Conceptual study of an advanced supersonic technology transport (AST-107) for transpacific range using low-bypass-ratio turbofan engines

An advanced supersonic technology configuration concept designated the AST-107, using a low bypass ratio turbofan engine, is described and analyzed. The aircraft had provisions for 273 passengers arranged five abreast. The cruise Mach number was 2.62. The mission range for the AST-107 was 8.48 Mm (4576 n.mi.) and an average lift drag ratio of 9.15 during cruise was achieved. The available lateral control was not sufficient for the required 15.4 m/s (30 kt) crosswind landing condition, and a crosswind landing gear or a significant reduction in dihedral effect would be necessary to meet this requirement. The lowest computed noise levels, including a mechanical suppressor noise reduction of 3 EPNdB at the flyover and sideline monitoring stations, were 110.3 EPNdB (sideline noise), 113.1 EPNdB (centerline noise) and 110.5 EPNdB (approach noise)

Shock and statistical acceleration of energetic particles in the interplanetary medium

Definite evidence for particle acceleration in the solar wind came around a decade ago. Two likely sources are known to exist: particles may be accelerated by the turbulence resulting from the superposition of Alfven and Magnetosonic waves (Statistical Acceleration) or they may be accelerated directly at shock fronts formed by the interaction of fast and slow solar wind (CIR's) or by traveling shocks due to sporadic coronal mass ejections. Naurally both mechanisms may be operative. In this work the acceleration problem was tackled numerically using Helios 1 and 2 data to create a realistic representation of the Heliospheric plasma. Two 24 hour samples were used: one where there are only wave like fluctuations of the field (Day 90 Helios 1) and another with a shock present in it (Day 92 of Helios 2) both in 1976 during the STIP 2 interval. Transport coefficients in energy space have been calculated for particles injected in each sample and the effect of the shock studied in detail

Simulator study of the low-speed handling qualities of a supersonic cruise arrow-wing transport configuration during approach and landing

A fixed-based simulator study was conducted to determine the low-speed flight characteristics of an advanced supersonic cruise transport having an arrow wing, a horizontal tail, and four dry turbojets with variable geometry turbines. The primary piloting task was the approach and landing. The statically unstable (longitudinally) subject configuration has unacceptable low-speed handling qualities with no augmentation. Therefore, a hardened stability augmentation system is required to achieve acceptable handling qualities, should the normal operational stability and control augmentation system fail. In order to achieve satisfactory handling qualities, considerable augmentation was required

Privacy and Identity Management in a Layered Pervasive Service Platform

Making pervasive computing reality is a challenging task mainly due to the multitude of functional requirements and technological constraints. In parallel to the honourable research progress in specific technologies, the Daidalos project assessed that in future there will be the need for a pervasive service platform with open interfaces in order to simplify service development and provisioning. The success of such a platform depends on the balance of different aspects, e.g. operational costs with revenue potentials, collection of personal data for context-awareness with privacy protection, manual control and transparency with enhanced user experience and simplicity. In this paper we show the Daidalos approach to privacy protection and identity management for a future pervasive service platform and its architecture. We show how user identities are structured to support dynamic context information while following regulations for privacy protection in Europe. Special focus is put on the trade-off between access control for privacy protection and user experience. This is achieved by automated identity selection, automatic derivation of fine-grained access control policies and their deployment. We also present gathered performance data and implementation details of our ID Broker concept

Ground-based and in-flight simulator studies of low-speed handling characteristics of two supersonic cruise transport concepts

Conventional and powered lift concepts for supersonic approach and landing tasks are considered. Results indicated that the transport concepts had unacceptable low-speed handling qualities with no augmentation, and that in order to achieve satisfactory handling qualities, considerable augmentation was required. The available roll-control power was acceptable for the powered-lift concept

Comparison of T1 mapping techniques for ECV quantification. histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR

BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated. METHODS: Multibreathhold T1 quantification with heart rate correction and single breath-hold T1 mapping using Shortened Modified Look-Locker Inversion recovery (ShMOLLI) were used in equilibrium contrast CMR to generate ECV values and compared in 3 ways.Firstly, both techniques were compared in a spectrum of disease with variable ECV expansion (n=100, 50 healthy volunteers, 12 patients with hypertrophic cardiomyopathy, 18 with severe aortic stenosis, 20 with amyloid). Secondly, both techniques were correlated to human histological collagen volume fraction (CVF%, n=18, severe aortic stenosis biopsies). Thirdly, an assessment of test:retest reproducibility of the 2 CMR techniques was performed 1 week apart in individuals with widely different ECVs (n=10 healthy volunteers, n=7 amyloid patients). RESULTS: More patients were able to perform ShMOLLI than the multibreath-hold technique (6% unable to breath-hold). ECV calculated by multibreath-hold T1 and ShMOLLI showed strong correlation (r(2)=0.892), little bias (bias -2.2%, 95%CI -8.9% to 4.6%) and good agreement (ICC 0.922, range 0.802 to 0.961, p<0.0001). ECV correlated with histological CVF% by multibreath-hold ECV (r(2)= 0.589) but better by ShMOLLI ECV (r(2)= 0.685). Inter-study reproducibility demonstrated that ShMOLLI ECV trended towards greater reproducibility than the multibreath-hold ECV, although this did not reach statistical significance (95%CI -4.9% to 5.4% versus 95%CI -6.4% to 7.3% respectively, p=0.21). CONCLUSIONS: ECV quantification by single breath-hold ShMOLLI T1 mapping can measure ECV by EQ-CMR across the spectrum of interstitial expansion. It is procedurally better tolerated, slightly more reproducible and better correlates with histology compared to the older multibreath-hold FLASH techniques

Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender

This work was funded by a grant from the Engineering and Physical Sciences Research Council (EP/G030693/1) and supported by the Oxford British Heart Foundation Centre of Research Excellence and the National Institute for Health Research Oxford Biomedical Research Centr

Tower-based greenhouse gas fluxes in a restored tidal freshwater wetland: A shared resource for research and teaching.

The goals of this study are: 1) to use an eddy-covariance system to continuously measure wetland-atmosphere CO2 and CH4 exchange in a restored forested wetland, 2) to quantity C sequestration in plant biomass and soils in restored (Kimages Creek watershed) and old-growth (Harris Creek watershed) forested wetlands, and 3) to establish a shared long-term, shared research and teaching platform centered on eddy-covariance tower measurements. Since the old-growth forest wetland has had longer to accumulate C, the current C stocks are likely much larger than those of the restored wetland; however, the rate of C accumulation (i.e., C sequestration or net ecosystem production) may be higher in young ecosystems (De Simon et al. 2 | Goodrich-Stuart (Stuart-Haëntjens) 2012). While natural wetlands generally offset the warming effect of CH4 emissions by also sequestering large amounts of CO2, but it has been suggested that, in the short-term, this may not hold true for restored wetlands (Petrescu et al. 2015). Very few restored wetlands have studied, however, so knowledge is lacking in this area

An Ab Initio Approach to the Solar Coronal Heating Problem

We present an ab initio approach to the solar coronal heating problem by modelling a small part of the solar corona in a computational box using a 3D MHD code including realistic physics. The observed solar granular velocity pattern and its amplitude and vorticity power spectra, as reproduced by a weighted Voronoi tessellation method, are used as a boundary condition that generates a Poynting flux in the presence of a magnetic field. The initial magnetic field is a potential extrapolation of a SOHO/MDI high resolution magnetogram, and a standard stratified atmosphere is used as a thermal initial condition. Except for the chromospheric temperature structure, which is kept fixed, the initial conditions are quickly forgotten because the included Spitzer conductivity and radiative cooling function have typical timescales much shorter than the time span of the simulation. After a short initial start up period, the magnetic field is able to dissipate 3-4 10^6 ergs cm^{-2} s^{-1} in a highly intermittent corona, maintaining an average temperature of $\sim 10^6$ K, at coronal density values for which emulated images of the Transition Region And Coronal Explorer(TRACE) 171 and 195 pass bands reproduce observed photon count rates.Comment: 12 pages, 14 figures. Submitted to Ap

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1). We aimed to identify genetic variants influencing liver cT1 and use genetics to understand mechanisms underlying liver fibroinflammatory disease and its link with other metabolic traits and diseases. Methods First, we performed a genome-wide association study (GWAS) in 14,440 Europeans in UK Biobank with liver cT1 measures. Second, we explored the effects of the cT1 variants on liver blood tests, and a range of metabolic traits and diseases. Third, we used Mendelian randomisation to test the causal effects of 24 predominantly metabolic traits on liver cT1 measures. Results We identified six independent genetic variants associated with liver cT1 that reached GWAS significance threshold (p<5x10-8). Four of the variants (rs75935921 in SLC30A10, rs13107325 in SLC39A8, rs58542926 in TM6SF2, rs738409 in PNPLA3) were also associated with elevated transaminases and had variable effects on liver fat and other metabolic traits. Insulin resistance, type 2 diabetes, non-alcoholic fatty liver and BMI were causally associated with elevated cT1 whilst favourable adiposity (instrumented by variants associated with higher adiposity but lower risk of cardiometabolic disease and lower liver fat) was found to be protective. Conclusion The association between two metal ion transporters and cT1 indicates an important new mechanism in steatohepatitis. Future studies are needed to determine whether interventions targeting the identified transporters might prevent liver disease in at risk individuals