Inhomogeneous universes in observational coordinates

Isotropic inhomogeneous dust universes are analysed via observational coordinates based on the past light cones of the observer's galactic worldline. The field equations are reduced to a single first--order {\sc ode} in observational variables on the past light cone, completing the observational integration scheme. This leads naturally to an explicit exact solution which is locally nearly homogeneous (i.e. {\sc frw}), but at larger redshift develops inhomogeneity. New observational characterisations of homogeneity ({\sc frw} universes) are also given.Comment: 17 pages LaTeX, no figures; to appear in Classical and Quantum Gravit

Restart: The Resurgence of Computer Science in UK Schools

Computer science in UK schools is undergoing a remarkable transformation. While the changes are not consistent across each of the four devolved nations of the UK (England, Scotland, Wales and Northern Ireland), there are developments in each that are moving the subject to become mandatory for all pupils from age 5 onwards. In this article, we detail how computer science declined in the UK, and the developments that led to its revitalisation: a mixture of industry and interest group lobbying, with a particular focus on the value of the subject to all school pupils, not just those who would study it at degree level. This rapid growth in the subject is not without issues, however: there remain significant forthcoming challenges with its delivery, especially surrounding the issue of training sufficient numbers of teachers. We describe a national network of teaching excellence which is being set up to combat this problem, and look at the other challenges that lie ahead

Is Your Small Business Prepared for a Crisis?

Recent well-publicized catastrophic events have increased the importance of crisis management for many large business managers. The issue of crisis management for small businesses has received little attention in the literature. This article examines the issue of crisis management for small business owners/managers. A small business crisis model is presented to enable business owners and consultants to consider the types of crises that might affect small firms. Guidelines are proposed for small business owners to use to anticipate crises that might affect their firms and to effectively prepare for these events

Harvester Productivity and Operator Fatigue: Working Extended Hours

Falling financial margins have prompted many owners of Australian harvesting businesses to extend normal working hours. After brief trial periods, most companies have again reverted to short-term and ad hoc solutions to meet peaks in demand. The harvesting industry is also being persuaded to operate extended hours under the guise of service-delivery and the `24-hour society', in response to customer demand. A poor understanding of human factors poses a threat to profitable harvesting, and contributes to low productivity on extended hours work regimes. Decreased operator productivity was observed in both shifts of a shiftwork operation. Experience in other industries have noted reduced operator alertness led to increases in the risk and severity of accidents and machine damage. Successful implementation of extended hours work regimes relies on addressing operational needs as well as recognising the human needs, managing productivity, safety, communications and maintenance

Regular spherical dust spacetimes

Physical (and weak) regularity conditions are used to determine and classify all the possible types of spherically symmetric dust spacetimes in general relativity. This work unifies and completes various earlier results. The junction conditions are described for general non-comoving (and non-null) surfaces, and the limits of kinematical quantities are given on all comoving surfaces where there is Darmois matching. We show that an inhomogeneous generalisation of the Kantowski-Sachs metric may be joined to the Lemaitre-Tolman-Bondi metric. All the possible spacetimes are explicitly divided into four groups according to topology, including a group in which the spatial sections have the topology of a 3-torus. The recollapse conjecture (for these spacetimes) follows naturally in this approach.Comment: Minor improvements, additional references. Accepted by GR

Exact isotropic cosmologies with local fractal number counts

We construct an exact relativistic cosmology in which an inhomogeneous but isotropic local region has fractal number counts and matches to a homogeneous background at a scale of the order of $10^2$ Mpc. We show that Einstein's equations and the matching conditions imply either a nonlinear Hubble law or a very low large-scale density.Comment: revised version, to appear Class. Q. Grav.; minor corrections following eqn 16, additional comments on relation to other work, some new reference

