The new method is tested with simulated image data. We discuss the correction for anisotropy of the PSF and propose a new technique involving measuring shapes from images which have been convolved with a re-circularizing PSF. We draw attention to a hitherto ignored noise related bias and show how this can be analyzed and corrected for. The analysis here draws heavily on the properties of real PSF's and we include as an appendix a brief review, highlighting those aspects which are relevant for weak lensing.Comment: 39 pages, 9 figure

Ratiometric sensing of fluoride ions using Raman spectroscopy

Ratiometric Raman spectroscopy represents a novel sensing approach for the detection of fluoride anions based on alkyne desilylation chemistry. This method enables rapid, anion selective and highly sensitive detection of fluoride in a simple paper-based assay format using a portable Raman spectrometer

Diffusion, phase behavior and gelation in a two-dimensional layer of colloids in osmotic equilibrium with a polymer reservoir

The addition of enough non-adsorbing polymer to an otherwise stable colloidal suspension gives rise to a variety of phase behavior and kinetic arrest due to the depletion attraction induced between the colloids by the polymers. We report a study of these phenomena in a two-dimensional layer of colloids. The three-dimensional phenomenology of crystal-fluid coexistence is reproduced, but gelation takes a novel form, in which the strands in the gel structure are locally crystalline. We compare our findings with a previous simulation and theory, and find substantial agreement

Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase

Non homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks in prokaryotes requires Ku and a specific multidomain DNA ligase (LigD). We present crystal structures of the primase/polymerisation domain (PolDom) of Mycobacterium tuberculosis LigD, alone and complexed with nucleotides. The PolDom structure combines the general fold of the archaeo-eukaryotic primase (AEP) superfamily with additional loops and domains that together form a deep cleft on the surface, likely used for DNA binding. Enzymatic analysis indicates that the PolDom of LigD, even in the absence of accessory domains and Ku proteins, has the potential to recognise DNA end-joining intermediates. Strikingly, one of the main signals for the specific and efficient binding of PolDom to DNA is the presence of a 5'-phosphate group, located at the single/double-stranded junction at both gapped and 3'-protruding DNA molecules. Although structurally unrelated, Pol lambda and Pol mu, the two eukaryotic DNA polymerases involved in NHEJ, are endowed with a similar capacity to bind a 5'-phosphate group. Other properties that are beneficial for NHEJ, such as the ability to generate template distortions and realignments of the primer, displayed by Pol lambda and Pol mu, are shared by the PolDom of bacterial LigD. In addition, PolDom can perform non-mutagenic translesion synthesis on termini containing modified bases. Significantly, ribonucleotide insertion appears to be a recurrent theme associated with NHEJ, maximised in this case by the deployment of a dedicated primase, although its in vivo relevance is unknown

Limits on a Composite Higgs Boson

Precision electroweak data are generally believed to constrain the Higgs boson mass to lie below approximately 190 GeV at 95% confidence level. The standard Higgs model is, however, trivial and can only be an effective field theory valid below some high energy scale characteristic of the underlying non-trivial physics. Corrections to the custodial isospin violating parameter T arising from interactions at this higher energy scale dramatically enlarge the allowed range of Higgs mass. We perform a fit to precision electroweak data and determine the region in the (m_H, Delta T) plane that is consistent with experimental results. Overlaying the estimated size of corrections to T arising from the underlying dynamics, we find that a Higgs mass up to 500 GeV is allowed. We review two composite Higgs models which can realize the possibility of a phenomenologically acceptable heavy Higgs boson. We comment on the potential of improvements in the measurements of m_t and M_W to improve constraints on composite Higgs models.Comment: 9 pages, 2 eps figures. Shortened for PRL; some references elminate

The Evolution of Private Equity: Corporate Restructuring in the UK, c.1945-2010

The paper analyses the role of private equity in restructuring the UK corporate economy. It develops a theoretical synthesis to show that the evolution of the PE industry and firms in which it invested were governed by the relations of corporate governance between investor and investee companies. Effective governance relations were a necessary condition for success and complement firm specific resources to create competitive advantage. Four case studies are used to show the contrasting effects of these determining factors, ICFC and Slater Walker, and the two waves of buy-out centred restructuring that developed with the maturity of the PE industry after 1980. In contrast to the evolutionary approach, the periodisations utilised in this study show that structural breaks associated with points of institutional reform are also necessary to make firm specific resource and governance determinants of competitive advantage operable

Delivering word retrieval therapies for people with aphasia in a virtual communication environment

Background: Delivering therapy remotely, via digital technology, can enhance provision for people with aphasia. EVA Park is a multi-user virtual island that can be used for such delivery. The first EVA Park study showed that daily language stimulation delivered via the platform improved functional communication and was positively received by users (Marshall et al, 2016; Amaya et al, 2018). This paper reports two single case studies, evaluating its capacity to deliver targeted language interventions. The first employed therapy for noun retrieval, using cued picture naming and modified Sematic Feature Analysis. The second employed modified Verb Network Strengthening Treatment (VNeST). Aims: This study aimed to determine if treatment delivery was feasible in EVA Park, as assessed by participant compliance, treatment fidelity and participants’ views. It explored the impact of the therapies on treated and untreated word production, connected speech and functional communication. Methods & Procedures: Two participants with aphasia each received 20 sessions of individual therapy in EVA Park, delivered over 5 weeks. Feasibility was assessed by measuring compliance with the therapy regime, recording and checking the fidelity of 20% of treatment sessions, and using post therapy interviews to explore participant views. Treatment outcomes were evaluated via repeated measures single case designs, in which assessments were administered twice before therapy, immediately post therapy and five weeks later. Outcome measures included Object Picture Naming (study 1), Sentence Elicitation Pictures (study 2), Naming 84 items from the Object and Action Naming Battery (study 2), Narrative Production (Study 2), the Northwestern Assessment of Verb and Sentences: Argument Structure Production Test (Study 2) and Communication Activities of Daily Living – 2 (Study 1 & 2). Outcomes & Results: Feasibility results were excellent. Both participants were fully compliant with the therapy regime. There was at least 90% fidelity with the treatment protocols and participant views were positive. Outcomes varied across the studies. The noun therapy significantly improved the naming of treated words, with good maintenance. Lexical gains were less evident on the Sentence Elicitation Pictures used in the VNeST study. Neither study demonstrated generalisation to untreated words, connected speech or functional communication. Conclusions: Two treatment approaches, designed for face to face delivery, could be delivered remotely in EVA Park. Outcomes for the noun treatment were comparable to previous evaluations. Comparisons with previous research were more challenging for VNeST, owing to differences in methodology. Further evaluations of other treatment approaches are warranted