The Apollo spacecraft: A chronology volume 4, 21 January 1966 - 13 July 1974

This final volume of the chronology is divided into three parts: (1) preparation for flight, the accident, and investigation; (2) recovery, spacecraft redefinition, and the first manned flight; and (3) man circles the moon, the Eagle lands, and manned space exploration. Congressional documents, official correspondence, government and contractor reports, memoranda, working papers, and minutes of meetings were used as primary sources. A relatively few entries are based on press releases and newspaper and magazine articles

Functionally Graded Materials by Laser Metal Deposition (preprint)

Fabrication of functionally graded materials (FGMs) by laser metal deposition (LMD) has the potential to offer solutions to key engineering problems over the traditional metalworking techniques. But the issues that need to be addressed while building FGMs are intermixing in the layers and cracking due to the residual stresses. This paper is to present the study of the effect of process parameters (laser power and travel speed) on the degree of dilution between the substrate (or, previous layer) and powder material for few metallurgical systems

An experimental study of the dual-fuel performance of a small compression ignition diesel engine operating with three gaseous fuels

A dual-fuel engine is a compression ignition (CI) engine where the primary gaseous fuel source is premixed with air as it enters the combustion chamber. This homogenous mixture is ignited by a small quantity of diesel, the ‘pilot’, that is injected towards the end of the compression stroke. In the present study, a direct-injection CI engine, was fuelled with three different gaseous fuels: methane, propane, and butane. The engine performance at various gaseous concentrations was recorded at 1500 r/min and quarter, half, and three-quarters relative to full a load of 18.7 kW. In order to investigate the combustion performance, a novel three-zone heat release rate analysis was applied to the data. The resulting heat release rate data are used to aid understanding of the performance characteristics of the engine in dual-fuel mode. Data are presented for the heat release rates, effects of engine load and speed, brake specific energy consumption of the engine, and combustion phasing of the three different primary gaseous fuels. Methane permitted the maximum energy substitution, relative to diesel, and yielded the most significant reductions in CO2. However, propane also had significant reductions in CO2 but had an increased diffusional combustion stage which may lend itself to the modern high-speed direct-injection engine

Microstructural Characterization of Diode Laser Deposited Ti-6Al-4V

Laser Direct Metal Deposition (DMD) is an effective approach to manufacturing or repairing a range of metal components. The process is a layer-by-layer approach to building up a three dimensional solid object. The microstructure influences mechanical properties of the deposited parts. Thus, it is important to understand the microstructural features of diode laser deposited parts. This paper presents a microstructure analysis of a diode laser deposited Ti-6Al-4V onto a Ti-6Al-4V substrate. laser deposited parts. This paper presents a microstructure analysis of a diode laser deposited Ti-6Al-4V onto a Ti-6Al-4V substrate

A Model for the Stray Light Contamination of the UVCS Instrument on SOHO

We present a detailed model of stray-light suppression in the spectrometer channels of the Ultraviolet Coronagraph Spectrometer (UVCS) on the SOHO spacecraft. The control of diffracted and scattered stray light from the bright solar disk is one of the most important tasks of a coronagraph. We compute the fractions of light that diffract past the UVCS external occulter and non-specularly pass into the spectrometer slit. The diffracted component of the stray light depends on the finite aperture of the primary mirror and on its figure. The amount of non-specular scattering depends mainly on the micro-roughness of the mirror. For reasonable choices of these quantities, the modeled stray-light fraction agrees well with measurements of stray light made both in the laboratory and during the UVCS mission. The models were constructed for the bright H I Lyman alpha emission line, but they are applicable to other spectral lines as well.Comment: 19 pages, 5 figures, Solar Physics, in pres

A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a Gynecologic Oncology Group partners study.

