185 research outputs found
Audit Committee Financial Experts: A Closer Examination Using Firm Designations
The Sarbanes-Oxley Act (SOX) requires the disclosure of whether the audit committee has a financial expert. We examine disclosures related to audit committee financial experts (ACFEs) in the first year that this disclosure requirement is in effect. We find that virtually all companies disclose whether an ACFE is on the audit committee, although the transparency of the disclosure regarding the ACFE’s background is limited. We also find that most ACFEs do not have a background in accounting or finance, although there are notable differences between stock exchanges on this dimension. In addition, we find that companies designate ACFEs who would not have been identified using extant research methods, and companies fail to voluntarily designate many individuals who appear to qualify as an ACFE, particularly if another audit committee member is already designated as an ACFE. Thus, some companies appear to be extremely conservative in designating directors as ACFEs, possibly due to concerns about the legal liability faced by designated ACFEs. Finally, we identify certain company characteristics that are associated with the designation or type of financial expert on the audit committee
Space biology initiative program definition review. Trade study 6: Space Station Freedom/spacelab modules compatibility
The differences in rack requirements for Spacelab, the Shuttle Orbiter, and the United States (U.S.) laboratory module, European Space Agency (ESA) Columbus module, and the Japanese Experiment Module (JEM) of Space Station Freedom are identified. The feasibility of designing standardized mechanical, structural, electrical, data, video, thermal, and fluid interfaces to allow space flight hardware designed for use in the U.S. laboratory module to be used in other locations is assessed
Space biology initiative program definition review. Trade study 3: Hardware miniaturization versus cost
The optimum hardware miniaturization level with the lowest cost impact for space biology hardware was determined. Space biology hardware and/or components/subassemblies/assemblies which are the most likely candidates for application of miniaturization are to be defined and relative cost impacts of such miniaturization are to be analyzed. A mathematical or statistical analysis method with the capability to support development of parametric cost analysis impacts for levels of production design miniaturization are provided
Space biology initiative program definition review. Trade study 4: Design modularity and commonality
The relative cost impacts (up or down) of developing Space Biology hardware using design modularity and commonality is studied. Recommendations for how the hardware development should be accomplished to meet optimum design modularity requirements for Life Science investigation hardware will be provided. In addition, the relative cost impacts of implementing commonality of hardware for all Space Biology hardware are defined. Cost analysis and supporting recommendations for levels of modularity and commonality are presented. A mathematical or statistical cost analysis method with the capability to support development of production design modularity and commonality impacts to parametric cost analysis is provided
Fraudulent financial reporting: 1998-2007 : an analysis of U.S. public companies
https://egrove.olemiss.edu/aicpa_assoc/1534/thumbnail.jp
Effect of Turbulence Modeling on Hovering Rotor Flows
The effect of turbulence models in the off-body grids on the accuracy of solutions for rotor flows in hover has been investigated. Results from the Reynolds-Averaged Navier-Stokes and Laminar Off-Body models are compared. Advection of turbulent eddy viscosity has been studied to find the mechanism leading to inaccurate solutions. A coaxial rotor result is also included
A 2-step approach to myeloablative haploidentical stem cell transplantation: a phase 1/2 trial performed with optimized T-cell dosing.
Studies of haploidentical hematopoietic stem cell transplantation (HSCT) have identified threshold doses of T cells below which severe GVHD is usually absent. However, little is known regarding optimal T-cell dosing as it relates to engraftment, immune reconstitution, and relapse. To begin to address this question, we developed a 2-step myeloablative approach to haploidentical HSCT in which 27 patients conditioned with total body irradiation (TBI) were given a fixed dose of donor T cells (HSCT step 1), followed by cyclophosphamide (CY) for T-cell tolerization. A CD34-selected HSC product (HSCT step 2) was infused after CY. A dose of 2 × 10(8)/kg of T cells resulted in consistent engraftment, immune reconstitution, and acceptable rates of GVHD. Cumulative incidences of grade III-IV GVHD, nonrelapse mortality (NRM), and relapse-related mortality were 7.4%, 22.2%, and 29.6%, respectively. With a follow-up of 28-56 months, the 3-year probability of overall survival for the whole cohort is 48% and 75% in patients without disease at HSCT. In the context of CY tolerization, a high, fixed dose of haploidentical T cells was associated with encouraging outcomes, especially in good-risk patients, and can serve as the basis for further exploration and optimization of this 2-step approach. This study is registered at www.clinicaltrials.gov as NCT00429143
Validating and optimising mismatch tolerance of Doppler backscattering measurements with the beam model
We use the beam model of Doppler backscattering (DBS), which was previously
derived from beam tracing and the reciprocity theorem, to shed light on
mismatch attenuation. This attenuation of the backscattered signal occurs when
the wavevector of the probe beam's electric field is not in the plane
perpendicular to the magnetic field. Correcting for this effect is important
for determining the amplitude of the actual density fluctuations. Previous
preliminary comparisons between the model and Mega-Ampere Spherical Tokamak
(MAST) plasmas were promising. In this work, we quantitatively account for this
effect on DIII-D, a conventional tokamak. We compare the predicted and measured
mismatch attenuation in various DIII-D, MAST, and MAST-U plasmas, showing that
the beam model is applicable in a wide variety of situations. Finally, we
performed a preliminary parameter sweep and found that the mismatch tolerance
can be improved by optimising the probe beam's width and curvature at launch.
