Massification of the Higher Education as a Way to Individual Subjective Wellbeing

The massification of the university education is inevitable process nowadays. On the one hand it allows solving the problem of knowledge generation and dissemination. On the other hand it helps individuals to achieve the subjective wellbeing, which is based on acquisition of knowledge that is necessary for the professional and individual orientation. In this article authors made an attempt to set tendency between individual's participation in the educational process and the acquisition of wellbeing's state. Taking into account modern trend of continuous education, authors as well suppose the existence of permanent wellbeing state. This statement is partially proven by social surveys and research's data, which has been conducted in Russia, Brazil, South Africa and other countries. Attractiveness and accessibility of education for people from different social groups determine the future level of public education. The rapid technological development of society, accessibility and mass character of educational programs, unconscious strivings of the major part of society to wellbeing must inevitably lead to the growth of average citizen's accomplishment

Effect of the Brown Coal-Based Feed Additive on Poultry Productivity Indicators

This study examined the effect of feed additives based on brown coal on the productivity indicators of laying hens. The Relict A® organo-mineral feed additive for livestock and poultry is a multi-component, gummatized product with a wide range of biological activity, accelerating the growth and development of the animal. Relict A® is an environmentally friendly supplement that does not contain hormones or synthetic compounds. The control group was fed complete feed without additives. The second, third and fourth groups were fed feed containing 0.04%, 0.06% and 0.10% of the studied additives, respectively. The amount of feed for each group of laying hens was strictly normalized in accordance with their age, according to the recommendations for this cross. The use of the Relict A® feed additive in the laying hens’ rations led to an increase in the average number of eggs per laying hen, a decrease in the cost of feed for producing 1 dozen eggs, and a reduction in the time when the poultry reached the peak egg laying intensity. Feeding the additive to laying hens reduced the cost of producing 1 dozen eggs in the experimental groups, and also increased the profitability of chicken eggs in comparison with the control. The best dose was to use 0.06% of Relict A® by weight of the feed. A 26.6% increase in laying hen egg production was found. Keywords: feed additives, laying hens, egg productivity, brown coa

TRADE UNION FACTORS IN THE IMPLEMENTATION OF ENVIRONMENTAL POLICY IN FRAMEWORK WITH THE SDGS, INTERNATIONAL ENVIRONMENTAL AGREEMENTS: THE EXAMPLE OF THE CIS COUNTRIES

The article examines the current trends in the trade union movement in chosen countries, their influence on the formation of the environmental agenda, as well as their ability to adapt the activities of trade unions to new challenges. Based on the example of the Commonwealth of Independent States (CIS) countries the paper explores the role of trade unions in the Sustainable Development Goals (SDGs) achievement. The analytical cut concerns the issues of the environmental component. The issue is considered from the perspective of the international environmental agreements as a tool to achieve such goals (Paris Climate Agreement, UNFCCC, Aarhus Convention). Since the results of the study showed that in the post-Soviet countries labor unions are deprived of a wide range of rights in the field of policy development, certain ways of development, and increasing their role in the context of adjustment to the SDGs in the field of ecology are proposed. This study is of interest to lawyers practicing in several fields at once, as it makes a significant contribution to the science of comparative law from the perspective of considering the relationship between environmental protection law, labor law, international policy, and legal initiatives on the SDGs

Subjective well-being as a result of the realization of projects of the elderly's involvement into the social life

The paper analyses the subjective well-being and Successful Aging concepts. Unbiased analysis of such conditions is rather problematic by virtue of such facts as time-specific emotional state, climate of residence, culture, current developments and etc. The study concludes that there is no correlation between subjective well-being and economic health or objective socioeconomic factors. The subjective well-being is influenced in most cases by subjective factors: one’s health status satisfaction, financial situation, the level of self-reliance or independence, family interaction and other human relations. But the main factor is the recognition of their mission by the elderly which places the faith and hope in their future modeling. Two categories of the elderly are sorted out for the study: the involved and noninvolved in social activity. The research concludes that any formal or informal activity of the elderly is one of the main factors of the successful aging. Pursuit of activities is uncharacteristic for noninvolved in social activity elderly people. The paper analyses the projects organized and implemented by not only the elderly people themselves but also state and social structures.. Conducted analysis indicates that the level of subjective well-being of the two categories of the elderly is increasing as the result of these projects realization

Russian sport economy: challenges and contradictions

The article shows that development of sport tends to be a factor of country competitiveness. Nowadays, there is a need to find new forms and methods of promotion and popularization of physical culture and sport, to create a single sports information space and to provide sports area with more effective management decisions. There were revealed the main challenges in sports area such as the difference of sports facilities in various regions of Russia, the creation of low-budget sports facilities, the development of qualitative modern material and technical base in educational institutions and another issue is qualified personnel training. Methods of achievement of the goals of strategy 2020 are also illustrated in the paper, that is getting large and medium-sized business involved in construction and operation of sports facilities as social one, creation of a single sports information space in order to control the workload of all the sports venues despite the fact of department affiliation

Screening of microorganisms producing biosurfactants from renewable substrates

Biosurfactants are one of the promising biotechnological products applied in agriculture. Their use, however, is currently far from economically viable, due to the expensive feedstock for the growth of microorganisms. The solution to this problem can be to reduce the cost of production by using organic waste as a nutrient substrate. In this study, oil-containing wastes were considered as substrates - waste frying sunflower oil and petroleum-contaminated soil. At the first stage of research, we screened native waste microorganisms capable of synthesizing biosurfactants. As a result of the study, strains with the ability to form biosurfactants were isolated. Six strains (A, B, C, D, E, F) were isolated from waste frying sunflower oil, two strains (A1, B1) were isolated from petroleum-contaminated soil. The highest yield of biosurfactants is typical for strains A and A1 - 0.429 and 0.502 mg ml-1, while the best ratio of biosurfactant mass to cell biomass is typical for strains A1 and E - 0.9 and 0.6. The most effective producer of biosurfactants turned out to be strain E with an emulsifying activity of E24 equal to 80% and a surface tension of the culture liquid of 27.1 mN m-1

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment