There\u27s No Stopping Us Now! Why Systematic Staff Training Keeps the Organization Moving Forward

Libraries have shifted from repositories of materials to centers of innovation and community-based learning. Many library services changed to accommodate the shift; some staff find this difficult and perplexing and it has led to technological wariness and resistance to change. To address this we developed a continuous in-house professional development program. We will discuss barriers and enablers to establishing a program and unintended benefits, such as reducing perceived inequalities among staff, increasing trust, and empowering staff

Dental Software Classification and Dento-Facial Interdisciplinary Planning Platform

Objective: Despite all advantages provided by the digital workflow, its application in clinical practice is still more focused on device manufacturing and clinical execution than on treatment planning and communication. The most challenging phases of treatment, comprehensive planning, diagnosis, risk assessment, and decision-making, are still performed without significant assistance from digital technologies. This article proposes a new dental software classification based on the digital workflow timeline, considering the moment of patient\u27s case acceptance as key in this classification, and presents the ideal software tools for each phase. Clinical Considerations: The proposed classification will help clinicians and dental laboratories to choose the most appropriate software during the treatment planning phase and integrate virtual plans with other software platforms for digitally guided execution. A dento-facial interdisciplinary planning platform virtually simulates interdisciplinary clinical procedures and assists in the decision-making process. Conclusions: The suggested classification assists professionals in different phases of the digital workflow and provides guidelines for improvement and development of digital technologies before treatment plan acceptance by the patient. Clinical Significance: Three-dimensional interdisciplinary simulations allow clinicians to visualize how each dental procedure influences further treatments. With this treatment planning approach, predictability of different procedures in restorative dentistry, orthodontics, implant dentistry, periodontal, and oral maxillofacial surgery is improved. © 2021 Wiley Periodicals LL

Optimisation of a new class of peptide-based MR1 contrast agent

To determine the effect rotational correlation time (rR) has on relaxivity, peptides of different lengths were investigated. Extending the length of the peptide had a negligible impact on folding, stability and inner-sphere water coordination. The relaxivity was found to be the same indicating that TR is not the limiting factor in this class of contrast agent. A peptide was designed with the potential to increase secondary sphere water coordination to the peptide exterior. No change in relaxivity was observed, compared to MB1-2, due secondary sphere H20 being located at too far from the paramagnetic Gd(III). Secondary sphere water coordination was further investigated when a water channel was identified. The channel allows water to come within close proximity of Gd(III), with the potential to increase relaxivity. D-amino acids were introduced in an attempt to block the water channel, but this had little impact. Finally, the biological activity of the peptides in biological systems was investigated. It was found that increased transmetalation occurred when the Gd(III) binding site was located at the Nterminus of the coiled coil. Cell lines were treated with Gd(MB 1-1 )3 at MRI relevant concentrations and cell death occurred when treated with clinically relevant concentrations of the metallo peptide

Senior Recital, Madison Bunch, flute

The presentation of this Senior Recital will fulfill in part the requirements for the Bachelor of Music degree in Performance. Madison Bunch studies flute with Dr. Tabatha Easley

Senior Recital, Kevin Newton, horn

The presentation of this senior recital will fulfill in part the requirements for the Bachelor of Music degree in Performance. Kevin Newton studies horn with Dr. Patrick Smith

Associations between low HDL, sex and cardiovascular risk markers are substantially different in sub-Saharan Africa and the UK : analysis of four population studies

Introduction Low high-density lipoprotein (HDL) is widely used as a marker of cardiovascular disease risk, although this relationship is not causal and is likely mediated through associations with other risk factors. Low HDL is extremely common in sub-Saharan African populations, and this has often been interpreted to indicate that these populations will have increased cardiovascular risk. We aimed to determine whether the association between HDL and other cardiovascular risk factors differed between populations in sub-Saharan Africa and the UK.Methods We compared data from adults living in Uganda and Malawi (n=26 216) and in the UK (n=8747). We examined unadjusted and adjusted levels of HDL and applied the WHO recommended cut-offs for prevalence estimates. We used spline and linear regression to assess the relationship between HDL and other cardiovascular risk factors.Results HDL was substantially lower in the African than in the European studies (geometric mean 0.9textendash1.2 mmol/L vs 1.3textendash1.8 mmol/L), with African prevalence of low HDL as high as 77geometric mean 3.3textendash3.9 mmol/L vs 4.6textendash5.4 mmol/L). In comparison with European studies the relationship between HDL and adiposity (body mass index, waist to hip ratio) was greatly attenuated in African studies and the relationship with non-HDL cholesterol reversed: in African studies low HDL was associated with lower non-HDL cholesterol. The association between sex and HDL was also different; using the WHO sex-specific definitions, low HDL was substantially more common among women (69textendash77 than men (41textendash59 in Uganda/Malawi.Conclusion The relationship between HDL and sex, adiposity and non-HDL cholesterol in sub-Saharan Africa is different from European populations. In sub-Saharan Africans low HDL is a marker of low overall cholesterol and sex differences are markedly attenuated. Therefore low HDL in isolation is unlikely to indicate raised cardiovascular risk and the WHO sex-based cut-offs are inappropriate.Data from the EXTEND study are available through application to the Peninsula Research Bank (https://exetercrfnihr.org/about/exeter-10000-prb/). For enquiries about access to the Exeter Family Study please contact BS ([email protected]). The MEIRU data are available through the LSHTM Research Data Compass (https://datacompass.lshtm.ac.uk/961/)

Testing the relative sensitivity of 102 ecological variables as indicators of woodland condition in the New Forest, UK.

Forests globally are facing an increasing number of threats from modified disturbance regimes, novel stressors and changing environmental conditions. This has ultimately resulted in declines in the ecological condition of many forest and woodland ecosystems, leading to widespread tree mortality and stand dieback. Effective indicators of overall woodland ecological condition are therefore needed for environmental monitoring and to support management responses. To test the effectiveness of different variables that could potentially be used as indicators of woodland condition, 102 variables that describe woodland structure, composition, functioning, edaphic conditions and disturbance regimes were assessed along 12 replicate gradients of beech stand dieback. Results indicated that 35 variables differed significantly between at least two stages of the dieback gradient, indicating their sensitivity to stand dieback. Seven of these indicators related to woodland species composition, two to functional processes, 20 to structural features, four to edaphic conditions, and two to disturbance regimes. These results demonstrate that effective indicators can potentially be identified for each of the ecological categories. Effective composition indicators included species richness of ectomycorrhizal fungi, ground flora and epiphytic lichens; functional indicators were soil respiration rate and net nitrification rate; edaphic conditions included soil Na:Ca ratio, exchangeable sodium, total carbon, Ca:Al ratio; structural indicators included canopy openness, litter cover, sward height, and volume of deadwood, and for disturbance the indicator was Equus dung density. Other measures, such as shrub cover and species richness of carabid beetles and spiders, were not found to vary significantly along the dieback gradients, and were therefore not identified as effective indicators. These results demonstrate the value of gradient analysis for evaluating indicators of woodland condition, but also highlight the need for multi-site studies to identify indicators with widescale applicability