22,059 research outputs found
Regulation of auditor change in Australia : audit pricing, reporting lag and equity valuation implications
University of Technology Sydney. Faculty of Business.This thesis provides evidence on the impact on two aspects of auditor change for Australian listed companies. Firstly, changes in audit partners are mandated, requiring partners rotate off engagements after a fixed tenure. Recently, practitioner based concerns about the costs of rotation for both auditors and clients have precipitated amendments to the rule in Australia, Canada and the UK. Evidence in this thesis shows a cost to clients and auditors in the form of increased in audit fees and audit reporting lag in the rotation year that corroborates anecdotal practitioner evidence. Secondly, the process of voluntarily changing audit firms (auditor switching) is regulated under a consent-based framework mitigating information flow to the market. In 2013, the Australian corporate regulator, the Australian Securities and Investments Commission (ASIC), sought stakeholder input on the information provided to the market under the consent framework to inform policy deliberations. This can be viewed as couching the possibility of a move towards adoption of a disclosure-based approach similar to the approach in the US and UK. Accordingly, this thesis investigates market reactions to auditor switch announcements. Results show no market reactions, consistent with the market not considering such disclosures to be informative. The overall findings presented in this thesis lend support to the adoption of amendments that allow for flexibility
Differences in Sexual Behavior & Contraceptive Use in Religious and Non-Religious Universities: A Comparison Using the National College Health Assessment
The primary purpose of this current study was (a) to determine if significant differences existed in sexual and contraceptive behaviors of the Christian university sampled and the secular collegiate institutions in the reference group, and (b) to understand if differences existed within the Christian sample, using data from the spring 2006 American College Health Association-National College Assessment (ACHANCHA, n = 94,806). Participants in the Christian sample were pulled from the reference group sample and broken down into Environmental Group (EG, n = 46) participants (those not endorsing a relationship with Jesus Christ as important), and the Religious Group1 (RG1 , n = 858) participants (those endorsing a relationship with Jesus Christ as important). These participants were compared to stratified, random-matched samples, for age and sex, to the Reference Groupa,b (RFa, n = 858; RFb, n = 46). Next, EG was compared to the stratified, random-matched sample Religious Group2 (RG2 , n =46) to determine differences in sexual behavior within the Christian university. Results showed significant differences in reported number of sexual partners and number of sexual activities between the Christian university and reference group, with fewer partners and activities for the Christian university. Contraceptive use differed little between the two populations, while a comparison of the Christian university (EG v. RG2 ) showed no difference in the reported number of sexual partners or oral sex activities, but a significant difference in reported vaginal and anal sexual activities, with fewer reported sexual activities for RG2 . These findings suggest significant differences did occur within the Christian university and between the reference group; and provide relevant information for choosing a university and depicts the impact of religiosity on the reduction of sexual activities
Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL
Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity. Instead, it seems that class II presentation of endogenous HCMV antigens in these cells allows recognition of virus infection. We characterized class II presentation of HCMV glycoprotein B (gB), a membrane protein that accumulates extensively in endosomes during virus assembly. Human CD4+ T cells specific for gB were both highly abundant in blood and cytolytic in vivo. gB-specific CD4+ T cell clones recognized gB that was expressed in glial, endothelial, and epithelial cells, but not exogenous gB that was fed to these cells. Glial cells efficiently presented extremely low levels of endogenous gB--expressed by adenovirus vectors or after HCMV infection--and stimulated CD4+ T cells better than DCs that were incubated with exogenous gB. Presentation of endogenous gB required sorting of gB to endosomal compartments and processing by acidic proteases. Although presentation of cellular proteins that traffic into endosomes is well known, our observations demonstrate for the first time that a viral protein sorted to endosomes is presented exceptionally well, and can promote CD4+ T cell recognition and killing of biologically important host cells
Boundary conditions of the RGE flow in the noncommutative geometry approach to particle physics and cosmology
We investigate the effect of varying boundary conditions on the
renormalization group flow in a recently developed noncommutative geometry
model of particle physics and cosmology. We first show that there is a
sensitive dependence on the initial conditions at unification, so that, varying
a parameter even slightly can be shown to have drastic effects on the running
of the model parameters. We compare the running in the case of the default and
the maximal mixing conditions at unification. We then exhibit explicitly a
particular choice of initial conditions at the unification scale, in the form
of modified maximal mixing conditions, which have the property that they
satisfy all the geometric constraints imposed by the noncommutative geometry of
the model at unification, and at the same time, after running them down to
lower energies with the renormalization group flow, they still agree in order
of magnitude with the predictions at the electroweak scale.Comment: 18 pages LaTeX, 13 png figure
Superfluid Bosons and Flux Liquids: Disorder, Thermal Fluctuations, and Finite-Size Effects
The influence of different types of disorder (both uncorrelated and
correlated) on the superfluid properties of a weakly interacting or dilute Bose
gas, as well as on the corresponding quantities for flux line liquids in
