Effects Of Silica Fume And Rice Husk Ash On The Properties Of Cement Paste And Concrete [TP882.3. B942 2008 f rb].

Wasap silika (SF) dan abu sekam padi (RHA) merupakan bahan buangan daripada pertanian serta industri yang telah beberapa dekad digunakan sebagai bahan pozolanik ataupun bahan gantian simen dalam konkrit. Silica fume (SF) and rice husk ash (RHA) are industrial and agricultural wastes which have been used in decades as pozzolanic materials or partial cement replacement materials in concrete

Diabetic Mastopathy: A Case Report and Literature Review

Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed

Microbiological and Biochemical Indicators for Anthropogenically Polluted Soils of the City Mednogorsk, Russia

This study is a bio-indicative evaluation of anthropogenically-polluted soils of the city Mednogorsk in orenburg region, Russia. This work evaluated – the total number of heterotrophic microorganisms, the number of iron- and manganese-oxidizing bacteria in the polluted soil samples, the activity of soil enzymes (dehydrogenase, catalase, invertase), and also the magnetic susceptibility of these soils (Kmag) – an index which shows the concentration of iron (Fe) in soil. 10 samples were analysed which showed the highest coefficient of magnetism (Kmag > 3) and also a reduced content in heterotrophic microorganisms compared to the control soil samples with Kmag invertase>catalase. This study reveals the possible use of these indicators as diagnostic tools for monitoring soils polluted with heavy metals.Key words: Heavy metals, Coefficient of magnetism, iron- and manganese oxidizing bacteria, Heterotrophic microorganisms, Dehydrogenase, Catalase, Invertase.IntroductionAs a result of anthropogenic pollution, significant amount of different xenobiotics are released into the environment among which the most dangerous are heavy metals (HM) [1]. Heavy metals accumulating in soils reduce its biological potential: changes the number, species composition, biomass and productivit

Characterization Of Cambodian Clays And Their Suitability For Ceramic Tiles Applications

The present work is aimed to provide detail scientific data on characterization of Cambodian clays and their suitability for ceramic tiles applications. The study covered three parts – Part I deals with characterization of the properties of the raw clay samples, Part II deals with investigation on changes of the properties between bulk and clay fraction (< 2 μm), and Part III deals with optimization of ceramic tile compositions incorporating Cambodian clays by using statistical design technique

Fuzzy Forests: Extending Random Forest Feature Selection for Correlated, High-Dimensional Data

In this paper we introduce fuzzy forests, a novel machine learning algorithm for ranking the importance of features in high-dimensional classification and regression problems. Fuzzy forests is specifically designed to provide relatively unbiased rankings of variable importance in the presence of highly correlated features, especially when the number of features, p, is much larger than the sample size, n (p n). We introduce our implementation of fuzzy forests in the R package, fuzzyforest. Fuzzy forests works by taking advantage of the network structure between features. First, the features are partitioned into separate modules such that the correlation within modules is high and the correlation between modules is low. The package fuzzyforest allows for easy use of the package WGCNA (weighted gene coexpression network analysis, alternatively known as weighted correlation network analysis) to form modules of features such that the modules are roughly uncorrelated. Then recursive feature elimination random forests (RFE-RFs) are used on each module, separately. From the surviving features, a final group is selected and ranked using one last round of RFE-RFs. This procedure results in a ranked variable importance list whose size is pre-specified by the user. The selected features can then be used to construct a predictive model

Characterization Of Cambodian Clays And Their Suitability For Ceramic Tiles Applications

The present work is aimed to provide detail scientific data on characterization of Cambodian clays and their suitability for ceramic tiles applications. The study covered three parts – Part I deals with characterization of the properties of the raw clay samples, Part II deals with investigation on changes of the properties between bulk and clay fraction (< 2 μm), and Part III deals with optimization of ceramic tile compositions incorporating Cambodian clays by using statistical design technique

Formation of the Acyl Chain within the Alkamides

poster abstractEchinacea, a coneflower species that is native to North America, are the most consumed medicinal plants in the United States and Europe. Their medicinal usage focuses on the treatment and prevention of colds, influenza, and other upper respiratory tract infections. In part, the traditional medicinal uses of Echinacea are attributed to their alkamide content. Structurally alkamides consist of an amine moiety acylated with a variety of fatty acids. To better describe the biosynthetic process leading to the formation of acyl chains within alkamides of Echinacea purpurea, stable isotope labeling experiments with analysis via LC/MS and NMR was undertaken. As previously reported from our lab, the acyl chains of alkamides are synthesized from fatty acid synthesis via HSQC NMR analysis of a tetraenoic isobutyl amide alkamide. As part of our continuing efforts to probe the acyl chain biosynthesis within E. purpurea, we herein report the HSQC NMR analysis of a proposed dienoic isobutyl amide alkamide that was labeled with a 70/30 [U-12C6]/[U-13C6]glucose mixture. The magnitude of 13C-13C one-bond coupling observed by NMR will allow for incorporation patterns to be determined and will help to elucidate the structure and biogenesis of this dienoic isobutyl amide alkamide

