31 research outputs found
Scalable and Transfer-Free Fabrication of MoS2/SiO2 Hybrid Nanophotonic Cavity Arrays with Quality Factors Exceeding 4000
We report the fully-scalable fabrication of a large array of hybrid molybdenum disulfide (MoS2) -silicon dioxide (SiO2) one-dimensional, free-standing photonic-crystal cavities capable of enhancement of the MoS2 photoluminescence at the narrow cavity resonance. We demonstrate continuous tunability of the cavity resonance wavelength across the entire emission band of MoS2 simply by variation of the photonic crystal periodicity. Device fabrication started by substrate-scale growth of MoS2 using chemical vapor deposition (CVD) on non-birefringent thermal oxide on a silicon wafer;it was followed by lithographic fabrication of a photonic crystal nanocavity array on the same substrate at more than 50% yield of functional devices. Our cavities exhibit three dominant modes with measured linewidths less than 0.2 nm, corresponding to quality factors exceeding 4000. All experimental findings are found to be in excellent agreement with finite difference time domain (FDTD) simulations. CVD MoS2 provides scalable access to a direct band gap, inorganic, stable and efficient emitter material for onchip photonics without the need for epitaxy and is at CMOS compatible processing parameters even for back-end-of-line integration;our findings suggest feasibility of cavity based line-narrowing in MoS2-based on-chip devices as it is required for instance for frequency-multiplexed operation in on-chip optical communication and sensing
Effect of Behavioral and Pelvic Floor Muscle Therapy Combined With Surgery Versus Surgery Alone on Incontinence Symptoms Among Women With Mixed Urinary Incontinence: The ESTEEM Randomized Clinical Trial
Nanoscale plasmonic phenomena in CVD-grown MoS2 monolayer revealed by ultra- broadband synchrotron radiation based nano-FTIR spectroscopy and near-field microscopy
Nanoscale plasmonic phenomena observed in single and bi-layers of molybdenum
disulfide (MoS2) on silicon dioxide (SiO2) are reported. A scattering type
scanning near-field optical microscope (s-SNOM) with a broadband synchrotron
radiation (SR) infrared source was used. We also present complementary optical
mapping using tunable CO2-laser radiation. Specifically, there is a
correlation of the topography of well-defined MoS2 islands grown by chemical
vapor deposition, as determined by atomic force microscopy, with the infrared
(IR) signature of MoS2. The influence of MoS2 islands on the SiO2 phonon
resonance is discussed. The results reveal the plasmonic character of the MoS2
structures and their interaction with the SiO2 phonons leading to an
enhancement of the hybridized surface plasmon-phonon mode. A theoretical
analysis shows that, in the case of monolayer islands, the coupling of the
MoS2 optical plasmon mode to the SiO2 surface phonons does not affect the
infrared spectrum significantly. For two-layer MoS2, the coupling of the extra
inter-plane acoustic plasmon mode with the SiO2 surface transverse phonon
leads to a remarkable increase of the surface phonon peak at 794 cm−1. This is
in agreement with the experimental data. These results show the capability of
the s-SNOM technique to study local multiple excitations in complex non-
homogeneous structures
Testbeds for Transition Metal Dichalcogenide Photonics: Efficacy of Light Emission Enhancement in Monomer vs. Dimer Nanoscale Antennae
Monolayer transition metal dichalcogenides are uniquely-qualified materials
for photonics because they combine well defined tunable direct band gaps and
selfpassivated surfaces without dangling bonds. However, the atomic thickness
of these 2D materials results in low photo absorption limiting the achievable
photo luminescence intensity. Such emission can, in principle, be enhanced via
nanoscale antennae resulting in; a. an increased absorption cross-section
enhancing pump efficiency, b. an acceleration of the internal emission rate via
the Purcell factor mainly by reducing the antennas optical mode volume beyond
the diffraction limit, and c. improved impedance matching of the emitter dipole
to the freespace wavelength. Plasmonic dimer antennae show orders of magnitude
hot-spot field enhancements when an emitter is positioned exactly at the
midgap. However, a 2D material cannot be grown, or easily transferred, to
reside in mid-gap of the metallic dimer cavity. In addition, a spacer layer
between the cavity and the emissive material is required to avoid non-radiative
recombination channels. Using both computational and experimental methods, in
this work we show that the emission enhancement from a 2D emitter- monomer
antenna cavity system rivals that of dimers at much reduced lithographic
effort. We rationalize this finding by showing that the emission enhancement in
dimer antennae does not specifically originate from the gap of the dimer
cavity, but is an average effect originating from the effective cavity
crosssection taken below each optical cavity where the emitting 2D film is
located. In particular, we test an array of different dimer and monomer antenna
geometries and observe a representative 3x higher emission for both monomer and
dimer cavities as compared to intrinsic emission of Chemical Vapor Deposition
synthesized WS2 flakes.Comment: 31 pages, 5 figure
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Erratum: Nanoscale Plasmonic Phenomena In Cvd-Grown Mos2 Monolayer Revealed By Ultra-Broadband Synchrotron Radiation Based Nano-Ftir Spectroscopy And Near-Field Microscopy: Publisher\u27S Note (Optics Express (2016) 24 (1154))
Nanoscale Plasmonic Phenomena In Cvd-Grown Mos2 Monolayer Revealed By Ultra-Broadband Synchrotron Radiation Based Nano-Ftir Spectroscopy And Near-Field Microscopy
Nanoscale plasmonic phenomena observed in single and bilayers of molybdenum disulfide (MoS2) on silicon dioxide (SiO2) are reported. A scattering type scanning near-field optical microscope (s-SNOM) with a broadband synchrotron radiation (SR) infrared source was used. We also present complementary optical mapping using tunable CO2-laser radiation. Specifically, there is a correlation of the topography of welldefined MoS2 islands grown by chemical vapor deposition, as determined by atomic force microscopy, with the infrared (IR) signature of MoS2. The influence of MoS2 islands on the SiO2 phonon resonance is discussed. The results reveal the plasmonic character of the MoS2 structures and their interaction with the SiO2 phonons leading to an enhancement of the hybridized surface plasmon-phonon mode. A theoretical analysis shows that, in the case of monolayer islands, the coupling of the MoS2 optical plasmon mode to the SiO2 surface phonons does not affect the infrared spectrum significantly. For two-layer MoS2, the coupling of the extra interplane acoustic plasmon mode with the SiO2 surface transverse phonon leads to a remarkable increase of the surface phonon peak at 794 cm-1. This is in agreement with the experimental data. These results show the capability of the s-SNOM technique to study local multiple excitations in complex nonhomogeneous structures
Gold Dispersion And Activation On The Basal Plane Of Single-Layer Mos2
Gold islands are typically associated with high binding affinity to adsorbates and catalytic activity. Here we present the growth of dispersed nanoscale gold islands on single layer MoS2, prepared on an inert SiO2/Si support by chemical vapor deposition. This study offers a combination of growth process development, optical characterization, photoelectron spectroscopy at submicron spatial resolution, and advanced density functional theory modeling for detailed insight into the electronic interaction between gold and single-layer MoS2. In particular, we find the gold density of states in Au/MoS2/SiO2/Si to be far less well-defined than Au islands on other 2-dimensional materials such as graphene, for which we also provide data. We attribute this effect to the presence of heterogeneous Au adatom/MoS2-support interactions within the nanometer-scale gold cluster. Theory predicts that CO will exhibit adsorption energies in excess of 1 eV at the Au cluster edges, where the local density of states is dominated by Au 5dz2 symmetry