Cytogenetic analysis of adult T-Cell leukemia/ lymphoma: evaluation of a Caribbean cohort

Adult T-cell leukemia/lymphoma (ATLL) is a rare and highly aggressive type of peripheral T-cell lymphoma associated with human T-lymphotropic virus, type I (HTLV-I) infection. ATLL has a long latency and only a small percentage of HTLV-I infected individuals develop ATLL, suggesting the requirement of additional genetic events for neoplastic transformation of HTLV-I infected lymphocytes. The disease is endemic in several regions of the world, in particular, southwestern Japan and the Caribbean basin. The clinical features of Caribbean ATLL have been reported to differ from Japanese cases, includ- ing a younger age at diagnosis, higher frequency of the lymphomatous subtype, and a more aggressive clinical course [1–7]. A number of publications have described the cytogenetic profile of Japanese ATLL [8–11]; however, cytogenetic data on Caribbean ATLL are limited [5,6]. In this study, we assessed the cytogenetic alterations in a large series of Caribbean ATLL cases to investigate whether the differences in the types and frequencies of karyotype abnormalities account for the reported differ- ences in clinical presentation and outcome between Japanese and Caribbean patients

Contributions to the Science of Environmental Impact Assessment: Three Papers on the Arctic Cisco (Coregonus autumnalis) of Northern Alaska

Editor's Introduction -- D. W. Norton; An Assessment of the Colville River Delta Stock of Arctic Cisco--Migrants from Canada? -- B. J. Gallaway, W. B. Griffiths, P. C. Craig, W. J. Gazey, and J. W. Helmericks; Temperature Preference of Juvenile Arctic Cisco (Coregonus autumnalis) From the Alaskan Beaufort Sea -- R. G. Fechhelm, W. H. Neill, and B. J. Gallaway; Modeling Movements and Distribution of Arctic Cisco (Coregonus autumnalis) Relative to Temperature-Salinity Regimes of the Beaufort Sea Near the Waterflood Causeway, Prudhoe Bay, Alaska. -- W. H. Neill, R. G. Fechhelm, B. J. Gallaway, J. D. Bryan, and S. W. Anderson; Notice to Author

The Beta Problem: A Study of Abell 262

We present an investigation of the dynamical state of the cluster A262. Existing optical line of sight velocities for select cluster galaxies have been augmented by new data obtained with the Automated Multi-Object Spectrograph at Lick Observatory. We find evidence for a virialized early-type population distinct from a late-type population infalling from the Pisces-Perseus supercluster ridge. We also report on a tertiary population of low luminosity galaxies whose velocity dispersion distinguishes them from both the early and late-type galaxies. We supplement our investigation with an analysis of archival X-ray data. A temperature is determined using ASCA GIS data and a gas profile is derived from ROSAT HRI data. The increased statistics of our sample results in a picture of A262 with significant differences from earlier work. A previously proposed solution to the "beta-problem" in A262 in which the gas temperature is significantly higher than the galaxy temperature is shown to result from using too low a velocity dispersion for the early-type galaxies. Our data present a consistent picture of A262 in which there is no "beta-problem", and the gas and galaxy temperature are roughly comparable. There is no longer any requirement for extensive galaxy-gas feedback to drastically overheat the gas with respect to the galaxies. We also demonstrate that entropy-floor models can explain the recent discovery that the beta values determined by cluster gas and the cluster core radii are correlated.Comment: 31 pages, 14 figures, AAS LaTeX v5.0, Encapsulated Postscript figures, to be published in The Astrophysical Journa

