Hormonal adaptations to different training intensities during the preparation of elite judokas for competition

Many efforts are made to quantify objectively the balance between training load and the athlete’s tolerance. The aim of the present study was to evaluate the balance between anabolic (i.e. testosterone and IGF-I) and catabolic (i.e. cortisol) hormones in elite judokas during their preparations (4 months) for the European championships. Five healthy elite Israeli judokas (four male, one female, age range 17–26 years) were tested at baseline, after two months of moderate training, after another one month of intense training, after one month of tapering down prior to the competition, and during the week after the championships. Hormonal level remained relatively unchanged during period of moderate training. Circulating levels of IGF-I and testosterone decreased and the cortisol/testosterone ratio increased during intense training. However, only the decrease in circulating IGF-I level reached statistical significance. Both levels of IGF-I and testosterone increased significantly, and the cortisol/testosterone ratio decreased significantly following tapering down, prior to the championships, compared to the levels during intense training. Changes in the balance of anabolic and catabolic hormones during the training season may help elite athletes and assist their coaches in their preparation for the competition

Improving Human Health in China Through Alternative Energy

In this study, we estimate the health benefits of more stringent alternative energy goals and the costs of reducing coal-fired power plant pollution in China projected in 2030. One of our two overarching alternative energy goals was to estimate the health benefits of complete elimination of coal energy, supplemented by natural gas and renewables. The second was a policy scenario similar to the U.S. 2013 Climate Action Plan (CAP), which played a pivotal role leading up to the 2015 Paris Climate Agreement. We used the Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) model created by the International Institute for Applied Systems Analysis for our model simulations. We found that 17,137-24,220 premature deaths can be avoided if coal energy is completely replaced by alternative energy, and 8,693-9,281 premature deaths can be avoided if coal energy is replaced by alternatives in a CAP-like scenario. A CAP-like scenario using emission-controls in coal plants costs $11-18 per person. Reducing coal energy in China under a CAP-like scenario would free up$9.4 billion in the annual energy budget to spend on alternatives, whereas eliminating the cost of coal energy frees up $32 billion. This study's estimates show that more stringent alternative energy targets in China are worth the investment in terms of health

Optical shield: measuring viscosity of turbid fluids using optical tweezers

The viscosity of a fluid can be measured by tracking the motion of a suspended micron-sized particle trapped by optical tweezers. However, when the particle density is high, additional particles entering the trap compromise the tracking procedure and degrade the accuracy of the measurement. In this work we introduce an additional Laguerre–Gaussian, i.e. annular, beam surrounding the trap, acting as an optical shield to exclude contaminating particles

Effect of local cold-pack application on systemic anabolic and inflammatory response to sprint-interval training: a prospective comparative trial

We evaluated the effect of cold ice-pack application following a brief sprint-interval training on the balance between anabolic mediators [growth hormone (GH), insulin-like growth factor-I (IGF-I), testosterone], catabolic markers (cortisol, IGFBP-1), and circulating pro [Interlukin-6 (IL-6) and IL-1β]- and anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra)]. Twelve males, elite junior handball players performed 4 × 250 m treadmill run, at 80% of each individual’s maximal speed, followed by a rest period with and without local cold-pack application. Pre, immediately post, and 60-min post-exercise blood samples were drawn. Exercise was associated with a significant increase in IL-6, GH, IGFBP-3, and testosterone levels. Local cold-pack application was associated with significant decreases in IL-1β, IL-1ra, IGF-I, and IGFBP-3 and a greater increase of IGFBP-1 during recovery. Local ice therapy immediately following sprint-interval training was associated with greater decreases in both pro- and anti-inflammatory cytokines and anabolic hormones supporting some clinical evidence for possible negative effects on athletic performance

Marginalization of end-use technologies in energy innovation for climate protection

Mitigating climate change requires directed innovation efforts to develop and deploy energy technologies. Innovation activities are directed towards the outcome of climate protection by public institutions, policies and resources that in turn shape market behaviour. We analyse diverse indicators of activity throughout the innovation system to assess these efforts. We find efficient end-use technologies contribute large potential emission reductions and provide higher social returns on investment than energy-supply technologies. Yet public institutions, policies and financial resources pervasively privilege energy-supply technologies. Directed innovation efforts are strikingly misaligned with the needs of an emissions-constrained world. Significantly greater effort is needed to develop the full potential of efficient end-use technologies

The 'High-with-Low' Scenario Narrative: Key Themes, Cross-Cutting Linkages, and Implications for Modelling

We define a global ‘High-with-Low’ scenario that delivers high wellbeing with low energy and material resource consumption while limiting global warming in line with Paris Agreement targets. The High-with-Low scenario comprises a rich thematic narrative and a quantitative framework for interpreting the narrative using systems and sectoral modelling tools at different scales. The three central themes of the High-with-Low scenario are decent living standards for all, innovation and granularity, and digitalization. Inter-linkages between these themes emphasize drivers of change towards a High-with-Low future that include decentralization, adaptability to local needs, accelerated diffusion through peer and network effects, and the management of complexity on shared infrastructures. However, the direction of change is not deterministic. The High-with-Low scenario envisages a set of specific and strong governance institutions for coordinating a highly distributed global sustainability transition. To help develop and enrich these narrative aspects, we also set out some guidelines and parameterisations for quantitative model interpretations of the High-with-Low scenario. These guidelines are not universally prescriptive but rather define a set of quantitative reference points against which model inputs, processes, and outputs can be iteratively tested for consistency. In particular, we emphasize the overall development pattern of the High-with-Low scenario as one of conditional convergence in which energy services for well-being increase substantially in the Global South catching up to levels maintained in the Global North, while associated resource use tends to converge, combining a contraction in the Global North with relatively modest increases in the Global South

Allogeneic transplantation for adult acute lymphoblastic leukemia: Intention to treat analysis of the EORTC ALL-4 phase III trial

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The muscle – fat duel or why obese children are taller?

BACKGROUND: Obesity the epidemic of our times appears to be a problem that is easy to resolve: just eat less and move more. However, this very common condition has turned out to be extremely troublesome, and in some cases even irreversible. METHODS: The interplay between less muscle and more fat tissue is discussed from physiological perspectives with an emphasis on the early years of childhood. RESULTS: It is suggested that the coordinated muscle-fat interactions lead to a fluctuating exchange economy rate. This bodily economic decision, slides between thrift (more fat) and prodigal (more muscle) strategies. The thrift strategy results not only in obesity and less physical activity but also in other maladies which the body is unable to manage. What leads to obesity (less muscle, more fat) might be very difficult to reverse at adulthood, prevention at childhood is thus recommended. CONCLUSION: Early recognition of the ailment (low muscle mass) is crucial. Based on studies demonstrating a 'rivalry' between muscle build-up and height growth at childhood, it is postulated that among the both taller and more obese children the percentage of children with lower muscle mass will be higher. A special, body/muscle-building gymnastics program for children is suggested as a potential early intervention to prevent the ill progress of obesity