Development of an Optical Slice for an RF and Optical Software Defined Radio

A key component in the Integrated Radio and Optical Communications project at the National Aeronautics and Space Administration's (NASA) Glenn Research Center (GRC) is the radio frequency (RF) and optical software defined radio (SDR). A NASA RF SDR might consist of a general purpose processor to run the Space Telecommunications Radio System (STRS) Architecture for radio command and control, a reconfigurable signal processing device such as a field programmable gate array (FPGA) which houses the waveform, and a digital to analog converter (DAC) for transmitting data. Prior to development, SDR architecture trades on how to combine the RF and optical elements were studied. A modular architecture with physically separate RF and optical hardware slices was chosen and the optical slice of an SDR was designed and developed. The Harris AppSTARTM platform, which consists of an FPGA processing platform with a mezzanine card targeted for RF communications, was used as the base platform in prototyping the optical slice. A serially concatenated pulse position modulation (SCPPM) optical waveform was developed. The waveform follows the standard described in the Consultative Committee for Space Data Systems (CCSDS) Optical Communications Coding and Synchronization Red Book. A custom optical mezzanine printed circuit board card was developed at NASA GRC for optical transmission. The optical mezzanine card replaces the DAC, which is used in the transmission of RF signals. This paper describes RF and optical SDR architecture trades, the Harris AppSTAR platform, the design of the SCPPM waveform, and the development of the optical mezzanine card

Development of an Optical Slice for an RF and Optical Software Defined Radio

A key component in the Integrated Radio and Optical Communications project at the National Aeronautics and Space Administration's (NASA) Glenn Research Center (GRC) is the radio frequency (RF) and optical software defined radio (SDR). A NASA RF SDR might consist of a general purpose processor to run the Space Telecommunications Radio System (STRS) Architecture for radio command and control, a reconfigurable signal processing device such as a field programmable gate array (FPGA) which houses the waveform, and a digital to analog converter for (DAC) transmitting data. Prior to development, SDR architecture trades on how to combine the RF and optical elements were studied. A modular architecture with physically separate RF and optical hardware slices was chosen and the optical slice of an SDR was designed and developed. The Harris AppSTAR("TM") platform, which consists of an FPGA processing platform with a mezzanine card targeted for RF communications, was used as the base platform in prototyping the optical slice. A serially concatenated pulse position modulation (SCPPM) optical waveform was developed. The waveform follows the standard described in the Consultative Committee for Space Data Systems (CCSDS) Optical Communions Coding and Synchronization Red Book. A custom optical mezzanine printed circuit board card was developed at NASA GRC for optical transmission. The optical mezzanine card replaces the DAC, which is used in the transmission of RF signals. This paper describes RF and optical SDR architecture trades, the Harris AppSTAR("TM") platform, the design of the SCPPM waveform, and the development of the optical mezzanine card

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery of chemotherapeutics agents and, in these studies, we apply this technology for therapeutic development in asthma. In these proof-of-concept experiments, we hypothesized that dexamethasone contained in self-assembling nanoparticles (Dex-NP) and delivered systemically would target the lung and decrease allergic lung inflammation and airways hyper-responsiveness to a greater degree than equivalent doses of dexamethasone (Dex) alone. We found that ovalbumin (Ova)-exposed mice treated with Dex-NP had significantly fewer total cells (2.78 ± 0.44 × 10(5) (n = 18) vs. 5.98 ± 1.3 × 10(5) (n = 13), P<0.05) and eosinophils (1.09 ± 0.28 × 10(5) (n = 18) vs. 2.94 ± 0.6 × 10(5) (n = 12), p<0.05) in the lung lavage than Ova-exposed mice alone. Also, lower levels of the inflammatory cytokines IL-4 (3.43 ± 1.2 (n = 11) vs. 8.56 ± 2.1 (n = 8) pg/ml, p<0.05) and MCP-1 (13.1 ± 3.6 (n = 8) vs. 28.8 ± 8.7 (n = 10) pg/ml, p<0.05) were found in lungs of the Dex-NP compared to control, and they were not lower in the Dex alone group. In addition, respiratory system resistance was lower in the Dex-NP compared to the other Ova-exposed groups suggesting a better therapeutic effect on airways hyperresponsiveness. Taken together, these findings from early-stage drug development studies suggest that the encapsulation and protection of anti-inflammatory agents such as corticosteroids in nanoparticle formulations can improve efficacy. Further development of novel drugs in nanoparticles is warranted to explore potential treatments for chronic inflammatory diseases such as asthma

