171 research outputs found
Structural Model of Relations between Classroom Environment, Achievement Goals, Reflective Thinking, Mathematics Performance among High School Girls
Abstract: In This study we investigate the mediating role of achievement goals and reflective thinking in relation between classroom environment and performance. The data was collected from 500 girls who were studying in high school. This sample was selected by multistage cluster sampling. Questionnaires have been administrated. academic performance was assessed by grades in mathematics. Data analysis indicated that the components of the classroom environment-involvement, student cohesiveness, task orientation- exerted direct and indirect influences on achievement goals, reflective thinking and student’s performance in mathematics. Findings evidently show that direct effect of students’ involvement on performance – approach goals is significant and involvement in assignment and class activity is a unique component which has a significant direct effect on math performance. Direct effect of cohesiveness on performance avoidance goals, task orientation on reflect and habitual act, mastery goals on understanding and critical thinking, performance approach on habitual act is significant. Totally, these results show that classroom environment- involvement component, cohesiveness and task orientation have direct and indirect effect on achievement goals, reflective thinking and student performance in mathematics. However we need further evidence to clarify some ambiguities
Case-Crossover Analysis of Air Pollution Health Effects: A Systematic Review of Methodology and Application
10 pages, 2 figures, 5 tables.-- PMID: 20356818 [PubMed].--PMCID: PMC2920078.-- Printed version published Aug 2010.BACKGROUND: Case-crossover is one of the most used designs for analyzing the health-related effects of air pollution. Nevertheless, no one has reviewed its application and methodology in this context.OBJECTIVE: We conducted a systematic review of case-crossover (CCO) designs used to study the relationship between air pollution and morbidity and mortality, from the standpoint of methodology and application.DATA SOURCES AND EXTRACTION: A search was made of the MEDLINE and EMBASE databases.Reports were classified as methodologic or applied. From the latter, the following information was extracted: author, study location, year, type of population (general or patients), dependent variable(s), independent variable(s), type of CCO design, and whether effect modification was analyzed for variables at the individual level.DATA SYNTHESIS: The review covered 105 reports that fulfilled the inclusion criteria. Of these, 24 addressed methodological aspects, and the remainder involved the design's application. In the methodological reports, the designs that yielded the best results in simulation were symmetric bidirectional CCO and time-stratified CCO. Furthermore, we observed an increase across time in the use of certain CCO designs, mainly symmetric bidirectional and time-stratified CCO. The dependent variables most frequently analyzed were those relating to hospital morbidity; the pollutants most often studied were those linked to particulate matter. Among the CCO-application reports, 13.6% studied effect modification for variables at the individual level.CONCLUSIONS: The use of CCO designs has undergone considerable growth; the most widely used designs were those that yielded better results in simulation studies: symmetric bidirectional and time-stratified CCO. However, the advantages of CCO as a method of analysis of variables at the individual level are put to little use.This study was supported by grant CIBERESP-MET-007 from the Consortium for Biomedical Research in Epidemiology and Public Health [CIBER en Epidemiología y Salud Pública (CIBERESP)], Spain. A.T. was funded by project PI080354 [Fondo de Investigaciones Sanitarias (FIS)] of the Subdirectorate-General for Research Evaluation and Development and by project 200930I008 [Consejo Superior de Investigaciones Científicas (CSIC)].This study was supported by grant CIBERESP-MET-007 from the Consortium for Biomedical Research in Epidemiology and Public Health [CIBER en Epidemiología y Salud Pública (CIBERESP)], Spain. A.T. was funded by project PI080354 [Fondo de Investigaciones Sanitarias (FIS)] of the Subdirectorate-General for Research Evaluation and Development and by project 200930I008 [Consejo Superior de Investigaciones Científicas (CSIC)].Peer reviewe
Rapid Sampling of Molecules via Skin for Diagnostic and Forensic Applications
Skin provides an excellent portal for diagnostic monitoring of a variety of entities; however, there is a dearth of reliable methods for patient-friendly sampling of skin constituents. This study describes the use of low-frequency ultrasound as a one-step methodology for rapid sampling of molecules from the skin.