Psychogenic amnesia: syndromes, outcome, and patterns of retrograde amnesia

There are very few case series of patients with acute psychogenic memory loss (also known as dissociative/functional amnesia), and still fewer studies of outcome, or comparisons with neurological memory-disordered patients. Consequently, the literature on psychogenic amnesia is somewhat fragmented and offers little of prognostic value for individual patients. In the present study, we reviewed the case records and neuropsychological findings in 53 psychogenic amnesia cases (3M:1F), in comparison with 21 consecutively recruited neurological memory-disordered patients and 14 healthy controls. In particular, we examined the pattern of retrograde amnesia on an assessment of autobiographical memory (the Autobiographical Memory Interview). We found that our patients with psychogenic memory loss fell into four distinct groups, which we categorised as: (i) fugue state, (ii) fugue-to-focal retrograde amnesia, (iii) psychogenic focal retrograde amnesia following a minor neurological episode, and (iv) patients with gaps in their memories. While neurological cases were characterised by relevant neurological symptoms, a history of a past head injury was actually more common in our psychogenic cases (p=0.012), perhaps reflecting a ‘learning episode’ predisposing to later psychological amnesia. As anticipated, loss of the sense of personal identity was confined to the psychogenic group. However, clinical depression, family/relationship problems, financial/employment problems, and failure to recognise the family were also statistically more common in that group. The pattern of autobiographical memory loss differed between the psychogenic groups: fugue cases showed a severe and uniform loss of memories for both facts and events across all time-periods, whereas the two focal retrograde amnesia groups showed a ‘reversed’ temporal gradient with relative sparing of recent memories. After 3-6 months, the fugue patients had improved to normal scores for facts and near-normal scores for events. By contrast, the two focal retrograde amnesia groups showed a lesser improvement and continued to show a reversed temporal gradient. In conclusion, the outcome in psychogenic amnesia, particularly those characterised by fugue, is better than generally supposed. Findings are interpreted in terms of Markowitsch’s and Kopelman’s models of psychogenic amnesia, and with respect to Anderson’s neuroimaging findings in memory inhibition

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design

Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but contain predominantly human coding sequence. Here we show that some humanised heavy chains can fold, form dimers and be secreted even in the absence of light chain. Quality control of recombinant antibody assembly in vivo is thought to rely upon folding of the heavy chain CH1 domain. This domain acts as a switch for secretion, only folding upon interaction with the light chain CL domain. We show that the secreted heavy-chain dimers contain folded CH1 domains and contribute to the heterogeneity of antibody species secreted during the expression of therapeutic antibodies. This subversion of the normal quality control process is dependent upon the heavy chain variable domain, is prevalent with engineered antibodies and can occur when only the Fab fragments are expressed. This discovery will impact on the efficient production of both humanised antibodies as well as the design of novel antibody formats

Affine Toda Solitons and Vertex Operators

Affine Toda theories with imaginary couplings associate with any simple Lie algebra ${\bf g}$ generalisations of Sine Gordon theory which are likewise integrable and possess soliton solutions. The solitons are \lq\lq created" by exponentials of quantities $\hat F^i(z)$ which lie in the untwisted affine Kac-Moody algebra ${\bf\hat g}$ and ad-diagonalise the principal Heisenberg subalgebra. When ${\bf g}$ is simply-laced and highest weight irreducible representations at level one are considered, $\hat F^i(z)$ can be expressed as a vertex operator whose square vanishes. This nilpotency property is extended to all highest weight representations of all affine untwisted Kac-Moody algebras in the sense that the highest non vanishing power becomes proportional to the level. As a consequence, the exponential series mentioned terminates and the soliton solutions have a relatively simple algebraic expression whose properties can be studied in a general way. This means that various physical properties of the soliton solutions can be directly related to the algebraic structure. For example, a classical version of Dorey's fusing rule follows from the operator product expansion of two $\hat F$'s, at least when ${\bf g}$ is simply laced. This adds to the list of resemblances of the solitons with respect to the particles which are the quantum excitations of the fields.Comment: Imperial/TP/92-93/29 SWAT/92-93/5 PU-PH-93/1392, requires newma