Lower extremity injury in female basketball players is related to a large difference in peak eversion torque between barefoot and shod conditions

AbstractBackgroundThe majority of injuries reported in female basketball players are ankle sprains and mechanisms leading to injury have been debated. Investigations into muscular imbalances in barefoot versus shod conditions and their relationship with injury severity have not been performed. The purpose of this study was to investigate the effects of wearing athletic shoes on muscular strength and its relationship to lower extremity injuries, specifically female basketball players due to the high incidence of ankle injuries in this population.MethodsDuring pre-season, 11 female collegiate basketball players underwent inversion and eversion muscle strength testing using an isokinetic dynamometer in both a barefoot and shod conditions. The difference between conditions was calculated for inversion and eversion peak torque, time to peak torque as well as eversion-to-inversion peak torque percent strength ratio for both conditions. Lower extremity injuries were documented and ranked in severity. The ranked difference between barefoot and shod conditions for peak torque and time to peak torque as well as percent strength ratio was correlated with injury ranking using a Spearman rho correlation (ρ) with an α level of 0.05.ResultsThe ranked differences in barefoot and shod for peak eversion and inversion torque at 120°/s were correlated with their injury ranking. Ranking of the athletes based on the severity of injuries that were sustained during the season was found to have a strong, positive relationship with the difference in peak eversion torque between barefoot and shod (ρ = 0.78; p = 0.02).ConclusionIt is possible that a large discrepancy between strength in barefoot and shod conditions can predispose an athlete to injury. Narrowing the difference in peak eversion torque between barefoot and shod could decrease propensity to injury. Future work should investigate the effect of restoration of muscular strength during barefoot and shod exercise on injury rates

Recession Depression: Mental Health Effects of the 2008 Stock Market Crash

Do sudden, large wealth losses affect mental health? We use exogenous variation in the interview dates of the 2008 Health and Retirement Study to assess the impact of large wealth losses on mental health among older U.S. adults. We compare cross-wave changes in wealth and mental health for respondents interviewed before and after the October 2008 stock market crash. We find that the crash reduced wealth and increased feelings of depression and use of antidepressant drugs, and that these effects were largest among respondents with high levels of stock holdings prior to the crash. These results suggest that sudden wealth losses cause immediate declines in subjective measures of mental health. However, we find no evidence that wealth losses lead to increases in clinically-validated measures of depressive symptoms or indicators of depression

Hydrogels for delivery of therapeutic compounds

In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.Board of Regents, University of Texas Syste

A Review of Parasites and Disease Impacting Moose in North America

Moose (Alces alces) are relative newcomers to North America, believed to have crossed the Beringian land bridge during the late Pleistocene, 10,000–15,000 years ago.  Their evolution in Asia may have left them relatively ill-prepared to cope with a suite of North American parasites that have proportionately greater impacts on moose than other cervids.  We review the current state of knowledge regarding impacts of parasites on North American moose populations, including brainworm (Parelaphostrongylus tenuis), arterial worm (Elaeophora schneideri), giant liver fluke (Fascioloides magna), winter tick (Dermacentor albipictus), and others.  We then pay specific attention to recent research and monitoring of moose, parasites, and disease, in the context of potentially declining moose populations in Montana and elsewhere. Notably we have preliminary evidence suggesting minimal impacts of winter ticks in Montana relative to the eastern US, but also a separate and poorly understood parasite- or disease-induced reduction of adult female moose survival in a southwest Montana population.  These results are preliminary and we discuss them as yielding more questions than answers thus far