The importance of having two X chromosomes

Historically, it was thought that the number of X chromosomes plays little role in causing sex differences in traits. Recently, selected mouse models have been used increasingly to compare mice with the same type of gonad but with one versus two copies of the X chromosome. Study of these models demonstrates that mice with one X chromosome can be strikingly different from those with two X chromosomes, when the differences are not attributable to confounding group differences in gonadal hormones. The number of X chromosomes affects adiposity and metabolic disease, cardiovascular ischaemia/reperfusion injury and behaviour. The effects of X chromosome number are likely the result of inherent differences in expression of X genes that escape inactivation, and are therefore expressed from both X chromosomes in XX mice, resulting in a higher level of expression when two X chromosomes are present. The effects of X chromosome number contribute to sex differences in disease phenotypes, and may explain some features of X chromosome aneuploidies such as in Turner and Klinefelter syndromes

The Effects of Perinatal Testosterone Exposure on the DNA Methylome of the Mouse Brain Are Late-Emerging

Background The biological basis for sex differences in brain function and disease susceptibility is poorly understood. Examining the role of gonadal hormones in brain sexual differentiation may provide important information about sex differences in neural health and development. Permanent masculinization of brain structure, function, and disease is induced by testosterone prenatally in males, but the possible mediation of these effects by long-term changes in the epigenome is poorly understood. Methods We investigated the organizational effects of testosterone on the DNA methylome and transcriptome in two sexually dimorphic forebrain regions—the bed nucleus of the stria terminalis/preoptic area and the striatum. To study the contribution of testosterone to both the establishment and persistence of sex differences in DNA methylation, we performed genome-wide surveys in male, female, and female mice given testosterone on the day of birth. Methylation was assessed during the perinatal window for testosterone\u27s organizational effects and in adulthood. Results The short-term effect of testosterone exposure was relatively modest. However, in adult animals the number of genes whose methylation was altered had increased by 20-fold. Furthermore, we found that in adulthood, methylation at a substantial number of sexually dimorphic CpG sites was masculinized in response to neonatal testosterone exposure. Consistent with this, testosterone\u27s effect on gene expression in the striatum was more apparent in adulthood. Conclusion Taken together, our data imply that the organizational effects of testosterone on the brain methylome and transcriptome are dramatic and late-emerging. Our findings offer important insights into the long-term molecular effects of early-life hormonal exposure

The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performance

BACKGROUND: Klinefelter syndrome (KS), caused by XXY karyotype, is characterized by low testosterone, infertility, cognitive deficits, and increased prevalence of health problems including obesity and diabetes. It has been difficult to separate direct genetic effects from hormonal effects in human studies or in mouse models of KS because low testosterone levels are confounded with sex chromosome complement. METHODS: In this study, we present the Sex Chromosome Trisomy (SCT) mouse model that produces XXY, XYY, XY, and XX mice in the same litters, each genotype with either testes or ovaries. The independence of sex chromosome complement and gonadal type allows for improved recognition of sex chromosome effects that are not dependent on levels of gonadal hormones. All mice were gonadectomized and treated with testosterone for 3 weeks. Body weight, body composition, and motor function were measured. RESULTS: Before hormonal manipulation, XXY mice of both sexes had significantly greater body weight and relative fat mass compared to XY mice. After gonadectomy and testosterone replacement, XXY mice (both sexes) still had significantly greater body weight and relative fat mass, but less relative lean mass compared to XY mice. Liver, gonadal fat pad, and inguinal fat pad weights were also higher in XXY mice, independent of gonadal sex. In several of these measures, XX mice also differed from XY mice, and gonadal males and females differed significantly on almost every metabolic measure. The sex chromosome effects (except for testis size) were also seen in gonadally female mice before and after ovariectomy and testosterone treatment, indicating that they do not reflect group differences in levels of testicular secretions. XYY mice were similar to XY mice on body weight and metabolic variables but performed worse on motor tasks compared to other groups. CONCLUSIONS: We find that the new SCT mouse model for XXY and XYY recapitulates features found in humans with these aneuploidies. We illustrate that this model has significant promise for unveiling the role of genetic effects compared to hormonal effects in these syndromes, because many phenotypes are different in XXY vs. XY gonadal female mice which have never been exposed to testicular secretions