A phase 2, randomized, placebo-controlled trial was conducted in women with recurrent epithelial ovarian carcinoma to evaluate the efficacy and safety of motolimod-a Toll-like receptor 8 (TLR8) agonist that stimulates robust innate immune responses-combined with pegylated liposomal doxorubicin (PLD), a chemotherapeutic that induces immunogenic cell death. Women with ovarian, fallopian tube, or primary peritoneal carcinoma were randomized 1 : 1 to receive PLD in combination with blinded motolimod or placebo. Randomization was stratified by platinum-free interval (≤6 versus >6-12 months) and Gynecologic Oncology Group (GOG) performance status (0 versus 1). Treatment cycles were repeated every 28 days until disease progression. The addition of motolimod to PLD did not significantly improve overall survival (OS; log rank one-sided P = 0.923, HR = 1.22) or progression-free survival (PFS; log rank one-sided P = 0.943, HR = 1.21). The combination was well tolerated, with no synergistic or unexpected serious toxicity. Most patients experienced adverse events of fatigue, anemia, nausea, decreased white blood cells, and constipation. In pre-specified subgroup analyses, motolimod-treated patients who experienced injection site reactions (ISR) had a lower risk of death compared with those who did not experience ISR. Additionally, pre-treatment in vitro responses of immune biomarkers to TLR8 stimulation predicted OS outcomes in patients receiving motolimod on study. Immune score (tumor infiltrating lymphocytes; TIL), TLR8 single-nucleotide polymorphisms, mutational status in BRCA and other DNA repair genes, and autoantibody biomarkers did not correlate with OS or PFS. The addition of motolimod to PLD did not improve clinical outcomes compared with placebo. However, subset analyses identified statistically significant differences in the OS of motolimod-treated patients on the basis of ISR and in vitro immune responses. Collectively, these data may provide important clues for identifying patients for treatment with immunomodulatory agents in novel combinations and/or delivery approaches. Clinicaltrials.gov, NCT 01666444

Interchange Slip-Running Reconnection and Sweeping SEP Beams

We present a new model to explain how particles (solar energetic particles; SEPs), accelerated at a reconnection site that is not magnetically connected to the Earth, could eventually propagate along the well-connected open flux tube. Our model is based on the results of a low-beta resistive magnetohydrodynamics simulation of a three-dimensional line-tied and initially current-free bipole, that is embedded in a non-uniform open potential field. The topology of this configuration is that of an asymmetric coronal null-point, with a closed fan surface and an open outer spine. When driven by slow photospheric shearing motions, field lines, initially fully anchored below the fan dome, reconnect at the null point, and jump to the open magnetic domain. This is the standard interchange mode as sketched and calculated in 2D. The key result in 3D is that, reconnected open field lines located in the vicinity of the outer spine, keep reconnecting continuously, across an open quasi-separatrix layer, as previously identified for non-open-null-point reconnection. The apparent slipping motion of these field lines leads to form an extended narrow magnetic flux tube at high altitude. Because of the slip-running reconnection, we conjecture that if energetic particles would be traveling through, or be accelerated inside, the diffusion region, they would be successively injected along continuously reconnecting field lines that are connected farther and farther from the spine. At the scale of the full Sun, owing to the super-radial expansion of field lines below 3 solar radii, such energetic particles could easily be injected in field lines slipping over significant distances, and could eventually reach the distant flux tube that is well-connected to the Earth

Tensile Creep and Creep-Recovery Behavior of a SiC-Fiber Si 3 N 4 -Matrix Composite

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65802/1/j.1151-2916.1993.tb03753.x.pd

Phenomenology As Philosophy and Method

Phenomenology is a philosophical movement that approaches the study of human beings and their culture differently from the logical positivist model used in the natural sciences and in special education. phenomenologists view the application of the logical positivist model to the study of human beings as inappropriate because the model does not address the uniqueness of human life. in this article, the theroetical assumptions and methodological orientations of phenomenology are discussed, followed by their applications to ways of doing research in special education.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68638/2/10.1177_074193259501600305.pd