Especificidades regionais do desenvolvimento inovador de sistemas socioeconômicos na Federação Russa

The Russian economy has a tendency to slow down and reduce real investment, which hinders the possibility of innovative development. This is largely a consequence of the situation in the credit sector, especially in terms of the practical inaccessibility of Bank lending to small and medium-sized businesses. The objectives of the work are to justify an effective mechanism for increasing the availability of credit resources for small and medium-sized businesses, directly focused on innovation. Overcoming the contradiction between the banks aspiration to commercial profit and ignoring the objective needs of national expanded reproduction, and expanding the availability of Bank lending for the participants of the innovation process at the present stage of Russian development are associated with the effective interaction of the SME Corporation and the banking system in the process of production cooperation. The results of the study can be used to develop new organizational, economic and management mechanisms and tools for financing innovation.La economía rusa tiene una tendencia a desacelerar y reducir la inversión real, lo que dificulta la posibilidad de un desarrollo innovador. Esto es en gran parte consecuencia de la situación en el sector crediticio, especialmente en términos de la inaccesibilidad práctica de los préstamos del Banco a las pequeñas y medianas empresas. Los objetivos del trabajo son justificar un mecanismo eficaz para aumentar la disponibilidad de recursos crediticios para las pequeñas y medianas empresas, centradas directamente en la innovación. Superar la contradicción entre la aspiración de los bancos al beneficio comercial e ignorar las necesidades objetivas de la reproducción ampliada nacional, y ampliar la disponibilidad de préstamos del Banco para los participantes del proceso de innovación en la etapa actual del desarrollo ruso están asociados con la interacción efectiva de la Corporación de PYME y el sistema bancario en el proceso de cooperación productiva. Los resultados del estudio pueden utilizarse para desarrollar nuevos mecanismos y herramientas de organización, económicos y de gestión para financiar la innovación.A economia russa tem a tendência de desacelerar e reduzir o investimento real, o que dificulta a possibilidade de desenvolvimento inovador. Isto é em grande parte uma consequência da situação no sector de crédito, especialmente em termos da inacessibilidade prática dos empréstimos do Banco às pequenas e médias empresas. Os objetivos do trabalho são justificar um mecanismo efetivo para aumentar a disponibilidade de recursos de crédito para pequenas e médias empresas, com foco direto na inovação. Superar a contradição entre o desejo dos bancos para benefício comercial e ignorar as necessidades objectivas da reprodução nacional expandida, e expandir a disponibilidade de empréstimos bancários para os participantes no processo de inovação no atual estágio de desenvolvimento da Rússia estão associados com a interação da SME Corporation e do sistema bancário no processo de cooperação produtiva. Os resultados do estudo podem ser usados para desenvolver novos mecanismos e ferramentas organizacionais, econômicas e de gestão para financiar a inovação

BODIPY–pyrene donor–acceptor sensitizers for triplet–triplet annihilation upconversion: the impact of the BODIPY-core on upconversion efficiency

Triplet–triplet annihilation upconversion (TTA-UC) is an important type of optical process with applications in biophotonics, solar energy harvesting and photochemistry. In most of the TTA-UC systems, the formation of triplet excited states takes place via spin–orbital interactions promoted by heavy atoms. Given the crucial role of heavy atoms (especially noble metals, such as Pd and Pt) in promoting intersystem crossing (ISC) and, therefore, in production of UC luminescence, the feasibility of using more readily available and inexpensive sensitizers without heavy atoms remains a challenge. Here, we investigated sensitization of TTA-UC using BODIPY–pyrene heavy-atom-free donor–acceptor dyads with different numbers of alkyl groups in the BODIPY scaffold. The molecules with four and six alkyl groups are unable to sensitize TTA-UC in the investigated solvents (tetrahydrofuran (THF) and dichloromethane (DCM)) due to negligible ISC. In contrast, the dyad with two methyl groups in the BODIPY scaffold and the dyad with unsubstituted BODIPY demonstrate efficient intersystem crossing (ISC) of 49–58%, resulting in TTA-UC with quantum yields of 4.7% and 6.9%, respectively. The analysis of the elementary steps of the TTA-UC process indicates that heavy-atom-free donor–acceptor dyads are less effective than their noble metal counterparts, but may equal them in the future if the right combination of solvent, donor–acceptor sensitizer structure, and new luminescent molecules as TTA-UC emitters can be found

