Determination of Gap in Accreditation Standards Establishment Process Using Zachman Framework at a Health-Educational Hospital

Background: Accreditation is usually a voluntary plan supported by a non-governmental institution and trained evaluators that examine the competency of organizations providing health service according to pre-specified performance standards. Objectives: The current study aimed to determine the degree of establishment of accreditation standards using logical framework of Zachman. Methods: This descriptive research was conducted during year 2015. The population of the study included people involved in the establishment of accreditation standards. Sampling was conducted in the form of complete enumeration according to 36 standards of accreditation. The instrument used for data collection was the “Logical framework of Zachman”. Columns of framework consisted of people involved in conducting the work (Who), the purpose of the work (Why), strategy of the work (What), work time (When), and sub-system of doing work (Where) and way of doing work (How), and rows of framework included the view of hospital chief, director/assistants of hospital, officials and personnel. Test chi-square was used to compare between accreditation standards text and studied hospital gap. Descriptive statistical method was used for variables. Results: People involved in doing work and sub-systems of doing work at the hospital were consistent with specified accreditation standards. In 27% of the standards, time interval of doing work in the hospital was not conducted according to accreditation standards. In terms of way of doing work, 25% of standards had not been established, and 26% of them had been established incompletely. During interviews, it was found that 59% of personnel of purpose of doing work, and 94% of them are not informed about the strategy of doing work, according to accreditation standards in the hospital. Conclusions: Uncertainties in the accreditation standards in dimensions of purpose, people involved, strategy and time interval of doing work, respectively, led to a lack of understanding the intention of author/developers of standards by personnel. As a result, this led to lack of complete establishment of accreditation standards in the studied hospital. Keywords: Accreditation, Establishment, Gap, Hospitals, Tehra

Molekulární prognostické a prediktivní markery u kolorektálního karcinomu

in English Colorectal cancer is currently one of the three major causes of cancer-related death. In order to help clinicians to treat colorectal cancer, it is necessary to introduce more effective tools that will improve not only early diagnosis, but also prediction of the most likely progression of the disease and response to chemotherapy. This thesis aims to describe the most accepted biomarkers among those proposed for use in CRC divided based on the clinical specimen that is examined (tissue, feces or blood) along with their restrictions. In relation to my research, the thesis will also focus on alternative splicing that has emerged as an important regulator and potential treatment target in CRC. Alterations in gene expression leading to colorectal carcinogenesis results in dysregulated levels of nucleic acids and proteins, which can be utilized for the identification of modern, minimally invasive molecular biomarkers. One of the alternative splicing factors are MBNL proteins. The goal of my work that will be presented here was to analyze gene expression of the MBNL family of regulators of alternative splicing in various stages of colorectal cancer development, together with the MBNL-target splicing events in FOXP1 and EPB41L3 genes and tumor-related CD44 variants. The study was done using...in Czech Kolorektální karcinom je v současné době jednou ze tří hlavních příčin úmrtí souvisejících s nádorovými onemocněními. Aby se klinickým lékařům pomohlo léčit kolorektální karcinom, je nutné zavést účinnější nástroje, které zlepší nejen včasnou diagnostiku, ale také predikci nejpravděpodobnější progrese onemocnění a reakce na chemoterapii. Tato práce si klade za cíl popsat nejpřijatelnější biomarkery mezi těmi, které jsou navrženy pro použití v CRC, rozdělené podle klinického vzorku, který je vyšetřován (tkáň, stolice nebo krev), spolu s jejich omezeními. Ve vztahu k mému výzkumu se práce zaměří také na alternativní sestřih, který se ukázal jako důležitý regulátor a potenciální cíl léčby v CRC. Změny v genové expresi vedoucí ke kolorektální karcinogenezi vedou k dysregulovaným hladinám nukleových kyselin a proteinů, které lze využít k identifikaci moderních, minimálně invazivních molekulárních biomarkerů. Jedním z alternativních spojovacích faktorů jsou MBNL proteiny. Cílem mé práce, která zde bude představena, byla analýza genové exprese rodiny MBNL regulátorů alternativního sestřihu v různých fázích vývoje kolorektálního karcinomu, spolu s událostmi sestřihu cíle MBNL v genech FOXP1 a EPB41L3 a CD44 souvisejícími s nádorem varianty. Studie byla provedena pomocí vzorků nádorové tkáně a...Ústav histologie a embryologieFaculty of Medicine in PilsenLékařská fakulta v Plzn

