32 research outputs found
A common variant near TGFBR3 is associated with primary open angle glaucoma
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/
licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic
contribution.We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most
significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart
from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10−33), we
observed one SNP showing significant association to POAG (CDC7–TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10−8). This
particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are
regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease
pathogenesis
A common variant near TGFBR3 is associated with primary open angle glaucoma
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10−33), we observed one SNP showing significant association to POAG (CDC7–TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10−8). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis
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Abstract Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array ), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, OR G-allele = 1.13, P meta = 1.60 × 10 −8 ). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis
Net Study - Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study
Background: Intralesional sodium stibogluconate (SSG) has become first
line therapy for localized cutaneous leishmaniasis (LCL). Aims: This
study compares the efficacy of intralesional SSG given alone with that
of intralesional SSG combined with intramuscular SSG. Methods:
Thirty-two patients aged between 5-56 years were included in the study.
The first group received three injections of intralesional SSG on
alternate days while the other group received three injections of
intralesional SSG similar to the first group and the rest of the
calculated dose as a simultaneous, intramuscular injection. Patients
were followed up every four weeks to assess for cure/ the need for
repeating the treatment. Results: Five patients from group 1 having
small nodular lesions of < six months duration were cured after 1-2
treatment cycles. However, six patients with mucosal lesions, large
lesions and lesions of > six months duration needed 3-5 treatment
schedules. Most plaques and mucosal lesions in seven patients in group
2 cleared with two treatment cycles. Conclusion: Intralesional
combined with intramuscular SSG appears more effective in LCL and gave
qualitatively superior healing than intralesional SSG given alon
Epitaxial Co metal thin film grown by pulsed laser deposition using oxide target
We report here the growth of epitaxial Co metal thin film on c-plane sapphire by pulsed laser deposition (RD) using Co:ZnO target utilizing the composition inhomogeneity of the corresponding plasma. Two distinct plasma composition regions have been observed using heavily alloyed Co0.6Zn0.4O target. The central and intense region of the plasma grows Co:ZnO film; the extreme tail grows only Co metal with no trace of either ZnO or Co oxide In between the two extremes, mixed phases (Co +Co-oxides +Co:ZnO) were observed. The Co metal thin film grown in this way shows room temperature ferromagnetism with large in plane magnetization similar to 1288 emu cm(-3) and a coerciviLy of similar to 230 Oe with applied field parallel to the film-substrate interface. Carrier density of the film is similar to 10(22) cm(-3). The film is epiLaxial single phase Co metal which is confirmed by both X-ray diffraction and transmission electron microscopy characierizaLions. Planar Hall Effect (PHE) and Magneto Optic Kerr Effect (MOKE) measurements confirm that the film possesses similar attributes of Co metal. The result shows that the epiLaxial Co metal thin film can be grown from its oxides in the PLD. (C) 2014 Elsevier B.V. All rights reserved
Altered cropping pattern and cultural continuation with declined prosperity following abrupt and extreme arid event at ~4,200 yrs BP: Evidence from an Indus archaeological site Khirsara, Gujarat, western India - Fig 2
<p>Archaeological artifacts recovered from Khirsara (A) Mature Harappan ceramics (painted and plain) (B) Red Ware Harappan pot (C) Gold beads (D) Fish hook made of copper (E) Copper objects (F) Beads of semiprecious stones (G) Seal with bison (H) Seal bearing Harappan characters. These antiquities have been stored at the office of Excavation Branch-V, ASI, Vadodara, Gujarat, India.</p
Photograph of trench AF-35 from where samples were taken for C isotope analysis.
<p>Right panel shows stratigraphic appearances with finds of archaeological artefacts. Depth-profiles of TOC (wt.%) and δ<sup>13</sup>C<sub>TOC</sub> of the trench AF-35 is shown in lower panels. Calibrated <sup>14</sup>C age based chronological constraints are shown as + symbols.</p
AMS measured <sup>14</sup>C dates of soil-sediment from the trench AF-35.
<p>The first sample* was dated with conventional Beta counting method at BSIP.</p