Graduates’ orientations to Higher Education and their retrospective experiences of teaching and learning

In this article, we sought a relation between orientation to higher education and curricular experiences, and elucidated the nature of transformative curricular experiences. Twenty-four graduates from humanities and science degrees in the year 2000 were interviewed approximately five years later to obtain their retrospective views on the purpose of higher education, as well as their undergraduate experiences of teaching and learning. Drawing on phenomenographic principles, four orientations to higher education were generated. Four participant cases are analyzed, representing each orientation to higher education. In the ‘gaining a qualification’ orientation, graduates valued being told what to learn, as well as learning practical skills. For the ‘preparation for a job’ orientation, graduates wanted lecturers who were good at conveying information, but they also valued project work, having some autonomy over learning and practical applications. In the ‘developing skills and learning how to think’ orientation, graduates valued being challenged and learning in groups, but also wanted to learn professional skills. In the ‘growing as an individual’ orientation, graduates valued being challenged, gaining different perspectives, developing critical thinking, learning about theory, interacting with lecturers, research, and study for its own sake. Some curricular experiences transformed thinking about the purpose of higher education, including learning through discussion in small groups, authentic learning tasks including inquiry-based assignments, exercises in developing critical thinking, opportunities to interact with teachers, opportunities to develop practical skills, experiencing different cultures and personal growth through lifestyle and social experiences. Our research has implications for advising students, as well as for teachers aiming to encourage a deep approach to learning

Moving beyond the front line: a 20-year retrospective cohort study of career trajectories from the Indigenous Health Program at the University of Queensland

This report examines critical success factors for enabling Aboriginal and Torres Strait Islander leadership across the health system as demonstrated by alumni of the University of Queensland (UQ) Indigenous Health Program (IHP) (1994–2005) who today work in various leadership roles throughout the country.\ua0It determines the enablers of professional success of these health leaders in various facets of the health system and investigates the impact of active participation in the community of Aboriginal and Torres Strait Islander health professionals over the course of a career. Through this analysis, the report further theorises the confluence of community, subjectivity, self-determination and health

Malassezia pachydermatis Carriage in Dog Owners

Malassezia pachydermatis is commonly carried on the hands of dog owners and may cause disease in immunocompromised persons

Conceptualizing and measuring distance in international business research:Recurring questions and best practice guidelines

Distance is a central concept in international business research, yet there is debate about the construct as well as its operationalization. In this editorial, we address three of the most important recurring questions posed by authors, editors, and reviewers by examining the theory, methods, and data of distance research. We discuss (1) how to theorize on distance, and (2) what method and (3) what data to use when constructing a distance index. We develop practical recommendations grounded in theory, illustrating and supporting them by calculating cross-country distance indices for all available country pairs and two of the most used distance indices: cultural and institutional. We show that, whereas a specific method to calculate distance may matter to some extent, the choice for a specific cultural or institutional framework to measure cultural or institutional distance has a major impact on country-pair distances. Overall, this editorial highlights the importance of matching data and method to the theoretical argument.</p

Understanding the Emergence of HIV-2 Group F, a Novel, Pathogenic HIV-2 Indigenous to Sierra Leone

