MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

open12siopenAron Badin R.; Bugi A.; Williams S.; Vadori M.; Michael M.; Jan C.; Nassi A.; Lecourtois S.; Blancher A.; Cozzi E.; Hantraye P.; Perrier A.L.Aron Badin, R.; Bugi, A.; Williams, S.; Vadori, M.; Michael, M.; Jan, C.; Nassi, A.; Lecourtois, S.; Blancher, A.; Cozzi, E.; Hantraye, P.; Perrier, A. L

Calculating WCET Estimates from Timed Traces

© The Author(s) 2015. This article is published with open access at Springerlink.comReal-time systems engineers face a daunting duty: They must ensure that each task in their system can always meet its deadline. To analyse schedulability they must know the worst-case execution time (WCET) of each task. However, determining exact WCETs is practically infeasible in cost-constrained industrial settings involving real-life code and COTS hardware. Static analysis tools that could yield sufficiently tight WCET bounds are often unavailable. As a result, interest in portable analysis approaches like measurement-based timing analysis (MBTA) is growing. We present an approach based on integer linear programming (ILP) for calculating a WCET estimate from a given database of timed execution traces. Unlike previous work, our method specifically aims at reducing overestimation, by means of an automatic classification of code executions into scenarios with differing worst-case behaviour. To ease the integration into existing analysis tool chains, our method is based on the implicit path enumeration technique (IPET). It can thus reuse flow facts from other analysis tools and produces ILP problems that can be solved by off-the-shelf solvers.Peer reviewe

Primary follicular and marginal-zone lymphoma of the breast: clinical features, prognostic factors and outcome: a study by the International Extranodal Lymphoma Study Group

Background: Primary breast lymphoma (PBL) of low-grade histology is a rare disease. This multicentric retrospective study was carried out to determine clinical features, prognosis and relapse. Patients and methods: Patients with histologically proven, previously untreated follicular or marginal-zone PBL (MZL PBL) diagnosed from 1980 to 2003 were included in the study. Major end points were progression-free survival (PFS), overall survival (OS) and potential prognostic factors. Results: We collected data on 60 cases of PBL [36 follicular and 24 marginal-zone lymphoma (MZL)]. Stage was IE or IIE in 57 patients and IVE in three patients due to bilateral breast involvement. Surgery, chemotherapy and radiotherapy (RT), alone or in combination, were used as first-line treatments in 67%, 42% and 52% of patients, respectively. Overall response rate was 98%, with a 93% complete response rate. Five-year PFS were 56% for MZL and 49% for follicular PBL (P = 0.62). Relapses were mostly in distant sites (18 of 23 cases); no patients relapsed within RT fields. Conclusions: Our data showed an indolent behaviour of MZL PBL, comparable to other primary extranodal MZL. Conversely, patients with follicular PBL had inferior PFS and OS when compared with limited-stage nodal follicular non-Hodgkin's lymphomas, suggesting an adverse prognostic role of primary breast localisation in this histological subgrou

Articles by Latin American Authors in Prestigious Journals Have Fewer Citations

Background: the journal Impact factor (IF) is generally accepted to be a good measurement of the relevance/quality of articles that a journal publishes. in spite of an, apparently, homogenous peer-review process for a given journal, we hypothesize that the country affiliation of authors from developing Latin American (LA) countries affects the IF of a journal detrimentally.Methodology/Principal Findings: Seven prestigious international journals, one multidisciplinary journal and six serving specific branches of science, were examined in terms of their IF in the Web of Science. Two subsets of each journal were then selected to evaluate the influence of author's affiliation on the IF. They comprised contributions (i) with authorship from four Latin American (LA) countries (Argentina, Brazil, Chile and Mexico) and (ii) with authorship from five developed countries (England, France, Germany, Japan and USA). Both subsets were further subdivided into two groups: articles with authorship from one country only and collaborative articles with authorship from other countries. Articles from the five developed countries had IF close to the overall IF of the journals and the influence of collaboration on this value was minor. in the case of LA articles the effect of collaboration (virtually all with developed countries) was significant. the IFs for non-collaborative articles averaged 66% of the overall IF of the journals whereas the articles in collaboration raised the IFs to values close to the overall IF.Conclusion/Significance: the study shows a significantly lower IF in the group of the subsets of non-collaborative LA articles and thus that country affiliation of authors from non-developed LA countries does affect the IF of a journal detrimentally. There are no data to indicate whether the lower IFs of LA articles were due to their inherent inferior quality/relevance or psycho-social trend towards under-citation of articles from these countries. However, further study is required since there are foreseeable consequences of this trend as it may stimulate strategies by editors to turn down articles that tend to be under-cited.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Latin Amer & Caribbean Ctr Hlth Sci Informat, BIREME PAHO WHO, São Paulo, BrazilUniversidade Federal de São Paulo, DIS Dept Informat Med, São Paulo, BrazilUniversidade Federal de São Paulo, DIS Dept Informat Med, São Paulo, BrazilFAPESP: 05/57665-8CNPq: 2006-0919Web of Scienc