Precios y tarifas de servicios públicos: evolución 1945-2018

Este trabajo ensambla un gran base de datos y se inscribe en la larga tradición de elaboración de estadísticas de precios de los servicios públicos en la Argentina y viene así a llenar un vacío al completar series que habían sido oficialmente discontinuadas o abandonadas en la Argentina, extendiéndolas hasta la actualidad. Constituye de este modo una contribución al estudio tarifario para diversos propósitos, incluyendo los de naturaleza histórica porque cubre más de 7 décadas de evidencia empírica. Se presenta una serie de precios y tarifas de servicios públicos y combustibles, con una amplia desagregación, para el período que cubre desde 1945 hasta 2018. El trabajo tiene valor histórico estadístico y provee hechos estilizados que ayudan a entender la morfología de los ciclos tarifarios en la Argentina. Estos comportamientos, tanto en tendencia como en fluctuaciones reales, han sido disimiles entre sectores. Las series tienen en el comienzo y final dos períodos marcados de deterioro real llamados el Gran Deterioro I y II que reflejan intervenciones generalizadas y profundas, en particular el segundo en donde la magnitud de la caída real tendió a sobresalir sobre cualquier impacto diferencial, en los índices que capturan impactos entre grupos de distintos ingresos.This paper assembles a large database and contributes to a long tradition of compiling statistics on prices of public services in Argentina and filling a gap by completing series that had been officially discontinued or abandoned in Argentina, extending them to the present. In this way, it constitutes a contribution to the study of public services prices for various analytical purposes, including those of a historical nature because it covers more than 7 decades of empirical evidence. Prices indexes for public services and fuels are presented, with a wide disaggregation, for the period that covers from 1945 to 2018. The work has historical statistical value and provides stylized facts that help to understand the morphology of the rate cycles in Argentina. This series behavior, both in trend and in real fluctuations, have been dissimilar across sectors. The series have at the beginning and end two marked periods of real deterioration called the Great Deterioration I and II that reflect generalized and profound interventions, in particular the second in which the magnitude of the fall in real terms tended to outweigh any difference in differential impacts, in the indices that capture impacts between different income groups.Facultad de Ciencias Económica

Isotope-coded protein labelling (ICPL) as a tool for the quantitative analysis of a bacterial proteome

Comunicaciones a congreso

Precios de empresas públicas y privatizadas reguladas : Teoría, medición para la Argentina y política económica

El objetivo de este proyecto es estudiar teórica y empíricamente para la Argentina, la problemática de la fijación de precios y tarifas de empresas públicas o privatizadas reguladas. El trabajo documenta la evolución de los precios y tarifas de servicios públicos y combustibles en la Argentina entre 1945 y 2019. Como en otros momentos de la historia estos precios fueron utilizados como instrumentos de política económica con fines estabilización, distribución del ingreso y aliento al crecimiento económico vía mejoras en los costos de las empresas. Se identifican dos periodos de gran deterioro tarifario real: 1945 a 1952 y 2003 a 2015 y varios ciclos tarifarios.Facultad de Ciencias Económica

La expansión de la Mosqueta de Corona Parda Leptopogon amaurocephalus sobre el corredor del Río Uruguay

La Mosqueta de Corona Parda (Leptopogon amaurocephalus) tiene una distribución amplia desde México hasta el norte de Argentina, donde ocupa la provincia de Misiones, el este de Formosa, el norte de Corrientes, y las provincias de Jujuy y Salta (Ridgely & Tudor 2009, de la Peña 2016). En el noreste de nuestro país se la considera una especie frecuente hasta la localidad de Santo Tomé (Darrieu 1987, Capllonch et al. 2005; Fig. 1). Hasta no hace mucho tiempo, la localidad más meridional que se conocía para la Mosqueta de Corona Parda era Yapeyú, en la costa del río Uruguay sobre la provincia de Corrientes (Nores et al. 2005). Recientemente Pagano et al. (2012) mencionaron su presencia en la Reserva Natural Punta Lara (provincia de Buenos Aires) en diferentes meses y con varios años de separación entre observaciones. En esta nota presentamos dos nuevas observaciones de esta mosqueta en la provincia de Buenos Aires, y los primeros registros para el sur de Corrientes y para la provincia de Entre Ríos.Fil: Grilli, Pablo Gervasio. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección Ornitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional Arturo Jauretche; ArgentinaFil: Jensen, Roberto Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología "Dr. Raúl A. Ringuelet". Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Limnología; ArgentinaFil: Ertola Navajas, Silvia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia

Background: Methotrexate (MTX) is an important component of the therapy for childhood acute lymphoblastic leukemia. Treatment with high-dose MTX often causes toxicity, recommending a dose reduction and/or cessation of treatment. Polymorphisms in genes involved in the MTX metabolism have been associated with toxicity with controversial results. The discrepancies could be due to differences in treatment protocols among studies, small, or non-homogeneous populations or the use of different toxicity criteria. The aim of the present study was to analyze the possible correlation of polymorphisms of genes involved in the MTX metabolism with the toxicity during therapy with the well-established LAL/SHOP protocol. Procedure: We analyzed 10 polymorphisms in seven genes (MTHFR, TS, SHMT1, RFC1, ABCB1, ABCG2, and SLCO1B1) from the MTX metabolism in 115 Spanish pediatric B-ALL patients, using MTX plasma concentration as an objective and quantifiable marker of toxicity. Results: We confirmed the suitability of MTX plasma levels as a toxicity marker. We found a statistically significant association between MTX plasma concentration and the SLCO1B1 rs11045879 CC genotype (P = 0.030). The rs4149081 AA genotype, in the same gene, could also be an indicator for high-MTX plasma concentrations. We did not find any significant association in the other genetic polymorphisms analyzed. Conclusions: Identification of the rs4149081 and rs11045879 SLCO1B1 polymorphisms in children with ALL could be a useful tool for monitoring patients at risk of low-MTX clearance in order to avoid MTX-related toxicity.ELL was supported by a predoctoral grant from the Basque Government. This project was supported by RTICS(RD/06/0020/0048) and Basque Government (iT-463-07 and 2006111015)

Effect of unsaturated fatty acid supplementation on digestion, metabolism and nutrient balance in dairy cows during the transition period and early lactation

The objective of this study was to evaluate the influence of unsaturated fatty acids in diets for dairy cows during the transition period and early lactation on intake, digestion and nutrient balance. Thirty-six multiparous and pregnant Holstein cows were randomly distributed to receive one of the experimental diets in the period from 35 days before the expected date of parturition to 84 days post-partum. Diets were fed as a total mixed ration and were as follows: control (C); soybean oil (SO), based on inclusion of 30 g/kg (DM basis); and calcium salts of unsaturated fatty acids (CS), based on inclusion of 30 g/kg (DM basis). Pre-partum dry matter intakes (DMI) of cows fed C, SO and CS were 11.9, 9.5 and 9.6 kg/d, respectively. Postpartum DMI was affected by experimental diets (18.5, 15.0 and 17.4 kg/d for C, SO and CS, respectively). The energy balance in the transition period of animals fed CS was 4.41 Mcal/d higher than cows fed SO and 1.3 Mcal/d higher than cows fed C. Supplementing cows with unsaturated fatty acid sources is a strategy for dairy cows in the transition perio

Bioeconomic evaluation of feeding strategies in milk production systems. 2. Alternative methodology: level of capital utilization

Objetivou-se desenvolver uma metodologia alternativa para avaliação bioeconômica de estratégias de alimentação para rebanhos leiteiros e avaliar a produtividade física e a eficiência bioeconômica de sistemas de alimentação para vacas em lactação quando utilizadas diversas estratégias de alimentação à base de volumosos para vacas de cinco níveis de produção de leite. Utilizou-se uma plataforma computacional desenvolvida com os programas CNCPS v.5.0 e planilhas eletrônicas do Microsoft Excell®, de forma a simular a produção e as exigências de nutrientes ao longo da lactação de uma vaca com cinco níveis de produção de leite. Utilizaram-se a metodologia alternativa "Ajuste para o Nível de Capital", foram observados diversos níveis de utilização de concentrados e capital gasto com alimentação por unidade de área e estimadas equações de regressão da produtividade (PROD/ha) e receita menos os custos com alimentação (LUCR/ha) por hectare, em função destes níveis. Esta metodologia não permitiu que ocorresse utilização de diferentes níveis de insumos e de capital por unidade de área, mesmo quando são avaliadas diferentes estratégias de alimentação. Os resultados obtidos comprovaram diferenças nas avaliações bioeconômicas realizadas pela metodologia "Ajuste para o Nível de Capital" em relação à "Tradicional". De modo geral, principalmente nos maiores níveis de utilização de capital por área, as estratégias baseadas em forragens de melhor qualidade apresentaram resultados superiores na PROD/ha e LUCR/ha. No entanto, nos níveis de menor utilização de capital por área, as estratégias baseadas em forrageiras de alta produtividade por hectare apresentaram melhores resultados nas variáveis analisadasThis work was carried out to development a alternative methodology for the bioeconomic evaluation of feeding strategies for dairy herds and evaluate the physical productivity and the bioeconomic efficiency of feeding systems for dairy cows when different feeding strategies forages based are used for cows of five levels of milk yield. The computational platform was developed with the programs CNCPS v5.0 and electronic spreadsheets of Microsoft Excell®, in way to simulate the production and demands of nutrients of a complete lactation for cows of different milk yield levels. Using the alternative methodology "Adjusts for the Level of Capital", were evaluated different levels of concentrate and capital expense with feeding per area unit and estimate regression equations of productivity (PROD/ha) and income over feed costs (RMCA/ha0 per hectare, in function of these levels. This methodology did not permit the occurrance of the use the different levels of input and capital per unit of area, specifically when are evaluated different feeding strategies. The obtained results showed differences in the bioeconomics evaluations carry out by the "Adjusts for the Level of Capital" methodology in relation to "Traditional" methodology. In general, mainly in the highest levels of use of capital per area, the feeding strategies based on forages of better quality showed the best results in PROD/ha and RMCA/ha. However, in the levels of smaller levels of use of capital per area, the feeding strategies based on forages of high productivity per hectare showed the better results in analyzed variable

Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia

Objectives Methotrexate (MTX) is an important component of therapy for pediatric acute lymphoblastic leukemia (ALL). Treatment with MTX often causes toxicity, which can necessitate dose reduction or treatment cessation. Interindividual differences in adverse reactions can be due to different factors, including polymorphisms in key genes. Recently, we confirmed the association between SLCO1B1 rs11045879 polymorphism and toxicity previously proposed by Treviño and colleagues. As SLCO1B1 is a transporter involved in MTX elimination, other polymorphisms in genes from this pathway could also have a role in MTX toxicity. The aim of the present study was to analyze in depth the role of polymorphisms in the genes of the MTX transport pathway as putative toxicity predictors in pediatric ALL. Methods We analyzed 384 single nucleotide polymorphisms in 12 transporter genes (SLCO1B1, SLCO1B3, SLCO1A2, ABCB1, ABCG2, ABCC1, ABCC2, ABCC3, ABCC4, SLC19A1, SLC22A6 and SLC22A8) and their correlation with different toxicity parameters in 151 pediatric ALL patients treated using the LAL/SHOP protocol. Results A significant association with MTX plasma levels was found for 21 polymorphisms from seven genes and 15 haplotypes. After correction, rs9516519 in ABCC4, rs3740065 in ABCC2, and haplotype GCGGG in ABCC2 remained significantly associated. Conclusion Our results suggest that polymorphisms in ABCC4 and ABCC2 could be novel markers for MTX toxicity in pediatric ALL.This project was supported by RTICC (RD/06/0020/0048), Basque Government (GIC10/71, SAI11/75, SAI10/03), and UPV/EHU (UFI11/35). E.L.L. was supported by a predoctoral grant from the Basque Government

A proteomic analysis of the salmonella RCSCDB system unraveling post.transcriptional regulation of metabolic genes

Comunicaciones a congreso

Arabidopsis responds to Alternaria alternata volatiles by triggering plastid phosphoglucose isomerase-independent mechanisms

Sánchez-López, Ángela María et al.Volatile compounds (VCs) emitted by phylogenetically diverse microorganisms (including plant pathogens and microbes that do not normally interact mutualistically with plants) promote photosynthesis, growth, and the accumulation of high levels of starch in leaves through cytokinin (CK)-regulated processes. In Arabidopsis (Arabidopsis thaliana) plants not exposed to VCs, plastidic phosphoglucose isomerase (pPGI) acts as an important determinant of photosynthesis and growth, likely as a consequence of its involvement in the synthesis of plastidic CKs in roots. Moreover, this enzyme plays an important role in connecting the Calvin-Benson cycle with the starch biosynthetic pathway in leaves. To elucidate the mechanisms involved in the responses of plants to microbial VCs and to investigate the extent of pPGI involvement, we characterized pPGI-null pgi1-2 Arabidopsis plants cultured in the presence or absence of VCs emitted by Alternaria alternata. We found that volatile emissions from this fungal phytopathogen promote growth, photosynthesis, and the accumulation of plastidic CKs in pgi1-2 leaves. Notably, the mesophyll cells of pgi1-2 leaves accumulated exceptionally high levels of starch following VC exposure. Proteomic analyses revealed that VCs promote global changes in the expression of proteins involved in photosynthesis, starch metabolism, and growth that can account for the observed responses in pgi1-2 plants. The overall data show that Arabidopsis plants can respond to VCs emitted by phytopathogenic microorganisms by triggering pPGI-independent mechanisms.This work was supported by the Comisión Interministerial de Ciencia y Tecnología and Fondo Europeo de Desarrollo Regional, Spain (grant nos. BIO2010–18239 and BIO2013–49125–C2–1–P), by the Government of Navarra (grant no. IIM010491.RI1), by the I-Link0939 project from the Ministerio de Economía y Competitividad, by the Ministry of Education, Youth, and Sports of the Czech Republic (grant no. LO1204 from the National Program of Sustainability), by Palacky University institutional support, by predoctoral fellowships from the Spanish Ministry of Science and Innovation (to A.M.S.-L. and P.G.-G.), and by postdoctoral fellowships from the Public University of Navarra (to M.B. and G.A.).Peer Reviewe