Calidad de Vida y Salud Mental en Adultos Adoptados

Ese trabajo analiza el ajuste psicológico y se comprueba un modelo teórico propuesto que relaciona la presencia de síntomas psicopatológicos con una peor calidad de vida relacionada con la salud (CVRS) de adultos adoptados. Participaron 177 adultos jóvenes adoptados (media 27.67 años). Se tomaron medidas de síntomas psicopatológicos (SCL-90), calidad de vida (SF-12), autoestima (RSES) y resiliencia (BRS). El modelo de mediación múltiple resultante indica que además de la relación directa entre psicopatología y CVRS, la resiliencia y la autoestima tienen un efecto amortiguador en esta relación. Como conclusiones, se evidencia el impacto de las dificultades en salud mental en la CVRS de personas adoptadas. La presencia de recursos psicológicos positivos, como resiliencia y autoestima, hace que dimensiones psicopatológicas como ansiedad, depresión, fobias o psicoticismo pierdan valor. Se sugiere incluir programas que potencien la resiliencia como estrategia para mejorar la salud y en los servicios de postadopción

Parental competences in fathers and mothers of very-low-birth-weight preterm infants

Objective: The goal was to analyze parental competences in Spanish families with very-low-birth-weight infants (≤32 weeks and/or less 1500 g) over 18 months of corrected age. Background: Parenting in families of very preterm infants is an interesting focus of research as we advance in the knowledge of how parental competences can have an important impact on child development. Method: Sixty-eight mothers and 56 fathers completed measures of parental competences, sociofamily risk, parental stress, social support, and emotional symptoms. Clinical characteristics and neonatal medical risk data were collected after birth. Statistical analyses were performed to compare parental competences with those of mothers and fathers of non-preterm infants. Generalized estimating equations were used for analysis, adjusted by family unit. Results: Mothers and fathers of preterm infants score higher in most dimensions of parental competences compared to a control group. Focusing on the preterm population, mothers score higher than fathers in daily involvement and mentalization and lower in parental self-care. When studied separately, we found different scores for fathers and mothers in parental competences (sociofamily risk, parental stress, social support, and emotional symptoms). Conclusion: Parents of preterm infants present better parental competences than parents of non-preterm infants when their children reach 18 months of age. It is important to consider the differences in parental competences between the mothers and fathers of these children. Implications: Our findings suggest the need to address parental competences to develop preventive and adaptive strategies in parents of preterm infants to promote positive parenting.This paper is part of the project PID2019‐110484RB‐I00 funded by MCIN/AEI/ 0.13039/501100011033. It was also funded by the 2017 (PI0052/2017) and 2019 (ITI‐0019‐2019) Cadiz‐integrated territorial initiative for biomedical research and the European Regional Development Fund (ERDF) 2014–2020, Andalusian Ministry of Health and Families, Spain. Funding informatio

Universidad y discapacidad. Diagnóstico sobre la inclusión de estudiantes con discapacidad en la Universidad de Córdoba.

El artículo presenta los resultados obtenidos en el primer estudio realizado por la Universidad de Córdoba, a través del Servicio de Atención a la Diversidad, sobre la inclusión de las personas con discapacidad en la comunidad universitaria. En el estudio participaron 81 estudiantes con discapacidad matriculados en la Universidad durante el curso académico 2016/17. Los participantes cumplimentaron el cuestionario (Cunidis-d), el cual recaba básicamente información sobre: adaptaciones curriculares, acción docente, accesibilidad y comunidad universitaria. La presente investigación recoge información valiosa a dos niveles: 1. Características descriptivas de la muestra de estudiantes con discapacidad de la UCO. 2. Tabulación de las opiniones dadas respecto a los grupos temáticos recogidos en el cuestionario.  The present article offers the results of the first study carried out by the University of Cordova, through the office of diversity and inclusion, on the inclusion of persons with disabilities in university. The study involved 81 students with disability enrolled in the University of Cordova during the academic year 2016/17.The participants completed a questionnaire (Cunidis-d), which collects information on curricular adaptations, teaching activity, accessibility and university community. This information is valuable at two levels: 1. descriptive characteristics of the analyzed sample. 2. Tabulation of the opinions according to the thematic groups included in the questionnaire.