Molecular Prognostic and Predictive Markers in Colorectal Cancer

in English Colorectal cancer is currently one of the three major causes of cancer-related death. In order to help clinicians to treat colorectal cancer, it is necessary to introduce more effective tools that will improve not only early diagnosis, but also prediction of the most likely progression of the disease and response to chemotherapy. This thesis aims to describe the most accepted biomarkers among those proposed for use in CRC divided based on the clinical specimen that is examined (tissue, feces or blood) along with their restrictions. In relation to my research, the thesis will also focus on alternative splicing that has emerged as an important regulator and potential treatment target in CRC. Alterations in gene expression leading to colorectal carcinogenesis results in dysregulated levels of nucleic acids and proteins, which can be utilized for the identification of modern, minimally invasive molecular biomarkers. One of the alternative splicing factors are MBNL proteins. The goal of my work that will be presented here was to analyze gene expression of the MBNL family of regulators of alternative splicing in various stages of colorectal cancer development, together with the MBNL-target splicing events in FOXP1 and EPB41L3 genes and tumor-related CD44 variants. The study was done using..

Memory and Its Effect on Adult Function

Memory capabilities, including its mechanisms and memory approaches weaken as age increases. However, the studies reveal that the content of memory, i.e. the knowledge stored in it, usually increases. Memory system includes sensory memory within which environmental information are recorded. Short-term memory is related to storing data at awareness level, whereas long-term memory is associated with  storing knowledge and past experiences. Psychological and physiological factors such as mental and physical health, nutrition, using narcotic substances and alcohol, and also stimulation during life may affect all functions of the elderly such as their memory. Unfortunately, many researchers overlooked the effects of these variables on subjects

The Efficacy of Structural Family Therapy in the Treatment of Children’s Anxiety Disorders

The present study aims at investigating the efficacy of “Structural Family Therapy” on treating children's "Separation Anxiety" through altering the family structure, and reducing parents' conflicts. Adopting a quasi- experimental method, the researcher performed pretest-posttest intervention and multivariate repeated measures. Forty families with at least one child suffering from Anxiety disorders were randomly assigned to two equal experimental and control groups.  The experimental group received similar treatment to the control group for nine sessions. In addition, the above mentioned groups participated in a follow-up session six weeks after the last intervention. Then a multi-modal assessment of anxiety was performed including Spence's "Children's Anxiety Scale" and a diagnostic interview based on DSM-IV-TR criteria (2000). Where as, the control group was kept intact.  The results revealed that the “Structural Family Therapy” is efficient in reducing children's Anxiety disorders (at p<0.005) such as obsessive-compulsive, generalized anxiety disorder, social phobia, panic disorder, and fear of injury

Additional file 2 of Modeling and optimizing in vitro percentage and speed callus induction of carrot via Multilayer Perceptron-Single point discrete GA and radial basis function

Additional file 2. Row data in 4xMS with 8 treatment by using 4 explants at 2 times

Additional file 1 of Modeling and optimizing in vitro percentage and speed callus induction of carrot via Multilayer Perceptron-Single point discrete GA and radial basis function

Additional file 1. Row data in MS with 8 treatment by using 4 explants at 2 times

Additional file 3 of Modeling and optimizing in vitro percentage and speed callus induction of carrot via Multilayer Perceptron-Single point discrete GA and radial basis function

Additional file 3. Row data in 8xMS with 8 treatment by using 4 explants at 2 times