First Late Ordovician conodont fauna in the Betic Cordillera (South Spain): a palaeobiogeographical contribution

The youngest Ordovician conodont fauna in SW Europe has been found in the Malaguide Complex of the Betic Cordillera, SE Spain. It is also the first Ordovician conodont fauna in the Western Mediterranean Alpine Orogen. The conodont association, attributed to the Hirnantian (upper part of the Amorphognathus ordovicicus Biozone), is characterized by the predominance of Walliserodus amplissimus and Scabbardella altipes and by the absence of Sagittodontina and Istorinus, typical of the Mediterranean Province. This fauna differs markedly from those of the same biozone recorded in the Spanish Variscan Orogen of the Iberian Massif, which are attributed to the Katian. The Malaguide fauna shows, however, striking similarity to faunas of the Carnic Alps and some resemblance to those of the Pyrenees, Northern England and North Wales. These features suggest that Palaeozoic terranes of the Betic Cordillera were located far to the east of their present location and displaced westward during the Alpine Orogeny

A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis.

The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis. Additionally, the human leukocyte antigen (HLA) region was comprehensively studied by imputing classical alleles and polymorphic amino acid positions. A linkage disequilibrium block of polymorphisms located in the HLA class II region surpassed the genome-wide level of significance (OR = 0.56, 95% CI = 0.46-0.68). Although no polymorphic amino acid positions were associated at the genome-wide level of significance, P-values of potential relevance were observed for the positions 13 and 11 of HLA-DRB1 (P = 6.67E-05, P = 1.88E-05, respectively). Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. In conclusion, our study suggests that IgA vasculitis is an archetypal HLA class II disease

Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status

INTRODUCTION: A study was conducted to determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. METHODS: The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test. RESULTS: A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; P = 0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (P = 0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR = 5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03. Interestingly, the association remained statistically significant (P = 0.0004, OR = 4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found. CONCLUSIONS: Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status.This study was supported by a grant from ‘Fondo de Investigaciones Sanitarias’ PI12/00193 (Spain). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain) (CD12/00425). FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013).Ye

Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

INTRODUCTION: To determine whether the PTPN22 (protein tyrosine phosphatase nonreceptor 22)/CSK (c-src tyrosine kinase) pathway is implicated in the susceptibility and clinical heterogeneity of Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. METHODS: A set of 329 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria and 515 sex and ethnically matched controls were recruited in this study. Two well-known CSK (CSK rs34933034 and CSK rs1378942) and two functional PTPN22 (PTPN22 rs2476601 (R620W) and PTPN22 rs33996649 (R263Q)) polymorphisms, previously associated with autoimmunity, were genotyped with TaqMan single nucleotide polymorphism (SNP) genotyping assays. RESULTS: No significant differences in the genotype and allele frequencies between HSP patients and controls were observed when the CSK rs34933034, CSK rs1378942, PTPN22 rs2476601 (R620W) and PTPN22 rs33996649 (R263Q) polymorphisms were analyzed independently. In keeping with this observation, no significant differences were found when we assessed these polymorphisms combined conforming haplotypes. In addition, there were no differences in the allele or genotype frequencies when HSP patients were stratified according the age at disease onset, sex, presence of arthralgia/arthritis, nephritis or gastrointestinal manifestations. CONCLUSIONS: Our results do not support association between PTPN22/CSK and HSP

Informe: Derecho del trabajo y de la seguridad social en España en 2013. Algunos puntos críticos

Este documento intenta reflejar algunos de los principales cambios y novedades del ordenamiento laboral español en 2013, levantando acta de cómo la mutabilidad de nuestro Derecho del Trabajo es imparable. Este informe, consciente de ello, ofrece una selección de elementos esenciales, a juicio de sus autores, especialistas en cada una de las materias, encuadrados en la Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social. En él, conforme a la organización de dicha Sección en grupos de trabajo, se abordan las novedades más relevantes en materia de derechos fundamentales inespecíficos, contratación laboral, vicisitudes del contrato de trabajo, Derecho colectivo, conciliación y corresponsabilidad, protección social y prevención de riesgos laborales. This paper tries to show some of the many changes and novelties in Spanish Labour Law during 2013, drawing up a record of the unstoppable character of our Labour legal system. This report offers a selection of essential elements, according to its authors, all of them specialists in each one of the subjects, being part of the Young Scholars’ Section of the Spanish Association for Labour and Social Security Law. According to the organization of the said Section in working groups, we can find novelties concerning unspecific fundamental rights, work contracts, the life of the work contract and collective Labour Law, reconciliation and co responsibility, social protection and occupational risk prevention