Universidad y discapacidad. Diagnóstico sobre la inclusión de estudiantes con discapacidad en la universidad de Córdoba

El artículo presenta los resultados obtenidos en el primer estudio realizado por la Universidad de Córdoba, a través del Servicio de Atención a la Diversidad, sobre la inclusión de las personas con discapacidad en la comunidad universitaria. En el estudio participaron 81 estudiantes con discapacidad matriculados en la Universidad durante el curso académico 2016/17. Los participantes cumplimentaron el cuestionario (Cunidis-d), el cual recaba básicamente información sobre: adaptaciones curriculares, acción docente, accesibilidad y comunidad universitaria. La presente investigación recoge información valiosa a dos niveles: 1. Características descriptivas de la muestra de estudiantes con discapacidad de la UCO. 2. Tabulación de las opiniones dadas respecto a los grupos temáticos recogidos en el cuestionarioThe present article offers the results of the first study carried out by the University of Cordova, through the office of diversity and inclusion, on the inclusion of persons with disabilities in university. The study involved 81 students with disability enrolled in the University of Cordova during the academic year 2016/17.The participants completed a questionnaire (Cunidis-d), which collects information on curricular adaptations, teaching activity, accessibility and university community. This information is valuable at two levels: 1. descriptive characteristics of the analyzed sample. 2. Tabulation of the opinions according to the thematic groups included in the questionnair

Morphofunctional and Molecular Assessment of Nutritional Status in Head and Neck Cancer Patients Undergoing Systemic Treatment: Role of Inflammasome in Clinical Nutrition

Malnutrition in patients with head and neck cancer is frequent, multifactorial and widely associated with clinical evolution and prognosis. Accurate nutritional assessments allow for early identification of patients at risk of malnutrition in order to start nutritional support and prevent sarcopenia. We aimed to perform a novel morphofunctional nutritional evaluation and explore changes in inflammasome-machinery components in 45 patients with head and neck cancer who are undergoing systemic treatment. To this aim, an epidemiological/clinical/anthropometric/biochemical evaluation was performed. Serum RCP, IL6 and molecular expression of inflammasome-components and inflammatory-associated factors (NOD-like-receptors, inflammasome-activation-components, cytokines and inflammation/apoptosis-related components, cell-cycle and DNA-damage regulators) were evaluated in peripheral-blood mononuclear-cells (PBMCs). Clinical-molecular correlations/associations were analyzed. Coherent and complementary information was obtained in the morphofunctional nutritional assessment of the patients when bioimpedance, anthropometric and ultrasound data were analyzed. These factors were also correlated with different biochemical and molecular parameters, revealing the complementary aspect of the whole evaluation. Serum reactive C protein (RCP) and IL6 were the most reliable parameters for determining patients with decreased standardized phase angle, which is associated with increased mortality in patients with solid malignancies. Several inflammasome-components were dysregulated in patients with malnutrition, decreased phase angle and dependency grade or increased circulating inflammation markers. A molecular fingerprint based on gene-expression of certain inflammasome factors (p27/CCL2/ASC) in PBMCs accurately differentiated patients with and without malnutrition. In conclusion, malnutrition induces a profound alteration in the gene-expression pattern of inflammasome-machinery components in PBMCs. A comprehensive nutritional assessment including novel morphofunctional techniques and molecular markers allows a broad characterization of the nutritional status in cancer patients. Profile of certain inflammasome-components should be further studied as potential targets for nutrition-focused treatment strategies in cancer patients

Aprendiendo mucho en muy poco tiempo -SFA y opresión-

Presentamos la experiencia de innovación docente desarrollada en la asignatura de Orientación Psicoeducativa, fundamentada en la metodología de Sensibilización-Formación y Acción. La actividad llevada a cabo ha sido evaluada mostrando como en el periodo de dos semanas los estudiantes han pasado de no saber nada respecto al análisis de un caso de opresión, a organizar debates y adquirir unos conocimientos que los han sorprendido hasta a ellos mismos. Los resultados son analizados desde cómo se mejora la percepción de la opresión, mejora la empatía y el empoderamiento del alumnado.We are introducing an innovative teaching experience developed in the course in Psycho-educational Guidance, based on the methodology of training and awareness-Action. The activity has been carried out showing assessed as in the period of two weeks students have gone from not knowing anything about the analysis of a case of oppression, to organize discussions on it and acquire knowledge that have surprised even themselves. The results are analyzed from how the perception of oppression is improved, enhancing empathy and empowerment of students

