Profit Analysis of Papaya Crops under Greenhouses as an Alternative to Traditional Intensive Horticulture in Southeast Spain

The high-yield agricultural model in Almería is based on eight different crops. Having led fruit and vegetable exports in Spain for more than 50 years, a decrease in melon and watermelon growing areas in Almería caused a change in supply that affected the model’s profit. Papaya cultivation could reactivate the profit of the agricultural model in Almería and also improve the available product range. The papaya crop needs greenhouse infrastructures high enough to contain the growth and size of the plants during a cycle crop, which is possible in most of the greenhouses of the Horticultural production model of Almería. The papaya harvests obtained in the region meet the quality requirements demanded by European markets. Furthermore, yields obtained are equal or higher than yields obtained by other producing countries. This crop improves profit compared with the profit obtained from the rotation of other horticultural crops that have been traditionally grown in the region

Myc-Related Mitochondrial Activity as a Novel Target for Multiple Myeloma

Mitochondria are involved in the development and acquisition of a malignant phenotype in hematological cancers. Recently, their role in the pathogenesis of multiple myeloma (MM) has been suggested to be therapeutically explored. MYC is a master regulator of b-cell malignancies such as multiple myeloma, and its activation is known to deregulate mitochondrial function. We investigated the impact of mitochondrial activity on the distinct entities of the disease and tested the efficacy of the mitochondrial inhibitor, tigecycline, to overcome MM proliferation. COXII expression, COX activity, mitochondrial mass, and mitochondrial membrane potential demonstrated a progressive increase of mitochondrial features as the disease progresses. In vitro and in vivo therapeutic targeting using the mitochondrial inhibitor tigecycline showed promising efficacy and cytotoxicity in monotherapy and combination with the MM frontline treatment bortezomib. Overall, our findings demonstrate how mitochondrial activity emerges in MM transformation and disease progression and the efficacy of therapies targeting these novel vulnerabilities

Management of acute diverticulitis with pericolic free gas (ADIFAS). an international multicenter observational study

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II-IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4-64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2-19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P <0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation

The Production and Quality of Different Varieties of Papaya Grown under Greenhouse in Short Cycle in Continental Europe

In Europe, papaya consumption is growing due to its nutritional properties. The proximity of consumer markets to Southeast Spain allows fruits to be harvested at a more advanced stage of maturity compared to exporting countries from outside Europe, a timeline which improves the quality of the papaya. Experiments have been carried out to assess the adaptation of papaya to protected cropping systems (under greenhouse) in the region. In this paper, we showed the results obtained in an experiment with five varieties, taking the most cultivated variety as control, which was grafted on its own female rootstock, in addition to another four new varieties that were introduced. Transplanting was made with early sex-identified plants in the nursery. Cultivation was developed in a 446-day cycle, almost 15 months and fruits were always harvested from the soil, due to the height that the plant reached in that period. The best yield parameters and fruit characteristics were obtained from hermaphrodite Intenzza papaya grafted on female papaya rootstock, although there were also other varieties which gave results that made possible its cultivation under this production system

Effects of the size of papaya (Carica papaya L.) seedling with early determination of sex on the yield and the quality in a greenhouse cultivation in continental Europe

One of the major problems when planting papaya using traditional methods is sex identification of the plant to obtain the highest yield from hermaphrodite fruits. The problem derives from the competence between plants, before sex identification, when three to four plants are planted together. This problem was solved applying a R.A.P.D. technique (Randomly Amplified Polymorphic DNA) in early sex-identification in the laboratory of the nursery with the first true leaf of the plant. Furthermore, economic costs and wasted vegetal material caused by removing female plants from production can be avoided by grafting hermaphrodite plants onto female plants. The nursery facilities for horticultural plants in Almería allow herbaceous grafting work, as well as the production of balanced relationship between aerial and root biomass. For this reason, an experiment was conducted to evaluate yield parameters in the planting of large and small, sex-identified plants. The plants grown were the main papaya cultivar produced in Continental Europe, called ‘Intenzza’, and a new cultivar called ‘Sweet Sense’. Within a greenhouse cultivation system in the South of Europe, the early stage sex-identified plants transplanted as “large plant” size gave higher yields in contrast with traditional methods of planting papaya, but the technique does not affect fruit size and retains sweetness. From a morphological point of view, although the growing and development technique is different it does not cause significant differences in the papaya by the time of harvest

iONE: an environment for experimentally assessing in-operation network planning algorithms

Huge amount of algorithmic research is being done in the field of optical networks, including Routing and Spectrum Allocation (RSA), elastic operations, spectrum defragmentation, and other re-optimization algorithms. Frequently, those algorithms are developed and executed on simulated environments, where many assumptions are done about network control and management issues. Those issues are relevant, since they might prevent algorithms to be deployed in real scenarios. To completely validate network - related algorithms, we developed an extensible control and management plane test - bed, named as iONE, for single layer and multilayer flexgrid-based optical networks. iONE is based on the Applications - Based Network Operations (ABNO) architecture currently under standardization by the IETF. iONE enables deploying and assessing the designed algorithms by defining workflows. This paper presents the iONE test - bed architecture, describe s its components, and experimentally demonstrate s its operation with a specific use-case.Peer ReviewedPostprint (published version

iONE: an environment for experimentally assessing in-operation network planning algorithms

Huge amount of algorithmic research is being done in the field of optical networks, including Routing and Spectrum Allocation (RSA), elastic operations, spectrum defragmentation, and other re-optimization algorithms. Frequently, those algorithms are developed and executed on simulated environments, where many assumptions are done about network control and management issues. Those issues are relevant, since they might prevent algorithms to be deployed in real scenarios. To completely validate network - related algorithms, we developed an extensible control and management plane test - bed, named as iONE, for single layer and multilayer flexgrid-based optical networks. iONE is based on the Applications - Based Network Operations (ABNO) architecture currently under standardization by the IETF. iONE enables deploying and assessing the designed algorithms by defining workflows. This paper presents the iONE test - bed architecture, describe s its components, and experimentally demonstrate s its operation with a specific use-case.Peer Reviewe

Cuadernos sobre salud y buen trato a la infancia y adolescencia en Andalucía

Publicado en la plataforma de la Red Sabia (Red de Salud y Buen Trato a la Infancia y la Adolescencia. http://www.redsabia.org/) de la Consejería de Igualdad, Salud y Políticas SocialesContiene: Cuaderno I: Intervención Integral desde salud ante el maltrato infantil. Enfoque de derechos de la Infancia; y, Cuaderno II: ¿Qué deben saber quienes trabajan en el sistema sanitario sobre el maltrato infantil?YesEstos cuadernos de trabajo sobre salud y buen arato a la infancia en Andalucía tienen por objetivo aportar un enfoque, un método de trabajo y unos instrumentos para mejorar y reforzar la reflexión y la práctica profesional relacionada con la prevención del maltrato infantil y la promoción del buen trato en la atención sanitaria a los niños, niñas y adolescentes, así como un tratamiento integral y de calidad a las víctimas infantiles de cualquier forma de violencia ejercida sobre ellos, siempre en colaboración con aquellas otras instituciones que configuran el sistema de atención a la infancia en Andalucía