Email for communicating results of diagnostic medical investigations to patients

<p>Background: As medical care becomes more complex and the ability to test for conditions grows, pressure on healthcare providers to convey increasing volumes of test results to patients is driving investigation of alternative technological solutions for their delivery. This review addresses the use of email for communicating results of diagnostic medical investigations to patients.</p> <p>Objectives: To assess the effects of using email for communicating results of diagnostic medical investigations to patients, compared to SMS/ text messaging, telephone communication or usual care, on outcomes, including harms, for health professionals, patients and caregivers, and health services.</p> <p>Search methods: We searched: the Cochrane Consumers and Communication Review Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 1 2010), MEDLINE (OvidSP) (1950 to January 2010), EMBASE (OvidSP) (1980 to January 2010), PsycINFO (OvidSP) (1967 to January 2010), CINAHL (EbscoHOST) (1982 to February 2010), and ERIC (CSA) (1965 to January 2010). We searched grey literature: theses/dissertation repositories, trials registers and Google Scholar (searched July 2010). We used additional search methods: examining reference lists and contacting authors.</p> <p>Selection criteria: Randomised controlled trials, quasi-randomised trials, controlled before and after studies and interrupted time series studies of interventions using email for communicating results of any diagnostic medical investigations to patients, and taking the form of 1) unsecured email 2) secure email or 3) web messaging. All healthcare professionals, patients and caregivers in all settings were considered.</p> <p>Data collection and analysis: Two review authors independently assessed the titles and abstracts of retrieved citations. No studies were identified for inclusion. Consequently, no data collection or analysis was possible.</p> <p>Main results: No studies met the inclusion criteria, therefore there are no results to report on the use of email for communicating results of diagnostic medical investigations to patients.</p> <p>Authors' conclusions: In the absence of included studies, we can draw no conclusions on the effects of using email for communicating results of diagnostic medical investigations to patients, and thus no recommendations for practice can be stipulated. Further well-designed research should be conducted to inform practice and policy for communicating patient results via email, as this is a developing area.</p&gt

Optical Colors of Intracluster Light in the Virgo Cluster Core

We continue our deep optical imaging survey of the Virgo cluster using the CWRU Burrell Schmidt telescope by presenting B-band surface photometry of the core of the Virgo cluster in order to study the cluster's intracluster light (ICL). We find ICL features down to mu_b ~ 29 mag sq. arcsec, confirming the results of Mihos et al. (2005), who saw a vast web of low-surface brightness streams, arcs, plumes, and diffuse light in the Virgo cluster core using V-band imaging. By combining these two data sets, we are able to measure the optical colors of many of the cluster's low-surface brightness features. While much of our imaging area is contaminated by galactic cirrus, the cluster core near the cD galaxy, M87, is unobscured. We trace the color profile of M87 out to over 2000 arcsec, and find a blueing trend with radius, continuing out to the largest radii. Moreover, we have measured the colors of several ICL features which extend beyond M87's outermost reaches and find that they have similar colors to the M87's halo itself, B-V ~ 0.8. The common colors of these features suggests that the extended outer envelopes of cD galaxies, such as M87, may be formed from similar streams, created by tidal interactions within the cluster, that have since dissolved into a smooth background in the cluster potential.Comment: 14 pages. Published in ApJ, September 201

THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA

Background Chronic lung infection with Pseudomonas aeruginosa remains a major cause of mortality and morbidity among individuals with CF. Expression of mediators promoting recruitment and differentiation of B cells, or supporting antibody production is poorly understood yet could be key to controlling infection. Methods BAFF was measured in BAL from children with CF, both with and without P. aeruginosa, and controls. Mice were intra-nasally infected with P. aeruginosa strain LESB65 for up to 7 days. Cellular infiltration and expression of B cell chemoattractants and B cell differentiation factor, BAFF were measured in lung tissue. Results BAFF expression was elevated in both P. aeruginosa negative and positive CF patients and in P. aeruginosa infected mice post infection. Expression of the B cell chemoattractants CXCL13, CCL19 and CCL21 increased progressively post infection. Conclusions In a mouse model, infection with P. aeruginosa was associated with elevated expression of BAFF and other B cell chemoattractants suggesting a role for airway B cell recruitment and differentiation in the local adaptive immune response to P. aeruginosa. The paediatric CF airway, irrespective of pseudomonal infection, was found to be associated with an elevated level of BAFF implying that BAFF expression is not specific to pseudomonas infection and may be a feature of the CF airway. Despite the observed presence of a potent B cell activator, chronic colonisation is common suggesting that this response is ineffective