ERK5 Is a Major Determinant of Chemical Sarcomagenesis : Implications in Human Pathology

Sarcoma is a heterogeneous group of tumors poorly studied with few therapeutic opportunities. Interestingly, the role of MAPKs still remains unclear in sarcomatous pathology. Here, we describe for the first time the critical role of ERK5 in the biology of soft tissue sarcoma by using in vitro and in vivo approaches in a murine experimental model of chemical sarcomagenesis. Indeed, our observations were extrapolated to a short series of human leiomyosarcoma and rhabdomyosarcomas. Furthermore, transcriptome analysis allows us to demonstrate the critical role of KLF2 in the biological effects of ERK5. Therefore, the data presented here open new windows in the diagnosis and therapy of soft tissue sarcomas. Sarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differentiation, showing an increased expression of ERK5. Indeed, this upregulation was also observed in human sarcomas of muscular origin, such as leiomyosarcoma or rhabdomyosarcoma. Moreover, in cell lines derived from these 3MC-induced tumors, abrogation of Mapk7 expression by using specific shRNAs decreased in vitro growth and colony-forming capacity and led to a marked loss of tumor growth in vivo. In fact, transcriptomic profiling in ERK5 abrogated cell lines by RNAseq showed a deregulated gene expression pattern for key biological processes such as angiogenesis, migration, motility, etc., correlating with a better prognostic in human pathology. Finally, among the various differentially expressed genes, Klf2 is a key mediator of the biological effects of ERK5 as indicated by its specific interference, demonstrating that the ERK5-KLF2 axis is an important determinant of sarcoma biology that should be further studied in human pathology

ERK5 Is a major determinant of chemical sarcomagenesis: implications in human pathology

Sarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differentiation, showing an increased expression of ERK5. Indeed, this upregulation was also observed in human sarcomas of muscular origin, such as leiomyosarcoma or rhabdomyosarcoma. Moreover, in cell lines derived from these 3MC-induced tumors, abrogation of Mapk7 expression by using specific shRNAs decreased in vitro growth and colony-forming capacity and led to a marked loss of tumor growth in vivo. In fact, transcriptomic profiling in ERK5 abrogated cell lines by RNAseq showed a deregulated gene expression pattern for key biological processes such as angiogenesis, migration, motility, etc., correlating with a better prognostic in human pathology. Finally, among the various differentially expressed genes, Klf2 is a key mediator of the biological effects of ERK5 as indicated by its specific interference, demonstrating that the ERK5–KLF2 axis is an important determinant of sarcoma biology that should be further studied in human pathology.This work has been supported with Grant RTI2018-094093-B-I00 funded by MCIN/AEI/10.13039/501100011033, “ERDF A way of making Europe” to RSP. Also supported with funds from Fundación Leticia Castillejo Castillo, Roche España and ACEPAIN to RSP and MJRH. RSP and MJRH’s Research Institute and the work carried out in their laboratory, received partial support from the European Community through the FEDER. JJ and EAL hold a predoctoral research contract cofounded by the European Social Fund and UCLM. OR holds a contract for accessing the Spanish System of Science, Technology, and Innovation (SECTI) funded by the University of Castilla-La Mancha (UCLM) and received partial support from the European Social Fund (FSE) through its Operative Program for Castilla-La Mancha (2007–2013)

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

Different azides and alkynes have been coupled via Cu-catalyzed 1,3-dipolar Huisgen cycloaddition to afford a novel family of N1- and C5-substituted 1,2,3-triazole derivatives that feature the propargylamine group typical of irreversible MAO-B inhibitors at the C4-side chain of the triazole ring. All the synthesized compounds were evaluated against human MAO-A and MAO-B. Structure-activity relationships and molecular modeling were utilized to gain insight into the structural and chemical features that enhance the binding affinity and selectivity between the two enzyme isoforms. Several lead compounds, in terms of potency (submicromolar to low micromolar range), MAO-B selective recognition, and brain permeability, were identified. One of these leads (MAO-B IC50 of 3.54 μM, selectivity MAO-A/MAO-B index of 27.7) was further subjected to reversibility and time-dependence inhibition studies, which disclosed a slow and irreversible inhibition of human MAO-B. Overall, the results support the suitability of the 4-triazolylalkyl propargylamine scaffold for exploring the design of multipotent anti-Alzheimer compounds endowed with irreversible MAO-B inhibitory activity