BODIPY–pyrene donor–acceptor sensitizers for triplet–triplet annihilation upconversion: the impact of the BODIPY-core on upconversion efficiency

Triplet–triplet annihilation upconversion (TTA-UC) is an important type of optical process with applications in biophotonics, solar energy harvesting and photochemistry. In most of the TTA-UC systems, the formation of triplet excited states takes place via spin–orbital interactions promoted by heavy atoms. Given the crucial role of heavy atoms (especially noble metals, such as Pd and Pt) in promoting intersystem crossing (ISC) and, therefore, in production of UC luminescence, the feasibility of using more readily available and inexpensive sensitizers without heavy atoms remains a challenge. Here, we investigated sensitization of TTA-UC using BODIPY–pyrene heavy-atom-free donor–acceptor dyads with different numbers of alkyl groups in the BODIPY scaffold. The molecules with four and six alkyl groups are unable to sensitize TTA-UC in the investigated solvents (tetrahydrofuran (THF) and dichloromethane (DCM)) due to negligible ISC. In contrast, the dyad with two methyl groups in the BODIPY scaffold and the dyad with unsubstituted BODIPY demonstrate efficient intersystem crossing (ISC) of 49–58%, resulting in TTA-UC with quantum yields of 4.7% and 6.9%, respectively. The analysis of the elementary steps of the TTA-UC process indicates that heavy-atom-free donor–acceptor dyads are less effective than their noble metal counterparts, but may equal them in the future if the right combination of solvent, donor–acceptor sensitizer structure, and new luminescent molecules as TTA-UC emitters can be found

Mixed FEM for Shells of Revolution Based on Flow Theory and its Modifications

For describing elastoplastic deformation, three versions of constitutive equations are used. The first version employs the governing equations of the flow theory. In the second version, elastic strain increments are defined the same way as in the flow theory, and the plastic strain increments are expressed in terms of stress increments using the condition of their proportionality to the components of the incremental stress deviator tensor. In the third version, the constitutive equations for a load step were obtained without using the hypothesis of separating strains into the elastic and plastic parts. To obtain them, the condition of proportionality of the components of the incremental strain deviator tensor to the components of the incremental stress deviator tensor was applied. The equations are implemented using a hybrid prismatic finite element with a triangular base. A sample calculation shows the advantage of the third version of the constitutive equations

Towards targeted colorectal cancer biopsy based on tissue morphology assessment by compression optical coherence elastography

Identifying the precise topography of cancer for targeted biopsy in colonoscopic examination is a challenge in current diagnostic practice. For the first time we demonstrate the use of compression optical coherence elastography (C-OCE) technology as a new functional OCT modality for differentiating between cancerous and non-cancerous tissues in colon and detecting their morphological features on the basis of measurement of tissue elastic properties. The method uses pre-determined stiffness values (Young’s modulus) to distinguish between different morphological structures of normal (mucosa and submucosa), benign tumor (adenoma) and malignant tumor tissue (including cancer cells, gland-like structures, cribriform gland-like structures, stromal fibers, extracellular mucin). After analyzing in excess of fifty tissue samples, a threshold stiffness value of 520 kPa was suggested above which areas of colorectal cancer were detected invariably. A high Pearson correlation (r =0.98; p <0.05), and a negligible bias (0.22) by good agreement of the segmentation results of C-OCE and histological (reference standard) images was demonstrated, indicating the efficiency of C-OCE to identify the precise localization of colorectal cancer and the possibility to perform targeted biopsy. Furthermore, we demonstrated the ability of C-OCE to differentiate morphological subtypes of colorectal cancer – low-grade and high-grade colorectal adenocarcinomas, mucinous adenocarcinoma, and cribriform patterns. The obtained ex vivo results highlight prospects of C-OCE for high-level colon malignancy detection. The future endoscopic use of C-OCE will allow targeted biopsy sampling and simultaneous rapid analysis of the heterogeneous morphology of colon tumors