high-temperature superconductors at low magnetic fields are reviewed,
investigated and compared. We exploit the formal analogy between superfluid
bosons and the statistical mechanics of directed lines, and explore the
influence of the different "imaginary time" boundary conditions appropriate for
a flux line liquid. For superfluids, we discuss the density and momentum
correlations, the condensate fraction, and the normal-fluid density as function
of temperature for two- and three-dimensional systems subject to a space- and
time-dependent random potential as well as conventional point-, line-, and
plane-like defects. In the case of vortex liquids subject to point disorder,
twin boundaries, screw dislocations, and various configurations of columnar
damage tracks, we calculate the corresponding quantities, namely density and
tilt correlations, the ``boson'' order parameter, and the tilt modulus. The
finite-size corrections due to periodic vs. open "imaginary time" boundary
conditions differ in interesting and important ways. Experimental implications
for vortex lines are described briefly.Comment: 78 pages, RevTex, 4 figures included (sorry, there are no ps-files
for the remaining 2 figures; if needed, please send mail to
[email protected]); brief erratum appended (2 pages
Measuring the impacts of Bus Rapid Transit on residential property values : The Beijing case
The authors acknowledge the financial support provided by the National Natural Science Foundation of China (Grant No. 41201102).Peer reviewedPostprin
Simulated Quantum Computation of Global Minima
Finding the optimal solution to a complex optimization problem is of great
importance in practically all fields of science, technology, technical design
and econometrics. We demonstrate that a modified Grover's quantum algorithm can
be applied to real problems of finding a global minimum using modest numbers of
quantum bits. Calculations of the global minimum of simple test functions and
Lennard-Jones clusters have been carried out on a quantum computer simulator
using a modified Grover's algorithm. The number of function evaluations
reduced from O(N) in classical simulation to in quantum
simulation. We also show how the Grover's quantum algorithm can be combined
with the classical Pivot method for global optimization to treat larger
systems.Comment: 6 figures. Molecular Physics, in pres
The diverse evolutionary paths of simulated high-z massive, compact galaxies to z=0
Massive quiescent galaxies have much smaller physical sizes at high redshift
than today. The strong evolution of galaxy size may be caused by progenitor
bias, major and minor mergers, adiabatic expansion, and/or renewed star
formation, but it is difficult to test these theories observationally. Herein,
we select a sample of 35 massive, compact galaxies (
M, M/kpc) at in the
cosmological hydrodynamical simulation Illustris and trace them forward to
to uncover their evolution and identify their descendants. By , the
original factor of 3 difference in stellar mass spreads to a factor of 20. The
dark matter halo masses similarly spread from a factor of 5 to 40. The
galaxies' evolutionary paths are diverse: about half acquire an ex-situ
envelope and are the core of a more massive descendant, a third survive
undisturbed and gain very little mass, 15% are consumed in a merger with a more
massive galaxy, and a small remainder are thoroughly mixed by major mergers.
The galaxies grow in size as well as mass, and only 10% remain compact by
. The majority of the size growth is driven by the acquisition of ex-situ
mass. The most massive galaxies at are the most likely to have compact
progenitors, but this trend possesses significant dispersion which precludes a
direct linkage to compact galaxies at . The compact galaxies' merger rates
are influenced by their environments, so that isolated or satellite
compact galaxies (which are protected from mergers) are the most likely to
survive to the present day.Comment: 19 pages, 10 figures, MNRAS accepted version including 2 new figure
Cannabis Exposure Decreases Need for Blood Pressure Support During General Anesthesia in Orthopedic Trauma Surgery.
Introduction: As cannabis use continues to increase in popularity, it is important to investigate how it impacts public health in all sectors of the population, including patients undergoing anesthetic management. This retrospective study focuses on the orthopedic trauma population presenting through an emergency department (ED) and receiving a urine drug screen (UDS) with subsequent urgent surgical intervention. We aimed to evaluate differences in response to general anesthesia in patients with exposure to THC, a major cannabinoid, compared to controls that screened negative for THC. Materials and Methods: All ED visits at UC Irvine, a level 1 trauma center between November 4, 2017 and January 7, 2020, were evaluated in this study. Only adult patients who received a UDS and underwent urgent orthopedic trauma surgery within 48 h of ED visit were included in this study. Additional inclusion criteria required an anesthesia time greater than 1 h as well as anesthesia induction and intubation while in the operating room. Overall, we analyzed a total of 221 adult patients. Discussion: When adjusting for demographic variability, there were statistically significant differences in response to general anesthesia between these two groups. The THC-positive (THC(+)) group was less likely to receive intraoperative vasopressors, had higher mean arterial blood pressure and mean diastolic blood pressure, needed less total fluid input and had a lower overall fluid balance. Chronic exposure to THC has been shown to downregulate cannabinoid 1 receptors and cause alterations in endocannabinoid tone. These are two potential mechanisms by which the THC(+) group in our study may have become more resistant to the typically observed hypotensive effects of general anesthesia. Conclusion: The present study suggests that prior use of cannabis, objectively assessed by urinalysis, results in a decreased need for blood pressure support during general anesthesia. The physiological basis for this phenomenon is unclear, but possible causes might include the downregulation of vascular cannabinoid receptor 1 and/or altered endocannabinoid levels after exposure to cannabis
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