MOÇO, O QUE TEM PRA LER? UM ESTUDO DO ACERVO PARA O PÚBLICO JUVENIL DA BIBLIOTECA PÚBLICA MUNICIPAL ANTÔNIO DIAS ANDRADE (ITABERABA/BA)

This article presents the results of a monographic study whose purpose was to analyze the collection of the Antônio Dias Andrade Municipal Public Library in the municipality of Itaberaba-BA with regard to materials for literary reading and adequacy of works aimed at young readers from Itaberaba. The methodology adopted for this was the documentary analysis of the collection of the library studied through the criteria for the composition of collections in public libraries established by the National Public Library System. The empirical study in question found that the collection aimed at the juvenile public of the Antônio Dias Andrade Municipal Public Library can be characterized as: science fiction, suspense narrative, fantastic elements (categories of collection composition); It has a very diversified collection with regard to literary typologies, namely: reference works, Brazilian literature, foreign literature, special materials, historical-documentary materials, children's literature. However, with regard to the collection aimed at the youth audience, it was noticed that the library is still very lacking in this regard, because when analyzing the entire bibliographic collection, it was observed that the library has only 10 books in its collection that can be categorized as juvenile literature and within other linguistic modalities regarding visual and sound materials, the library has materials that can be used by deaf and blind young people.O presente artigo apresenta os resultados de um estudo monográfico cujo propósito foi analisar o acervo da Biblioteca Pública Municipal Antônio Dias Andrade no que se refere aos materiais para leitura literária e adequação das obras voltadas para os leitores jovens Itaberabenses. A metodologia adotada para tal foi à análise documental do acervo da biblioteca estudada por meio dos critérios para composição de acervos em bibliotecas públicas estabelecidos pelo Sistema Nacional de Biblioteca Pública. O estudo empírico, em questão, constatou que o acervo voltado para o público juvenil da Biblioteca Pública Municipal Antônio Dias Andrade pode ser caracterizado como: ficção científica, narrativa de suspense, elementos fantásticos (categorias de composição de acervo); possui um acervo bem diversificado no que se refere às tipologias literárias, a saber: obras de referência, literatura brasileira, literatura estrangeira, materiais especiais, materiais histórico-documental, literatura infanto-juvenil. Porém, no que se refere ao acervo voltado para o público juvenil, percebeu-se que a biblioteca ainda é muito carente nesse quesito, pois ao analisar todo o acervo bibliográfico observou-se que a biblioteca possui somente 10 livros na sua coleção que podem ser categorizados como literatura juvenil e dentro de outras modalidades linguísticas no que tange a materiais de cunho visual e sonoro a biblioteca tem materiais que podem ser utilizados pelos jovens surdos e cegos

Anaesthetic benefits of a ternary drug delivery system (ropivacaine-in-cyclodextrin-in-liposomes) : in-vitro and in-vivo evaluation

To evaluate whether a ternary system composed of hydroxypropyl-beta-cyclodextrin (HP-beta CD) further encapsulated into egg phosphatidylcholine liposomes (LUV) could prolong the action and reduce the toxicity of ropivacaine (RVC). Dynamic light scattering and NMR were used to characterize the inclusion complex (RVC : HP-beta CD), liposomal (RVC : LUV) and ternary (LUV : RVC : HP-beta CD) systems containing 0.25% RVC. Their encapsulation efficiency, release kinetics, in-vitro cytotoxicity and in-vivo anaesthetic effect (paw-withdraw tests in mice) were also evaluated. Key findings 1 : 1 RVC : HP-beta CD inclusion complex was encapsulated in liposomes (220.2 +/- 20.3 nm size, polydispersity = RVC : HP-beta CD > RVC : LUV. Accordingly, in-vivo sensory block of free RVC (180 min) was prolonged ca. 1.7 times with the ternary system and RVC : HP-beta CD (300 min) and 1.3 times with RVC : LUV (240 min). These results confirm the suitability of this double-carrier system in clinical practice, to decrease the toxicity and prolong the anaesthesia time evoked by RVC723396408CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP309625/2017314/14457-

INFLUÊNCIA DA REFRIGERAÇÃO NA PRESERVAÇÃO DO NÚMERO TOTAL DE HEMÓCITOS DE CAMARÕES MARINHOS Litopenaeus vannamei CULTIVADOS UTILIZANDO-SE CITRATO DE SÓDIO

For carrying out blood cell count, the use anti-coagulants is necessary, and in the specific case of the hemolymph in shrimp, there is still no standard solution to avoid its coagulation. Sodium citrate is frequently used as anti-coagulant, because it has been previously proven to be efficient in the preservation of the hemocytes of the sea shrimp Litopenaeus vannamei. In 140 samples of hemolymph with sodium citrate (10%) in the ratio of 1:1, collected at 2 stages of cultivation, in dry and wet season, were examined for HTC immediately after collection and then again after storage in the refrigerator. All data were analyzed using modeling mathematics formulas (P < 0.05). After storage in the refrigerator, the number of cells decreased considerably. Therefore, the anticoagulant sodium citrate only preserved the hemolymph of the shrimp Litopenaeus vannamei for HTC when the count was done immediately after collection

Excipient-excipient interactions in the development of nanocarriers: an innovative statistical approach for formulation decisions

Excipient interaction has become essential knowledge for rational formulation design of nanoparticles. Nanostructured lipid carriers (NLCs) include at least three types of excipient, which enhance excipient interaction possibilities and relevance. The present article introduces an alternative approach for evaluating a great number of excipients with few samples, using NLC as a model delivery system. This approach is based on two sequential experiments using Hall-2 experimental design and analysis of excipient interactions in respect to their physicochemical properties by multilevel statistics. NLCs were prepared using a hot emulsification-ultrasonication method with lidocaine and nine excipients (solid lipids, oils and surfactants). The evaluated parameters were z-average size (DLS), dispersity (DLS), zeta potential (electrophoretic mobility) and entrapment efficiency (HPLC). Cetyl palmitate, beeswax, castor oil, capric/caprylic acid and polysorbate 80 all presented larger effects amongst the studied factors as well as a clear pattern of synergistic interactions. Following the verified trends, we produced an optimized NLC that exhibited all desirable physicochemical characteristics and a modified drug release profile. Our results demonstrate the methodology's robustness, which can be applied to other nanoparticles and establish a cost-effective excipient evaluation9CAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível SuperiorFAPESP – Fundação de Amparo à Pesquisa Do Estado De São PauloSem informação14/14457-