Chronicles of nature calendar, a long-term and large-scale multitaxon database on phenology

We present an extensive, large-scale, long-term and multitaxon database on phenological and climatic variation, involving 506,186 observation dates acquired in 471 localities in Russian Federation, Ukraine, Uzbekistan, Belarus and Kyrgyzstan. The data cover the period 1890-2018, with 96% of the data being from 1960 onwards. The database is rich in plants, birds and climatic events, but also includes insects, amphibians, reptiles and fungi. The database includes multiple events per species, such as the onset days of leaf unfolding and leaf fall for plants, and the days for first spring and last autumn occurrences for birds. The data were acquired using standardized methods by permanent staff of national parks and nature reserves (87% of the data) and members of a phenological observation network (13% of the data). The database is valuable for exploring how species respond in their phenology to climate change. Large-scale analyses of spatial variation in phenological response can help to better predict the consequences of species and community responses to climate change.Peer reviewe

Phenological shifts of abiotic events, producers and consumers across a continent

Ongoing climate change can shift organism phenology in ways that vary depending on species, habitats and climate factors studied. To probe for large-scale patterns in associated phenological change, we use 70,709 observations from six decades of systematic monitoring across the former Union of Soviet Socialist Republics. Among 110 phenological events related to plants, birds, insects, amphibians and fungi, we find a mosaic of change, defying simple predictions of earlier springs, later autumns and stronger changes at higher latitudes and elevations. Site mean temperature emerged as a strong predictor of local phenology, but the magnitude and direction of change varied with trophic level and the relative timing of an event. Beyond temperature-associated variation, we uncover high variation among both sites and years, with some sites being characterized by disproportionately long seasons and others by short ones. Our findings emphasize concerns regarding ecosystem integrity and highlight the difficulty of predicting climate change outcomes. The authors use systematic monitoring across the former USSR to investigate phenological changes across taxa. The long-term mean temperature of a site emerged as a strong predictor of phenological change, with further imprints of trophic level, event timing, site, year and biotic interactions.Peer reviewe

Organizational tools for overcoming the systemic contradictions of innovative development

The article discusses the systemic contradictions of innovative development of the Russian economy, which have proved very difficult to overcome either by market, state/corporate, management tools or planning. The methodological basis of the research is the principles of dialectical logic, which presuppose the consideration of the economy as a multifaceted category with objective and subjective characteristics. As a result, it becomes necessary to form new economic relations corresponding to the challenges of the knowledge economy. In conclusion, the integration of all the requirements is possible only within the framework of conceptualization and effective implementation of a national innovative digital platform

Cdk1 and Okadaic Acid-sensitive Phosphatases Control Assembly of Nuclear Pore Complexes in Drosophila Embryos

Disassembly and reassembly of the nuclear pore complexes (NPCs) is one of the major events during open mitosis in higher eukaryotes. However, how this process is controlled by the mitotic machinery is not clear. To investigate this we developed a novel in vivo model system based on syncytial Drosophila embryos. We microinjected different mitotic effectors into the embryonic cytoplasm and monitored the dynamics of disassembly/reassembly of NPCs in live embryos using fluorescently labeled wheat germ agglutinin (WGA) or in fixed embryos using electron microscopy and immunostaining techniques. We found that in live embryos Cdk1 activity was necessary and sufficient to induce disassembly of NPCs as well as their cytoplasmic mimics: annulate lamellae pore complexes (ALPCs). Cdk1 activity was also required for keeping NPCs and ALPCs disassembled during mitosis. In agreement recombinant Cdk1/cyclin B was able to induce phosphorylation and dissociation of nucleoporins from the NPCs in vitro. Conversely, reassembly of NPCs and ALPCs was dependent on the activity of protein phosphatases, sensitive to okadaic acid (OA). Our findings suggest a model where mitotic disassembly/reassembly of the NPCs is regulated by a dynamic equilibrium of Cdk1 and OA-sensitive phosphatase activities and provide evidence that mitotic phosphorylation mediates disassembly of the NPC