1,618 research outputs found

    War on the Wards: The collapse of health care infrastructure resulting from violent conflict

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    Introduction: While utilizing satellite images to verify reports of hospital damage resulting from armed conflict allows for remote assessment, the use of private satellites to gain access to images prohibits widespread use. The questions this study sought to answer were: Is it possible to replicate the findings of previous reports of hospital damage that used the services of private satellite imagery using open source software, such as Google Earth? What variations exist among the different sites where damage to hospitals is visible, and what gradation is possible? Is this methodology applicable to other examples of armed conflict? Methods: Using the map of bombed Syrian hospitals published and maintained by Physicians for Human Rights, hospitals were selected according to their location and the time period of the attack. These coordinates were entered into Google maps and once the attack was verified, a grade of damage was assigned. This methodology was then applied to reports of similar attacks in Iraq. Results: While much information can be gleaned from open source data such as Google Earth, the level of detail in satellite images is lower and coordinates data is less specific. [Further results pending.] Conclusion: There is room for the use of open source satellite technology to track and grade the damage done to health care infrastructure during armed conflict. [More conclusions pending.

    From Scalability to Subsidiarity in Addressing Online Harm

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    Large social media platforms are generally designed for scalability—the ambition to increase in size without a fundamental change in form. This means that to address harm among users, they favor automated moderation wherever possible and typically apply a uniform set of rules. This article contrasts scalability with restorative and transformative justice approaches to harm, which are usually context-sensitive, relational, and individualized. We argue that subsidiarity—the principle that local social units should have meaningful autonomy within larger systems—might foster the balance between context and scale that is needed for improving responses to harm

    The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

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    The widespread use of antibiotics in the past 80 years has saved millions of human lives, facilitated technological progress and killed incalculable numbers of microbes, both pathogenic and commensal. Human-associated microbes perform an array of important functions, and we are now just beginning to understand the ways in which antibiotics have reshaped their ecology and the functional consequences of these changes. Mounting evidence shows that antibiotics influence the function of the immune system, our ability to resist infection, and our capacity for processing food. Therefore, it is now more important than ever to revisit how we use antibiotics. This review summarizes current research on the short-term and long-term consequences of antibiotic use on the human microbiome, from early life to adulthood, and its effect on diseases such as malnutrition, obesity, diabetes, and Clostridium difficile infection. Motivated by the consequences of inappropriate antibiotic use, we explore recent progress in the development of antivirulence approaches for resisting infection while minimizing resistance to therapy. We close the article by discussing probiotics and fecal microbiota transplants, which promise to restore the microbiota after damage of the microbiome. Together, the results of studies in this field emphasize the importance of developing a mechanistic understanding of gut ecology to enable the development of new therapeutic strategies and to rationally limit the use of antibiotic compounds

    Competencies and Experiences Needed by Entry Level International Agricultural Development Practitioners

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    The use of competencies within extension can be an effective way of training and developing extension practitioners (Stone, 1997). In preparation for careers in tomorrow’s agricultural sector, the National Research Council (2009) recognized the need to expose college students to international perspectives. The purpose of this study was to determine the competencies and experiences that entry level agricultural development practitioners need in order to successfully work in an international setting. A modified Delphi method was used to achieve this purpose. A panel of experts in international agricultural development from non–government organizations, government organizations, and academic institutions were selected through snowball sampling (Goodman, 1961). The panelists agreed on 26 competencies and 7 experiences that entry level agricultural development practitioners working internationally should have before entering the profession. The results of this study should be used when planning, designing, and implementing agricultural extension education programs at the university level

    CaBP1 Regulates Both Ca and Ba currents through Ca(v)1.2 (L-type) Calcium Channels

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    Teaching Hidden History: A Case Study of Dialogic Scaffolding in a Hybrid Graduate Course

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    Using an expanded version of Alexander’s (2008) theory of dialogic teaching developed by Rojas-Drummond, Torreblanca, Pedraza, Vélez, and Guzmán (2013), this case study explored how instructors and students in a hybrid graduate course engaged in the process of dialogic teaching and learning (DTL). In particular, we examined the ways in which scaffolding strategies used in the course supported inquiry-based learning. Our findings suggest that instructors and students engaged in all five dimensions of DTL as defined by Rojas-Drummond et al. (2013), and illuminate the ways in which scaffolding can facilitate inquiry-based learning in interdisciplinary instructional settings

    A severe case of Pembrolizumab-induced triad of myasthenic crisis, myocarditis, and anti-SSA myositis

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    A man in his late 70s presented with one week of progressive chest and muscle pain, generalized weakness, and fatigue. He received a single infusion of pembrolizumab three weeks prior as adjuvant immunotherapy for stage IIb malignant melanoma after undergoing wide local surgical excision. He was started on steroids for pembrolizumab-induced myositis and myocarditis. Symptoms progressed to include severe dyspnea, dysphagia and eyelid ptosis requiring tracheostomy and PEG tube placement. Serologic studies ultimately confirmed myasthenia gravis and anti-SSA myositis.  He was emergently treated with plasma exchange, pyridostigmine, Intravenous Immunoglobulin (IVIG) and is making gradual improvement with physical therapy and oral prednisone taper. We report a severe case of Pembrolizumab-induced triad of myasthenic crisis, myocarditis with myositis specific anti-SSA 52kD Ab IgG autoantibody for the first time. More studies are needed to assess the clinical significance and prognostic value of this autoantibody in patients presenting with Pembrolizumab-induced triad
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