9,965 research outputs found
Introduction and evaluation of the ACS BCon basic course in Zaragoza, Spain
Background: The American College of Surgeons Bleeding Control Basic (BCon) course aimed at teaching hemorrhage control techniques in the USA had not yet been taught in Spain. The purpose of this study is to assess its implementation among students and healthcare employees in the Lozano Blesa University Hospital of Zaragoza, a middle-sized Spanish city.
Methods: The study was conducted in a University Hospital and at the University of Zaragoza, scheduling four free B-Con sessions from 2017 to 2018. Two groups were identified as forming the population: healthcare employees and medical students. An anonymous questionnaire was completed at the end of the course regarding content, applicability, usefulness, relevance, and satisfaction. Study variables were ranked from 0 to 10: poor (when graded from 0 to 3), fair (4 to 6) and good (7 to 10). Results were compared between the groups, expressed in percentages and ¿ 2 tested to analyze significant differences if any.
Results: Among the 83 individuals who completed the course, 46 were medical students and 37 healthcare employees; 61% women and 39% men; aged 21 years to 52 years. Attendees evaluated satisfaction with the highest grade (84%), followed by usefulness (73%), applicability (70%), and relevance (66%). There was no variable graded as poor. The comparison of perceptions between groups did not reveal statistical differences based on a 0.05 significance level.
Conclusion: We concluded that the B-Con course was valued as good for relevance, usefulness, applicability, and satisfaction by the majority of the studied population.
Level of Evidence: Level III
Residual dipolar coupling enhanced NMR spectroscopy and chiroptics: A powerful combination for the complete elucidation of symmetrical small molecules.
Connection of Isolated Stereoclusters by Combining C-13-RCSA, RDC, and J-Based Configurational Analyses and Structural Revision of a Tetraprenyltoluquinol Chromane Meroterpenoid from Sargassum muticum
The seaweed Sargassum muticum, collected on the southern coast of Galicia, yielded a tetraprenyltoluquinol chromane meroditerpene compound known as 1b, whose structure is revised. The relative configuration of 1b was determined by J-based configurational methodology combined with an iJ/DP4 statistical analysis and further confirmed by measuring two anisotropic properties: carbon residual chemical shift anisotropies (13C-RCSAs) and one-bond 1H-13C residual dipolar couplings (1DCH-RDCs). The absolute configuration of 1b was deduced by ECD/OR/TD-DFT methods and established as 3R,7S,11R
Magnetic and structural-properties of electrodeposited Co1-xPx amorphous ribbons
The specific magnetic moment, coercive force, anisotropy field, and saturation magnetostriction constant have been measured in Co(1-x)P(x) amorphous ribbons with 0.04 less-than-or-equal-to x less-than-or-equal-to 0.27. Differential scanning calorimetry, x-ray diffraction, and transmission electron microscopy analysis have been made in order to study the transition from the amorphous state to the crystalline one. Results suggest that transition takes place when x decreases from 0.19
Turbulent dissipation in the ISM: the coexistence of forced and decaying regimes and implications for galaxy formation and evolution
We discuss the dissipation of turbulent kinetic energy Ek in the global ISM
by means of 2-D, MHD, non-isothermal simulations in the presence of model
radiative heating and cooling. We argue that dissipation in 2D is
representative of that in three dimensions as long as it is dominated by shocks
rather than by a turbulent cascade. Energy is injected at a few isolated sites
in space, over relatively small scales, and over short time periods. This leads
to the coexistence of forced and decaying regimes in the same flow. We find
that the ISM-like flow dissipates its turbulent energy rapidly. In simulations
with forcing, the input parameters are the radius l_f of the forcing region,
the total kinetic energy e_k each source deposits into the flow, and the rate
of formation of those regions, sfr_OB. The global dissipation time t_d depends
mainly on l_f. In terms of measurable properties of the ISM, t_d >= Sigma_g
u_rms^2/(e_k sfr_OB), where Sigma_g is the average gas surface density and
u_rms is the rms velocity dispersion. For the solar neighborhood, t_d >=
1.5x10^7 yr. The global dissipation time is consistently smaller than the
crossing time of the largest energy-containing scales. In decaying simulations,
Ek decreases with time as t^-n, where n~0.8-0.9. This suggests a decay with
distance d as Ek\propto d^{-2n/(2-n)} in the mixed forced+decaying case. If
applicable to the vertical direction, our results support models of galaxy
evolution in which stellar energy injection provides significant support for
the gas disk thickness, but not models of galaxy formation in which this energy
injection is supposed to reheat an intra-halo medium at distances of up to
10-20 times the optical galaxy size, as the dissipation occurs on distances
comparable to the disk height.Comment: 23 pages, including figures. To appear in ApJ. Abstract abridge
Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia
The ISLAndS project II: The Lifetime Star Formation Histories of Six Andromeda dSphs
The Initial Star formation and Lifetimes of Andromeda Satellites (ISLAndS)
project uses Hubble Space Telescope imaging to study a representative sample of
six Andromeda dSph satellite companion galaxies. The main goal of the program
is to determine whether the star formation histories (SFHs) of the Andromeda
dSph satellites demonstrate significant statistical differences from those of
the Milky Way, which may be attributable to the different properties of their
local environments. Our observations reach the oldest main sequence turn-offs,
allowing a time resolution at the oldest ages of ~ 1 Gyr, which is comparable
to the best achievable resolution in the MW satellites. We find that the six
dSphs present a variety of SFHs that are not strictly correlated with
luminosity or present distance from M31. Specifically, we find a significant
range in quenching times (lookback times from 9 to 6 Gyr), but with all
quenching times more than ~ 6 Gyr ago. In agreement with observations of Milky
Way companions of similar mass, there is no evidence of complete quenching of
star formation by the cosmic UV background responsible for reionization, but
the possibility of a degree of quenching at reionization cannot be ruled out.
We do not find significant differences between the SFHs of the three members of
the vast, thin plane of satellites and the three off-plane dSphs. The primary
difference between the SFHs of the ISLAndS dSphs and Milky Way dSph companions
of similar luminosities and host distances is the absence of very late
quenching (< 5 Gyr ago) dSphs in the ISLAndS sample. Thus, models that can
reproduce satellite populations with and without late quenching satellites will
be of extreme interest.Comment: 24 pages, 11 figures, 3 tables, submitted to the Ap
La modelización tridimensional del flujo del agua subterránea y transporte de calor en la gestión de recursos geotérmicos someros en zonas urbanas
La planificación del uso geotérmico del agua subterránea en acuíferos someros urbanos requiere un modelo numérico capaz de reproducir los efectos de la explotación actual y ser capaz de predecir los impactos derivados de dicha actividad. En este trabajo se presenta el desarrollo preliminar de un modelo numérico que puede contribuir a mejorar la gestión de los recursos geotérmicos someros en la ciudad de Zaragoza. El modelo numérico permite implementar toda la información hidrogeológica y térmica recopilada, explicar esta información de forma coherente reproduciendo la física de fluidos y termodinámica en medios poroso s y predecir a medio y largo plazo los impactos producidos. Finalmente se muestran las posibilidades y ventajas derivadas del uso del modelo numérico en la gestión de permisos de concesión de derechos de explotación para nuevos aprovechamientos.
The management of the thermal use of groundwater in shallow urban aquifers requires a numerical model capable of reproducing the impacts of actual exploitations and of predicting further impacts in the future. In this work, the numerical model developed for the management of shallow geothermal resources in the city of Zaragoza (Spain) is presented. The model allows to explain the data coherent with the fluid physics and the heat transport in porous media and also provide predictions for the thermal impacts at mid- and long-term. Finally, the possibilities and advantages derived from the use of the numerical modelling for the concession process of new exploitation licenses are described
Immunosuppressive Minimization Strategies in Kidney Transplantation
The long-term graft survival in renal transplantation results is still controversial, the toxicity and adverse reactions of the immunosuppressive drugs are implicated, as well as cellular and humoral antigen-specific immune mechanisms; therefore, different strategies for adapting immunosuppression are used to reduce the complications associated with the use of these drugs. Calcineurin inhibitors (CNI) require an adequate dose-dependent concentration leading to the appearance of drug-related adverse reactions. The variability in the required dose of CNI leads to minimization strategies that do not result in a higher acute rejection (AR) incidence when compared to other immunosuppressive agents. Early steroid withdrawal is another strategy, although with an increase in AR, but without an impact on the function and survival of the renal graft. The reduction of mycophenolate mofetil to 1.5 g/day seems to be a therapeutic option, decreasing the infectious, hematological and gastrointestinal adverse reactions. Finally, alemtuzumab, bortezomib, belatacept and cellular therapies are in the search for the new treatments, whose premise is the induction of donor-specific nonresponse in the context of operational tolerance or mixed chimerism. The use of adapted and adequate immunosuppression has led to variable results and some are very encouraging; however, they must be validated with experimental studies
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