Study on the effect of contamination on the performance of X-ray telescopes

Modifications were made to the X-ray reflectometer located at the Space Sciences Laboratory, Marshall Space Flight Center. One was an automatic drive for the Large Micrometer Head. This system, interfaced with the Hewlett Packard Computer System, is used to record data and provides the X-ray reflectometer with an automated data-taking capability. Using this system, a complete scatter curve can be obtained automatically. Previously, it was necessary to manually reset the system after recording for each data point in the scatter curve. The second modification provided an externally controlled electrical drive to move the microfocus X-ray source along its axis. With this modification, one can translate the X-ray source while it is operating to locate the position providing maximum count rate

Considerations of electron beam propagation from space vehicles

Theoretical analysis of electron beam array propagation from spacecraf

Relationship of Driver Oncogenes to Long-Term Pemetrexed Response in Non--Small-Cell Lung Cancer.

BackgroundPemetrexed is approved in the treatment of advanced stage nonsquamous non-small-cell lung cancer (NSCLC). The length of response is variable, and we thus sought to identify which clinicopathologic characteristics are associated with long-term disease control with pemetrexed.Patients and methodsPatients with metastatic NSCLC received pemetrexed (with or without bevacizumab) for 12 months or longer, either as maintenance treatment after first-line platinum-based chemotherapy or as subsequent treatment. Clinical and pathologic characteristics were collected.ResultsOf a total of 196 patients who received pemetrexed starting in 2007, 25 patients were identified who received pemetrexed for over 1 year. Of these, 15 patients received pemetrexed with or without bevacizumab as maintenance treatment and 10 patients received pemetrexed as subsequent treatment. Fifteen (60%) of 25 patients had an oncogenic driver mutation as follows: 5 (20%) had ROS1 gene rearrangements, 4 (16%) had ALK gene rearrangements, 3 (12%) had KRAS mutations, 2 (8%) had epidermal growth factor receptor (EGFR) mutations, and 1 (4%) had an NRAS mutation. The median overall survival was 42.2 months (95% confidence interval, 37.4-61.3) and median progression-free survival was 22.1 months (95% confidence interval, 15.1-29.1). Patients with an oncogenic driver mutation had significantly better progression-free survival (P = .006) and overall survival (P = .001).ConclusionAmong patients with NSCLC who received pemetrexed for an extended time, those with ALK and ROS1 gene rearrangements were proportionally overrepresented compared with that anticipated in a general nonsquamous NSCLC population, and patients with oncogenic driver mutations had improved outcomes

Rio Mimbres Acequia Systems: An Oral History

This volume contains transcripts of interviews with various residents collected during the 1993 field phase of the survey of acequia systems in the Mimbres Valley. As noted in Volume 1, additional interviews were conducted with other residents, but were not recorded. Accordingly, no transcript of these interview sessions cannot be included here. The individuals interviewed, as well as the abbreviated names appearing in these transcripts, included John VonTress (JVT, age 57), Regis McSherry (RM, age 67), Sam Grijalva (age 73), Charles Disert (age 84), and Horace Bounds (HB, age 90). Vesta McSherry, appearing as VM in transcripts, provided additional information in the Regis McSherry interview. The narrative that results from compiling these quotations provides information about acequia systems extending back in time to approximately 1925. The actual transcripts are prefaced with excerpts from conversations with different individuals. These excerpts are organized according to specific topics pertaining to the construction, operation, and maintenance of floodwater irrigation systems in the Mimbres Valley. Topics include (1) water duty, (2) irrigation methods, (3) changes in crop production strategies, (4) the role of fatiga, ditch maintenance and the office of mayordomos, (5) derechos and rotation cycles, (6) characteristics and problems with ditches, and (7) sharecropping. Out of these quotations emerges a clearer picture of the problems associated with floodwater irrigation systems, as well as a detailed indication of the variety of solutions developed by local irrigators. The transcripts themselves deserve one further comment. Portions of the interview with Horace Bounds were adversely affected by what might be termed a major malfunction in the recording equipment. Words and phrases appearing in brackets are my reconstruction of the gist of the conversation and should not be considered direct quotations. Similar brackets appear in other interviews where I have inserted words or phrases to clarify what was being discussed.https://digitalrepository.unm.edu/cswr_dig_books/1004/thumbnail.jp