El derecho del trabajo y de la seguridad social en España en 2014

Este documento intenta reflejar algunos de los principales cambios y novedades del ordenamiento laboral español en 2014, levantando acta de cómo la mutabilidad de nuestro Derecho del Trabajo es imparable. Este informe, consciente de ello, ofrece una selección de elementos esenciales, a juicio de sus autores, especialistas en cada una de las materias, encuadrados en la Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social. En él, conforme a la organización de dicha Sección en grupos de trabajo, se abordan las novedades más relevantes en materia de derechos fundamentales inespecíficos, contratación laboral, vicisitudes del contrato de trabajo, Derecho colectivo, conciliación y corresponsabilidad, protección social y prevención de riesgos laborales. This paper tries to show some of the many changes and novelties in Spanish Labour Law during 2014, drawing up a record of the unstoppable character of our Labour legal system. This report offers a selection of essential elements, according to its authors, all of them specialists in each one of the subjects, being part of the Young Scholars’ Section of the Spanish Association for Labour and Social Security Law. According to the organization of the said Section in working groups, we can find novelties concerning unspecific fundamental rights, work contracts, the life of the work contract and collective Labour Law, work-life balance and co responsibility, social protection and occupational risk prevention

A brief summary of the Ordovician conodont faunas from the Iberian Peninsula

Ordovician conodont studies in the Iberian Peninsula were initiated by Fuganti and Serpagli (1968), who recognized 21 morphospecies included in 15 morphogenera in the Upper Ordovician Urbana Limestone from a single locality in the Central Iberian Zone. Two years later Boersma (in Hartevelt, 1970) identified several morphotaxa in the Upper Ordovician Estana Formation of the Central Pyrenees. In the type section of the Upper Ordovician Cystoid Limestone of the Eastern Iberian Cordillera, Carls (1975) recognised 31 conodont morphotaxa. These pioneer findings were followed by the contributions of Kolb (1978), Hafenrichter (1979), Robert (1980), Robardet (1982) and Sanz (1988), who increased the number of taxa and localities with Katian conodonts, mostly attributed to the Amorphognathus ordovicicus Zone. For twenty years, our knowledge on Ordovician conodonts came only from the single ubiquitous limestone unit that occurs in the upper part of many Iberian successions. Nonetheless, these are predominantly composed of terrigenous rocks (shales, siltstones and sandstones) which were deposited at high Gondwanan paleolatitudes near the South Pole (Gutiérrez-Marco et al., 2002, 2004). Then, some of these clastic deposits (siltstones, shales and storm-induced coquinoid lenses, sometimes calcareous) were also sampled for conodonts: while siltstones and shales produced only fragmentary specimens, bioclastic beds in tempestites yielded usually fragmentary, but recognisable, elements.Peer reviewe

First finding of upper Silurian and Lower Devonian conodonts from the Peloritani Mountains (NE Sicily, southern Italy).

In the Peloritani Mountains (NE Sicily), the Favoscuro west section (near Pizzo Leo, between Floresta and Roccella Valdemone, Messina Province) cross-cuts the Variscan basement of the Longi-Taormina Unit. This section, in the less deformed part, shows a mildly metamorphosed continuous 50-m-thick Palaeozoic succession of metamarls and calc-schists with a bed of nodular metalimestones occurring at the base and of calc-schists at the top. The basal bed yielded a conodont fauna consisting of several fragments of Pa elements of Ancoradella cf. A. ploeckensis Walliser, 1964 (Ludlow, Ancoradella ploeckensis - Polygnathoides siluricus zones). The topmost bed yielded one fragment of a Pa element of Polygnatus cf. P. kitabicus Yolkin, Weddige, Izokh & Erina, 1994 (early Emsian, Polygnathus kitabicus - Polygnathus excavatus zones). This conodont fauna, although not well preserved due to greenschist facies metamorphism and deformation, for the first time enables the recognition of upper Silurian and Lower Devonian rocks in the Peloritani Mountains. The Favoscuro west section studied herein is of important stratigraphic significance as it encompasses the Silurian/Devonian boundary