Background: AIDS is caused by infection with pathogenic strains of HIV-1 or 2. HIV-2 is broken into 9 groups, A-I. Groups A and B are epidemic in West Africa while the remaining groups are individual cases and are not known to be pathogenic. HIV-2F is an exception being both pathogenic and found in 2 persons, suggesting transmissibility. HIV's origins have been widely studied, however, questions remain. The simian ancestry of HIV is well established yet exactly how SIV adapted to HIV in humans is still unknown. Several theories have been put forth to explain HIV emergence from SIV including the serial passage theory of HIV emergence. Here we conduct an HIV survey in northern Sierra Leone (SL) to assess the public health threat of HIV-2F and also model the serial passage theory of emergence both in vivo and in vitro to elucidate mechanisms of adaptation. Materials and methods: For the human HIV study in northern SL, we enrolled persons presenting for a voluntarily HIV test following education and outreach activities and those referred for an HIV test. This is a targeted, higher risk population than the general population. Commercial HIV-1/2 rapid tests were used in the field. Proviral DNA was amplified with PCR methods and sequenced with Sanger methods. Parallel pigtailed (PTM) and rhesus macaque in vivo and in vitro models were used to test the serial passage theory of HIV emergence. Virus was detected with an HIV-2F specific qPCR and commercial SIV p27 Antigen ELISA. Illumina methods were used to deep sequence day 3 samples with peak virus loads. A SNP analysis was conducted to investigate virus variation over serial passage. Results: To date we have found the prevalence of HIV in the targeted sample population to be 6.36%. HIV-2 rates in the targeted sample were 0.50%, HIV-1 was 4.81% and apparent co-infections were seen in 1.06% of those tested. Two HIV-1 samples have been sequenced and typed to CRF02_AG. Attempts to PCR amplify proviral DNA from HIV-2 antibody positives were negative, possibly due to low virus load. In vitro, over serial passage, peak virus load decreased to undetectable, the opposite of what was expected. In fact, the in vitro serial passage results exactly contradict what was observed in a parallel in vivo serial passage experiment. In vivo we saw an increase in PVL over serial passage in the PTMs and viral escape in passages 2 and 3. SNP analysis showed mutations over serial passage allowing the virus to adapt to a new host in vivo. Conclusion: In this study we asked two main research questions. First, is HIV-2F a public health threat? This question remains unanswered due to our inability to sequence the HIV-2 samples collected in this study. However, the samples remain preserved for applying different techniques. We described HIV burden in a self-selected, at risk population in northern Sierra Leone providing the first HIV-2 data in 20 years. We also provided the first HIV-1 sequence data from Sierra Leoneans living in Sierra Leone, all previous data are from SL immigrants to Europe or the USA. The second question was, can the serial passage hypothesis of HIV emergence be modeled to elucidate the role of serial passage in HIV cross-species transmission, adaptation and diversity? We successfully showed that this can be done through the in vivo serial passage experiment in pigtailed macaques. Together the data from the field studies along with the in vivo and in vitro models presented in this thesis provide a better understanding of mechanisms of HIV emergence as well as much needed information about HIV distribution and genetic diversity in northern Sierra Leone

Old World Hantavirus Infection in Rattus Species and Risk Management in Urban Neighborhoods of New Orleans, Louisiana

Hantaviruses are lipid-enveloped, tri-segmented RNA viruses belonging to the family Bunyaviridae. Hantaviruses are divided taxonomically into Old World and New World groups that typically cause hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, respectively. Each hantavirus is specific to a rodent reservoir host. In 1983, isolation of an Old World hantavirus similar to Seoul virus (Tchoupitoulas virus) occurred from rats caught in New Orleans, Louisiana, but to date, this virus has not been associated with human disease. Since that time, no hantavirus surveillance has been conducted in this geographic area. We sought to determine if Old World hantaviruses still circulate in rodents in New Orleans and, if so, to decrease rat populations to reduce the risk of human-rodent interaction and the potential for disease transmission. Over a 3-year period, rodents were live-trapped using Sherman and Tomahawk traps. Blood and other tissues were collected and samples tested for the presence of Old World hantaviruses via Reverse transcriptase Polymerase Chain Reaction. Trap sites were identified through selected citizen service requests and routine municipal rodent management activities. Of the 172 roof rats and Norway rats collected, 3.6% tested positive, indicating continued presence of Old World hantaviruses in New Orleans. This study raised awareness of the continued risk of rodent-borne disease in the greater New Orleans area and spawned proactive management strategies on a city-wide basis, including neighborhood surveys, public education and awareness campaigns, and an aggressive rodenticide baiting program in areas with large rodent populations. Continued surveillance and detection of hantaviruses and other rodent-borne pathogens will help preserve the safety and health of New Orleans residents