This is potentially a design consideration for new DBS systems
The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs
The Coma cluster was the target of a HST-ACS Treasury program designed for
deep imaging in the F475W and F814W passbands. Although our survey was
interrupted by the ACS instrument failure in 2007, the partially completed
survey still covers ~50% of the core high-density region in Coma. Observations
were performed for 25 fields that extend over a wide range of cluster-centric
radii (~1.75 Mpc) with a total coverage area of 274 arcmin^2. The majority of
the fields are located near the core region of Coma (19/25 pointings) with six
additional fields in the south-west region of the cluster. In this paper we
present reprocessed images and SExtractor source catalogs for our survey
fields, including a detailed description of the methodology used for object
detection and photometry, the subtraction of bright galaxies to measure faint
underlying objects, and the use of simulations to assess the photometric
accuracy and completeness of our catalogs. We also use simulations to perform
aperture corrections for the SExtractor Kron magnitudes based only on the
measured source flux and half-light radius. We have performed photometry for
~73,000 unique objects; one-half of our detections are brighter than the
10-sigma point-source detection limit at F814W=25.8 mag (AB). The slight
majority of objects (60%) are unresolved or only marginally resolved by ACS. We
estimate that Coma members are 5-10% of all source detections, which consist of
a large population of unresolved objects (primarily GCs but also UCDs) and a
wide variety of extended galaxies from a cD galaxy to dwarf LSB galaxies. The
red sequence of Coma member galaxies has a constant slope and dispersion across
9 magnitudes (-21<M_F814W<-13). The initial data release for the HST-ACS Coma
Treasury program was made available to the public in 2008 August. The images
and catalogs described in this study relate to our second data release.Comment: Accepted for publication in ApJS. A high-resolution version is
available at http://archdev.stsci.edu/pub/hlsp/coma/release2/PaperII.pd
The Improving Rural Cancer Outcomes Trial: a cluster-randomised controlled trial of a complex intervention to reduce time to diagnosis in rural cancer patients in Western Australia.
BACKGROUND: Rural Australians have poorer survival for most common cancers, due partially to later diagnosis. Internationally, several initiatives to improve cancer outcomes have focused on earlier presentation to healthcare and timely diagnosis. We aimed to measure the effect of community-based symptom awareness and general practice-based educational interventions on the time to diagnosis in rural patients presenting with breast, prostate, colorectal or lung cancer in Western Australia. METHODS: 2 × 2 factorial cluster randomised controlled trial. Community Intervention: cancer symptom awareness campaign tailored for rural Australians. GP intervention: resource card with symptom risk assessment charts and local cancer referral pathways implemented through multiple academic detailing visits. Trial Area A received the community symptom awareness and Trial Area B acted as the community campaign control region. Within both Trial Areas general practices were randomised to the GP intervention or control. PRIMARY OUTCOME: total diagnostic interval (TDI). RESULTS: 1358 people with incident breast, prostate, colorectal or lung cancer were recruited. There were no significant differences in the median or ln mean TDI at either intervention level (community intervention vs control: median TDI 107.5 vs 92 days; ln mean difference 0.08 95% CI -0.06-0.23 P=0.27; GP intervention vs control: median TDI 97 vs 96.5 days; ln mean difference 0.004 95% CI -0.18-0.19 P=0.99). There were no significant differences in the TDI when analysed by factorial design, tumour group or sub-intervals of the TDI. CONCLUSIONS: This is the largest trial to test the effect of community campaign or GP interventions on timeliness of cancer diagnosis. We found no effect of either intervention. This may reflect limited dose of the interventions, or the limited duration of follow-up. Alternatively, these interventions do not have a measurable effect on time to cancer diagnosis
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