Sampling was performed using a brief exposure of 20 kHz ultrasound to skin in the presence of a sampling fluid. In vitro sampling from porcine skin was performed to assess the effectiveness of the method and its ability to sample drugs and endogenous epidermal biomolecules from the skin. Dermal presence of an antifungal drug—fluconazole and an abused substance, cocaine—was assessed in rats.
Ultrasonic sampling captured the native profile of various naturally occurring moisturizing factors in skin. A high sampling efficiency (79 ± 13%) of topically delivered drug was achieved. Ultrasound consistently sampled greater amounts of drug from the skin compared to tape stripping. Ultrasonic sampling also detected sustained presence of cocaine in rat skin for up to 7 days as compared to its rapid disappearance from the urine.
Ultrasonic sampling provides significant advantages including enhanced sampling from deeper layers of skin and high temporal sampling sensitivity
Exploring Variation and Predictors of Residential Fine Particulate Matter Infiltration
Although individuals spend the majority of their time indoors, most epidemiological studies estimate personal air pollution exposures based on outdoor levels. This almost certainly results in exposure misclassification as pollutant infiltration varies between homes. However, it is often not possible to collect detailed measures of infiltration for individual homes in large-scale epidemiological studies and thus there is currently a need to develop models that can be used to predict these values. To address this need, we examined infiltration of fine particulate matter (PM2.5) and identified determinants of infiltration for 46 residential homes in Toronto, Canada. Infiltration was estimated using the indoor/outdoor sulphur ratio and information on hypothesized predictors of infiltration were collected using questionnaires and publicly available databases. Multiple linear regression was used to develop the models. Mean infiltration was 0.52 ± 0.21 with no significant difference across heating and non-heating seasons. Predictors of infiltration were air exchange, presence of central air conditioning, and forced air heating. These variables accounted for 38% of the variability in infiltration. Without air exchange, the model accounted for 26% of the variability. Effective modelling of infiltration in individual homes remains difficult, although key variables such as use of central air conditioning show potential as an easily attainable indicator of infiltration
Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths
<p>Abstract</p> <p>Background</p> <p>Toxic exposures have been shown to influence maturation of the immune system during gestation. This study investigates the association between cord blood lymphocyte proportions and maternal exposure to air pollution during each gestational month.</p> <p>Methods</p> <p>Cord blood was analyzed using a FACSort flow cytometer to determine proportions of T lymphocytes (CD3<sup>+ </sup>cells and their subsets, CD4<sup>+ </sup>and CD8<sup>+</sup>), B lymphocytes (CD19<sup>+</sup>) and natural killer (NK) cells. Ambient air concentrations of 12 polycyclic aromatic hydrocarbons (PAH) and particulate matter < 2.5 micrometer in diameter (PM<sub>2.5</sub>) were measured using fixed site monitors. Arithmetic means of these pollutants, calculated for each gestational month, were used as exposure metrics. Data on covariates were obtained from medical records and questionnaires. Multivariable linear regression models were fitted to estimate associations between monthly PAH or PM<sub>2.5 </sub>and cord blood lymphocytes, adjusting for year of birth and district of residence and, in further models, gestational season and number of prior live births.</p> <p>Results</p> <p>The adjusted models show significant associations between PAHs or PM<sub>2.5 </sub>during early gestation and increases in CD3<sup>+ </sup>and CD4<sup>+ </sup>lymphocytes percentages and decreases in CD19<sup>+ </sup>and NK cell percentages in cord blood. In contrast, exposures during late gestation were associated with decreases in CD3<sup>+ </sup>and CD4<sup>+ </sup>fractions and increases in CD19<sup>+ </sup>and NK cell fractions. There was no significant association between alterations in lymphocyte distribution and air pollution exposure during the mid gestation.</p> <p>Conclusions</p> <p>PAHs and PM<sub>2.5 </sub>in ambient air may influence fetal immune development via shifts in cord blood lymphocytes distributions. Associations appear to differ by exposure in early versus late gestation.</p
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